18 research outputs found
Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial
- Author
- Abdel-Rahman Emaad
- Abhayaratna Walter
- Abramof Ness Rosane
- Acosta Idalia
- Adams Atoya
- Adawi Faiad
- Adler Sharon
- Ahmed Fayzal
- Aizenberg Diego
- Ajani Dilawar
- Al-Karadsheh Amer
- Albota Adrian
- Alferi Dino
- Alicic Radica
- Alla Sreedhara
- Allison D
- Almeida Edgar
- Alpizar Salazar Melchor
- Amer Joseph
- Amod Aslam
- Andrawis Nabil
- Antonio Bossi Carlo
- Antsiferov Mikhail
- Antunes Daniela
- Araki Hideo
- Arango Clara
- Arcos Edgar
- Arif Ahmed
- Arif Imrozia
- Arkhipov Mikhail
- Armaly Zaher
- Aroca Gustavo
- Asprusten Emil
- Atar Shaul
- Avila Pardo Sandro
- Awad Ahmed
- Axthelm Christoph
- Azizad Masoud
- Azizah Aziz Nor
- B Brouwer C
- Babikova Jana
- Babkin Andrey
- Badak Ozer
- Bahrami Michael
- Bajcsi Dora
- Baker John
- Bala Cornelia
- Ballesteros Rosa
- Bansal Shweta
- Barag Steven
- Barakzoy Ahmad
- Baranov Vitaliy
- Barbarash Olga
- Barbonta Hortensia
- Barney Mark
- Barre Paul
- Barrera Sandra
- Barreto Carlos
- Barreto Germ\ue1n
- Bartolacci In\ue9s
- Bashir Khalid
- Bashkin Amir
- Bastidas Adrian Miriam
- Bautista Albert
- Bautista Jose
- Bech Jesper
- Beddhu Srinivasan
- Beltr\ue1n L\uf3pez Nelly
- Ben Chetrit Sydney
- Benitez Diego
- Benjamin Sabrina
- Berar Yanay Noa
- Berenji Ramin
- Bertram Pitt
- Bertsch John
- Besada Diego
- Bhana Sindeep
- Bhargava Anuj
- Bilz Stefan
- Birkenfeld Andreas
- Birriel Jose
- Bittar Julio
- Blanco Guillermo
- Bleich David
- Boletis Ioannis
- Bondarets Iryna
- Bonora Enzo
- Bornfreund Jonathan
- Boshnyashka Radostina
- Botelho Roberto
- Botero Rodrigo
- Botsyurko Volodymyr
- Bouarich Hanane
- Brada Michal
- Brandao Ilidio
- Brar Harjeet
- Braun Hermann
- Brezina Jiri
- Brian Susan
- Brietzke Stephen
- Brito Claudia
- Bruchfeld Annette
- Bruno Giorda Carlo
- Brusco Osvaldo
- Bu Ruifang
- Bucek Petr
- Buganova Ingrid
- Burgner Anna
- Busch Klaus
- Busch Robert
- Butrymowicz Patrycja
- C Bakker R
- C\ue1rdenas Tatiana
- Caceaune Elena
- Cai Hanqing
- Calabr\uf2 Paolo
- Calero Francesca
- Canadas Rafael
- Canani Luis
- Caramori Maria
- Cardona Jose
- Cariou Bertrand
- Carlo Maggi Davide
- Carlos Palma Juan
- Carlos Prieto Juan
- Carlson Brian
- Carpio Jose
- Carvalho Rui
- Case Christopher
- Castro Cristina
- Catindig Elizabeth
- Catrinoiu Doina
- Cayli Murat
- Cereto Castro Fernando
- Cerqueira Maria
- Chahin Mariano
- Chang Chiz-Tzung
- Chantrel Fran\ue7ois
- Chen Dejun
- Chen Nan
- Chen Qinkai
- Cheng Jinluo
- Chernikova Viktoriia
- Chernin Gil
- Chernyavskaya Elena
- Chew Wong Alfredo
- Christina Nowack
- Chuang Lee-Ming
- Chung ChoonHee
- Ciechanowski Kazimierz
- Cieslik Grazyna
- Cigarr\ue1n Guldris Secundino
- Cimino Roberto
- Clavel Sylvaine
- Clodi Martin
- Cobos Jorge
- Colman Peter
- Colquhoun David
- Constantin Ciprian
- Contzen Christel
- Conway James
- Coronel Julian
- Cortes-Maisonet Gregorio
- Cortes-Maisonet Gregorio
- Cournoyer Serge
- Crawford Veronica
- Cristina Gregorini Maria
- Cruz Humberto
- Cruzado Garrit Josep
- Cure Carlos
- Curiac Dan
- Cutfield Rick
- Dandillaya Ramprasad
- Dang Cuong
- Danos Peter
- Darawsha Mahmud
- de \uc1lvaro Fernando
- de Paula Rogerio
- Deerochanawong Chaicharn
- Degenhardt Stefan
- Demko Arkadiy
- Derwahl Karl
- Dhanireddy Soni
- Din Zia
- Distiller Larry
- Dixon Bradley
- Dolores Mart\uednez Esteban M\uaa
- Donath Marc
- Donets Oleksandra
- Dong Junwu
- Dong Youping
- Doshi Ankur
- Doubel Peter
- Dreval Alexander
- Drexel Heinz
- Du Yuming
- Dumas Richard
- Dumitrescu Adriana
- Dunn Peter
- Dur\ue1n Carlos
- Duyck Francis
- Dzupina Andrej
- E Costa Fernando Teixeira
- Ebenbichler Christoph
- Ebisui Osamu
- Edelsberger Tomas
- Edin Anton
- Eduardo Figueiredo Carlos
- Eduardo Salles Joao
- Efrati Shai
- Ekinci Elif
- El Shahawy Mahfouz
- El-Shahawy Mohammed
- Elbert Alicia
- Elias Mazen
- Eliaschewitz Freddy
- Eliasson Ken
- Emdin Michele
- Engelen Wendy
- Eren Necmi
- Eriksen Erik
- Ermakova Polina
- Escalada San Mart\uedn Javier
- Escobedo de la Pe\uf1a Jorge
- Esteves Cesar
- Eugenia Canziani Maria
- Eustace Joe
- Evans John
- Faber Jens
- Fadda George
- Fang Sum Chee
- Fang Yi
- Fangh\ue4nel Salm\uf3n Guillermo
- Farah Ghassan
- Farber Evgeny
- Farooq Umar
- Fauvel Jean-Pierre
- Fernando Roland
- Fiaccadori Enrico
- Fikry Sameh
- Fink Raymond
- Finnes Trine
- Fiorina Paolo
- First Brian
- Fitz-Patrick David
- Flack John
- Fliesser-G\uf6rzer Evelyn
- Fluck Patrick
- Fogelfeld Leon
- Fonseca Vivian
- Forti Adriana
- Franek Edward
- Frank Malin
- Frias Juan
- Fujita Naruhiro
- Furuya Ryuichi
- Fushtey Ivan
- G Lieverse A
- Galcer\ue1n Josep
- Gallouj Karim
- Galphin Claude
- Galyavich Albert
- Gansevoort Ron
- Garc\ueda Hern\ue1ndez Pedro
- Garc\ueda Luis
- Garcia-Mayol Luis
- Gaysina Leyla
- Gelersztein Elizabeth
- George L Bakris
- Georgiev Dimitar
- Gerasimos Filippatos
- Giebel Thomas
- Gillard Pieter
- Giorgio Battaglia Giovanni
- Gislason Gunnar
- Glandt Mariela
- Goldstein Gary
- Goluch Richard
- Gonz\ue1lez Albarr\ue1n Olga
- Gonz\ue1lez G\ue1lvez Guillermo
- Gonz\ue1lez Gonz\ue1lez Jos\ue9
- Gonz\ue1lez Fernando
- Gonzalez Edgar
- Gonzalez-Abreu Francisco
- Gordeev Ivan
- Gore Ashwini
- Gouet Didier
- Grachova Mariia
- Grant David
- Grossman Ehud
- Guan Tianjun
- Guerci Bruno
- Guerrot Dominique
- Guia Jose
- Gul Ibrahim
- Gulakova Drahomira
- Gumprecht Janusz
- Guo Weiying
- Guron Gregor
- Gushterova Valentina
- Guti\ue9rrez Ochoa Ramiro
- Guzm\ue1n Gustavo
- H Boonstra A
- H\uf8ivik Hans
- Habwe Violet
- Hagemeier Robert
- Hagenow Andreas
- Halabi Majdi
- Haller Hermann
- Halpern Stephen
- Hamamoto Yoshiyuki
- Hamasaki Akihiro
- Hamet Pavel
- Hamilton Maxine
- Hammoud Jamal
- Handelsman Stuart
- Hangaard J\uf8rgen
- Hanna Fahmy
- Hanusch Ursula
- Hao Chuanming
- Harcsa Eleonora
- Hart Randolph
- Hartman Israel
- Hasalova Zapletalova Jitka
- Hasnul Halimi Bin Wan Hasan Wan
- Hasslacher Christoph
- Hatazaki Masahiro
- Hatunic Mensud
- Hatziagelaki Erifili
- Hayashi Terumasa
- Heigerick Glenn
- Heitor Susana
- Hellberg Olof
- Hellgren Margareta
- Henein Sam
- Hern\ue1ndez Jaras Julio
- Hern\ue1ndez Eric
- Hernandez German
- Hernandez-Cassis Carlos
- Herrera Carlos
- Higashi Takayuki
- Hirohata Yoshihide
- Hissa Miguel
- Hoffmann Michal
- Hola Olga
- Holian John
- Honkasalo Mikko
- Honkasalo Mikko
- Horacek Thomas
- Horinouchi Shuji
- Hornova Lucie
- Houdova Jana
- Hougardy Jean-Michel
- Hrmova Helena
- Humaloja Kari
- Hung Cheng-Chieh
- Hwang YouCheol
- Ibarra Jaime
- Ibern\uf3n Meritxell
- Imoto Hirofumi
- Inagaki Akemi
- Inagaki Masayuki
- Ioannidis Ioannis
- Ipatko Irina
- Iranmanesh Ali
- Irizar Santana Sa\ufal
- Isayeva Anna
- Ishii Masao
- Ishiko Tamayo
- Jackson Timothy
- Jain Mahendra
- Jamerson Kenneth
- Jansen van Rensburg Dirkie
- Jaramillo Carlos
- Jaramillo Nicol\ue1s
- Jaroslaw Pacyk Grzegorz
- Jiang Fangfang
- Jiang Ju-Ying
- Jiang Sheng
- Jinnouchi Hideaki
- Johnson Karen
- Joshi Mukesh
- Joshi Shaifali
- Juhl Claus
- Juli\ue1n Segura de la Morena Jos\ue9
- Jungmair Wolfgang
- Kahal Hassan
- Kalashnikova Marina
- Kalathil Dhanya
- Kalina Akos
- Kanai Hidetoshi
- Kananen Kristiina
- Kanda Daisuke
- Kanehara Hideo
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- Karasek David
- Karlsson Thomas
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- Kattah William
- Kawamitsu Katsunori
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- Krarup Thure
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- Kubota Miyuki
- Kuchar Jiri
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- Kurnatowska Ilona
- Kusano Yoshiro
- Kutejova Vlasta
- Kvitkova Lyudmila
- Kyriakidou Christina
- L Penne E
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- Ludvik Bernhard
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- Lurie Alexander
- M Barendregt J N
- M van Leendert Ruud J
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- Ma Jianhua
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- Wu Mai-Szu
- Wu Ming-Ju
- Wu Tianfeng
- Wudi Krisztina
- Wuerzner Gregoire
- Wynne Katie-Jane
- Xing Changying
- Xiong Fei
- Xu Ning
- Xu Xudong
- Yagil Yoram
- Yajima Ken
- Yakhontov Davyd
- Yale Jean-Francois
- Yamada Daishiro
- Yamada Masayo
- Yamagata Kazuo
- Yamakawa Fumiko
- Yamakawa Ken
- Yamasaki Yoshimitsu
- Yambe Yuko
- Yanai Hidekatsu
- Yang Jinkui
- Yasuda Tetsuyuki
- Yenicerioglu Yavuz
- Yeung Vincent
- Yilmaz Huseyin
- Yin Aiping
- Yoncheva-Mihaylova Mariana
- Young Park Cheol
- Yuan Lee Li
- Yupanqui Hern\ue1n
- Yuryev Michael
- Zakharova Elena
- Zalevskaya Alsu
- Zanozina Olga
- Zaoui Philippe
- Zeig Steven
- Zeng Longyi
- Zhang Hao
- Zhang Yanlin
- Zhang Ying
- Zhao Zhiquan
- Zhdanova Elena
- Zheng Hongguang
- Zhong Ling
- Zhong Liyong
- Zhu Dalong
- Zhukova Larisa
- Zilahi Zsolt
- Zsom Marianna
- Zukermann Robert
- Zykova Tatyana
- Publication venue
- 'S. Karger AG'
- Publication date
- 01/01/2019
- Field of study
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049
Biochemical and structural properties of a lectin purified from seeds of the legume Parkia nitida Miq.
- Author
- Publication venue
- Publication date
- 01/01/2023
- Field of study
As the main carbohydrate-binding proteins, lectins are responsible for several biological functions, although their specific roles are still being unveiled. In the current work, a jacalin-related lectin from the seeds of Parkia nitida (Fabaceae family, Mimosoideae subfamily) was isolated by a combination of saline precipitation, mannose affinity chromatography, and gel filtration chromatography. The lectin, henceforth designated as PNL, demonstrated remarkable similarity to other Parkia lectins at the biochemical and structural levels. Overall, PNL is a stable lectin with a molecular mass of 48,760.3 Da, composed of 451 amino acid residues that fold into 3 side-by-side β-prism domains, each with its own carbohydrate-recognition domain specific to mannosides. Additionally, PNL displays a degree of toxicity against Artemia sp., albeit weaker than similar lectins. In conclusion, a representative of the Mimosoideae subfamily of legumes could be purified and characterized. This represents an advance in the understanding of Mimosoideae lectins, a group of unique proteins that receive significantly less focus in the plant lectin field
A concept for integrated care pathways for atopic dermatitis-A GA 2 LEN ADCARE initiative
- Author
- Abdul Latiff Amir Hamzah
- Aggelidis Xenofon
- Augustin Matthias
- Balan Radu-Gheorghe
- Bangert Christine
- Beck Lisa
- Bedbrook Anna
- Berardi Alejandro
- Bernstein Jonathan A.
- Bertolin Colilla Marta
- Bieber Thomas
- Bindslev-Jensen Carsten
- Bousquet Jean
- Bruscky Dayanne
- Buyuktiryaki Betul
- Canonica G. Walter
- Castro Carla
- Chanturidze Natia
- Chong-Neto Herberto Jose
- Chu Chia-Yu
- Chularojanamontri Leena
- Cork Michael
- Criado Roberta Fachini Jardim
- Curto-Barredo Laia
- Custovic Adnan
- Darsow Ulf
- de Bruin-Weller Marjolein
- de Pablo Ana
- Del Giacco Stefano
- Deleuran Mette
- Deleva Jovanova Tanja
- Douladiris Nikolaos
- Duarte Bruno
- Dubakiene Ruta
- Eller Esben
- Emurlai Arben
- Engel-Yeger Batya
- Ensina Luis Felipe
- Filho Nelson Rosario
- Flohr Carsten
- Fomina Daria
- Francuzik Wojciech
- Galimberti Maria Laura
- Giménez-Arnau Ana M
- Girolomoni Giampiero
- Godse Kiran
- Gotua Maia
- Hide Michihiro
- Hoetzenecker Wolfram
- Hunzelmann Nicolas
- Irvine Alan D
- Jack Carolyn
- Kanavarou Ioanna
- Katoh Norito
- Kinaciyan Tamar
- Kocatürk Emek
- Kulthanan Kanokvalai
- Lapeere Hilde
- Lau Susanne
- Machado Forti Nastri Mariana
- Makris Michael
- Mansour Eli
- Marsland Alexander
- Morelo Rocha Felix Mara
- Mortz Charlotte Gotthard
- Moschione Castro Ana Paula
- Nettis Eustachio
- Nicolas J. F.
- Nosbaum Audrey
- Odemyr Mikaela
- Papapostolou Niki
- Parisi Claudio A. S.
