10 research outputs found
Relationship between the expression of cyclooxygenase 2 and MDR1/P-glycoprotein in invasive breast cancers and their prognostic significance
- Author
- A Goldhirsch
- A Jemal
- A Kanzaki
- A RistimÀki
- A RistimÀki
- Andrzej Wojnar
- C Denkert
- C Denkert
- C Denkert
- C Denkert
- Carsten Denkert
- CW Elston
- D Ratnasinghe
- DA Decker
- E Hennequin
- G Davies
- G Gasparini
- G Nardone
- H Lage
- H Lage
- Hermann Lage
- I Mori
- Jan Kornafel
- K Nooter
- Katarzyna Szczuraszek
- LH Sobin
- Maciej Zabel
- Manfred Dietel
- Marek Pudelko
- MM Gottesman
- P Eifel
- Pawel Surowiak
- PL Fitzgibbons
- Rafal Matkowski
- RW Brueggemeier
- SC Linn
- SS Sun
- V Materna
- VA Patel
- Verena Materna
- W Remmele
- WT Beck
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity
- Author
- A. Abraheem
- A. Agasou
- A. Ahmed
- A. Ali
- A. Allan
- A. Altabaibeh
- A. Alvaro
- A. Aspinwall
- A. Ayers
- A. Bamford
- A. Barron
- A. Bashyal
- A. Bellini
- A. Bociek
- A. Botello
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- A. Brayne
- A. Brown
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- A. Carter
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- A. Cowton
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- A. Daniels
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- A. E. Heron
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- A. Easthorpe
- A. Evans.
- A. Fofano
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- Maciej Bura
- Maddalena Fratelli
- Magdalena Niemira
- Magdalena Ochab
- Malak Abedalthagafi Manal Alaamery
- Malcolm G. Semple
- Manola Pisani
- Manu Shankar-Hari
- Marc M. Berger
- Marcello Maffezzoni
- Marcin Moniuszko
- Marco Castori
- Marco Falcone
- Marco Feri
- Marco Gori
- Marco MandalaÌ
- Marco Rizzi
- Marco Tanfoni
- Marco Vecchia
- Margherita Baldassarri
- Mari Ward
- Maria Antonietta Mazzei
- Maria Antonietta Mencarelli
- Maria Bandini
- Maria Lorubbio
- Maria Palmieri
- Maria Teresa La Rovere
- Marie Zechner
- Marie Zechner
- Mario Capasso
- Mario Tumbarello
- Mario U. Mondelli
- Markus M. NoÌthen
- Marta Colaneri
- Marta Corridi
- Mary Ann Belli
- Massimiliano Fabbiani
- Massimo Antonio Di Pietro
- Massimo Carella
- Massimo Girardis
- Massimo Vaghi
- Matteo Bassetti
- Matteo Della Monica
- Matteo Siano
- Maurizio Bussotti
- Maurizio Sanarico
- Maurizio Sanguinetti
- Maurizio Spagnesi
- Max Head Fourman
- Max Head Fourman
- Melania Degli Antoni
- MeneÌ Roberto
- Michael HultstroÌm
- Michael HultstroÌm
- Miklos Lipcsey
- MikloÌs Lipcsey
- Mirco Lenzi
- Mirella Bruttini
- Miriam Lucia Carriero
- Miriana DâAlessandro
- Mirjam Lista
- Miroslaw Czuczwar
- MirosĆaw Kwasniewski
- Mohamed Fawzy
- Moneera Alsuwailm
- Monika Pazgan-Simon
- N. Ahmad
- N. Bandla
- N. Baxter
- N. Bhatia
- N. Boyle
- N. Capps
- N. Clarke
- N. Crisp
- N. Davidson
- N. Dormand
- N. Grau
- N. Harris
- N. Jacques
- N. Keenan
- N. Lancaster
- N. Love
- N. MacCallum
- N. Michalak-Glinska
- N. Motherwell
- N. Muchenje
- N. Nikitas
- N. Pathan
- N. Pattison
- N. Proudfoot
- N. Rea
- N. Richardson
- N. Rodden
- N. Roe
- N. Rogers
- N. Runciman
- N. Schumacher
- N. Schunki
- N. Slawson
- N. Staines
- N. Thomson
- N. Truman
- N. White
- Nicholas Parkinson
- Nick Parkinson
- Nicky Day
- Nicola Picchiotti
- Nicolas Casadei
- Nicole Ludwig
- Nora Aljawini
- O. Adanini
- O. Akinkugbe
- O. Ezeobu
- O. Hamilton
- O. Jones
- O. Kelsall
- O. Mercer
- O. Mitchelmore
- O. Olufuwa
- O. Prysyazhna
- O. Zongo
- Olaf H. Riess
- Oliver Witzke
- Oreste De Vivo
- P. Alexander
- P. Anderson
- P. Austin
- P. Bamford
- P. Barry
- P. Boyle
- P. Clark
- P. Coghlan
- P. Doble
- P. Donnison
- P. Ebano
- P. Gondo
- P. Grant
- P. Harding
- P. Henderson
- P. Hutton
- P. Jackson
- P. MacGoey
- P. May
- P. McConnell
- P. Mercer
- P. OâBrien
- P. OâNeil
- P. Parkinson
- P. Parsons
- P. Paul
- P. Polgarova
- P. Ranga
- P. Rice
- P. Rogers
- P. Saunderson
- P. Shanmugasundaram
- P. Springle
- P. Szedlak
- P. Turner
- P. Williams
- Pamela Raggi
- Paola Bergomi
- Paola Petrocelli
- Paolo Cameli
- Paolo Piacentini
- Patrizia Casprini
- Patrizia Zucchi
- Paul Finernan
- PaweĆ Olszewski
- Peter J. M. Openshaw
- Pier Giorgio Scotton
- Pierpaolo Parravicini
- Pietro Pinoli
- Piotr Wasilewski
- R. Astin-Chamberlain
- R. Barber
- R. Baruah
- R. Bi
- R. Bolton
- R. Bowles
- R. Boyle
- R. Bradley
- R. Campbell
- R. Campbell
- R. Chan
- R. Charlesworth
- R. Clark
- R. Crawley
- R. Crowe
- R. Cusack
- R. Davies
- R. Doonan
- R. Flanagan
- R. Gascoyne
- R. Girach
- R. Gomez
- R. Griffiths
- R. Hall
- R. Hamill
- R. Haque
- R. Harford
- R. Harper
- R. Herdman-Grant
- R. Howle
- R. Jacob
- R. Jha
- R. Johnson
- R. Jones
- R. Joy
- R. Kanu
- R. Kapoor
- R. Kausar
- R. Khade
- R. Kitson
- R. Kumar
- R. Lean
- R. Lim
- R. Loosley
- R. M. Genetu
- R. Marshall
- R. OâLeary
- R. Parasomthy
- R. Parker
- R. Partridge
- R. Penn
- R. Pepermans Saluzzio
- R. Pollard
- R. Price
- R. Prout
- R. Pugh
- R. Raobaikady
