Search for Low Mass Exotic mesonic structures. Part I: experimental results

Recently, several papers discussed on the existence of a low mass new structure at a mass close to M=214.3 MeV. It was suggested that the $\Sigma^{+}$ disintegration: $\Sigma^{+}\to$pP$^{0}$, P$^{0}\to\mu^{-}\mu^{+}$ proceeds through an intermediate particle P$^{0}$ having such mass. The present work intends to look at other new or available data, in order to observe the eventual existence of small narrow peaks or shoulders in very low mesonic masses. Indeed narrow structures were already extracted from various data in dibaryons, baryons and mesons (at larger masses that those studied here).Comment: 7 pages 11 figure

Fission studies with 140 MeV α\bm{\alpha}-Particles

Binary fission induced by 140 MeV $\alpha$-particles has been measured for $^{\rm nat}$Ag, $^{139}$La, $^{165}$Ho and $^{197}$Au targets. The measured quantities are the total kinetic energies, fragment masses, and fission cross sections. The results are compared with other data and systematics. A minimum of the fission probability in the vicinity $Z^2/A=24$ is observed.Comment: 4 figures, 2 table

Polarization phenomena in the reaction NN to NNpi near threshold

First calculations for spin-dependent observables of the reactions $pp \to pp\pi^0$, $pp \to pn\pi^+$ and $pp \to d\pi^+$ near threshold are presented, employing the J\"ulich model for pion production. The influence of resonant (via the excitation of the $\Delta (1232)$) and non-resonant p-wave pion production mechanisms on these observables is examined. For the reactions $pp \to pn\pi^+$ and $pp \to d\pi^+$ nice agreement of our predictions with the presently available data on spin correlation coefficents is observed whereas for $pp \to pp\pi^0$ the description of the data is less satisfying.Comment: 10 pages, 4 figure

Complete next-to-leading order calculation for pion production in nucleon-nucleon collisions at threshold

Based on a counting scheme that explicitly takes into account the large momentum sqrt(M m_pi) characteristic for pion production in nucleon-nucleon collisions we calculate all diagrams for the reaction NN --> NN pi at threshold up to next-to-leading order. At this order there are no free parameters and the size of the next-to-leading order contributions is in line with the expectation from power counting. The sum of loop corrections at that order vanishes for the process pp --> pp pi^0 at threshold. The total contribution at next-to-leading order from loop diagrams that include the delta degree of freedom vanishes at threshold in both reaction channels pp --> pp pi^0, pn pi^+.Comment: 9 pages, 4 figure

Production of the 1S0 diproton in the pp -> pp pi0 reaction at 0.8 GeV

The pp -> pp pi0 differential cross section has been measured with the ANKE spectrometer at COSY-Juelich for pion cms angles between 0 and 15.4 degrees at a proton beam energy of 0.8 GeV. The selection of diproton pairs with an excitation energy E_{pp} < 3 MeV ensures that the final pp system is dominantly in the spin-singlet 1S0 state. The kinematics are therefore very similar to those of pp -> d pi+ but with different spin and isospin transitions. The results will thus provide a crucial extra test of pion production models in nucleon-nucleon collisions. The cross sections, which are over two orders of magnitude smaller than those of pp -> d pi+, show a forward dip, even stronger than that seen at lower energies. This behaviour is well reproduced in a theoretical model that includes P-wave Delta-N states.Comment: 10 pages, 5 eps figures, prepared using elsart.cl

Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33

GTPases act as molecular switches to control many cellular processes, including signalling, protein translation and targeting. Switch activity can be regulated by external effector proteins or intrinsic properties, such as dimerization. The recognition and translocation of pre-proteins into chloroplasts [via the TOC/TIC (translocator at the outer envelope membrane of chloroplasts/inner envelope membrane of chloroplasts)] is controlled by two homologous receptor GTPases, Toc33 and Toc159, whose reversible dimerization is proposed to regulate translocation of incoming proteins in a GTP-dependent manner. Toc33 is a homodimerizing GTPase. Functional analysis suggests that homodimerization is a key step in the translocation process, the molecular functions of which, as well as the elements regulating this event, are largely unknown. In the present study, we show that homodimerization reduces the rate of nucleotide exchange, which is consistent with the observed orientation of the monomers in the crystal structure. Pre-protein binding induces a dissociation of the Toc33 homodimer and results in the exchange of GDP for GTP. Thus homodimerization does not serve to activate the GTPase activity as discussed many times previously, but to control the nucleotide-loading state. We discuss this novel regulatory mode and its impact on the current models of protein import into the chloroplast

Molecular mechanism for the subversion of the retromer coat by the Legionella effector RidL

Microbial pathogens employ sophisticated virulence strategies to cause infections in humans. The intracellular pathogen Legionella pneumophila encodes RidL to hijack the host scaffold protein VPS29, a component of retromer and retriever complexes critical for endosomal cargo recycling. Here, we determined the crystal structure of L. pneumophila RidL in complex with the human VPS29?VPS35 retromer subcomplex. A hairpin loop protruding from RidL inserts into a conserved pocket on VPS29 that is also used by cellular ligands, such as Tre-2/Bub2/Cdc16 domain family member 5 (TBC1D5) and VPS9-ankyrin repeat protein for VPS29 binding. Consistent with the idea of molecular mimicry in protein interactions, RidL outcompeted TBC1D5 for binding to VPS29. Furthermore, the interaction of RidL with retromer did not interfere with retromer dimerization but was essential for association of RidL with retromer-coated vacuolar and tubular endosomes. Our work thus provides structural and mechanistic evidence into how RidL is targeted to endosomal membranes.ACKNOWLEDGMENTS: We thank Ander Vidaurrazaga (Centro de Investigación Cooperativa en Biociencias) for technical assistance and Devanand Bondage (National Institute of Child Health and Human Development) for proliferation assays of Legionella pneumophila. This study made use of the Diamond Light Source (Oxfordshire, United Kingdom), the European Synchrotron Radiation Facility (Grenoble, France), and the ALBA synchrotron beamline BL13-XALOC, funded in part by the Horizon 2020 programme of the European Union, iNEXT (H2020 Grant 653706). We thank all the staff from these facilities for technical and human support. This work was supported by the Spanish Ministry of Economy and Competitiveness Grant BFU2014-59759-R (to A.H.); the Severo Ochoa Excellence Accreditation SEV-2016-0644; and the Intramural Program of the Eunice Kennedy Shriver National Institute of Child Health and Human development (Projects ZIA HD001607 and ZIA HD008893). M.R.-M. is supported by a pre-doctoral fellowship from the Basque Government (PRE_2016_2_0249)