- Paudel Sushil
- Peter Jonny
- Pokharel Prakash
- Puig Sanz Lluís
- Quint Tamara
- Ramon German Dario
- Regateiro Frederico
- Ricci Giampaolo
- Rosario Cristine
- Sackesen Cansin
- Schmid-Grendelmeier Peter
- Serra-Baldrich E
- Siemens Kristina
- Smith Cathrine
- Staubach Petra
- Stevanovic Katarina
- Su-Kücük Özlem
- Sussman Gordon
- Tavecchio Simona
- Teovska Mitrevska Natasa
- Thaci Diamant
- Toubi Elias
- Traidl-Hoffmann Claudia
- Treudler Regina
- Universitat Autònoma de Barcelona
- Vadasz Zahava
- van Hofman Ingrid
- Ventura Maria Teresa
- Wang Zhao
- Weng Yew Yik
- Werfel Thomas
- Wollenberg Andreas
- Worm Margitta
- Yang Ariana
- Zhao Zuotao
- Zuberbier Torsten
- Zwiener Ricardo
- Publication venue
- Publication date
- 01/01/2023
- Field of study
The integrated care pathways for atopic dermatitis (AD-ICPs) aim to bridge the gap between existing AD treatment evidence-based guidelines and expert opinion based on daily practice by offering a structured multidisciplinary plan for patient management of AD. ICPs have the potential to enhance guideline recommendations by combining interventions and aspects from different guidelines, integrating quality assurance, and describing co-ordination of care. Most importantly, patients can enter the ICPs at any level depending on AD severity, resources available in their country, and economic factors such as differences in insurance reimbursement systems. The GA 2 LEN ADCARE network and partners as well as all stakeholders, abbreviated as the AD-ICPs working group, were involved in the discussion and preparation of the AD ICPs during a series of subgroup workshops and meetings in years 2020 and 2021, after which the document was circulated within all GAL 2 EN ADCARE centres. The AD-ICPs outline the diagnostic procedures, possible co-morbidities, different available treatment options including differential approaches for the pediatric population, and the role of the pharmacists and other stakeholders, as well as remaining unmet needs in the management of AD. The AD-ICPs provide a multidisciplinary plan for improved diagnosis, treatment, and patient feedback in AD management, as well as addressing critical unmet needs, including improved access to care, training specialists, implementation of educational programs, assessment on the impact of climate change, and fostering a personalised treatment approach. By focusing on these key areas, the initiative aims to pave the way for a brighter future in the management of AD
A concept for integrated care pathways for atopic dermatitis—A GA2LEN ADCARE initiative
- Author
- Adnan Custovic
- Alan Irvine
- Alejandro Berardi
- Alexander Marsland
- Amir Abdul Latiff
- Ana dePablo
- Ana M. Giménez‐Arnau
- Ana Paula Moschione Castro
- Andreas Wollenberg
- Anna Bedbrook
- Arben Emurlai
- Ariana Yang
- Audrey Nosbaum
- Batya Engel‐Yeger
- Betul Buyuktiryaki
- Bruno Duarte
- Cansin Sackesen
- Carla Castro
- Carolyn Jack
- Carsten Bindslev‐Jensen
- Carsten Flohr
- Cathrine Smith
- Charlotte Gotthard Mortz
- Chia‐Yu Chu
- Christine Bangert
- Claudia Traidl‐Hoffmann
- Claudio A. S. Parisi
- Cristine Rosario
- Daria Fomina
- Dayanne Bruscky
- Diamant Thaci
- Eli Mansour
- Elias Toubi
- Emek Kocatürk
- Esben Eller
- Esther Serra‐Baldrich
- Eustachio Nettis
- Frederico Regateiro
- German Dario Ramon
- Giampaolo Ricci
- Giampiero Girolomoni
- Giorgio Walter Canonica
- Gordon Sussman
- Herberto Jose Chong‐Neto
- Hilde Lapeere
- Ingrid vanHofman
- Ioanna Kanavarou
- J. F. Nicolas
- Jean Bousquet
- Jonathan A. Bernstein
- Jonny Peter
- Kanokvalai Kulthanan
- Katarina Stevanovic
- Kiran Godse
- Kristina Siemens
- Laia Curto Barredo
- Leena Chularojanamontri
- Lisa Beck
- Luis Felipe Ensina
- Luis Puig
- Maia Gotua
- Mara Morelo Rocha Felix
- Margitta Worm
- Maria Laura Galimberti
- Maria Teresa Ventura
- Mariana Machado Forti Nastri
- Marjolein deBruin‐Weller
- Marta Bertolin Colilla
- Matthias Augustin
- Mette Deleuran
- Michael Cork
- Michael Makris
- Michihiro Hide
- Mikaela Odemyr
- Natasa Teovska Mitrevska
- Natia Chanturidze
- Nelson Rosario Filho
- Nicolas Hunzelmann
- Niki Papapostolou
- Nikolaos Douladiris
- Norito Katoh
- Peter Schmid‐Grendelmeier
- Petra Staubach
- Prakash Pokharel
- Radu‐Gheorghe Balan
- Regina Treudler
- Ricardo Zwiener
- Roberta F. J. Criado
- Ruta Dubakiene
- Simona Tavecchio
- Stefano DelGiacco
- Susanne Lau
- Sushil Paudel
- Tamar Kinaciyan
- Tamara Quint
- Tanja Deleva Jovanova
- Thomas Bieber
- Thomas Werfel
- Torsten Zuberbier
- Ulf Darsow
- Wojciech Francuzik
- Wolfram Hoetzenecker
- Xenofon Aggelidis
- Yik Weng Yew
- Zahava Vadasz
- Zhao Wang
- Zuotao Zhao
- Özlem Su‐Kücük
- Publication venue
- Wiley
- Publication date
- 01/01/2023
- Field of study
Abstract Introduction The integrated care pathways for atopic dermatitis (AD‐ICPs) aim to bridge the gap between existing AD treatment evidence‐based guidelines and expert opinion based on daily practice by offering a structured multidisciplinary plan for patient management of AD. ICPs have the potential to enhance guideline recommendations by combining interventions and aspects from different guidelines, integrating quality assurance, and describing co‐ordination of care. Most importantly, patients can enter the ICPs at any level depending on AD severity, resources available in their country, and economic factors such as differences in insurance reimbursement systems. Methods The GA2LEN ADCARE network and partners as well as all stakeholders, abbreviated as the AD‐ICPs working group, were involved in the discussion and preparation of the AD ICPs during a series of subgroup workshops and meetings in years 2020 and 2021, after which the document was circulated within all GAL2EN ADCARE centres. Results The AD‐ICPs outline the diagnostic procedures, possible co‐morbidities, different available treatment options including differential approaches for the pediatric population, and the role of the pharmacists and other stakeholders, as well as remaining unmet needs in the management of AD. Conclusion The AD‐ICPs provide a multidisciplinary plan for improved diagnosis, treatment, and patient feedback in AD management, as well as addressing critical unmet needs, including improved access to care, training specialists, implementation of educational programs, assessment on the impact of climate change, and fostering a personalised treatment approach. By focusing on these key areas, the initiative aims to pave the way for a brighter future in the management of AD
NEOTROPICAL ALIEN MAMMALS: a data set of occurrence and abundance of alien mammals in the Neotropics
- Author
- Abra Fernanda D
- Abrahão Carlos Roberto
- Abreu Camila Matias Goes de
- Acevedo-Charry Orlando
- Age Stefani Gabrieli
- Aguiar Erick Francisco Silva de
- Akkawi Paula
- Alberici Vinicius
- Albuquerque Anna Carolina Figueiredo de
- Alencar Raony de Macêdo
- Alexandrino Eduardo
- Almeida Rocha Juliana Monteiro de
- Alvarez Martin R
- Alves do Prado Helena
- Alves Giselle Bastos
- Alves Rafael Souza Cruz
- Alves-Eigenheer Milene
- Amaku Marcos
- Amaral Paulo Roberto
- Anderson Christopher Brian
- Anderson Elizabeth P
- Andrade Gabrielle Ribeiro de
- Andrade Maria Augusta
- Andrade Rubia Santana
- Andrade-Núñez María José
- Antas Paulo de Tarso Zuquim
- Antunes Alexsander Zamorano
- Aoki Camila
- Araújo Ana Caroline L
- Araújo Luciana Souza
- Araújo Valquíria Cabral
- Arimoro Omolabake Alhambra Silva
- Arrabal Juan Pablo
- Arroyo-Gerala Paulina
- Astete Samuel
- Back Franco Silvana
- Bager Alex
- Bailey Larissa Lynn
- Ballari Sebastián A
- Banhos Dos Santos Áureo
- Baptiste Maria Piedad
- Barbier Eder
- Barbosa Adriana Loeser Dos Santos
- Barcos Umberto Cotrim
- Barreto-Lima André Felipe
- Barrios-Garcia M Noelia
- Barros Maria Claudene
- Barros Marília A S
- Barros Pollyanna Alves de
- Barros-Battesti Darci Moraes
- Bassini-Silva Ricardo
- Bastazini Vinícius Augusto Galvão
- Batista Graziele Oliveira
- Bazilio Sérgio
- Beca Gabrielle
- Bechara Isabel Muniz
- Beduschi Julia
- Behling Greici Maia
- Bejarano Vanesa
- Beltrão Mayara Guimarães
- Beltrão-Mendes Raone
- Benedetti Maximiliano Augusto
- Benitez Verónica Victoria
- Bercê William
- Bergallo Helena de Godoy
- Bergel Mariano Maudet
- Bernardi Itiberê Piaia
- Bertagni de Camargo Bruna
- Bertassoni Alessandra
- Bessa Rafael
- Bezerra Bruna M
- Bicca-Marques Júlio César
- Bocchiglieri Adriana
- Boere Vanner
- Bogoni Juliano André
- Bonjorne Lilian
- Bopp Luciano Tessare
- Borgnia Mariela
- Borja Miranda André
- Bovendorp Ricardo S
- Bovo Alex Augusto Abreu
- Braga Caryne
- Braz Alan Gerhardt
- Brennand Pamella Gusmão de Goés
- Brocardo Carlos Rodrigo
- Bueno Cecília
- Burs Kathrin
- Buscariol Daiane
- Bôlla Daniela A S
- Calaça Analice Maria
- Camargo Paulo Henrique S A
- Camilo André Restel
- Camino Micaela
- Campos Zilca
- Campêlo Anielise da Conceição
- Canale Gustavo R
- Canassa Nathália Fernandes
- Candelária Lana Pavão
- Cantagallo Devids Camila
- Caputo Carin
- Carlos Henrique Santiago Alberto
- Carrano Eduardo
- Carreira Daiane
- Caruso Flavia
- Carvalho Danianderson Rodrigues
- Carvalho Diana Letícia Kruger Pacheco
- Carvalho Fernando
- Carvalho Santiago
- Carvalho William Douglas
- Casanova Diogo Cavenague
- Casazza Egberto da Fonseca
- Cassano Camila Righetto
- Castro Érika Paula
- Castro-Prieto Jessica
- Cavalcanti Sandra
- Cervini Marcelo
- Cestari Cesar
- Cesário Clarice Silva
- Cezila Beatriz Azevedo
- Chacón Pacheco Julio Javier
- Chein Alonso André
- Cherem Jorge José
- Chiarello Adriano Garcia
- Ciocheti Giordano
- Cirignoli Sebastián
- Coelho Igor Pfeifer
- Coitiño Banquero Hugo Ignacio
- Contreras-Moreno Fernando M
- Corassa Arrais Ricardo
- Cordeiro José Luís Passos
- Cordeiro-Estrela Pedro
- Corrêa Matheus Rocha Jorge
- Cortez Sara
- Cossa Natalia
- Costa Claudia Guimarães
- Costa Francys E da Veiga da
- Costa Jociel Ferreira
- Costa Rômulo Theodoro
- Costa Sebastián Andrés
- Coutinho Marcos E
- Couto Dayvid Rodrigues
- Cravino Alexandra
- Cáceres Nilton Carlos
- Córdoba Diego
- D'Bastiani Elvira
- da Cunha Cristina Jaques
- da Cunha Rogério Grassetto Teixeira
- da Rocha Guilherme Casoni
- da Rocha Patrício Adriano
- da Rosa Oliveira Nicole
- da Silva de Oliveira Allan Jefferson
- da Silva Leonardo Henrique
- da Silva Luciano Ferreira
- da Silva Marcelo
- da Silva Mônica Andrade
- da Silva Raquel Costa
- da Silva Virgínia Santiago
- Daga Vanessa Salete
- Dantas Santos Marcos Pérsio
- Dantas José Oliveira
- de Aguiar Gabriel Lima
- de Albuquerque Natasha Moraes
- de Almeida Curi Nelson Henrique
- de Amorim Danilo Angelucci
- de Andrade Layla Reis
- De Angelo Carlos
- de Aquino Ana Carla Medeiros Morato
- de Araujo Verônica Parente Gomes
- de Azevedo Fernanda Cavalcanti
- de Bustos Soledad
- de Cassia Bianchi Rita
- de Faria Peres Pedro Henrique
- de Freitas Junior Mozart Caetano
- de la Cruz Godoy Juan Camilo
- de la Cruz-Félix Keynes
- de la Maza Javier
- de la Peña-Cuéllar Erika
- de la Torre Antonio
- de Lima Elson Fernandes
- de Lázari Patrick Ricardo
- de Matos José Roberto
- de Miguel Andrés
- de Moraes Pires Walna Micaelle
- de Morais Kimberly Danielle Rodrigues
- de Oliveira Dilmar Alberto Goncalves
- de Oliveira Geovana Linhares
- de Oliveira Mateus Yan
- de Oliveira Ramonna
- de Paula Almir
- de Paula Rogério Cunha
- de Pina Ligia Ferracine
- de Sousa Luziene Conceição
- de Souza Franco Leandro
- de Souza Jonathas Linds
- de Souza Rafael Cerqueira Castro
- de Thoisy Benoit
- Del Castillo Hugo
- Del Vechio Koike Christine
- Denkiewicz Natalia Mariana
- Detogne Nathália
- Devlin Allison
- Di Bitetti Mario S
- Di Blanco Yamil
- Dias Douglas de Matos
- Dias Ricardo Augusto
- Dierings Geverson Luiz
- do Nascimento Maria Histele Sousa
- Domit Maria Dolores Alves Dos Santos
- Dornas Rubem Augusto da Paixão
- Dos Reis Matheus Gonçalves
- Doutel Ribas Cynthia
- Duarte da Silva Victor Hugo
- Duarte Gabriela Teixeira
- Duarte Herbert de Oliveira B
- Duarte José Maurício Barbanti
- Dáttilo Wesley
- Endo Whaldener
- Entringer Júnior Hilton
- Ermenegildo Hiago
- Esbérard Carlos Eduardo Lustosa
- Esperandio Isadora Beraldi
- Espíndola Hack Robson Odeli
- Falcão Jéssica Caroline de Faria
- Faria Michel Barros
- Farias Patrick
- Fasola Laura
- Favarini Marina Ochoa
- Feijó Anderson
- Felicio Artur Luiz de Almeida
- Fernandes Arthur Soares
- Fernandes Maria Emília de Avelar
- Fernandes-Ferreira Hugo
- Fernandez Fernando Antonio Dos Santos
- Ferrari Stephen Francis
- Ferraz Daniel da Silva
- Ferraz Katia Maria Paschoaletto Micchi de Barros
- Ferreguetti Atilla Colombo
- Ferreira Antunes de Oliveira Cintia
- Ferreira Neto José Soares
- Ferreira Aluane Silva
- Ferreira Fernando
- Ferreira Guilherme Braga
- Ferreira Juliana Rodrigues
- Ferreira Jéssica Paloma
- Ferreira Paula Modenesi
- Fieker Carolline Zatta
- Figueiredo Camila
- Figuerêdo Duarte Moraes Marcela
- Filippini Alexandre
- Flores Peredo Rafael
- Fonseca Fabiana Luques
- Fornitano Larissa
- Fraga Elmary da Costa
- Fragoso Carlos Eduardo
- Francisco Ana Karina
- Francisco Talitha Mayumi
- Fróes da Silva Rodrigo Medina
- Fusco-Costa Roberto
- Gabriel Francisco Homem
- Galetti Jr, Pedro Manoel
- Galetti Mauro
- Galiano Daniel
- Galliez Maron
- Gallo Jorge Alberto
- Galvão da Silva Marco Aurélio
- García Loaiza Lina Marcela
- García-Olaechea Alvaro
- García-R Sebastian
- Gasparotto Vinícius Peron de Oliveira
- Gatica Ailin
- Gatti Andressa
- Geraldi Vilma Clarice
- Gessulli Rodrigo Delmonte
- Gestich Carla Cristina
- Giovanelli João Gabriel Ribeiro
- Girardi Fabiane
- Godim Tayanna Medonça da Silva
- Godoi Mauricio N
- Gomes Ana Paula Nascimento
- Gonsioroski Gustavo
- González Enrique M
- Gonçalves da Silva Lucas
- Gonçalves Fernando
- Gonçalves Larissa Oliveira
- Gonçalves Pablo Rodrigues
- Gouvea Jéssica Abonízio
- Gozzi Ana Cecilia
- Graipel Maurício Eduardo
- Grelle Carlos E V
- Grotta Neto Francisco
- Guaragni Samara Arsego
- Guedes da Silva Fernanda
- Guerreiro Marcello
- Guichón M Laura
- Guidoni-Martins Karlo Gregório
- Guijosa-Guadarrama Emiliano
- Guimarães Luiza Neves
- Gurgel Filho Newton
- Gómez-Valencia Bibiana
- Haberfeld Mario Burke
- Hannibal Wellington
- Hartz Sandra Maria
- Hegel Carla Grasiele Zanin
- Heliodoro Gabriela
- Hernández-Pérez Edwin
- Hinojosa Javier
- Hofmann Gabriel Selbach
- Homem Daniel Henrique
- Hoogesteijn Rafael
- Hufnagel Ludmila
- Hurtado Cindy M
- Ibanez Martins Fernando
- Iezzi María Eugenia
- Ikuta Cássia Yumi
- Ingberman Bianca
- Islas Camila Alvez
- Jacinavicius Fernando de Castro
- Jerusalinsky Leandro
- Jesús-Espinosa Daniel
- Jimenez Segura Luz Fernanda
- Jiménez Romero Germán
- Juarez Keila MacFadem
- Jácomo Anah Tereza de Almeida
- Kaizer Mariane C
- Kanaan Vanessa
- Kanda Claudia Zukeran
- Kasper Carlos Benhur
- Keesen Ferreira Fabíola
- Kerches Rogeri Patrícia
- Kindel Andreas
- Knogge Christoph
- Kubiak Bruno Busnello