- R. Reece-Anthony
- R. Rikunenko
- R. Rojo
- R. Saha
- R. Sandu
- R. Shaw
- R. Shokkar
- R. Simms
- R. Stead
- R. Stewart
- R. Sundaram
- R. Tully
- R. Tutton
- R. Vincent
- R. Walker
- R. Wilcox
- R. Wolf-Roberts
- R. Worner
- R. Wulandari
- Rachel Law
- Radja Badji
- Raffaele Bruno
- Raffaele Scala
- Ranran Zhai
- Regina Podlasin
- Renzo Scaggiante
- Riccardo Colombo
- Richard Clark
- Rita Perna
- Robert Bals
- Robert Flisiak
- Robert Frithiof
- Robert Frithiof
- Roberta Russo
- Rosangela Artuso
- Ross Hendry
- Rossella Tita
- Ruth Armstrong
- S. Agrawal
- S. Allen
- S. Allibone
- S. Anderson
- S. Archer
- S. Bano
- S. Bean
- S. Beavis
- S. Bell
- S. Bennett
- S. Benyon
- S. Bird
- S. Blowes
- S. Board
- S. Bonner
- S. Buckley
- S. Campos
- S. Cathcart
- S. Chapman
- S. Charlton
- S. Cherian
- S. Chukkambotla
- S. Clamp
- S. Clark
- S. Clements
- S. Coetzee
- S. Cole
- S. Cornell
- S. Cutler
- S. Dale
- S. Donlon
- S. Farnell-Ward
- S. Fowler
- S. Garrioch
- S. Gibson
- S. Gopal
- S. Gurung Rai
- S. Henderson
- S. Hierons
- S. Hope
- S. Humphreys
- S. Hussain
- S. Jenkins
- S. Jhanji
- S. Jones
- S. Jose
- S. Joseph
- S. Kaul
- S. Keenan
- S. Keith
- S. Kennedy-Hay
- S. Kimber
- S. Kumar
- S. Latham
- S. Leaver
- S. Lee
- S. Leggett
- S. MacFadyen
- S. Manna
- S. Marriott
- S. Masuko
- S. McIvor
- S. McKechnie
- S. Mellor
- S. Mepham
- S. Metherell
- S. Mitchard
- S. Mohamed Ally
- S. Monnery
- S. Moore
- S. Morrison
- S. Moultrie
- S. Mtuwa
- S. Mulla
- S. Munt
- S. Murdoch
- S. OâSullivan
- S. Packham
- S. Patch
- S. Pearson
- S. Pitts
- S. Preston
- S. Purvis
- S. Quaid
- S. Ray
- S. Roche
- S. Rose
- S. Rundell
- S. Salmi
- S. Sathe
- S. Selvanayagam
- S. Shelton
- S. Shepardson
- S. Siddiqui
- S. Sousa Arias
- S. Spencer
- S. Srikaran
- S. Stone
- S. Swann
- S. Tilbey
- S. Turki
- S. Turney
- S. Twiss
- S. Wadd
- S. Whiteley
- S. Williams
- S. Wood
- S. Yussuf
- Sabino Scolletta
- Sabrina Ravaglia
- Said I. Ismail
- Salam Massadeh
- Sandra Uszok
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara Bulow Anderberg
- Sara Clohisey
- Sara Clohisey
- Sara Clohisey Peter Horby
- Sara Modica
- Sarah Galien
- Sarah Iacopini
- Sarah Law
- Sarah McCafferty
- Sauro Luchi
- Saverio Giuseppe Parisi
- Selina Rolker
- Serafina Valente
- Serena Ludovisi
- Serghei Mangul
- Sergio Daga
- Silvia Baroni
- Silvia Cappelli
- Simona Dei
- Simona Marcantonio
- Simona Sarzi-Braga
- Simone Furini
- Slawomir Czaban
- SMelling
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Busani
- Stefano Ceri
- Stefano Rusconi
- Sten Rubertsson
- Stephan Ossowski
- Susan Walker
- Susanna Croci
- Susanna Guerrini
- SĆawomir Pancewicz
- T. Anderson
- T. Arden
- T. Baird
- T. Behan
- T. Bemand
- T. Cosier
- T. Coventry
- T. Duncan
- T. Felton
- T. Geary
- T. Hazleton
- T. Joefield
- T. Kannan
- T. Marsden
- T. Martin
- T. McHugh
- T. Newman
- T. Nortcliffe
- T. O. Jones
- T. Pogreban
- T. Rees
- T. Samakomva
- T. Smith
- T. Smith
- T. Szakmany
- T. Varghes
- T. Williams
- T. Wood
- Tammy Gilchrist
- Thorsten Brenner
- Tim Walsh
- Tiziana Bachetti
- Tomas Luther
- Tommaso Matucci
- Tony Wackett
- Torsten Feldt
- Trevor Paterson
- Tullio Trotta
- U. Poultney
- Ulrike Protzer
- Umberto Zuccon
- Urszula Korotko
- Urszula Lechowicz
- Urszula Polowianiuk
- V. Amin
- V. Anumakonda
- V. Bastion
- V. Cannons
- V. Crickmore
- V. Gopal
- V. Irvine
- V. Kasipandian
- V. Krishnamurthy
- V. Lake
- V. Linnett
- V. Martinson
- V. Nagarajan
- V. Page
- V. Parris
- V. Parris
- V. Pristopan
- V. Ratnam
- V. Riversâ
- V. Sarathy
- V. Thomas
- V. Thwaites
- V. Tuckey
- V. Turner
- V. Wagstaff
- V. Waugh
- Valentina Anemoli
- Valentina Borgo
- Valentina Perticaroli
- Verena Keitel
- Veronique Vitart
- W. Harrison
- W. Khaliq
- W. Khaliq
- W. McCormick
- W. Woodyatt
- Wadha Al-Muftah
- WES/WGS Working Group Within the HGI
- Wiktoria Izdebska
- Wilna Oosthuyzen
- X. Qiu
- Xia Shen
- Y. Baird
- Y. Choudhury
- Y. Hussain
- Y. Jackson
- Y. Thirlwall
- Yanara Marincevic-Zuniga
- Yang Wu
- Yaser Al-Sarraj
- Z. Alldis
- Z. Belagodu
- Z. Bradshaw
- Z. Coton
- Z. Daly
- Z. Farzad
- Z. Fernandez
- Z. Garland
- Z. Maqsood
- Z. Omar
- Z. Prime
- Z. Scott
- Zhijian Yang
- Publication venue
- Publication date
- 01/01/2022
- Field of study
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)
Antigens derived from the mucin MUC1 : Solution and solid-phase synthesis of saccharides, peptides and glycopeptides
- Author
- Publication venue
- UmeÄ : Kemi
- Publication date
- 01/01/2008
- Field of study
