Impact of Tumor LINE-1 Methylation Level and Neoadjuvant Treatment and Its Association with Colorectal Cancer Survival

Recent studies suggest that long-interspersed nucleotide element-1 (LINE-1) hypomethylation is commonly found in colorectal cancer (CRC), and is associated with worse prognosis. However, the utility of LINE-1 methylation on the prognosis of CRC is still controversial, and may be due to the fact that some clinical and pathological features may affect LINE-1 methylation. Thus, the aim of this study was to assess the prognostic value of tumor LINE-1 methylation in CRC, through their association with the CRC clinical and pathological characteristics. Survival of sixty-seven CRC patients was evaluated according to the median of tumor LINE-1 methylation, as well as pathological and oncological variables. We also studied the association between LINE-1 methylation and pathological features, and finally, we assessed the overall and disease-free survival of LINE1 methylation, stratified by neoadjuvant treatment and further checked by multivariate Cox regression to assess the statistical interactions. LINE-1 was hypomethylated in the CRC tumor with respect to the tumor adjacent-free area (p < 0.05), without association with any other clinical and oncological features, nor with overall and disease-free survival rates for CRC. Relevantly, in neoadjuvant treatment, LINE-1 methylation was associated with survival rates. Thus, disease-free and overall survival rates of treated CRC patients were worse in the hypomethylated LINE-1 tumors than those with normal LINE-1 methylation (p = 0.004 and 0.0049, respectively). Indeed, LINE-1 was hypermethylated more in the treated patients than in the non-treated patients (p < 0.05). The present study showed that tumor LINE-1 hypomethylation was associated with worse survival rates in only treated patients. Our data suggest an interactive effect of neoadjuvant treatment and tumor LINE-1 methylation, which could be a specific-tissue biomarker to predict survival of the treated patients, and help to personalize treatment in CRC

Geology of the late Pliocene - Pleistocene Acoculco caldera complex, eastern Trans-Mexican Volcanic Belt (Mexico)

We present a new 1:80,000-scale geologic map of the Acoculco caldera (Ac) located between the states of Puebla and Hidalgo in eastern México. The map, encompassing an area of 856 km2, is grounded on an ArcMap data set and is supported by nine new 40Ar/39Ar dates. The caldera lies upon Cretaceous limestones and Miocene to Pliocene volcanic rocks (13–3 Ma). The caldera consists of 31 lithostatrigraphic units formed between 2.7 and 0.06 Ma that include a wide variety of volcanic landforms (cinder cones, lava domes). The caldera has a semi-circular shape (18–16 km) bounded by the Atotonilco scarp to the north, the NW–SE Manzanito fault to the west, and scattered vents to the east and southern parts. The distribution of the Acoculco ignimbrite, the lithic breccia, and lacustrine sediments define the caldera ring fault. Late Pleistocene activity and pervasive hydrothermal alteration suggest a high geothermal potential in the area. © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Journal of MapsThis study was funded by Grant 207032 of the Centro Mexicano de Inovación en Energía Geotérmica (CeMIE Geo) project P15 to J.L. Macías. JM is grateful for the MECD (PRX16/00056) grant.Peer reviewe

The EURONEAR lightcurve survey of Near Earth Asteroids 2017–2020

This is the fourth data paper publishing lightcurve survey work of 52 Near Earth Asteroids (NEAs) using 10 telescopes available to the EURONEAR network between 2017 and 2020. Forty six targets were not observed before our runs (88% of the sample) but some of these were targeted during the same oppositions mainly by Brian Warner. We propose new periods for 20 targets (38% of the sample), confirming published data for 20 targets, while our results for 8 targets do not match published data. We secured periods for 15 targets (29% of the sample), candidate periods for 23 objects (44%), tentative periods for 11 asteroids (21%), and have derived basic information about 3 targets (6% of the sample). We calculated the lower limit of the ellipsoid shape ratios a/b for 46 NEAs (including 13 PHAs). We confirmed or suggested 4 binary objects, recommending two of them for follow-up during future dedicated campaigns

The EURONEAR Lightcurve Survey of Near Earth Asteroids 2017–2020

This is the fourth data paper publishing lightcurve survey work of 52 Near Earth Asteroids (NEAs) using 10 telescopes available to the EURONEAR network between 2017 and 2020. Forty six targets were not observed before our runs (88% of the sample) but some of these were targeted during the same oppositions mainly by Brian Warner. We propose new periods for 20 targets (38% of the sample), confirming published data for 20 targets, while our results for 8 targets do not match published data. We secured periods for 15 targets (29% of the sample), candidate periods for 23 objects (44%), tentative periods for 11 asteroids (21%), and have derived basic information about 3 targets (6% of the sample). We calculated the lower limit of the ellipsoid shape ratios a/b for 46 NEAs (including 13 PHAs). We confirmed or suggested 4 binary objects, recommending two of them for follow-up during future dedicated campaigns

Chronic kidney disease and mortality risk among older patients with type 2 diabetes mellitus (ZODIAC-24).

Item does not contain fulltextOBJECTIVE: to investigate the association between a decreased estimated glomerular filtration rate (eGFR), albuminuria and mortality in elderly patients with type 2 diabetes mellitus (T2DM). DESIGN: prospective observational cohort study. Setting: primary care. Subjects: eight hundred and ten patients, >/=65 years with T2DM. Analyses were performed in age strata: 65-75 (n = 471), >75 (n = 339) years. METHODS: Cox proportional hazard modelling was used to investigate the association between eGFR, albuminuria and all-cause and cardiovascular mortality after a median follow-up of 9.8 years. RESULTS: an eGFR 75 years increased cardiovascular mortality was observed when eGFR was 60 ml/min/1.73 m(2) and normo-albuminuria, fully adjusted HRs for cardiovascular mortality were 2.26 (1.04-4.92) and 4.86 (2.33-10.15) for those aged 65-75 years, an eGFR of 45-60 ml/min/1.73 m(2) and normo-albuminuria or albuminuria, respectively; HRs were 1.33 (0.67-2.66) and 2.01 (1.02-3.94), respectively, for those >75 years. CONCLUSIONS: an eGFR of 45-60 ml/min/1.73 m(2) in T2DM patients is associated with increased mortality in patients aged 65-75 years but not in those >75 years. Albuminuria is associated with increased mortality in patients >65 years.1 mei 201