- Köhler Bianca
- La Sala Luciano Francisco
- La Serra Leonardo
- Lacerda Ana Cristyna Reis
- Landgref Filho Paulo
- Landis Mariana Bueno
- Lanna Andre
- Layme Viviane Maria Guedes
- Leandro-Silva Victor
- Leite de Oliveira Aline Cristina
- Leite de Oliveira Márcio
- Leles Bruno Pereira
- Lemos Frederico Gemesio
- Lemos Hudson de Macedo
- Lermen Isabel Salgueiro
- Lessa Gisele
- León Pérez Rodrigo
- Lim Burton K
- Lima da Silva Marina
- Lima Fernando
- Lima Ingrid M S
- Lima Marcela Guimarães Moreira
- Lira Paula Koeler
- Lombardi Pryscilla Moura
- Lopez David Echeverri
- Lorini Maria Lucia
- Loyola Rafael
- Lugarini Camile
- Luiz Micheli Ribeiro
- Luiz Thais Guimaraes
- Luna Cecília Licarião Barreto
- Luza André Luís
- Lyra Luiz Henrique
- López-Fuerte Cristina F
- Macedo Leandro
- Machado da Silva Douglas
- Magezi Gabriel S
- Maggiorini Erica Vanessa
- Magioli Marcelo
- Magnusson William
- Malerba Martina
- Mangini Paulo Rogério
- Mangione Antonio
- Maras Gustavo A
- Marcili Arlei
- Marinho Paulo Henrique
- Marinho-Filho Jader
- Marini Miguel Ângelo
- Marins João Rafael Gomes de Almeida
- Marques Costa Leonardo
- Marques Leandro de Oliveira
- Marques Marinêz Isaac
- Marques Rosane Vera
- Martensen Alexandre Camargo
- Martin Paula Sanches
- Martin-Albarracin Valeria L
- Martins Maísa Ziviani Alves
- Martins Simone Rebouças
- Martins Waldney Pereira
- Martín Lucía
- Martínez Lanfranco Juan Andrés
- Martínez-Nambo Erik Daniel
- Massara Rodrigo Lima
- Mauro Rodiney de Arruda
- Maués Paula Cristina Rodrigues de Almeida
- Medeiro Akyllan Zoppi
- Megale Nicoli
- Meiga Ana Yoko Ykeuti
- Mella Méndez Isac
- Melo Dias Mateus
- Melo Fabiana Cristina S Alves de
- Melo Fabiano Rodrigues de
- Melo Geruza Leal
- Melo Marcos Antônio
- Mendes de Oliveira Ana Cristina
- Mendes Pontes Antonio Rossano
- Mendes Yuri Raia
- Micheletti Tatiane
- Miller Jacqueline R
- Miranda João M D
- Miretzki Michel
- Monteiro Miguel Coutinho Moretta
- Morais Bianca Cruz
- Morato Ronaldo Gonçalves
- Moreira Adryelle Francisca de Souza
- Moreira Danielle de Oliveira
- Moreira Leandro Santana
- Moreira Thamy De Almeida
- Moreli Fantacini Felipe
- Moreno Daniele Janina
- Morini Maria Santina de Castro
- Mottin Viviane
- Moura Mauricio Osvaldo
- Mourthe Italo
- Mourão Guilherme
- Munhoes Leticia Prado
- Möcklinghoff Lydia
- Nagy-Reis Mariana B
- Nakagawa Bruno K
- Nascimento Ariel Guilherme Santos do
- Nascimento Daiane Chaves do
- Nava Alessandra Ferreira Dales
- Neri Fernanda Maria
- Nobre Andrezza Bellotto
- Nobre Rodrigo de Almeida
- Nodari Joana Zorzal
- Nova León Laura Johanna
- Nunes André Valle
- Núñez-Regueiro Maurício M
- Ochoa Ana Cecilia
- Ochotorena de Freitas Thales Renato
- Olifiers Natalie
- Oliveira Igor
- Oliveira Leonardo de Carvalho
- Oliveira Luiz Flamarion Barbosa de
- Oliveira Marcela Alvares
- Oliveira Marcelo Juliano Rabelo
- Oliveira-Santos Luiz Gustavo Rodrigues
- Oliveira-Silva Liany Regina B
- Olímpio Ana Priscila Medeiros
- Onofrio Valeria Castilho
- Orsi Mário Luís
- Orsini Vinícius Santana
- Oshima Júlia Emi de Faria
- Paglia Adriano Pereira
- Pagoto Anderson
- Pagotto Renata Valls
- Paldês Gonçales Amane
- Palmeira Francesca Belem Lopes
- Panigai Gabriel Ferreira Vianna Di
- Paolino Roberta Montanheiro
- Parahyba Campos Bruno A T
- Pardini Renata
- Parrish Juan Felipe Reátiga
- Paschoal Ana Maria de Oliveira
- Pasqualotto Nielson
- Passamani Marcelo
- Passos Fernandode Camargo
- Patel Filipe M
- Patrocínio Dennis Nogarolli
- Paulino Neto Hipólito Ferreira
- Pays Olivier
- Pedreira Paula Anabel
- Pedrosa Felipe
- Pedroso Rayssa
- Pedó Ezequiel
- Pellegrin Aiesca
- Pena Hilda Fátima de Jesus
- Percequillo Alexandre Reis
- Pereira Mendes Calebe
- Pereira Adriele Aparecida
- Pereira Alan Deivid
- Pereira Vinicius José Alves
- Pereira-Ribeiro Juliane
- Perilli Miriam Lucia Lages
- Perillo Lucas Neves
- Perine Michell
- Peroni Nivaldo
- Perovic Pablo
- Pessoa da Silva Felipe
- Peters Felipe Bortolotto
- Peña-Mondragón Juan L
- Pincheira-Ulbrich Jimmy
- Pinha Patricia Ribeiro Salgado
- Pinheiro Paula Fabiana
- Pinho Fernando Ferreira de
- Piovezan Ubiratan
- Piratelli Augusto João
- Pires Alexandra Dos Santos
- Pires José Salatiel Rodrigues
- Pisciotta Kátia Regina
- Post David M
- Potrich Ana Paula
- Prado Alessandra Dos Santos Venturini do
- Puertas Fernando Henrique
- Pônzio Marcella do Carmo
- Queirolo Diego
- Querido Luciano Carramaschi de Alagão
- Quintilham Lucas Lacerda Toth
- Rajão Henrique
- Ramos Lima Saulo
- Ramos Danielle Leal
- Ramos Yan Gabriel Celli
- Rampim Lilian Elaine
- Ramírez-Bautista Pedro
- Renaud Pierre-Cyril
- Reppucci Juan
- Ribeiro Bruno R
- Ribeiro Fernando Silvério
- Ribeiro Igor Kintopp
- Ribeiro Juliana Fernandes
- Ribeiro Milton Cezar
- Ribeiro Renan Lieto Alves
- Ribeiro Yuri Geraldo Gomes
- Rivadeneira Edgar Federico
- Rivero Marina
- Rocha Alessandro
- Rocha Carlos Frederico Duarte
- Rocha Fabiana Lopes
- Rodarte Raisa Reis de Paula
- Rodrigues Flávio Henrique Guimarães
- Rodrigues Thiago Ferreira
- Rodríguez-Calderón Yenifer G
- Rodríguez-Planes Lucía Inés
- Roesler Ignacio
- Roig Henrique Llacer
- Rojas Bonzi Viviana
- Rojas Ana
- Rolim Samir Gonçalves
- Roque Fábio de Oliveira
- Rosa Graviola Gabriela
- Rosa Beatris Felipe
- Rosa Clarissa Alves da
- Rosario Maria Cristina Ferreira do
- Rosas Ribeiro Patrícia
- Rudolf Juan Carlos
- Ruffino Paulo Henrique Peira
- Ruiz-Esparza Juan
- Russell James Charles
- Sabino-Santos Jr, Gilberto
- Sales Munerato Marina
- Sales Lilian P
- Salvador Carlos Henrique
- Sampaio Rebeca Ferreira
- Sampaio Ricardo
- Santana Gindomar Gomes
- Santos Cyntia Cavalcante
- Santos Eduardo Marques
- Santos Jean Pierre
- Santos Paloma Marques
- Sanvicente Lopez Mauro
- Saranholi Bruno Henrique
- Sartorello Leonardo Rodrigues
- Sartorello Ricardo
- Scarascia Pietro de Oliveira
- Schuchmann Karl-Ludwig
- Schuck Gabriela
- Sebastião Harley
- Secco Helio Kinast Cruz
- Seibert Jardel Brandão
- Seixas Cristiana Simão
- Seoane Nicolás Fernando
- Severo Magnus Machado
- Siciliano Salvatore
- Silva de Almeida Marcelo
- Silva Oliveira Camila Raquel
- Silva Pereira Monicque
- Silva Diego Afonso
- Silva Ita de Oliveria
- Silva Jean Carlos Ramos
- Silva Katyucha Von Kossel de Andrade
- Silva Ramon Lima
- Silveira Dos Santos Juliana
- Silveira Leandro
- Silvestre de Sousa Saulo Meneses
- Soares Pinheiro Marcell
- Solari Torres Sergio
- Souza Agnis Cristiane de
- Souza-Alves João Pedro
- Sponchiado Jonas
- Srbek-Araujo Ana Carolina
- Subalusky Amanda
- Sánchez Lalinde Catalina
- Sánchez Amadeo
- Talamoni Sônia A
- Tamasauskas Bruna
- Tavares André
- Tavares Davi Castro
- Tedesco Carla Denise
- Teixeira Fernanda Zimmermann
- Tellaeche Cintia
- Tellarini Juan Francisco
- Thompson Jeffrey J
- Tiepolo Liliani Marilia
- Tirelli Flávia Pereira
- Toledo Gustavo Alves da Costa
- Tomas Walfrido Moraes
- Tortato Fernando
- Tortato Marcos Adriano
- Towns Valeria
- Trinca Cristiano Trapé
- Trovati Roberto Guilherme
- Twardowsky Ramalho Bonikowski Renata
- Tôrres Natália Mundim
- Ubaid Flávio Kulaif
- Vale Mariana Moncassim
- Valenzuela Alejandro Eduardo Jorge
- Varela Diego
- Venticinque Eduardo Martins
- Vera Y Conde Carla Fabiane de
- Verona Carlos Eduardo
- Vieira Carlos Leonardo
- Vieira Emerson Monteiro
- Vieira Marcus V
- Vitule Jean R S
- Vogliotti Alexandre
- Vélez-García Felipe
- Winter Marina
- Xavier da Silva Marina
- Xavier Mariana Sampaio
- Yanosky Alberto
- Zago Silva Luciana
- Zaluar Marina Trancoso
- Zanella Noeli
- Zanin Marina
- Zanirato Gisele Lamberti
- Zanoni Juliani Bruna
- Zecchini Gebin João Carlos
- Zenni Rafael D
- Zocche Jairo José
- Publication venue
- Publication date
- 01/11/2020
- Field of study
Biological invasion is one of the main threats to native biodiversity. For a species to become invasive, it must be voluntarily or involuntarily introduced by humans into a nonnative habitat. Mammals were among first taxa to be introduced worldwide for game, meat, and labor, yet the number of species introduced in the Neotropics remains unknown. In this data set, we make available occurrence and abundance data on mammal species that (1) transposed a geographical barrier and (2) were voluntarily or involuntarily introduced by humans into the Neotropics. Our data set is composed of 73,738 historical and current georeferenced records on alien mammal species of which around 96% correspond to occurrence data on 77 species belonging to eight orders and 26 families. Data cover 26 continental countries in the Neotropics, ranging from Mexico and its frontier regions (southern Florida and coastal-central Florida in the southeast United States) to Argentina, Paraguay, Chile, and Uruguay, and the 13 countries of Caribbean islands. Our data set also includes neotropical species (e.g., Callithrix sp., Myocastor coypus, Nasua nasua) considered alien in particular areas of Neotropics. The most numerous species in terms of records are from Bos sp. (n = 37,782), Sus scrofa (n = 6,730), and Canis familiaris (n = 10,084); 17 species were represented by only one record (e.g., Syncerus caffer, Cervus timorensis, Cervus unicolor, Canis latrans). Primates have the highest number of species in the data set (n = 20 species), partly because of uncertainties regarding taxonomic identification of the genera Callithrix, which includes the species Callithrix aurita, Callithrix flaviceps, Callithrix geoffroyi, Callithrix jacchus, Callithrix kuhlii, Callithrix penicillata, and their hybrids. This unique data set will be a valuable source of information on invasion risk assessments, biodiversity redistribution and conservation-related research. There are no copyright restrictions. Please cite this data paper when using the data in publications. We also request that researchers and teachers inform us on how they are using the data
Brazilian Flora 2020: Leveraging the power of a collaborative scientific network
- Author
- Abreu Fernanda
- Abreu Maria
- Abreu Vanessa H.R.
- Acuña‐castillo Rafael
- Afonso Edgar A.L.
- Agra Leandro A.N.N.
- Agra Maria
- Aguiar Daniel P.P.
- Aires Elisa
- Almeda Frank
- Almeida Eduardo
- Almeida Gracineide S.S.
- Almeida Mariana
- Almeida Nicolli B.C.
- Almeida Rafael
- Almeida Roberto B.P.
- Almeida Thaís
- Alves Daniela
- Alves Flávio
- Alves Karina N.L.
- Alves Maria B.B.
- Alves Rodolfo
- Amaral André L.S.
- Amaral Maria C.E.
- Amorim André M.A.
- Amorim Bruno
- Amorim Eduardo
- Amorim Vivian
- Amélio Leandro
- Andrade Ivanilza
- Andrade Ray
- Andreata Regina H.P.
- Andrino Caroline
- André Thiago
- Anjos Cassiane
- Antar Guilherme
- Antonicelli Mirian C.A.
- Antunes Lorena l.C.
- Aona Lidyanne Y.S.
- Arana Marcelo
- Aranha João L.M.
- Araujo Andréa
- Araujo Cintia A.T.
- Araujo Flávia
- Araújo Anderson G.A.
- Araújo Camila
- Araújo Mário H.T.
- Arbo Maria
- Arnou Emily
- Asprino Renata
- Assis Francine
- Assis Leandro C.S.
- Assis Marta
- Athayde Filho Francisco
- Athiê‐souza Sarah
- Azevedo Igor H.F.
- Bacci Lucas
- Barbosa Camilo V.O.
- Barbosa Juliana
- Barbosa Maria Regina V.
- Barbosa‐silva Rafael
- Barboza Gloria
- Barcellos Ian
- Barcelos Flávia R.B.
- Barcelos Laísa
- Barreto Kamilla l.
- Barros Fábio
- Barros Thamires l.A.
- Barros‐barreto Maria B.B.
- Bastos Cid J.P.
- Bastos Cláudia
- Batista João A.N.
- Batista Marcella M.I.
- Baumgratz José Fernando A.
- Bautista Hortencia
- Benelli Adarilda
- Berguecio Nicolás
- Bernacci Luís
- Beyer Maila
- Bezerra Andrea C.C.
- Bezerra Luísa M.P.A.
- Bezerra Yuri R.L.
- Bianchetti Luciano
- Bicudo Carlos E.M.
- Bigio Narcísio
- Biral Leonardo
- Bissoli Vinícius
- Bittencourt Felipe
- Bochorny Thuane
- Bohn Amabily
- Bohs Lynn
- Bojacá Gabriel F.P.
- Boldorini Abril
- Boldrini Ilsi
- Bolson Mônica
- Bordin Juçara
- Bordon Natali
- Borges Rafael A.X.
- Borges Rodrigo l.
- Bortoluzzi Roseli l.C.
- Bove Claudia
- Bovini Massimo
- Braga João M.A.
- Braga Nayara S.S.
- Branco Suema
- Brauner Laiana
- Braz Denise
- Bringel João B.A.
- Brito Antonio l.V.T.
- Brito Eliete
- Bruniera Carla
- Buchoski Monica
- Buck William
- Bueno Norma
- Bueno Vinicius
- Buril‐vital Maria T.A.
- Burton George
- Büneker Henrique
- Bünger Mariana
- Cabral Andressa
- Cabral Elsa l.
- Cabral Fernanda
- Cabral Tiara
- Caddah Mayara
- Caires Claudenir
- Caires Taiara
- Calazans Luana S.B.
- Caldas Diana K.D.
- Calió Maria
- Calvo Joel
- Camargo Rodrigo
- Camelo Mel
- Campos‐rocha Antonio
- Canestraro Bianca
- Canto‐dorow Thais
- Cantuária Patrick
- Cara Álison l.
- Cardoso Andréia
- Cardoso Domingos B.O.S.
- Cardoso Jesiane
- Cardoso Leandro J.T.
- Cardoso Pedro
- Cardozo Andrey l.
- Carmo Dimas
- Carmo João A.M.
- Carneiro Camila
- Carneiro Cláudia
- Carrijo Tatiana
- Caruzo Maria B.R.
- Carvalho Catarina
- Carvalho Dariane A.S.
- Carvalho Fernanda
- Carvalho Jefferson
- Carvalho Maria l.S.
- Carvalho‐silva Micheline
- Castello Ana C.D.
- Castro E Silva Isabella
- Castro Márcia
- Catenacci Fernanda
- Cavalcanti Laise
- Cavalcanti Taciana
- Cavalheiro Larissa
- Cervi Armando
- Chacon Roberta
- Chagas Aline
- Chagas Earl C.O.
- Chautems Alain
- Chauveau Olivier
- Chequín Renata
- Christ Anderson l.
- Christ Jheniffer
- Cidrão Bruno
- Clark Lynn
- Coelho Alexa A.O.P.
- Coelho Guilherme
- Coelho Marcus A.N.
- Coelho Rubens l.G.
- Colletta Gabriel
- Colli‐silva Matheus
- Conceição Adilva
- Conceição Tulio
- Condack João P.S.
- Contro Fernanda l.
- Cordeiro Inês
- Cordeiro Luciana
- Cordeiro Wesley P.F.S.
- Costa E Silva Maria
- Costa Andrea
- Costa Daniel
- Costa Denise
- Costa Fabiane
- Costa Fernanda S.N.
- Costa Francisco C.P.
- Costa Géssica A.G.
- Costa Isabelle G.C.M.
- Costa Itayguara
- Costa Jeferson
- Costa Jorge A.S.
- Costa José G.S.
- Costa Maria T.R.
- Costa Mitchel I.A.
- Costa Suzana
- Costa Thiago
- Costa Tiago
- Costa‐lima James l.
- Cota Matheus M.T.
- Couceiro Yuri S.V.
- Coutinho Thales
- Couto Dayvid
- Couto Ricardo
- Couvo Anielly
- Cyrillo Stephany
- Cárdenas Gabriela
- Câmara Paulo E.A.S.
- Cândido Elisa
- Côrtes Ana l.A.
- Dal Molin Luis
- Dalastra Claudenice
- Dalcin Eduardo Couto
- Damasceno Rafaella G.L.
- de Lazzari Lara R.P.
- Deble Leonardo
- Delfini Carolina
- Delgado Junior Geadelande
- Delgado‐salinas Alfonso
- Della Aline
- Delprete Piero
- Dematteis Massimiliano
- Dettke Greta
- Devecchi Marcelo
- Dewes Talita
- Di Maio Fernando
- Dias Kauê N.L.
- Dias Micheli
- Dias Pedro
- Dittrich Vinícius A.O.
- Domínguez Yoannis
- Dorneles Mariane
- Dressler Stefan
- Duarte Marilia
- Duran Juan D.T.
- Dutilh Julie H.A.
- Dutra Letícia l.
- Dutra Valquíria
- Díaz Yani C.A.
- Dórea Marcos
- Echternacht Livia
- Eggers Lilian
- Erkens Roy H.J.
- Eslabão Marcelo
- Espírito Santo Fábio
- Esser Hans‐joachim
- Essi Liliana
- Esteves Gerleni l.
- Esteves Roberto l.
- Everling Joel
- Ezcurra Cecilia
- Facco Marlon
- Fader Andrea A.C.
- Falcão Marcus J.A.
- Fantecelle Laura
- Farco Gabriela
- Faria Allan l.A.