Mucin is a term used to describe a large family of heavily glycosylated proteins which are present on the surfaces of secretory epithelial cells and are overexpressed by many carcinomas. Membrane-bound mucin MUC1 is of special interest. Its backbone consists of repeating units of twenty amino acids with five potential glycosylation sites. These sites are expanded to structures like the T (GalÎČ(1->3)GalNAcα-Ser/Thr) and Tn (GalNAcα-Ser/Thr) antigens by the action of various glycosyltransferases. In different types of carcinomas these epitopes are being terminated by sialic acid residues to form among others: 2,3-sialyl-T and sialyl-Tn structures due to the elevated levels of different sialyltransferases. Solid-phase synthesis of the selected antigens derived from the mucin MUC1 has been developed and optimized. A chemoenzymatic approach has been used to effectively prepare 2,3-sialyl-T and 2,6-sialyl-Tn glycopeptides. The formation of intramolecular sialic acid lactones in presence of acetic acid was investigated. The stability of lactones formed from 2,3-sialyl-T towards water was studied using NMR spectroscopy and it appeared that 1''->2' lactone displayed remarkable strength to hydrolysis and it was suggested as a candidate for cancer vaccine. Gel-phase 19F NMR spectroscopy is known to be a very good tool to characterize resin-bound products using fluorinated protecting groups and linker molecules. The hydrophobic peptide LLLLTVLTV, which is a fragment from the MUC1 signal sequence, was prepared using solid-phase synthesis according to a modified Fmoc protocol with more active coupling reagent, stronger base, and the isopropylidene dipeptide Fmoc-Leu-Thr-(ΚMe,Mepro)-OH. Gel-phase 19F NMR spectroscopy was used to evaluate peptide chain aggregation and coupling and deprotection efficiency. A carbamate linker strategy proved to be effective in solid-phase synthesis of serine-based neoglycolipids with terminal amino functionality. Neoglycolipids were covalently bound to secondary amines in microtiter plates using squaric acid ester methodology. These arrays have potential to study the interactions between carbohydrates and e.g. proteins and microbes. The new fluorinated α-amino protective group [1-(4-(4-fluorophenyl)-2,6-dioxocyclohexylidene)ethyl] Fde was developed. This group is cleaved with hydrazine in DMF solution. By using amino acids protected with this group, it was possible to quantify the efficiency of peptide coupling using gel-phase 19F NMR spectroscopy
Synthesis of orthogonally protected 2,6âdiazaspiro[3.5]nonane and 2,6-diazaspiro[3.4]octane analogs as versatile building blocks in medicinal chemistry
- Publication venue
- Publication date
- 01/01/2015
- Field of study
A detailed synthesis of spirocyclic amine analogs is described for the first tim
Formation of lactones from sialylated MUC1 glycopeptides
- Author
- Acquotti
- Anna Lindgren
- Bernatowicz
- Blixt
- Boons
- Bothner-By
- Braunschweiler
- Brocke
- Brocke
- Brockhausen
- Broddefalk
- Bubb
- Celso A. Reis
- Danishefsky
- Danishefsky
- Ding
- Dziadek
- Elofsson
- Ernst
- Flegel
- Fronza
- Gendler
- George
- Gobom
- Hanisch
- Jan Kihlberg
- Kay
- Kim
- Kirschner
- Kurosawa
- Lee
- Maciej Pudelko
- Marcos
- Mathieux
- Mikael Elofsson
- Nakahara
- Nicolaou
- Norberg
- Nores
- Ragupathi
- Rance
- Ray
- Rink
- Schwardt
- Sjölin
- Sprengard
- Stahl
- Takano
- Taylor-Papadimitriou
- Taylor-Papadimitriou
- Terabayashi
- Tobias Tengel
- Toyokuni
- Unverzagt
- Wilstermann
- Wilstermann
- Wishart
- Xia
- Yu
- Publication venue
- 'Royal Society of Chemistry (RSC)'
- Publication date
- 01/01/2006
- Field of study
Association between self-reported functional capacity and general postoperative complications: analysis of predefined outcomes of the MET-REPAIR international cohort study
- Author
- Afonso Diana
- Albrecht Svenja
- Alexis Alexandros
- Andreeva Antonia
- Arabadzhieva Daniela
- Arun Oguzhan
- Ayuso Mercedes
- Bacer Barbara
- Bacuzzi Alessandro
- Barisin Stjepan
- Barrio Javier
- Basso Morena
- Becerra-BolanÌos AÌngel
- Beck-Schimmer Beatrice
- Bellissima Agrippino
- Belskii Vladislav
- Bergmann Lars
- Bignami Elena
- Bischoff Petra
- Boix EstefaniÌa
- Bolliger Daniel
- Bona Francesco
- Bonnet Jean François
- Bossolasco Matteo
- Bubenek-Turconi Serban
- Buggy Donal J.
- Cabral Luis
- Calleja Paul
- Carollo Melissa
- CarraminÌana Albert
- CarraÌo AndreÌ
- Castella Alberto
- Chalkias Athanasios
- Chammartin FreÌdeÌrique
- Chew Michelle
- Chiumello Davide
- CiÌndea Iulia
- Coca-Martinez Miquel
- Coelho Miguel
- Copotoiu Sanda-Maria
- Corneci Dan
- Cortegiani Andrea
- Cotoia Antonella
- Crisman Marco
- Cusack Barbara
- Czajka Szymon
- De Baerdemaeker Luc
- De Giorgi Francesco
- De Hert Stefan
- Des Deserts Marc Danguy
- Dilmen Ozlem Korkmaz
- Dincer Muserref Beril
- Dirzu Dan Sebastian
- Djurdjevic Mirjana
- Donald de Boer Hans
- Drummond Andrew
- Ducrocq Nicolas
- Ekmekçi Perihan
- Enlund Anna
- Epema Anne
- Erkoc Suheyla Karadag
- Espeter Florian
- Federico Antonio
- Filipovic Miodrag
- Fleischmann Edith
- Font Anna Peig
- ForeÌs MariÌa Isabel
- Gajdosz Anna
- Ganter Michael Thomas
- Gehrke Christian
- Gerber Thomas Jan
- Gil SaÌnchez JoseÌ Maria
- Gillmann Hans-JoÌrg
- Goettel Nicolai
- GolubovicÌ Mladjan
- GonzaÌlez Astrid Batalla
- Grape Sina
- Gritsan Alexey
- Gupta Anil
- Guzzetti Luca
- HageboÌlling Friederike
- Hasani Antigona
- Hazen Yannick
- HipoÌlito Carla
- Hollmann Markus W.
- Howell Simon J.
- Huhn Ragnar
- Innes Richard
- Ionescu Daniela
- Jackson Matthew
- Jonikaite Lina
- Kalman Sigridur
- Kamber Firmin
- Karolak Igor
- Kaznacheeva Kseniya
- Kemper Johann
- Khoronenko Viktoria E.
- Klemann Anna Katharina
- Kluzik Anna
- Knock James
- Kohaupt Lena
- Koltka Ahmet Kemalettin
- Koopman Seppe
- Koszel Tomasz
- Kotfis Katarzyna
- Kotzinger Oskar
- Kowark Ana
- Kramer Mira
- Krzych Lukasz
- Kubisz-Pudelko Agnieszka
- Kuzmanovska Biljana
- Lagarto Filipa
- Larmann Jan
- Latham Scott
- LatisÌŠ Mihai Dan
- Lopez Maria Bermudez
- Lurati Buse Giovanna
- M'Pembele ReneÌ
- M'Pembele ReneÌ
- Madhuri Thumuluru Kavitha
- Malinovska-Nikolovska Liljana
- Marchand Bahareh
- Marco Gregorio
- Margarit Simona
- Matute PurificacioÌn
- Mauermann Eckhard
- Meco Basak Ceyda
- Meier Sonja
- Mirabella Lucia
- Moise Alida
- Moppett Iain
- Morrison Stuart
- MouraÌo Joana
- MunÌoz Enrique Alday
- Nallbani Rajmonda
- Neumann Claudia
- Nienhaus Johannes
- Nienhaus Johannes
- Novazzi Cecilia
- Nuth Sandra
- Olivares Mercedes Cabellos
- Oprea Ioana Sorina
- Ott Klaus
- Ovezov Alexey
- Ozcelik Menekse
- PabjanÌczyk Izabela
- Perdomo Juan Manuel
- Petre Bogdan Sorel
- Piazza Ornella
- Piekarski Florian
- Pinto Bernardo Bollen
- Pinto Rita
- Pirzer Raphael
- Poredos Peter
- Preckel Benedikt
- Pregernig Andreas
- Rach Patric Rene
- Ragazzi Riccardo
- Ramos Cristina
- Ramsden Fiona
- Rekatsina Martina
- Reschreiter Henrik
- Rex Steffen
- Ribeiro Daniel
- RodriÌguez-PeÌrez Aurelio
- Roth Sebastian
- Roth Sebastian
- Rueffert Henrik
- Russe Benedikt
- Santos Julia Hernando
- Santos Nuno
- Saracoglu Kemal Tolga
- Schening Anna
- Schneebeli Daniela
- Schubert Ann-Kristin
- Schultze Cornelia
- Seeberger Esther
- ServeÌn Marta GineÌ
- Short Anthony
- Soler Anna Artigas
- Solmaz Filiz Alkaya
- Spadaro Savino
- Sponholz Christoph
- Spyraki Maria
- Stroda Alexandra
- Stroeder Jakob
- StudzinÌska Dorota
- Szczeklik Wojciech
- Tenge Theresa
- Tesoro Simonetta
- Theodoraki Kassiani
- Tomala Simon
- Tomescu Dana
- Toninelli Arturo
- Toso Fiorenza
- Tsaousi Georgia
- Turhan Sanem C.
- Tuzhikov Michael
- Unic-Stojanovic Dragana
- Unterberg Matthias
- Valeanu Liana
- Van Lier Felix
- van Waes Judith
- Vasian Horatiu
- Vasilaki Maria
- Verbarg Nele
- Vernetta Diana
- Vetrugno Luigi
- Volta Carlo Alberto
- Walker James
- Wallden Jakob
- Wanner Patrick Mark
- Weigand Markus A.
- White Louise
- Witzler Jette
- Wulf Hinnerk
- Zaimi Donika
- Zarbock Alexander
- Zegan-BaranÌska MaĆgorzata
- Zenha SeÌrgio
- ZÌukowski Maciej
- Publication venue
- Publication date
- 06/02/2024
- Field of study
Management and outcomes in critically ill nonagenarian versus octogenarian patients
- Author
- Aguilar Gerardo
- Ahmed Hazem
- Aidoni Zoi
- Aikaterini Kounougeri
- AllgÀuer Sebastian
- Andersen Finn H.
- Andersen Finn H.
- Artigas Antonio
- Baird Yolanda
- Balasubramaniam Madhu
- Ball Jonathan
- Barros InĂȘs
- Barth Eberhard
- Bastiansen Anders
- Belkhair Wesal Ali
- Bell Louise
- Belskiy Vladislav
- Berkius Johan
- Besch Guillaume
- Biernacka Aleksandra
- Blanco Jacobo Bacariza
- Bolger Clare
- Boroli Filippo
- Boulanger Carole
- Boulanger Carole
- Boumendil Ariane
- Breidablik Alena Breidablik Alena
- Brorsson Camilla
- Bruno Raphael Romano
- Bruno Raphael Romano
- Brusa Stefania
- Burtin Philippe
- Buysscher Pieter De
- Calamai Italo
- Candeias Nuno
- Carvalho JoĂŁo Teles
- Castanera Jeremy
- Catorze Nuno
- Cecconi Maurizio
- Chagnon Jean-Luc
- Charron Cyril
- Christensen Steffen
- Cilloniz Catia
- Collins Amy
- Cornet Alexander D.
- Cracchiolo Andrea Neville
- Cramer Christine
- Cubero Patricia Jimeno
- Cupitt Jason
- Cwyl Katarzyna
- Cyrankiewicz Waldemar
- Czuczwar Miroslaw
- Dahle BĂ„rd E. S.
- De Geer Lina
- De Gordoa Laura Ortiz-Ruiz
- de Jager Peter
- De Lange Dylan W.
- De Lange Dylan W.
- de Neve Nikolaas
- Dieck Thorben
- Dieperink Willem
- Djibré Michel
- Dormans Tom
- Dowling Susan
- Dubler Simon
- Ebelt Henning
- Eckert Philippe
- Eixarch Gaspar
- Elhadi Ahmed
- Elhadi Muhammed
- Elkmann Thomas
- Eller Philipp
- Enevoldsen Mathilde Hummelmose
- Evans Jane
- Faraldi Loredana
- Faulkner Maria
- Fernandes Pinto Alexandre
- Fernandes Ana Margarida
- FernĂĄndez NoemĂ Llamas
- Ferreira Isabel Amorim
- Filipe Helder
- Finazzi Stefano
- FjĂžlner Jesper
- Flaatten Hans
- Flioni Elli Niki
- Franz Marcus
- Frey Christian
- Fuest Kristina
- Galbois Arnaud
- Galkin Piotr
- Garcon Pierre
- Gawda Ryszard
- Gerritsen Rik T.