- Faria Ana P.G.
- Faria Aparecida
- Faria Jair
- Faria Maria
- Farias Sabrina
- Farias‐singer Rosana
- Farinaccio Maria
- Fernandes Aluisio
- Fernandes Ana
- Fernandes Fernando
- Fernandes José
- Fernandes Rozijane
- Fernandes Thiago
- Fernandes Ulisses
- Fernando Emanoel M.P.
- Ferreira Carlos D.M.
- Ferreira Fabrício
- Ferreira Gabriel
- Ferreira João P.R.
- Ferreira Priscila P.A.
- Ferreira Silvana
- Ferrucci María
- Fiaschi Pedro
- Fidanza Karina
- Filardi Fabiana L.R.
- Filgueiras Tarciso
- Firetti Fabiana
- Fleischmann Andreas
- Florentín Javier
- Florentín Mariela
- Flores Andréia
- Flores Jerônimo M.M.
- Flores Thiago
- Fonseca Luiz H.M.
- Fontelas Jean
- Fontella‐pereira Jorge
- Forster Wellington
- Forzza Rafaela
- Fraga Claudio
- Fraga Fernanda R.M.
- Fraga Santiago
- Francisco Jéssica N.C.
- França Flávio
- França Juliana R.K.G.
- Freire‐fierro Alina
- Freitas Fernanda
- Freitas Joelcio
- Freitas Maria
- Fritsch Peter
- Funez Luís
- Furtado Samyra
- Gaem Paulo
- Gaglioti André l.
- Gagnon Edeline
- Gama Beatriz R.A.
- Garcia Flávia C.P.
- Gasper André l.
- Gerace Samuele
- Giacomin Leandro l.
- Giaretta Augusto
- Gil André S.B.
- Gissi Danilo
- Giuffre Pamela M.W.
- Giulietti Ana
- Giussani Liliana
- Goebel Gabriela
- Goes Monique
- Goldenberg Renato
- Gomes Beatriz
- Gomes Fernanda
- Gomes Mario
- Gomes‐da‐silva Janaína
- Gomes‐klein Vera l.
- Gonella Paulo
- Gonzaga Augusto F.N.
- Gonzaga Diego
- Gonzatti Felipe
- González Favio
- Gonçalez Victor
- Gonçalves Ana P.S.
- Gonçalves Deise J.P.
- Gouvêa Yuri
- Graham Shirley A.T.
- Gregório Bernarda
- Grings Martin
- Groppo Milton
- Grossi Mariana
- Guarçoni Elidio A.E.
- Guedes Felipe
- Guedes Juliana
- Guerra Ethiéne
- Guimarães Elsie
- Guimarães Leonardo R.S.
- Guimarães Paulo J.F.
- Gurgel Ely S.C.
- Gutiérrez Diego
- Góes Luiz A.A.
- Hall Climbiê
- Harley Raymond
- Hassemer Gustavo
- Hattori Eric K.O.
- Hechenleitner Paulina
- Hefler Sonia
- Heiden Gustavo
- Henning Tilo
- Henriques Diego
- Hensold Nancy
- Hinoshita Lucas K.R.
- Hirai Regina
- Hirao Yasmin
- Hiriart Florencia
- Hopkins Michael J.G.
- Hoyos‐gómez Saúl
- Huamantupa Isau
- Hurbath Fernanda
- Iganci João R.V.
- Ilkiu‐borges Anna l.
- Imig Daniela
- Indriunas Alexandre
- Inácio Camila
- Jacques Eliane l.
- Jacques Suara S.A.
- Jaimes Juliana
- Jardim Jomar
- Jesus Jôane
- Jesus Priscila
- Jiménez‐mejías Pedro
- Johnson David
- Jordão Lucas S.B.
- Jordão Valner M.M.
- Jorge Taciane
- Kaehler Miriam
- Kameyama Cíntia
- Kataoka Eric
- Kessous Igor
- Kilipper Julia
- Kinoshita Luiza
- Klein Viviane
- Klitgaard Bente
- Knapp Sandra
- Koch Ana
- Koch Ingrid
- Kochanovski Fábio
- Kominami Gabriel F.G.
- Konno Tatiana U.P.
- Koschnitzke Cristiana
- Kotovski Emília
- Kriebel Ricardo
- Külkamp Josimar
- Labiak Paulo
- Leal Brígida
- Leal Eduardo
- Leite Wellerson
- Leite Áurea C.F.
- Leitman Paula
- Lewis Gwilym
- Lima Adriana
- Lima Alexandre
- Lima Duane F.S.
- Lima Eliene
- Lima Haroldo
- Lima Jessica
- Lima Laura C.P.
- Lima Laíce F.G.
- Lima Letícia
- Lima Lucas
- Lima Luis F.P.
- Lima Rita
- Lima Vanessa l.
- Link‐perez Melanie
- Lirio Elton
- Lobão Adriana
- Loeuille Benoit F.P.
- Lohmann Lúcia
- Loiola Maria I.B.
- Lombardi Julio
- Longhi‐wagner Hilda
- Lopes Gabriel S.R.
- Lopes Jenifer
- Lopes Letícia
- Lopes Raimundo
- Lopes Rosana
- Lorencini Tiago
- Lorenzi Harri
- Lourenço Ana R.L.
- Lourenço Arthur
- Louzada Rafael
- Lovo Juliana
- Lozano Eduardo
- Luber Jaquelini
- Lucas Dióber
- Lucas Eve
- Luebert Federico
- Lughadha Eimear Nic
- Luizi‐ponzo Andrea
- Luna Bruna
- Luna Naédja K.M.
- Luz Cíntia l.S.
- López Maria
- Lüdtke Raquel
- M.D. Cardozo Nállarett
- Machado Anderson F.P.
- Machado Evandro
- Machado Talita
- Maciel Jefferson
- Maciel Sebastião
- Magalhães Rodrigo
- Magenta Mara A.G.
- Maia Leonor
- Maia Talita
- Mamede Maria C.H.
- Mansano Vidal
- Marchioretto Maria
- Margalho Luciano
- Marinho Lucas
- Marques Danilo
- Marquete Ronaldo
- Marra Raquel
- Martins Angela
- Martins Marcos B.S.
- Martins Milena
- Martins Márcio l.L.
- Martins Renata
- Martins Suzana
- Masson Victória
- Matias Ligia
- Matos Agnes M.M.V.
- Matos Andreza
- Matos Fernando
- Matozinhos Carolina
- Mattos Cilene M.J.
- Mattos Leticia
- Matzenauer William
- Mauad Anna V.S.R.
- Maya‐lastra Carlos
- Mayo Simon
- Mazine Fiorella
- Medeiros Débora
- Medeiros Erika V.S.S.
- Medeiros Herison
- Medeiros Maria C.M.P.
- Meerow Alan
- Meireles Jose
- Meireles Leonardo
- Meirelles Julia
- Melchor‐castro Briggitthe
- Mello Zelia
- Mello‐silva Renato
- Melo André l.
- Melo Caio V.V.D.
- Melo Efigenia
- Melo José I.M.
- Mendes Jone C.R.
- Mendes Maria C.Q.
- Mendes‐silva Ingrid
- Meneguzzo Thiago E.C.
- Menezes Cristine
- Menezes Felipe G.P.
- Menezes Mariângela
- Menini Neto Luiz
- Mentz Lilian
- Mesquita Antônio l.
- Messias Patrícia
- Mezzonato‐pires Ana
- Michelangeli Fabián
- Miguel João
- Miguel Laila
- Milward‐de‐azevedo Michaele
- Miotto Silvia T.S.
- Miranda Cecília
- Miranda Vitor F.O.
- Mitchell John
- Molina José M.P.
- Mondin Cláudio
- Monge Marcelo
- Monteiro Daniele
- Monteiro Fernanda K.S.
- Monteiro Raquel
- Monteiro Silvana H.N.
- Monteiro Thiago
- Monzoli João V.L.
- Moore Paloma G.P.
- Mora Martha
- Moraes Marta
- Moraes Mónica
- Morales Juan
- Morales Matías
- Moran Robbin
- Moreira Andréia D.R.
- Moreira André l.C.
- Moreira Ariane
- Moreira Bianca
- Moreira Giselle l.
- Moreira Kassio V.C.
- Moreira Pablo F.F.
- Morim Marli
- Morokawa Rosemeri
- Moroni Pablo
- Mota Aline
- Mota Michelle C.A.
- Mota Nara F.O.
- Moura Beryl E.L.
- Moura Carlos Wallace N.
- Moura Ingridy
- Moura Luíza
- Moura Ricardo l.
- Moura Tania
- Mundim Júlia
- Muniz Filho Eduardo
- Muniz Francisca
- Muniz Leticia
- Mynssen Claudine
- Nakajima Jimi
- Nascimento Janaina G.A.
- Nascimento José
- Nascimento Silvia
- Nepomuceno Francisco A.A.
- Nervo Michelle
- Nery Eduardo
- Neves Beatriz
- Nogueira Matheus G.C.
- Nunes Annelise
- Nunes Clebiana
- Nunes Teonildes
- Nóbrega Giseli
- O'Leary Nataly
- Oellgaard Benjamin
- Oliveira Adriana l.R.
- Oliveira Ana C.S.
- Oliveira Andreza G.S.
- Oliveira Aron
- Oliveira Bárbara
- Oliveira Caetano
- Oliveira Fernanda M.C.
- Oliveira Filipe G.A.
- Oliveira Gleison
- Oliveira Gustavo
- Oliveira Hermeson
- Oliveira Iasmin l.C.
- Oliveira José F.C.
- Oliveira Joésili C.P.
- Oliveira Juliana
- Oliveira Juliana R.P.M.
- Oliveira Leticia G.R.
- Oliveira Lilian F.A.
- Oliveira Lorena
- Oliveira Luciana S.D.
- Oliveira Marcia C.R.
- Oliveira Marcos G.M.
- Oliveira Marise H.V.
- Oliveira Marla I.U.
- Oliveira Márcio l.B.
- Oliveira Regina
- Oliveira Renata
- Oliveira Reyjane
- Oliveira Rodrigo C.G.
- Oliveira Sylvia
- Oliveira Ykaro
- Orlandini Priscila
- Orsolano Guilherme
- Pacífico Ricardo
- Paglia Isis
- Paiva Gabrielle C.P.
- Paixão Liliane
- Pastore José F.B.
- Pastore Mayara
- Pastori Tamara
- Paucar Jenny O.A.
- Paula‐souza Juliana
- Pederneiras Leandro
- Peichoto Myriam
- Peixoto Ariane l.
- Pell Susan
- Pellegrini Marco O.O.
- Pena Nelson T.L.
- Pennington Richard
- Peralta Denilson
- Pereira Amanda P.N.
- Pereira Andreza S.S.
- Pereira Jovani B.S.
- Pereira Maria
- Pereira Paulo E.E.
- Pereira Sidney
- Pereira‐silva Rafaela
- Perez Ana P.F.
- Pessoa Cleiton
- Pessoa Clenia
- Pessoa Edlley
- Pessoa Maria C.R.
- Petrongari Fernanda
- Philbrick Thomas
- Pignal Marc
- Pimenta Karena
- Pinto Rafael
- Pioner Natália
- Pirani José
- Pizzardo Raquel
- Plos Anabela
- Ponce Marta
- Pontes Juliana
- Pontes Ricardo A.S.
- Pontes Tiago
- Pontes‐pires Aline
- Pott Vali
- Prado Jefferson
- Prado Thainá
- Praia Talita
- Prance Ghillean
- Prange Carolina
- Prata Ana P.N.
- Prochazka Luana
- Proença Carolyn E.B.
- Prudêncio Renato X.A.
- Pscheidt Allan
- Quaresma Aclebia
- Quaresma Aline
- Queiroz George
- Queiroz Luciano
- Queiroz Rubens
- Quinet Alexandre
- Ramos Eliana
- Ramos Geraldo J.P.
- Rando Juliana
- Rebouças Natanael
- Reginato Marcelo
- Reis Miguel M.R.
- Reis Priscila
- Reis‐silva Genilson
- Ribas Osmar
- Ribeiro André R.O.
- Ribeiro Carolina l.
- Ribeiro José E.L.S.
- Ribeiro Michel
- Ribeiro Pétala
- Ribeiro Rayane T.M.
- Ribeiro Ricardo
- Ribeiro Rogério
- Riina Ricarda
- Ritter Mara
- Rivadavia Fernando
- Rivera Vanessa l.
- Rizzo Beatriz
- Rocha Antônio E.S.
- Rocha Lamarck
- Rocha Maria J.R.
- Rodrigues Carine
- Rodrigues Christchellyn
- Rodrigues Izabella M.C.
- Rodrigues Marianna
- Rodrigues Rodrigo Sampaio
- Rodrigues Rodrigo Schütz
- Rodríguez Juan F.C.
- Rodríguez Pedro
- Rollim Isis
- Romanini Rebeca
- Romero María
- Romero Rosana
- Romão Gerson
- Romão Marcos V.V.
- Roque Nádia
- Rosa Bárbara
- Rosa Patrícia
- Rosa Priscila
- Rossa Iago
- Rossetto Elson F.S.
- Rossi Lucia
- Rossini Josiene
- Rosário Alessandro
- Royer Carla
- Rua Gabriel
- Saavedra Mariana
- Saka Mariana
- Sakuragui Cassia
- Salas Roberto
- Sales Margareth
- Salgado Vanina
- Salimena Fátima R.G.
- Salino Alexandre
- Salvador Rafael
- Sampaio Daniela
- Sancho Gisela
- Sano Paulo
- Santana Jéssica C.O.
- Santana Karoline
- Santana Mariana
- Santiago Augusto C.P.
- Santos Alessandra
- Santos Amanda P.B.
- Santos Ana C.A.S.
- Santos Andrea K.A.
- Santos Carlos A.G.
- Santos Emanuelle l.
- Santos Felipe
- Santos Fernanda
- Santos João U.M.
- Santos Karin
- Santos Leidiana l.
- Santos Matheus
- Santos Otilene
- Santos Rafaela
- Santos Renata G.P.
- Santos Thaíla V.A.
- Santos Thiago
- Santos Vanessa
- Santos‐silva Fernanda
- Santos‐silva Juliana
- Saraiva Deisy
- Sarkinen Tiina
- Sartori Ângela l.B.
- Sassone Agostina
- Sauthier Luana
- Scalon Viviane
- Scatigna André
- Schaefer Juliana
- Scheidegger Najla M.B.
- Schliewe Marcos
- Schmidt Eduard D.L.
- Schneider Angelo
- Schneider Layla J.C.
- Schuettpelz Eric
- Schwartsburd Pedro
- Schwarz Elizabeth
- Scudeler Ana l.
- Sebastiani Renata
- Secco Ricardo
- Secretti Elisangela
- Segalla Rosane
- Seleme Elidiene
- Semir João
- Senna Luisa
- Setubal Robberson
- Shimizu Gustavo
- Shirasuna Regina
- Silva Filho Pedro J.S.
- Silva Adaíses S.M.
- Silva Aline V.M.
- Silva Amanda l.
- Silva Anádria
- Silva Caroline C.A.
- Silva Cassio
- Silva Christian
- Silva Cintia
- Silva Diego
- Silva Dilana
- Silva Fabio
- Silva Fernanda
- Silva Francismeire
- Silva Gabriel
- Silva Gledson
- Silva Guilherme
- Silva Gustavo H.L.
- Silva João P.S.
- Silva Juliana l.
- Silva Juliene F.M.
- Silva Leonardo
- Silva Lucas
- Silva Luciana
- Silva Luiza
- Silva Marcio R.P.
- Silva Marcos
- Silva Marcus F.O.
- Silva Maria S.D.
- Silva Maria l.B.
- Silva Márcio
- Silva Nilda M.F.
- Silva Otávio l.M.
- Silva Rafael
- Silva Raphael
- Silva Renata S.A.
- Silva Renato
- Silva Ronaldo
- Silva Saura
- Silva Suelma
- Silva Tatiane
- Silva Thaynara
- Silva Tânia R.S.
- Silva Wanderson l.S.
- Silva‐castro Milene
- Silva‐cobra Gisele
- Silva‐gonçalves Kelly
- Silveira Fernanda
- Silveira João
- Silveira Thamyres
- Simon Marcelo
- Simão‐bianchini Rosangela.
- Simões Ana
- Simões André
- Siniscalchi Carolina
- Siqueira Carlos
- Smidt Eric
- Smith Alan
- Smith Nathan
- Snak Cristiane
- Soares Abel E.R.
- Soares Arthur
- Soares Edson l.C.
- Soares Kelen
- Soares Luanda
- Soares Marcos V.B.
- Soares Maria l.C.
- Soares Polyana
- Soares Raimundo
- Sobrado Sandra
- Sobral Marcos
- Somner Genise
- Sothers Cynthia
- Sousa Ana A.C.
- Sousa Danilo J.L.
- Sousa Francisco
- Sousa Gardene
- Sousa Hian C.F.
- Sousa Leandro O.F.
- Sousa Mayco W.S.
- Sousa Valdeci
- Souza Aline
- Souza Bruno
- Souza Elnatan
- Souza Filipe
- Souza Luzia
- Souza Marcelo
- Souza Maria A.D.
- Souza Raquel M.B.S.
- Souza Vinicius
- Souza Élvia
- Souza‐buturi Fátima
- Spina Andréa
- Stadnik Aline M.S.
- Staggemeier Vanessa
- Stapf María N.S.
- Stefano Rodrigo
- Stehmann João Renato
- Stern Stephen
- Streher Nathália
- Suchoronczek Andréia
- Sundue Michael
- Sylvestre Lana
- Sá Cyl F.C.
- São‐mateus Wallace M.B.
- Takeuchi Cátia
- Tardivo Rosângela
- Taylor Nigel
- Teixeira Michella D.R.
- Teles Aristônio
- Temponi Livia
- Thode Verônica
- Thomas William
- Tierno Lorena
- Tissot‐squalli Mara
- Toledo Cássio A.P.
- Torke Benjamin
- Torres Alicia
- Torres Daniela S.C.
- Torres‐leite Filipe
- Tozzi Ana M.G.A.
- Trad Rafaela
- Trevisan Rafael
- Trierveiler‐pereira Larissa
- Trovó Marcelo
- Tuler Amélia
- Tyrrell Christopher
- Udulutsch Renata
- Uribbe Fernando
- Vahl Daiane
- Valadares Rodrigo
- Valdemarin Karinne
- Valduga Eduardo
- Valente Emilia
- Valls Jose F.M.