- Gola Wojciech
- Gommers Diederik
- GomĂ Gemma
- Graf Tobias
- Grecu Irina
- Guerot Emmanuel
- Guidet Bertrand
- Guidet Bertrand
- Haas Lenneke
- Hahn Michael
- Haringman Jasper
- Hart Ciaran
- Helbok Raimund
- Henning Jeremy
- Hergafi Leila
- Hoiting Oscar
- Horacek Michael
- Hovaere Maud Mousset
- Humphreys Sally
- Husted Andreas
- Hymczak Hubert
- Innes Richard
- Jacob Reni
- Jaimes MariĂĄn IrazĂĄbal
- Jannestad Bente
- Jensen Jan Peter
- Joannidis Michael
- Joannidis Michael
- Jones Joanne
- Jung Christian
- Kapoor Ritoo
- Kelm Malte
- Khaled Ala
- Khaliq Waqas
- Klepstad PĂ„l
- Kluzik Anna
- Konstantinia Vryza
- Kourelea Stylliani
- Koutsikou Anastasia
- Koutsodimitropoulos Ioannis
- Kozera Natalia
- KoĆciuczuk Urszula
- Krzych Lukasz J.
- Kubisz-Pudelko Agnieszka
- Kudlinski Bartosz
- LangĂžrgen JĂžrund
- Lawton Tom
- Lea-Hagerty Megan
- Leaver Susannah
- Leaver Susannah
- Lichtenauer Michael
- LipiĆska-Gediga MaĆgorzata
- Lord Jenny
- Lores Africa
- Love Nicholas
- LĂłpez-Cuenca Sonia
- Maciejewski Dariusz
- Maia Jose
- Maizel Julien
- Mane Tarkeshwari
- Marinakis Giorgos
- Marsh Brian
- Marsh Brian
- Martin-Loeches Ignacio
- Maseda Emilio
- Mentec Hervé
- Messika Messika
- Meybohm Patrick
- MikaÄiÄ Marijana
- Mira Angela Prado
- Morandi Alessandro
- Moreno Rui
- Morgan Patrick
- Morigi Aristide
- Motherway Catherine
- Muessig Johanna M.
- Mupudzi Mc Donald
- Nalapko Yuriy
- Nalapko Yuriy
- NasiĆowski PaweĆ
- Nauska Jessica
- Neou Evangelia
- Nollet Joke
- North Julie
- Nseir Saad
- Oeyen Sandra
- Ogbeide Vongayi
- on behalf of the VIP2 study group [missing]
- Papathanakos Georgios
- Pedersen Jonas Juul
- Perez-Torres David
- Piechota Mariusz
- Pietruszko Marek
- Pinto Bernardo Bollen
- Pope Alan
- Prol-Silva Estefania
- Pugh Richard
- Quenot Jean-Pierre
- Rabe Christian
- Rahmel Tim
- Raitsiou Bogdan
- Raj Ashok S.
- Randell Georgina
- Read Chris
- Reay Michael
- Rice Eva
- Rigaud Jean-Philippe
- Rime Anne-Karin
- Rodriguez Enver
- Rolin Nathalie
- Romen Antoine
- Rose Steve
- Rosman Jérémy
- Rovina Nikoletta
- Salaunkey Kiran
- Santos Ana Rita
- Savary Guillaume
- Savine Rachel
- Schaller Stefan J.
- Schefold Joerg C.
- Schefold Joerg C.
- Schering Stefan
- Schiöler Fredrik
- Schmutz René
- Schuster Michael
- Sendur PaweĆ
- Serwa Marta
- Sivik Joakim
- Sjöqvist Anders
- SjĂžbĂže Britt
- Slapgard Anita
- Solek-Pastuszka Joanna
- Soliman Ivo W.
- Sousa Cristina
- Spittle Nick Spittle Nick
- Spivey Michael
- Spray Dominic
- Stefaniak Jan
- Steiner Stephan
- Strand Kristian
- Strietzel Hans Frank
- StudziĆska Dorota
- Swinnen Walter
- Szczeklik Wojciech
- SĂžlling Christoffer
- Tarek Ahmed
- Tasioudis Polychronis
- Thevenin Didier
- Thiringer Karin Kleiven
- Thomsen Jakob Edelberg
- Tiercelet Kelly
- Tomasa Teresa
- Tsimpoukas Fotios
- TĂžien Kirsti
- Vakalos Aristeidis
- Valentin Andreas
- Valette Xavier
- van Boven Eva
- van den Berg Lettie
- Velasco Gonzalo Navarro
- Vettoretti Lucie
- Villamayor Mercedes Ibarz
- Vinsonneau Christophe
- Vizcaychipi Marcela
- Wakefield Phillipa
- Walther Sten
- Walther Sten
- Watson Ximena
- Welters Ingeborg D.
- Wernly Bernhard
- Westberg Henrik
- White Nigel
- Williams Patricia
- Yıldız Ismail
- Yovenko Ihor
- Zafeiridis Tilemachos
- Zatorski PaweĆ
- Zidianakis Vasiiios
- ZiÄtkiewicz MirosĆaw
- Zorska Joanna
- Zukowski Maciej
- Ăhman Christina Agvald
- Ărsnes Dorthe
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Background: Intensive care unit (ICU) patients age 90 years or older represent a growing subgroup and place a huge financial burden on health care resources despite the benefit being unclear. This leads to ethical problems. The present investigation assessed the differences in outcome between nonagenarian and octogenarian ICU patients.
Methods: We included 7900 acutely admitted older critically ill patients from two large, multinational studies. The primary outcome was 30-day-mortality, and the secondary outcome was ICU-mortality. Baseline characteristics consisted of frailty assessed by the Clinical Frailty Scale (CFS), ICU-management, and outcomes were compared between octogenarian (80-89.9 years) and nonagenarian (>= 90 years) patients. We used multilevel logistic regression to evaluate differences between octogenarians and nonagenarians.
Results: The nonagenarians were 10% of the entire cohort. They experienced a higher percentage of frailty (58% vs 42%; p < 0.001), but lower SOFA scores at admission (6 +/- 5 vs. 7 +/- 6; p < 0.001). ICU-management strategies were different. Octogenarians required higher rates of organ support and nonagenarians received higher rates of life-sustaining treatment limitations (40% vs. 33%; p < 0.001). ICU mortality was comparable (27% vs. 27%; p = 0.973) but a higher 30-day-mortality (45% vs. 40%; p = 0.029) was seen in the nonagenarians. After multivariable adjustment nonagenarians had no significantly increased risk for 30-day-mortality (aOR 1.25 (95% CI 0.90-1.74; p = 0.19)).