- van den Berg Cássio
- Vasconcelos Liziane
- Vasconcelos Thaís N.C.
- Vasques Diego
- Vaz Angela M.S.F.
- Versiane Ana F.A.
- Versieux Leonardo
- Via Do Pico Gisela
- Viana Pedro l.
- Vianna Filho Marcelo D.M.
- Vianna Suelen
- Vidal João
- Vidal Kaio V.A.
- Vieira Fábio C.S.
- Vieira Jaqueline
- Vieira João P.S.
- Vieira Lucas l.A.
- Vieira Tamara A.F.
- Vieira Tiago l.
- Viera‐barreto Jéssica
- Vignoli‐silva Márcia
- Vilas Bôas‐bastos Silvana
- Villarreal Juan
- Vincent Michael
- Vita Marcela
- Vitta Fabio
- Viveros Raquel
- Viviurka Fernanda
- Vogel Ely Cleusa
- Volet Danilo
- Völtz Rafael
- Wallnöfer Bruno
- Walter Bruno M.T.
- Wanderley Maria G.L.
- Watanabe Mauricio T.C.
- Weber Philipy A.P.
- Weigend Maximilian
- Welker Cassiano A.D.
- Windisch Paulo
- Yoshikawa Vania
- Zamengo Henrique
- Zanatta Maria R.V.
- Zannin Ana
- Zappi Daniela
- Zeferino Laís
- Zelenski Andréia
- Zimbrão Geraldo
- Zuloaga Fernando
- Zuntini Alexandre
- Ângulo María
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2022
- Field of study
International audienceThe shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous countries worldwide have devoted considerable effort to Target 1 of the Global Strategy for Plant Conservation (GSPC), which called for the preparation of a working list of all known plant species by 2010 and an online world Flora by 2020. Brazil is a megadiverse country, home to more of the world's known plant species than any other country. Despite that, Flora Brasiliensis, concluded in 1906, was the last comprehensive treatment of the Brazilian flora. The lack of accurate estimates of the number of species of algae, fungi, and plants occurring in Brazil contributes to the prevailing taxonomic impediment and delays progress towards the GSPC targets. Over the past 12 years, a legion of taxonomists motivated to meet Target 1 of the GSPC, worked together to gather and integrate knowledge on the algal, plant, and fungal diversity of Brazil. Overall, a team of about 980 taxonomists joined efforts in a highly collaborative project that used cybertaxonomy to prepare an updated Flora of Brazil, showing the power of scientific collaboration to reach ambitious goals. This paper presents an overview of the Brazilian Flora 2020 and provides taxonomic and spatial updates on the algae, fungi, and plants found in one of the world's most biodiverse countries. We further identify collection gaps and summarize future goals that extend beyond 2020. Our results show that Brazil is home to 46,975 native species of algae, fungi, and plants, of which 19,669 are endemic to the country. The data compiled to date suggests that the Atlantic Rainforest might be the most diverse Brazilian domain for all plant groups except gymnosperms, which are most diverse in the Amazon. However, scientific knowledge of Brazilian diversity is still unequally distributed, with the Atlantic Rainforest and the Cerrado being the most intensively sampled and studied biomes in the country. In times of “scientific reductionism”, with botanical and mycological sciences suffering pervasive depreciation in recent decades, the first online Flora of Brazil 2020 significantly enhanced the quality and quantity of taxonomic data available for algae, fungi, and plants from Brazil. This project also made all the information freely available online, providing a firm foundation for future research and for the management, conservation, and sustainable use of the Brazilian funga and flora
Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies
- Author
- Aage Christiansen
- Aaradhana Adhikari
- Aaron Venti
- Aayesha Qadeer
- Abdellatif Benslama
- Abigail Beane
- Abu Hena Mostafa Kamal
- Abul Faiz
- Adam B Schlichting
- Adam Bell Bell
- Adenilton M R Ampinelli
- Aditya Uppalapati
- Adrian Donnelly
- Adriana M Fernandez
- Adrien Robine
- Aftab Akhtar
- Agreta Gecaj-Gashi
- Ahmed Farooq
- Ahmed S Al Jabbary
- Ahmet Dilek
- Ahmet Sukru Denker
- Ai Y Hang
- Aiman Tulaimat
- Akihiro Takaba
- Akinori Uchiyama
- Akira Hirata
- Akm Shamsul Alam
- Akut Aytulun
- Alain Combes
- Alain M Dive
- Alain Mercat
- Alain U Alisasis
- Alan Zazu
- Alastair Rose
- Alberto Deicas
- Alec A Tallet Alfonso
- Alejandro A Saez
- Alejandro Ebeid
- Alejandro G Castro
- Alejandro R Bruhn
- Alek Kumar
- Alessandro Bacuzzi
- Alessandro Protti
- Alessia Mattei
- Alex Mcleod
- Alex Morton
- Alexandra Ceniceros-Barros
- Alexandra J Williams
- Alexandra Marcu
- Alexandra Siqueira Colombo
- Alexandre Biasi Cavalcanti
- Alexandre Biasi Cavalcanti
- Alexandre Chan
- Alexandre Demoule
- Alexandre Guilherme Ribeiro de Carvalho
- Alexandre Molin
- Alexandre Molin
- Alexey I Gritsan
- Alfons Arizmendi
- Aline Ascoli
- Alison Ghosh
- Alistair Nichol
- Alistair Roy Roy
- Alma Cani
- Alvaro Ramirez-Gutierrez
- Amadeu Martinez
- Amanda Cowton
- Amanda Krstevski
- Amanda Maria R R de Oliveira
- Amanda Skinner
- Amanda Whileman
- Amine Ali Zeggwagh
- Amine Ali Zeggwagh
- Amy McInerney
- Ana Carolina P Antônio
- Ana Carolina Peçanha
- Ana G França
- Ana M Araujo
- Ana M Pellicer
- Anais Briquet
- Anand Dongre
- Anatole Harrois
- Anders Aneman
- Anders Larsson
- Andre Japiassu
- Andre Luiz Baptiston Nunes
- Andre Luiz Baptiston Nunes
- Andre Vercueil
- Andrea Coppadoro
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Lombardo
- Andrea N Cracchiolo
- Andrea Tinnirello
- Andreas Barratt-Due
- Andreas W Reske
- Andrej Sribar
- Andrew Bentley
- Andrew Corner
- Andrew Ferguson
- Andrew J Burtenshaw
- Andrey A Gazenkampf
- André Peretti Torelly
- Angela Delsing
- Angela Pinder
- Aniko D Frigyik
- Anil Hormis
- Anil P Hormis
- Anitha Shenoy
- Anna Hunt
- Anna Oscarsson Tibblin
- Anna Rossi
- Anna T Dowling
- Anna Walker
- Anna-Karin Morin
- Anne Adolfsson
- Anne B Guttormsen
- Annop Piriyapatsom
- Antero do Vale Fernandes
- Antoine Pronovost
- Antonino Giarratano
- Antonio Artigas
- Antonio Braschi
- Antonio Carlos Nogueira
- Antonio G Jimenez
- Antonio Jorge Pereira
- Antonio L Ruiz-Aguilar
- Antonio P Nassar Jr
- Antonio Paulo Nassar Junior
- António M Alvarez
- António M Messias
- Aogan C O'Muircheartaigh
- Areef Ahsan
- Areej Javeed
- Ariel Chena
- Arnaud Follin
- Arshad Taqi
- Arvind K Baronia
- Ary Serpa Neto
- Ashley Schomer
- Ashok S Raj
- Asisclo J Villagomez
- Asisclo Villagomez
- Asma Ben Souissi
- Asma Navasakulpong
- Asoka Gunaratne
- Atta Ur Rehman
- Aurelia M Martinho
- Aylin Seven
- Bao H Zhu
- Barbara Brunettini
- Barbara do Cs Martins
- Barrett T Kitch
- Barry Dixon
- Barry Kennedy
- Basak Ceyda Meco
- Batoul Khoundabi
- Beatriz C Tan
- Behzad Nadjm
- Ben Creagh-Brown
- Bernard Goubaux
- Bernhard Holzgraefe
- Bhagyesh Shah
- Bhuvana Krishna
- Bimal Kudavidanage
- Bin Li
- Bingyu Qin
- Bojan Jovanovic
- Boris G Villamagua
- Brenno Cardoso Gomes
- Brigit L Roberts
- Brit Å Sjøbø
- Bruno Franco Mazza
- Bruno Gelée
- Bruno S Oliveira
- Candelaria De Haro
- Carlo A Volta
- Carlo Alberto Volta
- Carlos A Pellegrini
- Carlos Eduardo Barboza
- Carlos Munhoz
- Carlos S Pereira
- Carly Brown
- Carmen Scott
- Carolina Quintana Grijalba
- Carolina S Insaurralde
- Carolina Serra
- Caroline Berghe
- Caroline C MacFie
- Caroline Wreybrown
- Cassia Righy
- Cassiano Teixeira
- Catalina Forteza
- Catherine Plowright
- Cecilia Carbayo-Gorriz
- Cecilia Hermosa
- Ceri E Battle
- Cesar A Cortez
- Cesar Milstein
- Cesar P Pere
- Chamila Pilimatalawwe
- Charlene Bigot
- Charlene Le Moal
- Charlotte Downes
- Chathurani Sigera
- Chern Min Voon
- Cheryl Padilla-Harris
- Chinni Krishna Kasi
- Chloe Hughes
- Christian C Rylander
- Christian Dellera
- Christian Frey
- Christian M Ramirez-Alfaro
- Christian Schlegel
- Christina Whitehead
- Christine Boyd
- Christine Brown
- Christine Ryan
- Christoph Muench
- Christopher J Scott
- Christopher Nutt
- Christopher Smalley
- Christopher Tainter
- Chunting Wang
- Claine Judy
- Clair Harris
- Claire Kaloo
- Claire Matthews
- Claire Miller
- Claire Pegg
- Claire Reynolds
- Clare Bullock
- Clare Mellis
- Clare Mellis
- Claude Guérin
- Claudia A Ortiz
- Claudia R Estrella
- Claudio H Gonçalves
- Claudio Piras
- Claudio Piras
- Claudio Piras
- Colette Seasman
- Colette Seasman
- Colin K Grissom
- Colin Mcarthur
- Colin S Black
- Cora Lavigne Moreira
- Corcoles G Virgilio
- Corinne Leemann-Refondini
- Cristiane Ritter
- Cristiane Tomasi Damiani
- Cristina M Cox
- Cristina Prata Amendola
- Cristina Santos
- Cristina Santos
- Cédric Daubin
- Daisuke Niimi
- Dale J Yeatts
- Dalton de Souza Barros
- Damien Roux
- Dan E Corneci
- Dan Hadfield
- Dana R Tomescu
- Daniel Aragão
- Daniel Beraldo
- Daniel Collins
- Daniel da Cunha Ribeiro
- Daniel F McAuley
- Daniel Hadfield
- Daniel Hull
- Daniel O Beraldo
- Daniel Prado
- Daniel R Crouch
- Daniel R Gonzalez
- Daniel V Collins
- Daniela Albiero
- Daniela M Palma
- Daniela N Vasquez
- Daniele M Combaux
- Danielle A Fawkes
- Danielle C Fontenele
- Danielle J Hacking
- Danielle Nobrega
- Danielle Reuter
- Danny McAuley
- Dany Goldgran-Toledano
- Dat Vu Quoc
- Davi Cristovao
- David D Llinares Moya
- David Pogson
- David Rogerson
- David Shaw
- David W Wrathall
- Davide D'Antini
- Dawn Trodd
- Debabrata Banik
- Debbie Weller
- Deborah M Inskip
- Deborah Smith
- Deborah Wilson
- Deeban Ganesan
- Demet Aydin
- Denis Doyen
- Denise Donaldson
- Denise Griffin
- Dharshinie Dorasamy
- Diego Pastor Marcos
- Dimitrios Matamis
- Dina Gomaa
- Dina Gomaa
- Dina Ismail
- Dk Maizatul Aiman B Pg Hj Ismail
- Donald A Irvine
- Donall O'Croinin
- Donatella Mestria
- Dora Mannarino
- Dorel Sandesc
- Dorothy M Breen
- Dorothée Carpentier
- Dulce M Dector
- Dyanne Moysés Dalcomune
- Dácil Parrilla Toribio
- Ed Bajwa
- Eddy Fan
- Edel A Meaney
- Edgardo E Tabhan
- Edgardo Nuñez
- Edgardo Tabhan
- Edison Moraes
- Eduardo Beck
- Eduardo Di Lauro
- Eduardo F Labarca
- Eimhin S Dunne
- Eizo Watanabe
- Elaine Ferreira
- Eldar Søreide
- Electra E Stamou
- Elena Frati
- Elena Gallego Curto
- Elena Perez Losada
- Eleni K Mouloudi
- Eleni V Massa
- Eliana Bernadete Caser
- Eliane Bernadete Caser
- Elie H Zogheib
- Eliezer Silva
- Elisa Estenssoro
- Elisa Seghelini
- Elisabetta Pecci
- Elise P Sauvadet
- Ellada V Kiourtzieva
- Elton Afonso Lopes
- Emanuel Cirstea
- Emilio M Osman
- Emma L Willett
- Emre Erbabacan
- Enrique A Piacentini
- Enrique Cereijo
- Eoin Young
- Erika E Borotto
- Erin Nishikawa
- Erna Alberts
- Esther Bermejo Lopez
- Esther Diaz-Rodriguez
- Ettore R Vascotto
- Eva O Nagy
- Evangelos Kalaitzis
- Evelin Drociunas Pacheco
- Evgeny Grigoriev
- Evren Senturk
- Ewan C Goligher
- Fa C Zhou
- Fabien Grelon
- Fabienne D Simonis
- Fabienne D Simonis
- Fabio Tarantino
- Fabrice Daviaud
- Fahd Amir
- Fan Zhang
- Farah Idrees
- Farooq Brohi
- Farshad Heidari
- Fatma Ulger
- Fayez M Kheir
- Feda Kahveci
- Federico Gordo
- Fekri Abroug
- Felipe A Aliaga
- Felipe Dal-Pizzol
- Felipe Saddy
- Felipe T Martinez
- Ferdinando Raimondi
- Fernanda Eugênia Fernandes
- Fernando Borges Rodriguez
- Fernando G George
- Fernando José da Silva Ramos
- Fernando Rios
- Ferran Roche-Campo
- Filipa M Barros
- Finn H Andersen
- Flavia A Loiacono
- Flavia Ribeiro Machado
- Francesco L Santoli
- Francesco Mojoli
- Francesco Raponi
- Francis Schneider
- Francisca G Cazorla-Barranquero
- Francisco Esteve
- Francisco Javier Flores Mejia
- Francisco P Huerta
- Francisco Soriano
- Francois Beloncle
- Frank Stansil
- Frank Van Haren
- Frank Van Haren
- Frantz Berkelmans
- Frederico Bruzzi Carvalho
- Fredrik Schiöler
- Fredy A Montes Oscanoa
- Fredy S Lora
- Fumihito Ito
- Fábio Poianas Giannini
- Gabriel Démpaire
- Gabriele Sales
- Gabrielle C Hanlon
- Gaetan Béduneau
- Galen Henderson
- Garcia M Elisabet
- Gareth P Sellors
- Gary H Mills
- Gautier Buzancais
- Gayle Clifford
- Ged Dempsey
- Gemma Rialp
- Gerard Curley
- Ghaleb Almekhlafi
- Ghanem M Mustafa
- Ghassan Kamel
- Giacomo Bellani
- Giacomo Monti
- Gianluca Zani
- Giannis A Zacharas
- Gilda Cinnella
- Giorgio A Iotti
- Giovana Colozza Mecatti
- Giovanna Occhipinti
- Giovanna Panarello
- Giulia Crapelli
- Giuseppe Foti
- Giuseppe Melchionda
- Gonzalo Navarro
- Greet Hermans
- Guilherme Schettino
- Guillaume Barberet
- Guillaume Carteaux
- Guillermo Bugedo
- Guillermo M Albaiceta
- Gulay Eren
- Gustavo A Plotnikow
- Gustavo Affonso de Oliveira
- Gustavo M Montanha
- Gustavo Pittini
- Guy M Francois
- Gyan Kayashta
- Gyorgy Frendl
- Güldem Turan
- Ha Nguyen Thi Thanh
- Haibo Qiu
- Haibo Qiu
- Haitao Liu
- Hamidreza Jamaati
- Hanane Ezzouine
- Hannah Crowther
- Hans Kedelv
- Hans-Bernd F Hopf
- Hasan M Al Dorzi
- Hazel Spencer
- Heather Blaylock
- Hector H Leon Yoshido
- Heera L Mahto
- Heidi Dawson
- Hektor Sula
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- Helen Green Green
- Helen J Rodgers
- Helen Robertson
- Helen Rodgers
- Helen S Wong
- Helen Talbot
- Helen Wong
- Helena Barcraft-Barnes
- Helga Ceunen
- Helga Ceunen
- Hellen M Van Wezel
- Henrik Appelberg
- Henrik Reschreiter
- Henrik Reschreiter
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- Hermann Wrigge
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- Hernan Gianinetto
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- Herve Lebbinck
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- Hiroshi Imai
- Hiroyasu Kimura
- Hiroyuki Honda
- Hiroyuki Suzuki
- Hiroyuki Tanaka
- Hitesh Batra
- Hua X Wang
- Huanzhang Shao
- Hui Han
- Huiying Zhao
- Hulya Ulusoy
- Huseyin Toman
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- Ingeborg Welters
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- Isabel M Serra
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- Javier Blanco
- Javier E Salas
- Javier G Alonso
- Javier Hurtado
- Javier Hurtado
- Javier Hurtado
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- Jian Liu
- Jignesh Shah
- Jing Kong
- Jing L Liu
- Joan M Lynch
- Joana M Estilita
- Joanna Wessbergh
- Joanne B Robles
- Joanne Howe
- Johan Decruyenaere
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- Shazia Choudry
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- Shin Nunomiya
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- Shou H Wang
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- Shu H Qin
- Shuhei Matsumoto
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- Souheil Elatrous
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- Stefan Bolon
- Stefania Aguirre
- Stella Metherell
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- Stephanie Janes
- Stephen Wright
- Steve Rose
- Steve Windebank
- Stuart Mckechnie
- Subhal B Dixit
- Sudha V Sagar
- Sue Glenn
- Suleyman S Derman
- Suming Zhou
- Sunisa Chatmongkolchart
- Suraiya Nazneed
- Suresh Pillai
- Suresh Shindhe
- Susan M Marum
- Susan Melbourne
- Susan Tyson
- Susana Temprano
- Susannah Leaver
- Susanne Schäfer
- Suthat Rungruanghiranya
- Suzana Alves Silva
- Syed Muneeb Ali
- Syed Tariq Reza
- Syeda Nafisa Khatoon
- Sylvie Ricome
- Szabolcs Rugonfalvi
- Sánchez I Rafael
- Sébastien Jochmans
- Sérgio Felix Pinto
- Sílvia Moulin
- T John Trinder
- T Sottiaux
- Tadaaki Takada
- Tai Pham
- Takeshi Ueda
- Tamas Szakmany
- Tananchai Petnak
- Tanja A Treschan
- Tanveer Hussain
- Tao Yu
- Taohidul Majid Taohid
- Tarek Dendane
- Tarikul Hamid
- Tasmin Patel
- Tatjana Simurina
- Teresa Honrubia
- Terri-Ann Sewell
- Tharwat M Aisa
- Theonymfi G Papavasilopoulou
- Thiago Lisboa
- Thomas Baltus
- Thomas C Blakeman
- Thomas Collyer
- Thomas Kander
- Thomas Staudinger
- Thuy Duong Bich
- Théia Forny Wanderley Castellões
- Tiago Macruz
- Tie H Qin
- Tim Wenham
- Tom Hatton
- Tomas P Roser
- Tomaz Mesar
- Tomaz Mesar
- Tommaso Fossali
- Tomoaki Hashida
- Tomofumi Harasawa
- Tomoyuki Nakamura
- Toni E Mckenna
- Toshikazu Abe
- Tracey Evans
- Trevor W Oetting
- Troy S B Rowne
- Tài Pham
- Udomsak Silachamroon
- Ugur Goktas
- Ulysses V A Silva
- Una Poultney
- Unase Buyukkocak
- Upeka Samaranayake
- Ushio Higashijima
- Valeria I Cerrato
- Valerie M Banner-Goodspeed
- Vallish K Bhardwaj
- Vallverdu P Imma
- Valéria Maria Campos Rezende
- Vanessa Linnett
- Vanessa M Sales
- Vanessa Oliveira
- Vania A Brito
- Varsha Kadaba
- Vasilis Ourailogloy
- Venika Manoharan
- Venkatapura J Ramesh
- Veronica Villar
- Vesna Bumbasierevic
- Vesna Bumbasirevic
- Vicente Cés de Souza Dantas
- Vijayanand Palaniswamy
- Vincenzo Pota
- Vincenzo Russotto
- Vincenzo Schiavone
- Viratch Tangsujaritvijit
- Virginie Lemiale
- Visanthi Pinto
- Vivek Kakar
- Vladimir Cerny
- Vlasta Klaric
- Wahid Altaf
- Wajdi Maazouzi
- Wei H Zhu
- Wei Wang
- Weihua Lu
- Wenkui Yu
- Wenwen Li
- Werner Schmid
- William Stigler
- Xavier Wittebole
- Xian Y Zhao
- Xiao B Huang
- Xiao L Li
- Xiaoming Luo
- Xing Y Zhang
- Xinyu Li
- Y A Hasitha Dilhani
- Ya Q Wu
- Yaasen Arabi
- Yan Gao
- Yaseen M Arabi
- Yasuaki Ogino
- Yavuz Orak
- Yen Lam Minh
- Yi Han
- Yimin Li
- Yonghao Xu
- Yoshihiro Yamaji
- Yoshinobu Kameyama
- Youssef Haddad
- Youzhong An
- Yozo Kashiwa
- Yu D Di
- Yuan N Gao
- Yuan Y Li
- Yuanhua Lu
- Yves D Jarquin-Badiola
- Zerrin Demirtürk
- Zhe Zhai
- Zheng L Ye
- Zhenyang He
- Zhou Li-Xin
- Álvaro Réa-Neto
- Ángela Algaba
- Ángela González-Salamanca
- Çiler Zincircioglu
- Érica Aranha Suzumura
- Ênio Rego
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies.
Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality.
Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42·4% vs 44·2%; absolute difference -1·69 [-9·58 to 6·11] p=0·67; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5-8] vs 6 [5-8] cm H2O; p=0·0011). ICU mortality was higher in MICs than in HICs (30·5% vs 19·9%; p=0·0004; adjusted effect 16·41% [95% CI 9·52-23·52]; p<0·0001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0·80 [95% CI 0·75-0·86]; p<0·0001).
Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods
- Author
- Abdukahil Sheryl Ann
- Abdulkadir Nurul Najmee
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Abrous Amal
- Absil Lara
- Acker Andrew
- Adachi Shingo
- Adam Elisabeth
- Adriano Enrico
- Adrião Diana
- Ageel Saleh Al
- Ahmed Shakeel
- Aiello Marina
- Ainscough Kate
- Airlangga Eka
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alberti Angela
- Alegesan Senthilkumar
- Alegre Cynthia
- Alessi Marta
- Alex Beatrice
- Alexandre Kévin
- Alfoudri Huda
- Ali Adam
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Amira Nur
- Ammerlaan Heidi
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart Séverine
- Anthonidass Sivanesen
- Antonelli Massimo
- Anwar Kazi Rubayet
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Arancibia Francisco
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Asaki Motohiro
- Asensio Angel
- Ashley Elizabeth A.
- Ashraf Muhammad
- Assie Jean Baptiste
- Asyraf Amirul
- Atique Anika
- Attanyake AM Udara Lakshan
- Auchabie Johann
- Auger Christelle Chantalat
- Aumaitre Hugues
- Auvet Adrien
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J. Kenneth
- Baird J Kevin
- Bak Erica
- Bakakos Agamemnon
- Bakar Nazreen Abu
- Bal Andriy
- Balakrishnan Mohanaprasanth
- Balan Valeria
- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
- Barbalho Renata
- Barbosa Nicholas Yuri
- Barclay Wendy S.
- Barnett Saef Umar
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Basri Muhammad Fadhli Hassin
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Bee Ker Hong
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beltrão Beatriz Amorim
- Beluze Marine
- Benech Nicolas
- Benjiman Lionel Eric
- Benkerrou Dehbia
- Bennett Suzanne
- Bento Luís
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- Berge Marcel van den
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- Bihan Clément Le
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- Brien Fionnuala O
- Bris Cyril Le
- Browne Alex
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- Brusse-Keizer Marjolein
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- Butnaru Denis
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- Callaghan Annmarie O
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- Cooke Graham S.
- Copland Mary
- Cordel Hugues
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- D'Aragon Frédérick
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- da Silva Filipe Ana
- Da Silva Fernanda Dias
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- Dagens Andrew
- Dahly Darren
- Dalton Heidi
- Dalton Jo
- Daly Seamus
- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A
- Dantas Jorge
- Darshana B. P. Sanka Ruwan Sri
- de Brito Carlos Alexandre Antunes
- de Castro Maisa Guimarães
- de Jong Menno
- de Loughry Gillian
- de Mendoza Diego
- De Montmollin Etienne
- de Oliveira França Rafael Freitas
- de Piero Maria
- de Pinho Oliveira Ana Isabel
- De Rosa Rosanna
- De Rose Cristina
- de Silva Thushan
- de Velde Stijn Van
- de Vries Peter
- Deacon Jillian
- Dean David
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- Dechert William
- Deconninck Lauren
- Decours Romain
- Defous Eve
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- Delaveuve Eric
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- Delfos Nathalie M.
- Deligiannis Ionna
- Dell'Amore Andrea
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- Demonchy Elisa
- Denis Emmanuelle
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- Diamantis Sylvain
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- Didier Kévin
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- Dimet Jérôme
- Dinot Vincent
- Diop Fara
- Diouf Alphonsine
- Dishon Yael
- Djossou Félix
- Docherty Annemarie B.
- Doherty Helen
- Dominguez Carmen Infante
- Dondorp Arjen M
- Dong Andy
- Donnelly Christl A.
- Donnelly Maria
- Donohue Chloe
- Donohue Sean
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- Fakar Zul
- Falher Georges Le
- Faria Pedro
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- Fernandes Jorge
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- Finlayson William
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- Foster Denise
- Foti Giuseppe
- Fourn Erwan
- Fowler Robert A.
- Fraher Marianne
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John F
- Freire Marcela Vieira
- Friedrich Caren
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- Fry Stéphanie
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- Fukuda Masahiro
- G Argin
- Gaborieau Valérie
- Gaci Rostane
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- ghisulal praveen kumar
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- Grable Margarite
- Graf Jeronimo
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- Grandin Edward Wilson
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- Granier Pascal
- Grasselli Giacomo
- Green Christopher A.
- Greene Courtney
- Greenhalf William
- Greffe Segolène
- Greve Frank van Someren
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- Groenendijk Albert
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- Gu Yusing
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- Haber Daniel
- Habraken Hannah
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- Hall Matthew
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- Hamer Ansley
- Hamers Raph L.
- Hamidfar Rebecca
- Hammond Naomi
- Hammond Terese
- Han Lim Yuen
- Haniffa Rashan
- Hao Kok Wei
- Hardwick Hayley
- Harrison Ewen M.
- Harrison Janet
- Harrison Samuel Bernard Ekow
- Hartman Alan
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- Hoshino Koji
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- Hough Catherine L.
- Houltham Stuart
- Hssain Ali Ait
- Hsu Jimmy Ming-Yang
- Hulot Jean-Sébastien
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- Huo Stella
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- Ijaz Samreen
- Ikram M. Arfan
- Illana Carlos Cañada
- Illes Hajnal-Gabriela
- Imbert Patrick
- Inácio Hugo
- Ing Yun Sii
- Iñiguez Jonathan Samuel Chávez
- Iosifidis Elias
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- Javidfar Jeffrey
- Jaworsky Denise
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- Jelani Anilawati Mat
- Jenum Synne
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- Jimenez Juan Fernado Masa
- Joe Ong Yiaw
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- Jourdain Mercé
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- Kay Christy
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- Keating Seán
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- Keshav Sharma
- Kestelyn Evelyne
- Khalid Imrana
- Khalil Antoine
- Khan Coralie
- Khan Irfan
- Kherajani Krish
- Kho Michelle E
- Khoo Denisa
- Khoo Ryan
- Khoo Saye
- Kiat Khor How
- Kida Yuri
- Kiiza Peter
- Kildal Anders Benjamin
- Kim Jae Burm
- Kimmoun Antoine
- Kindgen-Milles Detlef
- King Alexander
- Kitamura Nobuya
- Klenerman Paul
- Klont Rob
- Knight Stephen R
- Kobbe Robin
- Kodippily Chamira
- Komatsu Mamoru
- Korten ISARIC Collaborator
- Kosgei Caroline
- Kpangon Arsène
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- Krishnan Sudhir
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- Kumar Deepali
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- L'Her Erwan
- Lachatre Marie
- Lacoste Marie
- Laffey John G.
- Lafhej Nadhem
- Lagrange Marie
- Laine Fabrice
- Lairez Olivier
- Lambert Marc
- Lamontagne François
- Langelot-Richard Marie
- Langlois Vincent
- Lantang Eka Yudha
- Lanza Marina
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- Lawrence Teresa
- Le Minh
- Leal Ema
- Leathlobhair Niamh Ni
- Lee Biing Horng
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- Lee Su Hwan
- Lee Todd C.
- Lee Yi Lin
- Leeming Gary
- Lefebvre Bénédicte
- Lefebvre Laurent
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- Lemee Véronique
- Lemeur Anthony
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- Lene Ha Sha
- Lennon Jenny
- Leone Marc
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- Lesens Olivier
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- Levy Bruno
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- Levy-Marchal Claire
- Lewandowska Katarzyna
- Liang Janet
- Liegeon Geoffrey
- Lim Kah Chuan
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- Lina Bruno
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- Lizotte Patricia
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- Lolong Navy
- Loon Leong Chee
- Lopes Diogo
- Lopez-Colon Dalia
- Lopez-Revilla Jose W.
- Lordemann Anja Grosse
- Loschner Anthony L.
- Loubet Paul
- Loufti Bouchra
- Louis Guillame
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- Low Lee Lee
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- Luna Carlos M.
- Lungu Olguta
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- Luque Nestor
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- Mahieu Rafael
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- Maia Ana Raquel
- Maier Lars S.
- Maillet Mylène
- Maitre Thomas
- Majori Maria
- Malaque Ceila Maria Sant‘Ana
- Malfertheiner Maximilian
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- Manda Victoria
- Mandei Jose M.
- Mandelbrot Laurent
- Manetta Frank
- Mankikian Julie
- Manning Edmund
- Manuel Aldric
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- Marino Daniel
- Marino Flávio
- Markowicz Samuel
- Marques Ana
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- Martin Emily
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- Martin-Loeches Ignacio
- Martinez F. Eduardo
- Martinot Martin
- Martins Ana
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- McArthur Colin
- McCanny Peter
- McCarthy Aine
- McCarthy Anne
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- McConnochie Rachael
- McDermott Sherry
- McDonald Sarah E.
- McElroy Aine
- McElwee Samuel
- McEneany Victoria
- McEvoy Natalie
- McGeer Allison
- McKay Chris
- McKeown Johnny
- McLean Kenneth A.
- McNally Paul
- McNicholas Bairbre
- McPartlan Elaine
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- Mentzer Alexander J.
- Mercier Emmanuelle
- Mercier Noémie
- Merckx Antoine
- Mergeay-Fabre Mayka
- Mergler Blake
- Merson Laura
- Merson Laura
- Meschi Tiziana
- Mesinovic Munib
- Mesquita António
- Mestre Soizic Le
- Meta Roberta
- Metwally Osama
- Meybeck Agnès
- Meyer Dan
- Meynert Alison M.
- Meysonnier Vanina
- Meziane Amina
- Mezidi Mehdi
- Michelanglei Céline
- Michelet Isabelle
- Mihelis Efstathia
- Mihnovit Vladislav
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- Miranda-Maldonado Hugo
- Misnan Nor Arisah
- Moal Gwenaël Le
- Mohamed Nik Nur Eliza
- Mohamed Tahira Jamal
- Mohammed Nassima Si
- Mohd-Hanafiah Farah Nadia
- Moin Asma
- Moing Vincent Le
- Molinos Elena
- Molloy Brenda
- Mone Mary
- Monteiro Agostinho
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- Montes Claudia
- Montrucchio Giorgia
- Moore Sarah
- Moore Shona C.
- Morlaes Louis Gerbaud
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- Morton Ben
- Motherway Catherine
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- Mouquet Hugo
- Moyet Julien
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- Müller Fredrik
- Müller Karl Erik
- Myrodia Dimitra Melia
- Nagard Hervé Le
- Nagpal Dave
- Nagrebetsky Alex
- Narasimhan Mangala
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- Neant Nadège
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- Netten Carolien van
- Neumann Emily
- Ng Pauline Yeung
- Nghi Anthony
- Nguyen Duc
- Nichol Alistair D
- Nitayavardhana Prompak
- Nonas Stephanie
- Noordin Nurul Amani Mohd
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- Norman Lisa
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- Noursadeghi Mahdad
- Nowicka Karolina
- Nowinski Adam
- Nseir Saad
- null null
- null null
- Nunez Jose I
- Nuñez Maria Angelica Rivera
- Nurnaningsih Nurnaningsih
- Nusantara Dwi Utomo
- Nyamankolly Elsa
- O'Callaghan Annmarie
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- Oh Tak-Hyuk
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- Oliveira João
- Oliveira Larissa
- Olliaro Piero
- Olliaro Piero L.
- Ong David S. Y.
- Ong Jee Yan
- Oña Edwin Fernando Paredes
- Oosthuyzen Wilna
- Opavsky Anne
- Openshaw Peter
- Orozco-Chamorro Claudia Milena
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- Othman Siti Zubaidah
- Ouamara Nadia
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- Oziol Eric
- Pagadoy Maïder
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- Palacios Amanda
- Palen Job van der
- Palmarini Massimo
- Panarello Giovanna
- Panda Prasan Kumar
- Pang Lai Hui
- Panigada Mauro
- Pansu Nathalie
- Papadopoulos Aurélie
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- Usman Asad
- Uva Maria Sousa
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- Val-Flores Luís
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- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Varrone Michael
- Vasconcelos Malte Kohns
- Vasudayan Shoban Raj
- Vauchy Charline
- Vecham Pavan Kumar
- Veen Ilonka van
- Veeran Shaminee
- Veislinger Aurélie
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- Verbon Annelies
- Vickers James
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- Villoldo Andrea
- Vishwanathan Gayatri
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vongsouvath Manivanh
- Vonkeman Harald
- Voort Peter Van der
- Vuotto Fanny
- Wahab Noor Hidayu
- Wahab Suhaila Abdul
- Wahid Nadirah Abdul
- Wainstein Marina
- Webb Steve
- Wei Jia
- Weil Katharina
- Wen Tan Pei
- Werf Sylvie Van Der
- Wesselius Sanne
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- Wham Murray
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- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Sue
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- Williams Virginie
- Willigen Hugo Van
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- Wong Xin Ci
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- Wong Yew Sing
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- Xian Gan Ee
- Xian Lim Saio
- Xuan Kuan Pei
- Xynogalas Ioannis
- Yacoub Sophie
- Yakop Siti Rohani Binti Mohd
- Yamazaki Masaki
- Yarad Elizabeth
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yeoh Chian Hui
- Yerkovich Stephanie
- Yiaye Touxiong
- Yiu Ng Wing
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zabert Gustavo E
- Zacharowski Kai
- Zahid Masliza
- Zahran Maram
- Zaidan Nor Zaila Binti
- Zambon Maria
- Zambrano Miguel
- Zanella Alberto
- Zawadka Konrad
- Zaynah Nurul
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- Publication date
- 16/07/2024
- Field of study
By September 2022, more than 600 million cases of SARS-CoV-2 infection have been reported globally, resulting in over 6.5 million deaths. COVID-19 mortality risk estimators are often, however, developed with small unrepresentative samples and with methodological limitations. It is highly important to develop predictive tools for pulmonary embolism (PE) in COVID-19 patients as one of the most severe preventable complications of COVID-19. Early recognition can help provide life-saving targeted anti-coagulation therapy right at admission. Using a dataset of more than 800,000 COVID-19 patients from an international cohort, we propose a cost-sensitive gradient-boosted machine learning model that predicts occurrence of PE and death at admission. Logistic regression, Cox proportional hazards models, and Shapley values were used to identify key predictors for PE and death. Our prediction model had a test AUROC of 75.9% and 74.2%, and sensitivities of 67.5% and 72.7% for PE and all-cause mortality respectively on a highly diverse and held-out test set. The PE prediction model was also evaluated on patients in UK and Spain separately with test results of 74.5% AUROC, 63.5% sensitivity and 78.9% AUROC, 95.7% sensitivity. Age, sex, region of admission, comorbidities (chronic cardiac and pulmonary disease, dementia, diabetes, hypertension, cancer, obesity, smoking), and symptoms (any, confusion, chest pain, fatigue, headache, fever, muscle or joint pain, shortness of breath) were the most important clinical predictors at admission. Age, overall presence of symptoms, shortness of breath, and hypertension were found to be key predictors for PE using our extreme gradient boosted model. This analysis based on the, until now, largest global dataset for this set of problems can inform hospital prioritisation policy and guide long term clinical research and decision-making for COVID-19 patients globally. Our machine learning model developed from an international cohort can serve to better regulate hospital risk prioritisation of at-risk patients
Implementation of Recommendations on the Use of Corticosteroids in Severe COVID-19
- Author
- Aasiyah Rashan
- Abby Hurd
- Abdou Gai
- Abdulrahman Al-Fares
- Abhijit Duggal
- Abigail Beane
- Abubacarr Jagne
- Adam Ali
- Adam Hall
- Adam Nowinski
- Adrian Ceccato
- Adrian Streinu-Cercel
- Adrian Tey
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Agamemnon Bakakos
- Agnès Meybeck
- Agnès Sommet
- Agnieszka Oldakowska
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Haji Ab Rahman
- Ailbhe Cullen
- Ailbhe Hayes
- Aine McCarthy
- Aine McElroy
- Aisling Murphy
- Akram Zaaqoq
- Al-Awwab Dabaliz
- Alan Hartman
- Alasdair Nazerali-Maitland
- Albert Groenendijk
- Albert Sotto
- Alberto Uribe
- Alberto Zanella
- Albertus Beishuizen
- Aldo Rafael
- Aldric Manuel
- Alejandro Martín-Quiros
- Aleksander Rygh Holten
- Aleksandr Beljantsev
- Alessandra Notari
- Alex Browne
- Alex Nagrebetsky
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J Mentzer
- Alexander Zoufaly
- Alexandra Bedossa
- Alexandra Sperry
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Alexandros Cavayas
- Alexis F Turgeon
- Ali Ait Hssain
- Ali Hachemi
- Alicia Gonzalez
- Alif Adlan Mohd Thabit
- Alina Kalicinska
- Aline-Marie Florence
- Alison M Meynert
- Alistair D Nichol
- Aliya Mohammed Alameen
- Allison McGeer
- Alpha Diallo
- Alphonsine Diouf
- Am Udara Lakshan Attanyake
- Amal Abrous
- Amanda Corley
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amar Bhatt
- Ami Stuart
- Amiel A Dror
- Amirul Asyraf
- Amna Faheem
- Amy Lester-Grant
- Amy Stone
- Ana Catarino
- Ana Chora Sousa
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Ana Isabel de Pinho Oliveira
- Ana L Rios
- Ana Marques
- Ana Martins
- Ana Motos
- Ana Raquel Maia
- Anatoliy Gavrylov
- Anca Streinu-Cercel
- Anders Benjamin Kildal
- Anders Benteson Nygaard
- Anders Tveita
- Andra-Maris Post
- Andre Real
- Andrea Angheben
- Andrea Cortegiani
- Andrea Dell'Amore
- Andrea Kelly
- Andrea Rossanese
- Andrea Villoldo
- Andreas Lind
- Andrew Acker
- Andrew Dagens
- Andrew Hershey
- Andrew Letizia
- Andrew Udy
- Andrey Svistunov
- André Cabie
- André Dias
- André Roberto
- Andriy Bal
- Andy Law
- Angel Asensio
- Angel Sanchez-Miralles
- Angela Alberti
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anjellica Chen
- Ankana Satya
- Anna Beltrame
- Anna Ciullo
- Anna Greti Everding
- Anna Jung
- Anna Roca
- Anne Conrad
- Anne Guillaumot
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne Opavsky
- Anne-Hélène Boivin
- Anne-Marie Guerguerian
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B Docherty
- Annmarie O Callaghan
- Ansley Hamer
- Anthony L Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Anton Prinssen
- Antoni Torres
- Antonia Ho
- Antonia Ricchiuto
- Antonio Arcadipane
- Antonio Lalueza
- Antonio Loforte
- Antonio Pesenti
- António Mesquita
- Anuraj Shankar
- Aoife Driscoll
- Aoife Kelly
- Aquiles Rodrigo Henriquez-Trujillo
- Arabella Fahy
- Ardiyan Apriyana
- Argin G
- Arianne Joy Corpuz
- Arie Zainul Fatoni
- Arjen M Dondorp
- Arnaud Scherpereel
- Arne Søraas
- Arsène Kpangon
- Arthur Garan
- Ary Serpa Neto
- Asad Usman
- Asfia Sultana
- Asgar Rishu
- Asma Moin
- Astarini Hidayah
- Atie Suwarti
- Atif Siddiqui
- Audrey Dubot-Pérès
- Aurelius Bonfasius
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Aurore Bousquet
- Axelle Braconnier
- Ayodhia Pitaloka
- B P Sanka Ruwan Sri Darshana
- Bailey Cassandra
- Bailey Williams
- Bairbre McNicholas
- Bakary K Dibba
- Bambang Pujo Semedi
- Bato Hammarström
- Beathe Kiland Granerud
- Beatrice Alex
- Beatriz Amorim Beltrão
- Behzad Nadjm
- Ben Morton
- Benedict Sim Lim Heng
- Benigno Ferreira
- Benjamin Bach
- Benjamin Lefèvre
- Benjamin Smood
- Benjamine Sarton
- Benoit Visseaux
- Benoît Roze
- Benoît Thill
- Bernard Cholley
- Bernardo Ferreira
- Bernhard Roessler
- Bertrand Dussol
- Bénédicte Lefebvre
- Bianca DeBenedictis
- Biing Horng Lee
- Birgitte Stiksrud
- Blake Mergler
- Blandine Rammaert
- Bouchra Loufti
- Bountoy Sibounheuang
- Brenda Molloy
- Brenda Reeve
- Brian Marsh
- Brigid Flynn
- Brigitte Elharrar
- Bruno Levy
- Bruno Lina
- Bruno Pastene
- Bruno Sarmento Banheiro
- Bryan Whelan
- Burrell Aidan J C
- Caitriona Cody
- Calvin Wong
- Cameron J Fairfield
- Camile Bouisse
- Camille Couffignal
- Camirand-Lemyre Félix
- Caren Friedrich
- Carine Roy
- Carla Eira
- Carlos Alexandre Antunes de Brito
- Carlos Cañada Illana
- Carlos Lumbreras Bermejo
- Carlos M Luna
- Carlos Pimentel
- Carmen Infante Dominguez
- Carolien van Netten
- Caroline Martins Rego
- Caroline Mudara
- Carolline Araujo
- Carrol Gamble
- Cassidy Codan
- Cassie Lawrence
- Catarina Espírito Santo
- Catarina Pires
- Catarina Silva
- Catherine A Shaw
- Catherine Blier
- Catherine Chakveatze
- Catherine Chirouze
- Catherine L Hough
- Catherine Marquis
- Catherine Motherway
- Cecile Azoulay
- Cecilia Canepa
- Ceila Maria Sant Ana Malaque
- Celina Turchi Martelli
- Cécile Goujard
- Cécile Mear-Passard
- Cécile Tromeur
- Cécile Yelnik
- Cédric Joseph
- Cédric Laouénan
- Céline Dorival
- Céline Ficko
- Céline Michelanglei
- César Vieira
- Chamira Kodippily
- Chan Chee Eng
- Chantre Lima
- Charlene Da Silveira
- Charles Roberts
- Charline Vauchy
- Charlotte Charpentier
- Charlotte Salmon Gandonniere
- Charlotte Summers
- Chian Hui Yeoh
- Chiara Piubelli
- Chiara Robba
- Chiara Vitiello
- Chih-Hsien Wang
- Chika Akwani
- Christel Arnold-Day
- Christelle Delmas
- Christelle Paul
- Christelle Tual
- Christian Prebensen
- Christian Rabaud
- Christiana Kartsonaki
- Christl A Donnelly
- Christophe Fraser
- Christophe Rapp
- Christopher A Green
- Christy Kay
- Citarella Barbara Wanjiru
- Claire Andréjak
- Claire Kelly
- Claire Levy-Marchal
- Claire Roger
- Clara Mouton Perrot
- Clare Jackson
- Clark D Russell
- Claudia Bianco
- Claudia Figueiredo-Mello
- Claudia Milena Orozco-Chamorro
- Claudia Montes
- Claudia Sepulveda
- Claudina Cruz
- Claudine Badr
- Claudio Duarte Fonseca
- Cleide Barrigoto
- Clément Le Bihan
- Clotilde Allavena
- Coilin Smyth
- Colin McArthur
- Colin McCloskey
- Colleen Curran
- Coralie Tardivon
- Corine Delsing
- Cornelius Rau
- Cosimo Cristella
- Courtney Greene
- Cristina De Rose
- Cristinava Vajdovics
- Cynthia Braga
- Cyril Cadoz
- Cyril Le Bris
- Dafsah Juzar
- Dag Henrik Reikvam
- Daisuke Kasugai
- Dalia Lopez-Colon
- Damien Bouhour
- Dan Meyer
- Daniel Glikman
- Daniel Haber
- Daniel Herr
- Daniel Ivulich
- Daniel Munblit
- Daniel Perez
- Daniela Guerreiro
- Danielle Jaafar
- Danilo Buonsenso
- Danoy Chommanam
- Dario Sinatti
- Darren Dahly
- Darshana Hewa Kandamby
- Dave Nagpal
- David Bellemare
- David Brewster
- David Dean
- David L Robertson
- David Maslove
- David Richardson
- David S Y Ong
- David Stuart
- David Thomson
- David Zucman
- Davide Chiumello
- Debby Bogaert
- Decy Subekti
- Deepali Kumar
- Deepashankari Suppiah
- Deirdre Flynn
- Delphine Bachelet
- Delphine Bergeaud
- Delphine Lariviere
- Demetrios Kutsogiannis
- Denis Butnaru
- Denis Garot
- Denis Malvy
- Denisa Khoo
- Denise Battaglini
- Denise Foster
- Denise Jaworsky
- Denise Richardson
- Denisse Bazan Dow
- Derbrenn OConnor
- Desy Rusmawatiningtyas
- Detlef Kindgen-Milles
- Diana Adrião
- Diana Hernandez
- Diana Póvoas
- Diane Descamps
- Diane Ponscarme
- Didier Laureillard
- Diego Bastos Porto
- Diego de Mendoza
- Diego Fernando Bautista Rincon
- Diego Franch-Llasat
- Dimitra Melia Myrodia
- Dinesh Kuriakose
- Diogo Borges
- Diogo Lopes
- Djura Piersma
- Domenico Luca Grieco
- Domingue Marie-Pier
- Dominic So
- Dominique Deplanque
- Dominique Luton
- Dori-Ann Martin
- Dorothea Rosenberger
- Dorothy Breen
- Dounia Bouhmani
- Douwe F Postma
- Dr Rajesh Mohan Shetty
- Drashti Patel
- Dubravka Supic
- Duc Nguyen
- Dwi Utomo Nusantara
- Dyah Kanyawati
- Dzawani Muhamad
- Edel Meaney
- Eder Caceres
- Edmund Manning
- Edouard Soum
- Edward Wilson Grandin
- Efstathia Mihelis
- Eglantine Ferrand Devouge
- Egle Saviciute
- Eibhlin Higgins
- Eka Airlangga
- Eka Yudha Lantang
- Elaine Conway
- Elaine Gilroy
- Elena Molinos
- Elias Iosifidis
- Elisa Demonchy
- Elisabeth Adam
- Elisabeth Botelho-Nevers
- Elisabetta Spinuzza
- Elise Artaud-Macari
- Elizabeth A Ashley
- Elizabeth Yarad
- Ellen Shadowitz
- Elmi Theron
- Elodie Curlier
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- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thomas Staudinger
- Thushan de Silva
- Tiago Isidoro
- Tiffany Trouillon
- Timo Brandenburger
- Timothy M Uyeki
- Ting Soo Chow
- Tiphaine Goulenok
- Tirupakuzhi Vijayaraghavan Bharath Kumar
- Tjard Schermer
- Todd C Lee
- Tom Fletcher
- Tom Solomon
- Tomoyuki Endo
- Toni Duculan
- Tony Trapani
- Toshiki Yokoyama
- Touxiong Yiaye
- Tristan Gigante
- Trude Steinsvik
- Tze Vee Soh
- Tze Yuan Tee
- Umberto D'Alessandro
- Usuf Effua
- Vadim Tieroshyn
- Valentine Campana
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Valla Sahraei
- Vanessa Sancho-Shimizu
- Vanessa Teotonio
- Vanina Meysonnier
- Vegard Skogen
- Ventzislava Petrov-Sanchez
- Véronique Lemee
- Vicente Souza-Dantas
- Victor Fomin
- Victoria Janes
- Victoria Manda
- Victoria Shaw
- Viladeth Praphasiri
- Vilmaris Quinones-Cardona
- Vincent Dinot
- Vincent Dubee
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinothini Krishnan
- Virginie Williams
- Víctor Quirós González
- Vladislav Mihnovit
- Volkan Korten
- Wai Ching Sin
- Walter Picard
- Wei Han Hoh
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Dechert
- William Finlayson
- William Greenhalf
- Wilna Oosthuyzen
- Wils Evert-Jan
- Wim Dieperink
- Wing Yiu Ng
- Xavier Duval
- Xin Ci Wong
- Yael Dishon
- Yan Chyi Tan
- Yanay Gorelik
- Yaseen Arabi
- Yash Doshi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Yih-Sharng Chen
- Ymkje Stienstra
- Yoan Lavie-Badie
- Yoann Donohue
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yuri Kida
- Yusing Gu
- Yvelynne Kelly
- Yves Levy
- Zeno Bisoffi
- Zhang Duan Tham
- Zul Amali Che Kamaruddin
- Zulfiqar Sandhu
- Publication venue
- Publication date
- 01/12/2023
- Field of study
Importance: Research diversity and representativeness are paramount in building trust, generating valid biomedical knowledge, and possibly in implementing clinical guidelines. Objectives: To compare variations over time and across World Health Organization (WHO) geographic regions of corticosteroid use for treatment of severe COVID-19; secondary objectives were to evaluate the association between the timing of publication of the RECOVERY (Randomised Evaluation of COVID-19 Therapy) trial (June 2020) and the WHO guidelines for corticosteroids (September 2020) and the temporal trends observed in corticosteroid use by region and to describe the geographic distribution of the recruitment in clinical trials that informed the WHO recommendation. Design, setting, and participants: This prospective cohort study of 434 851 patients was conducted between January 31, 2020, and September 2, 2022, in 63 countries worldwide. The data were collected under the auspices of the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC)-WHO Clinical Characterisation Protocol for Severe Emerging Infections. Analyses were restricted to patients hospitalized for severe COVID-19 (a subset of the ISARIC data set). Exposure: Corticosteroid use as reported to the ISARIC-WHO Clinical Characterisation Protocol for Severe Emerging Infections. Main outcomes and measures: Number and percentage of patients hospitalized with severe COVID-19 who received corticosteroids by time period and by WHO geographic region. Results: Among 434 851 patients with confirmed severe or critical COVID-19 for whom receipt of corticosteroids could be ascertained (median [IQR] age, 61.0 [48.0-74.0] years; 53.0% male), 174 307 (40.1%) received corticosteroids during the study period. Of the participants in clinical trials that informed the guideline, 91.6% were recruited from the United Kingdom. In all regions, corticosteroid use for severe COVID-19 increased, but this increase corresponded to the timing of the RECOVERY trial (time-interruption coefficient 1.0 [95% CI, 0.9-1.2]) and WHO guideline (time-interruption coefficient 1.9 [95% CI, 1.7-2.0]) publications only in Europe. At the end of the study period, corticosteroid use for treatment of severe COVID-19 was highest in the Americas (5421 of 6095 [88.9%]; 95% CI, 87.7-90.2) and lowest in Africa (31 588 of 185 191 [17.1%]; 95% CI, 16.8-17.3). Conclusions and relevance: The results of this cohort study showed that implementation of the guidelines for use of corticosteroids in the treatment of severe COVID-19 varied geographically. Uptake of corticosteroid treatment was lower in regions with limited clinical trial involvement. Improving research diversity and representativeness may facilitate timely knowledge uptake and guideline implementation
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
- Author
- Abbas Ali
- Abdukahil Sheryl Ann
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Absil Lara
- Acharya Subhash
- Acker Andrew
- Adrião Diana
- Ahmed Shakeel
- Ainscough Kate
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Al Ageel Saleh
- Al Qasim Eman
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alegesan Senthilkumar
- Alegre Cynthia
- Alessi Marta
- Alex Beatrice
- Alexandre Kévin
- Alfoudri Huda
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Altaf Aneela
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart Séverine
- Antonelli Massimo
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Aryal Diptesh
- Asensio Angel
- Asif Namra
- Asim Mohammad
- Assie Jean Baptiste
- Atif Minahel
- Atique Anika
- Attanyake A. M. Udara Lakshan
- Auchabie Johann
- Auger Christelle Chantalat
- Aumaitre Hugues
- Auvet Adrien
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J. Kenneth
- Bak Erica
- Bakakos Agamemnon
- Bal Andriy
- Balan Valeria
- Balazote Pablo Serrano
- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
- Barbalho Renata
- Barclay Wendy S.
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Barrio Noelia García
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Bergeaud Delphine
- Bergin Hazel
- Bermejo Carlos Lumbreras
- Bermúdez Juan Luis Cruz
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bissuel François
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-Hélène
- Bolze Pierre-Adrien
- Bompart François
- Borges Diogo
- Borie Raphaël
- Bosse Hans Martin
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camile
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brickell Kathy
- Brien Fionnuala O.