Conclusion: After adjustment for confounders, nonagenarians demonstrated no higher 30-day mortality than octogenarian patients. In this study, being age 90 years or more is no particular risk factor for an adverse outcome. This should be considered- together with illness severity and pre-existing functional capacity - to effectively guide triage decisions
Frailty is associated with long-term outcome in patients with sepsis who are over 80Â years old : results from an observational study in 241 European ICUs
- Author
- Aguilar Gerardo
- Ahmed Hazem
- Aidoni Zoi
- Aikaterini Kounougeri
- AllgÀuer Sebastian
- Andersen Finn H
- Andersen Finn H
- Artigas Antonio
- Baird Yolanda
- Balasubramaniam Madhu
- Ball Jonathan
- Barros InĂȘs
- Barth Eberhard
- Bastiansen Anders
- Belkhair Wesal Ali
- Bell Louise
- Belskiy Vladislav
- Berkius Johan
- Besch Guillaume
- Biernacka Aleksandra
- Blanco Jacobo Bacariza
- Bolger Clare
- Boroli Filippo
- Boulanger Carole
- Boulanger Carole
- Boumendil Ariane
- Breidablik Alena Breidablik Alena
- Brorsson Camilla
- Bruno Raphael Romano
- Brusa Stefania
- Burtin Philippe
- Calamai Italo
- Candeias Nuno
- Carvalho JoĂŁo Teles
- Castaneray Jeremy
- Catorze Nuno
- Cecconi Maurizio
- Chagnon Jean-Luc
- Charron Cyril
- Cilloniz Catia
- Collins Amy
- Cornet Alexander D
- Cracchiolo Andrea Neville
- Cramer Christine
- Cubero Patricia Jimeno
- Cupitt Jason
- Cwyl Katarzyna
- Cyrankiewicz Waldemar
- Czuczwar Miroslaw
- Dahle BĂ„rd E S
- De Buysscher Pieter
- De Geer Lina
- De Gordoa Laura Ortiz-Ruiz
- de Jager Peter
- de Lange Dylan
- de Lange Dylan W
- de Neve Nikolaas
- Dieck Thorben
- Dieperink Willem
- Djibré Michel
- Dormans Tom
- Dowling Susan
- Dubler Simon
- Ebelt Henning
- Eckert Philippe
- Eixarch Gaspar
- Elhadi Ahmed
- Elhadi Muhammed
- Elkmann Thomas
- Eller Philipp
- Enevoldsen Mathilde Hummelmose
- Evans Jane
- Faulkner Maria
- Fernandes Ana Margarida
- FernĂĄndez NoemĂ Llamas
- Ferreira Isabel Amorim
- Filipe Helder
- FjĂžlner Jesper
- Flaatten Hans
- Flioni Elli Niki
- Franz Marcus
- Frey Christian
- Fuest Kristina
- Galbois Arnaud
- Galkin Piotr
- Garcon Pierre
- Gawda Ryszard
- Gerritsen Rik T
- Gola Wojciech
- Gommers Diederik
- GomĂ Gemma
- Graf Tobias
- Grecu Irina
- Guerot Emmanuel
- Guidet Bertrand
- Guidet Bertrand
- Haas Lenneke
- Haas Lenneke E M
- Hahn Michael
- Haringman Jasper
- Hart Ciaran
- Helbok Raimund
- Henning Jeremy
- Hergafi Leila
- Hoiting Oscar
- Horacek Michael
- Hovaere Maud Mousset
- Humphreys Sally
- Husted Andreas
- Hymczak Hubert
- Ibarz Mercedes
- Innes Richard
- Jacob Reni
- Jaimes MariĂĄn IrazĂĄbal
- Jannestad Bente
- Jensen Jan Peter
- Joannidis Michael
- Joannidis Michael
- Jones Joanne
- Jung Christian
- Kapoor Ritoo
- Khaled Ala
- Khaliq Waqas
- Klepstad PĂ„l
- Kluzik Anna
- Konstantinia Vryza
- Kourelea Stylliani
- Koutsikou Anastasia
- Koutsodimitropoulos Ioannis
- Kozera Natalia
- KoĆciuczuk Urszula
- Krzych Lukasz J
- Kubisz-Pudelko Agnieszka
- Kudlinski Bartosz
- LangĂžrgen JĂžrund
- Lawton Tom
- Lea-Hagerty Megan
- Leaver Susannah
- Leaver Susannah
- LipiĆska-Gediga MaĆgorzata
- Lord Jenny
- Lores Africa
- Love Nicholas
- LĂłpez-Cuenca Sonia
- Maciejewski Dariusz
- Maia Jose
- Maizel Julien
- Mane Tarkeshwari
- Marinakis Giorgos
- Marsh Brian
- Marsh Brian
- Martin-Loeches Ignacio
- Maseda Emilio
- Mentec Hervé
- Messika Messika
- Meybohm Patrick
- MikaÄiÄ Marijana
- Mira Angela Prado
- Morandi Alessandro
- Moreno Rui
- Morgan Patrick
- Morigi Aristide
- Motherway Catherine
- Mupudzi McDonald
- Nalapko Yuriy
- Nalapko Yuriy
- Nalapko Yuriy
- NasiĆowski PaweĆ
- Nauska Jessica
- Neou Evangelia
- Nollet Joke
- North Julie
- Nseir Saad
- Oeyen Sandra
- Ogbeide Vongayi
- Papathanakos Georgios
- Pedersen Jonas Juul
- Perez-Torres David
- Piechota Mariusz
- Pietruszko Marek
- Pinto Alexandre Fernandes
- Polychronis Tasioudis
- Pope Alan
- Prol-Silva Estefania
- Pugh Richard
- Quenot Jean-Pierre
- Rabe Christian
- Rahmel Tim
- Raitsiou Bogdan
- Raj Ashok S
- Randell Georgina
- Read Chris
- Reay Michael
- Rice Eva
- Rigaud Jean-Philippe
- Rime Anne-Karin
- Rodriguez Enver
- Rolin Nathalie
- Romen Antoine
- Rose Steve
- Rosman Jérémy
- Rovina Nikoletta
- Salaunkey Kiran
- Santos Ana Rita
- Savary Guillaume
- Savine Rachel
- Schaller Stefan J
- Schefold Joerg C
- Schefold Joerg C
- Schering Stefan
- Schiöler Fredrik
- Schmutz René
- Schuster Michael
- Sendur PaweĆ
- Serwa Marta
- Sivik Joakim
- Sjöqvist Anders
- SjĂžbĂže Britt
- Slapgard Anita
- Solek-Pastuszka Joanna
- Sousa Cristina
- Spittle Nick Spittle Nick
- Spivey Michael
- Spray Dominic
- Stefaniak Jan
- Steiner Stephan
- Strand Kristian
- Strietzel Hans Frank
- StudziĆska Dorota
- Swinnen Walter
- Szczeklik Wojciech
- SĂžlling Christoffer
- Tarek Ahmed
- Thevenin Didier
- Thiringer Karin Kleiven
- Thomsen Jakob Edelberg
- Tiercelet Kelly
- Tomasa Teresa
- Tsimpoukas Fotios
- TĂžien Kirsti
- Vakalos Aristeidis
- Valette Xavier
- van Boven Eva
- van den Berg Lettie
- Velasco Gonzalo Navarro
- Vettoretti Lucie
- Villamayor Mercedes Ibarz
- Vinsonneau Christophe
- VIP2 study group [missing]
- Vizcaychipi Marcela
- Wakefield Phillipa
- Walther Sten
- Walther Sten
- Watson Ximena
- Welters Ingeborg D
- Westberg Henrik
- White Nigel
- Williams Patricia
- Yıldız Ismail
- Yovenko Ihor
- Zafeiridis Tilemachos
- Zatorski PaweĆ
- Zidianakis Vasiiios
- ZiÄtkiewicz MirosĆaw
- Zorska Joanna
- Zukowski Maciej
- Ărsnes Dorthe
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2021
- Field of study
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- AbellĂĄn Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Akçay Ăzlem
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
- Albers Michael
- Alcolea Natalia GonzĂĄlez
- Aleem Muhammad
- Alegre InĂȘs
- Alegre Javier Martinez
- Alexandre Flavia
- Alexandrescu Corina
- Alexnder Abelevich
- Alexopoulou Kalliopi
- Alfonso Beatriz AmorĂłs
- Ali Ahmed
- Ali Che Saniati Che
- Ali Danish
- Ali Madeeha
- Ali Mahmoud Abdelwahab
- Ali Manhal Hashim
- Ali Noura Al
- Alikhanli Jhale
- Aliyeva Zumrud
- Aliyu Mohammed
- Aljawder Hasan
- Allen Kate
- Almahmeed Ebrahim
- Alonso Alfredo
- Alonso Javier Etreros
- Alsamneh Muneer
- Alsayadi Ramzi
- Altinel Yuksel
- Altintoprak Fatih
- Altomare Donato F
- Alvarenga Isabella
- Alvarez Laura Jimenez
- Alvarez-Bautista Francisco Emmanuel
- Alvarez-DĂez Marcos
- Alves Brenda Chayanny
- Amadigwe Rita
- Amado Andreia
- Amado FabĂola
- Amador Cristina GarcĂa
- Amanullah Nazli
- Amaral HĂ©lida Aline Tomacheski
- Amaral Luis
- Amin-Tai Hizami
- Aminu Bashiru
- Amir Ahmad Suhaimi
- Ammar Ahmed Siddique
- Ammar Mona Ahmed
- Ammendola Michele
- Ammerata Giorgio
- Amorim Edgar
- Ancans Guntis
- Anderson Tom
- Andrade Diogo
- Andrejevic Predrag
- AndrĂ©s Beatriz DĂaz San
- Anestiadou Elissavet
- Ang Chin Wee
- Angelo Franceschi
- Anokhin Evgeny
- Anoldo Pietro
- Antakia Ramez
- Anton Majd
- Antonelli Serena
- Antropoli Carmine
- Anula Rocio
- Anwar Jamal
- Anyadike Florence
- Apostolakidou Magda
- Apostolidi Eirini
- Aprea Giovanni
- Arabadzhiev Angel
- Arakawa Satoshi
- Arauz Jazmin
- Aravindan U
- Aremu Abdurrahman
- Aremu Isiaka
- Argawy Osama
- Arican Can
- Arida Zahed Abu
- Armellin Claudia
- Arnaoutoglou Eleni
- Arreguy-Borges Kanthya
- Artigot Mariano
- Arturi Alessandro
- Arulappan Nirupama
- Arya Shobhit
- Arynov Ardak
- Asaad Peter
- Asano Yukio
- Ascari Francesca
- Asgarov Mohsum
- Ashmawy Soad
- Aslam Muhammad Imran
- Assimakopoulou Elena
- Assis Ana
- Astilleta Romina
- Atanasov Boyko
- Atendido Tiffany
- Athanasakis Elias
- Atici Semra Demirli
- Avellaneda Nicholas
- Avellaneda Nicolas
- Avseren Goksu
- Awead Marwa
- Ayandipo Omobolaji
- Aybar Engin
- Aydin Funda
- Aydin Gaye
- Ayoub Kusay
- Aytac Erman
- Aytaç Erman
- Azevedo Jose
- Azevedo Patricia
- Azhar Najia
- Aziz Gowhar
- Azman Zairul Azwan Mohd
- AĆkar Ahmet
- Babatunde Olanrewaju
- Badawi Marwa
- Baek Jeong-Heum
- Baez Noelia FernĂĄndez
- Baeza-Murcia Melody
- Bagnardi Francesco
- Baharom Salahudin
- Baik Seung Hyuk
- Baimakhanov Abylai
- Bains Lovenish
- Baker Aleksandra
- Bakmaz Bernarda
- Bala Abubakar Muhammad
- Balaban Vladimir
- Balalis Dimitrios
- Balasubramaniam Dinesh
- Balathayalan Yathev
- Baldi Claudio
- Balestri Riccardo
- Balfour James
- Ballah Abubakar
- Ballian Nikiforos
- Balooshi Iman Al
- Baloyiannis Ioannis
- Bamford Richard
- Bandar Mahdi Al
- Banham Gail
- Bannoud Mohammad Hassan
- Baptista Victor
- Baral Jörg
- Barbalace Nicolas
- Barbato Giuseppe
- Barbosa Anderson
- Bareka Metaxia
- Baris Baver
- Barradas Renato
- Barreda Sara Castillo
- Barrena-Blazquez Silvestra
- Barton Jess
- Bartosiak Katarzyna
- Bashilkina Olga
- Bashir Mohammed
- Basile Raffaele
- Basnyat Pradeep
- Batool Sana
- Bautista Wilson Manuel SĂĄnchez
- Bayhan ZĂŒlfĂŒ
- Bayo José Manuel Muros
- BayĂłn Raquel Ălvaro
- Baños Pedro Antonio Parra
- Beard David
- Bedzhanyan Arkady
- Behilil Chakib
- Bekele Kebebe
- Belarmino Armin
- Belay Million
- Belev Nikolay
- Bellato Vittoria
- BeltrĂĄn de Heredia Juan
- Belvedere Angela
- Benetti Emilio
- Benetti Sara
- Bengueddach Aicha
- Benjelloun El Bachir
- Benkabbou Amine
- Bennett James
- Bensafir Salim
- Bergamini Carlo
- Bernotaite Vlada
- Beron Reinaldo Isaacs
- Bethune Robert
- Bezede Cosmin
- Beznosenko Andriy
- Bhangu Aneel
- Bhargava Aman
- Bhat Rama Rani Krishna
- Bianchi Romina
- Bianco Francesco
- Bigoni Irene
- Binetti Margherita
- Bintintan Vasile
- Biondi Alberto
- Biondo Santino Antonio
- Bisgin Tayfun
- Bisheet George
- Bissett Ian
- Biswas Jyotirmoy
- Blackwell Sue
- Blanco Pablo
- Blanco Raquel RĂos
- Blanco-Colino Ruth
- Blasco Laura Fraile
- Blazquez-Martin Alma
- Bobadilla Billy Jimenez
- Bocancia Raluca
- Boccia Giuseppe
- Bogatikov Alexander
- Bolanle Olajide Edward
- Bomfa-Barbosa Alysson
- Bompou Effrosyni
- Bonardello Michela
- Bonci Eduard-Alexandru
- Bordom Daniel Osei
- Borges Filipe
- Borghi Felice
- Boschiero Matheus Negri
- Bose Bodhisattva
- Bouchagier Konstantinos
- Boudjenan-Serradj Nabil
- Boudoux Sabrina
- Bourazani Maria
- Boyce Stephen
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bradulskis Saulius
- Brainsa Eneida
- Brandström Gustav
- Braumille Markus
- Bravo Ana Minaya
- Bravo Raquel
- Bredikhin Mikhail
- Brito Noelia
- Bruni Andrea
- Buccianti Piero
- Buchs Nicolas
- Buchwald Pamela
- Budnikova Ina
- BudrikienÄ Rima
- Buey Lourdes
- Buijs Louis
- Buleje Jorge Alejandro Benavides
- Burlov Nikita
- Butt Anam
- Byshetty Rajendar
- Bywater Edward
- Bzikha Ilham
- BĂĄnky BalĂĄzs
- BĂŠlum Jens Kristian
- Caballero-Delgado Javier
- Cabrera Claudia
- Cafranga EstĂbaliz GutiĂ©rrez
- Cagnazzo Federica
- Calabria Mariangela
- Calabro' Marcello
- Caliendo Domenico
- Calin Camelia
- Caliskan Cemil
- Callan Rory
- Callari Cosimo
- Caltea Mihaela
- Calvo Almudena Castro
- Camacho Amparo
- Cammarata Francesco
- Campanati Renato
- Campanelli Michela
- Campbell Marion
- Canals LucĂa Otazu
- Canda Aras Emre
- Cano-Matias Auxiliadora
- Cao Victor Hugo Bruno
- Capolupo Gabriella Teresa
- Cappiello Antonio
- Capuano Marianna
- Capusan Alina
- Carannante Filippo
- Carbone Ludovico
- Cardelli Stefano
- Carden Claire
- Cardoso Diogo
- Caricato Marco
- Carlin Patricia Saez
- Carlini Massimo
- Carlos Sandra
- Carneros Virginia Jimenez
- Carosso Fabio
- Caroço Teresa Vieira
- Carpelan Anu
- Carpenter Holly
- Carrascosa-Morales Irene
- Carrie Augusto
- Carrizo Claudia
- Carta Giuseppina
- Carvalho Alexandre
- Carvello Michele
- Casanova Daniel
- Cascais Raquel
- Cassia Gabriela
- Castaldi Antonio
- Castaño Renata
- Castiglioni Simone
- Castillo Enrique Roca
- Castro Marta Cuartero
- Catalano Pablo
- Cato Liam
- Caz Esra
- Cebolla Elena Sagarra
- Cecchini Ilaria
- CeldrĂĄn Rebeca GonzĂĄlez
- Celik Hale Kefeli
- Ceretti Andrea Pisani
- Ceron Silvia Ferrer
- Cervellera Maurizio
- Cervone Carmela
- Chacko Anil
- Chandrasinghe Pramodh
- Charakopoulou Alexandra
- Chardalias Leonidas
- Chaturvedi Arun
- Chatzikomnitsa Paraskevi
- Chaudhari Abhishek
- Chaudhry Sanjay
- Chawla Tabish
- Chee Corissa
- Chen Nevin
- Cheng Kuang I
- Chiarugi Massimo
- Chisthi Meer
- Chitnis Abhishek
- Chitul Andrei
- Chmielewski Gaspard
- Cholewa Hanna
- Chornet Marta RosellĂł
- Chowdhary Manish
- Chowdhury Sharfuddin
- Chowdhury Sharfuddin M
- Chowdri Nisar
- Christensen Peter
- Christodoulidis Grigorios
- Chrysos Emmanuel
- Chua Lorna
- Chubukova Natlia
- Chung Jun Seong
- Church Robert
- Chwat Carina
- Ciabattari Paula
- Cianchi Fabio
- Cianci Pasquale
- Ciccarese Angelo Antonio
- Ciftci Ahmet Burak
- Cigagna Luca
- Cini Charles
- Ciotarla Danut Constantin
- Cirocchi Nicholas
- Ciubotaru Cezar
- Ciulli Cristina
- Ck Harikumar
- Clark Thomas
- Clarke Nicola
- Coccolini Federico
- Codes Lina
- Coelho Ana Margarida
- Cois Alessandro
- Coladonato Massimiliano
- Colak Elif
- Coldwell Chris
- Collins Jen
- Colombo Francesco
- ColĂĄs-Ruiz Enrique
- Conceição Luis
- Conde Juan Guillermo Ais
- Connolly Lewis
- Conversano Ivana
- Convertini Ornella
- Cook Esther
- Cooke Fiachra
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- Yılmaz GĂŒlseren
- Yilmazlar Tuncay
- YiÄit Direnç
- Yoldas Tayfun
- Yonekura Hiroshi
- Yorkmui Liu
- Yoshino Kenji
- Younes Lina
- Young Trudi
- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- ZadroĆŒna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
- Zanoni Andrea
- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah KaÄan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Ălvarez-Llano Laura
- Ăngelo Miguel Duarte
- ĂSullivan Sara Nuñez
- Ăzçelik Mehmet Faik
- Äoza Ivo
- Ćanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)