- Browne Alex
- Browne Shaunagh
- Brusse-Keizer Marjolein
- Buchtele Nina
- Buesaquillo Christian
- Bugaeva Polina
- Buisson Marielle
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O.
- Calligy Kate
- Calvache Jose Andres
- Campana Valentine
- Campbell Paul
- Camões João
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardellino Chiara Simona
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja Inês
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Casanova Maire-Laure
- Cascão Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castrillón Henry
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavayas Alexandros
- Ceccato Adrian
- Cely Lina Morales
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chapplain Jean-Marc
- Chas Julie
- Chaudry Mobin
- Chen Anjellica
- Chen Yih-Sharng
- Cheng Matthew Pellan
- Cheret Antoine
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chirouze Catherine
- Chiumello Davide
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chopin Marie-Charlotte
- Cidade Jose Pedro
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Emma
- Clarke Jennifer
- Clohisey Sara
- Cobb Perren J.
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Coles Megan
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Combs Pamela
- Connor Marie
- Conrad Anne
- Contreras Sofía
- Conway Elaine
- Cooke Graham S.
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
- Cortegiani Andrea
- Corvaisier Grégory
- Costigan Emma
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Cousse Stéphanie
- Cregan Rachel
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Cummings Matthew J.
- Curley Ger
- Curlier Elodie
- Curran Colleen
- Custodio Paula
- Cárcel Sheila
- da Silva Filipe Ana
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew
- Dahly Darren
- Dalton Heidi
- Dalton Jo
- Daly Seamus
- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A.
- Dantas Jorge
- Darshana B. P. Sanka Ruwan Sri
- de Brito Carlos Alexandre Antunes
- de Castro Maisa Guimarães
- de la Calle Guillermo Maestro
- de Loughry Gillian
- de Mendoza Diego
- De Montmollin Etienne
- de Oliveira França Rafael Freitas
- de Pinho Oliveira Ana Isabel
- De Rosa Rosanna
- de Silva Thushan
- de Vries Peter
- Deacon Jillian
- Dean David
- Debard Alexa
- Debray Marie-Pierre
- DeCastro Nathalie
- Dechert William
- Deconninck Lauren
- Decours Romain
- Defous Eve
- Delacroix Isabelle
- Delaveuve Eric
- Delavigne Karen
- Dell’Amore Andrea
- Delmas Christelle
- Delobel Pierre
- Delsing Corine
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Descamps Diane
- Desvallées Mathilde
- Devouge Eglantine Ferrand
- Dewayanti Santi
- Dhanger Pathik
- Diallo Alpha
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose
- Diaz Priscila
- Diaz Rodrigo
- Didier Kévin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet Jérôme
- Dinot Vincent
- Diop Fara
- Diouf Alphonsine
- Dishon Yael
- Djossou Félix
- Docherty Annemarie B.
- Doherty Helen
- Dominguez Carmen Infante
- Dondorp Arjen M.
- Donnelly Christl A.
- Donnelly Maria
- Donohue Chloe
- Donohue Sean
- Donohue Yoann
- Doran Peter
- Dorival Céline
- Douglas James Joshua
- Dournon Nathalie
- Dow Denisse Bazan
- Downer Triona
- Downey Joanne
- Downing Mark
- Drake Tom
- Driscoll Aoife
- Dubee Vincent
- Dubos François
- Ducancelle Alexandre
- Dudman Susanne
- Dunand Paul
- Dunning Jake
- Duplaix Mathilde
- Duque Sara
- Durante-Mangoni Emanuele
- Durham Lucian
- Dussol Bertrand
- Duthoit Juliette
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- D’Aragon Frédérick
- D’Ortenzio Eric
- Echeverria-Villalobos Marco
- Egan Siobhan
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Ellerbroek Jacobien
- Eloy Philippine
- Elshazly Tarek
- Enderle Isabelle
- Endo Tomoyuki
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Escher Martina
- Esperatti Mariano
- Esperou Hélène
- Esposito-Farese Marina
- Estevão João
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Evers Mirjam
- Fabre Isabelle
- Fabre Marc
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J.
- Fakar Zul
- Fareed Komal
- Faria Pedro
- Farooq Ahmed
- Fatoni Arie Zainul
- Faure Karine
- Favory Raphaël
- Fayed Mohamed
- Feely Niamh
- Feeney Laura
- Fernandes Jorge
- Fernandes Marília Andreia
- Fernandes Susana
- Ferrand François-Xavier
- Ferraz Mário
- Ferreira Benigno
- Ferreira Bernardo
- Ferreira Isabel
- Ferreira Sílvia
- Ferrer-Roca Ricard
- Ferriere Nicolas
- Ferrão Joana
- Ficko Céline
- Figueiredo-Mello Claudia
- Fiorda Juan
- Flament Thomas
- Flateau Clara
- Fletcher Tom
- Florio Letizia Lucia
- Flynn Deirdre
- Foley Claire
- Foley Jean
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foster Denise
- Foti Giuseppe
- Fourn Erwan
- Fowler Robert A.
- Fraher Marianne
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John F.
- Freire Marcela Vieira
- French Craig
- Friedrich Caren
- Fry Stéphanie
- Fuentes Nora
- Fuentes Yuli V.
- Fukuda Masahiro
- G Argin
- Gaborieau Valérie
- Gaci Rostane
- Gagliardi Massimo
- Gagnard Jean-Charles
- Gagneux-Brunon Amandine
- Gaião Sérgio
- Gallagher Phil
- Gamble Carrol
- Gandonniere Charlotte Salmon
- Garan Arthur
- Garcia Rebekha
- Garcia-Gallo Esteban
- Garcês Rui Caetano
- García Ruth N. Jorge
- Garimella Navya
- Garot Denis
- Garrait Valérie
- Gauli Basanta
- Gault Nathalie
- Gavin Aisling
- Gavrylov Anatoliy
- Gaymard Alexandre
- Gebauer Johannes
- Geraud Eva
- Germano Nuno
- Ghosn Jade
- Giani Marco
- Gibson Jess
- Gigante Tristan
- Gilg Morgane
- Gilroy Elaine
- Giordano Guillermo
- Girvan Michelle
- Gissot Valérie
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Golob Jonathan
- Gominet Marie
- Gonzalez Alicia
- González Víctor Quirós
- Gonçalves Bronner P.
- Gordon Patricia
- Gorenne Isabelle
- Goubert Laure
- Goujard Cécile
- Goulenok Tiphaine
- Grable Margarite
- Graf Jeronimo
- Grandin Edward Wilson
- Granerud Beathe Kiland
- Granier Pascal
- Grasselli Giacomo
- Green Christopher A.
- Greene Courtney
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Griffee Matthew
- Griffiths Fiona
- Groenendijk Albert
- Gruner Heidi
- Gu Yusing
- Guedj Jérémie
- Guego Martin
- Guellec Dewi
- Guerguerian Anne-Marie
- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
- Guimard Thomas
- Gómez-Junyent Joan
- Haalboom Marieke
- Haber Daniel
- Habraken Hannah
- Hachemi Ali
- Hadri Nadir
- Haidri Fakhir
- Hakak Sheeba
- Hall Adam
- Hall Matthew
- Halpin Sophie
- Hameed Jawad
- Hamer Ansley
- Hamidfar Rebecca
- Hammond Terese
- Haniffa Rashan
- Hardwick Hayley
- Harrison Ewen M.
- Harrison Janet
- Harrison Samuel Bernard Ekow
- Hasan Mohd Shahnaz
- Hashmi Junaid
- Hashmi Madiha
- Hayat Muhammad
- Hayes Ailbhe
- Hays Leanne
- Heerman Jan
- Heggelund Lars
- Hendry Ross
- Hennessy Martina
- Hentzien Maxime
- Herreros José Miguel Cisneros
- Hershey Andrew
- Hesstvedt Liv
- Hidayah Astarini
- Higgins Dawn
- Higgins Eibhilin
- Higgins Rupert
- Hinchion Rita
- Hinton Samuel
- Hitoto Hikombo
- Ho Antonia
- Hoctin Alexandre
- Hoffmann Isabelle
- Hoiting Oscar
- Holt Rebecca
- Holten Aleksander Rygh
- Holter Jan Cato
- Horby Peter
- Horcajada Juan Pablo
- Hoshino Koji
- Hoshino Kota
- Houas Ikram
- Hough Catherine L.
- Hssain Ali Ait
- Hsu Jimmy Ming-Yang
- Hulot Jean-Sébastien
- Humaid Felwa Bin
- Huo Stella
- Hurd Abby
- Hussain Iqbal
- Ibáñez-Prada Elsa D.
- Ijaz Samreen
- Ikram Arfan
- Illes Hajnal-Gabriela
- Imbert Patrick
- Imran Mohammad
- Imtiaz Aftab
- Inácio Hugo
- Ippolito Mariachiara
- Isgett Sarah
- Isidoro Tiago
- Isnard Margaux
- Ivulich Daniel
- Iñiguez Jonathan Samuel Chávez
- Jaafar Danielle
- Jaafoura Salma
- Jabot Julien
- Jackson Clare
- Jamieson Nina
- Jaquet Pierre
- Jaud-Fischer Coline
- Jaureguiberry Stéphane
- Jego Florence
- Jenum Synne
- Jiménez Miguel Pedrera
- Joseph Cédric
- Joseph Mark
- Joshi Swosti
- Jourdain Mercé
- Jouvet Philippe
- Jung Anna
- Juzar Dafsah
- Kafif Ouifiya
- Kaguelidou Florentia
- Kali Sabina
- Kalomoiri Smaragdi
- Kandamby Darshana Hewa
- Kandel Chris
- Kanwal Darakhshan
- Kartsonaki Christiana
- Kataria Anant
- Katz Kevin
- Kay Christy
- Keane Hannah
- Keating Seán
- Kelly Andrea
- Kelly Aoife
- Kelly Claire
- Kelly Niamh
- Kelly Sadie
- Kelly Yvelynne
- Kelsey Maeve
- Kennon Kalynn
- Kernan Maeve
- Kerroumi Younes
- Keshav Sharma
- Khalid Imrana
- Khalid Osama
- Khalil Antoine
- Khan Coralie
- Khan Irfan
- Khan Quratul Ain
- Khan Rashid Nasim
- Khanal Sushil
- Khatak Abid
- Khawaja Amin
- Kho Michelle E.
- Khoo Saye
- Khoso Nasir
- Kida Yuri
- Kiiza Peter
- Kildal Anders Benjamin
- Kimmoun Antoine
- Kindgen-Milles Detlef
- Kitamura Nobuya
- Klenerman Paul
- Klont Rob
- Knight Stephen R.
- Kobbe Robin
- Kodippily Chamira
- Koirala Sabin
- Kosgei Caroline
- Kpangon Arsène
- Krawczyk Karolina
- Kruglova Oksana
- Kumar Deepali
- Kumar Mukesh
- Kuriakose Dinesh
- Kurtzman Ethan
- Kutsogiannis Demetrios
- Kutsyna Galyna
- Kyriakoulis Konstantinos
- Lachatre Marie
- Lacoste Marie
- Laffey John G.
- Lagrange Marie
- Laine Fabrice
- Lairez Olivier
- Lakhey Sanjay
- Lalueza Antonio
- Lambert Marc
- Lamontagne François
- Langelot-Richard Marie
- Langlois Vincent
- Lantang Eka Yudha
- Lanza Marina
- Laouénan Cédric
- Laribi Samira
- Lariviere Delphine
- Lasry Stéphane
- Latif Naveed
- Launay Odile
- Laureillard Didier
- Lavie-Badie Yoan
- Law Andrew
- Lawrence Cassie
- Lawrence Teresa
- Le Bihan Clément
- Le Bris Cyril
- Le Falher Georges
- Le Fevre Lucie
- Le Hingrat Quentin
- Le Maréchal Marion
- Le Mestre Soizic
- Le Moal Gwenaël
- Le Moing Vincent
- Le Nagard Hervé
- Le Turnier Paul
- Le Minh
- Leal Ema
- Leathlobhair Niamh Ni
- Lee James
- Lee Jennifer
- Lee Su Hwan
- Lee Todd C.
- Leeming Gary
- Lefebvre Bénédicte
- Lefebvre Laurent
- Lefèvre Benjamin
- LeGac Sylvie
- Lelievre Jean-Daniel
- Lellouche François
- Lemaignen Adrien
- Lemee Véronique
- Lemeur Anthony
- Lemmink Gretchen
- Lennon Jenny
- Leone Marc
- Leone Michela
- Lescure François-Xavier
- Lesens Olivier
- Lesouhaitier Mathieu
- Lester-Grant Amy
- Levy Bruno
- Levy Yves
- Levy-Marchal Claire
- Lewandowska Katarzyna
- León Rafael
- Liaquat Ali
- Liegeon Geoffrey
- Lim Wei Shen
- Lima Chantre
- Lina Bruno
- Lind Andreas
- Lingas Guillaume
- Lion-Daolio Sylvie
- Liu Keibun
- Livrozet Marine
- Lizotte Patricia
- Loforte Antonio
- Lolong Navy
- Lopes Diogo
- Lordemann Anja Grosse
- Loschner Anthony L.
- Loubet Paul
- Loufti Bouchra
- Louis Guillame
- Lourenco Silvia
- Lovelace-Macon Lara
- Lowik Marije
- Lucet Jean Christophe
- Luna Carlos M.
- Luong Liem
- Luque Nestor
- Luton Dominique
- Lwin Nilar
- Lyons Ruth
- L’Her Erwan
- Maasikas Olavi
- Mabiala Oryane
- Machado Moïse
- Machado Sara
- Macheda Gabriel
- Madiha Hashmi
- Mahieu Rafael
- Mahy Sophie
- Maia Ana Raquel
- Maier Lars S.
- Maillet Mylène
- Maitre Thomas
- Malaque Ana
- Malfertheiner Maximilian
- Malik Nadia
- Mallon Paddy
- Maltez Fernando
- Malvy Denis
- Manda Victoria
- Mandelbrot Laurent
- Mankikian Julie
- Manning Edmund
- Manuel Aldric
- Marino Daniel
- Marino Flávio
- Markowicz Samuel
- Marques Ana
- Marquis Catherine
- Marsh Brian
- Marsh Laura
- Marshal Megan
- Marshall John C.
- Martelli Celina Turchi
- Martin Emily
- Martin-Blondel Guillaume
- Martin-Loeches Ignacio
- Martinot Martin
- Martins Ana
- Martins João
- Martins Nuno
- Martucci Gennaro
- Martynenko Olga
- Marwali Eva Miranda
- Maslove David
- Mason Sabina
- Masood Sobia
- Matan Moshe
- Mathew Meghena
- Mathieu Daniel
- Mattei Mathieu
- Matulevics Romans
- Maulin Laurence
- Maxwell Michael
- Maynar Javier
- Mazzoni Thierry
- Mc Evoy Natalie
- Mc Sweeney Lisa
- McArthur Colin
- McArthur Colin
- McCarthy Aine
- McCarthy Anne
- McCloskey Colin
- McConnochie Rachael
- McDermott Sherry
- McDonald Sarah E.
- McElroy Aine
- McElwee Samuel
- McEneany Victoria
- McGeer Allison
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- Müller Karl Erik
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- Ng Pauline Yeung
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- Ong David S. Y.
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- Orakzai Saijad
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- O’Callaghan Annmarie
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- Palacios Mario
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- Payen Jean-François
- Peelman Florent
- Peiffer-Smadja Nathan
- Peigne Vincent
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- Pelosi Paolo
- Peltan Ithan D.
- Pereira Rui
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- Pesenti Antonio
- Pestre Vincent
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- Petrovic Michele
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- Ponscarme Diane
- Post Andra-Maris
- Postma Douwe F.
- Povoa Pedro
- Powis Jeff
- Prapa Sofia
- Preau Sébastien
- Prebensen Christian
- Preiser Jean-Charles
- Prinssen Anton
- Pritchard Mark G.
- Priyadarshani Gamage Dona Dilanthi
- Proença Lucia
- Pudota Sravya
- Pulicken Mathew
- Purcell Gregory
- Puéchal Oriane
- Póvoas Diana
- Quesada Luisa
- Quinones-Cardona Vilmaris
- Quist-Paulsen Else
- Quraishi Mohammed
- Rabaud Christian
- Rabindrarajan Ebenezer
- Rafael Aldo
- Rafiq Marie
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- Rainieri Fernando
- Ramachandran Pratheema
- Ramakrishnan Nagarajan
- Ramalho José
- Rammaert Blandine
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- Rangappa Rajavardhan
- Ranjan Ritika
- Rapp Christophe
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- Rashan Thalha
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- Tagherset Lysa
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- Teixeira João
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- Thompson Shaun
- Thomson David
- Thomson Emma C.
- Thwaites Ryan S.
- Tierney Paul
- Tieroshyn Vadim
- Timashev Peter S.
- Timsit Jean-François
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- Turtle Lance C. W.
- Twardowski Pawel
- Téoulé François
- Uchiyama Makoto
- Udayanga P. G. Ishara
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M.
- Vajdovics Cristinava
- Val-Flores Luís
- Valran Amélie
- Van de Velde Stijn
- van den Berge Marcel
- van der Palen Job
- van der Valk Paul
- Van Der Vekens Nicky
- Van der Voort Peter
- Van Der Werf Sylvie
- van Gulik Laura
- Van Hattem Jarne
- van Netten Carolien
- van Veen Ilonka
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Vasconcelos Malte Kohns
- Vauchy Charline
- Vecham Pavan Kumar
- Veislinger Aurélie
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vickers James
- Vidal José Ernesto
- Vieira César
- Vijayan Deepak
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Vijayaraghavan Bharath Kumar Tirupakuzhi
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vonkeman Harald
- Vuotto Fanny
- Wang Chih-Hsien
- Webb Steve
- Wei Jia
- Weil Katharina
- Wesselius Sanne
- West T. Eoin
- Wham Murray
- Whelan Bryan
- White Nicole
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Suzette
- Williams Virginie
- Wils Evert-Jan
- Wong Calvin
- Xynogalas Ioannis
- Yamazaki Masaki
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yerkovich Stephanie
- Yiu Ng Wing
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zahran Maram
- Zambon Maria
- Zanella Alberto
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 13/09/2022
- Field of study
Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs).
Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support.
Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83-7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97-2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14-1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25-1.30]).
Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable