68 research outputs found
Second-Order Semi-Discretized Schemes for Solving Stochastic Quenching Models on Arbitrary Spatial Grids
Reaction-diffusion-advection equations provide precise interpretations for many important phenomena in complex interactions between natural and artificial systems. This paper studies second-order semi-discretizations for the numerical solution of reaction-diffusion-advection equations modeling quenching types of singularities occurring in numerous applications. Our investigations particularly focus at cases where nonuniform spatial grids are utilized. Detailed derivations and analysis are accomplished. Easy-to-use and highly effective second-order schemes are acquired. Computational experiments are presented to illustrate our results as well as to demonstrate the viability and capability of the new methods for solving singular quenching problems on arbitrary grid platforms
On a deterministic mathematical model which efficiently predicts the protective effect of a plant extract mixture in cirrhotic rats
In this work, we propose a mathematical model that describes liver evolution and concentrations of alanine aminotransferase and aspartate aminotransferase in a group of rats damaged with carbon tetrachloride. Carbon tetrachloride was employed to induce cirrhosis. A second groups damaged with carbon tetrachloride was exposed simultaneously a plant extract as hepatoprotective agent. The model reproduces the data obtained in the experiment reported in [Rev. Cub. Plant. Med. 22(1), 2017], and predicts that using the plants extract helps to get a better natural recovery after the treatment. Computer simulations show that the extract reduces the damage velocity but does not avoid it entirely. The present paper is the first report in the literature in which a mathematical model reliably predicts the protective effect of a plant extract mixture in rats with cirrhosis disease. The results reported in this manuscript could be used in the future to help in fighting cirrhotic conditions in humans, though more experimental and mathematical work is required in that case
Compromising between European and US allergen immunotherapy schools: Discussions from GUIMIT, the Mexican immunotherapy guidelines
Background: Allergen immunotherapy (AIT) has a longstanding history and still remains the only disease-changing treatment for allergic rhinitis and asthma. Over the years 2 different schools have developed their strategies: the United States (US) and the European. Allergen extracts available in these regions are adapted to local practice. In other parts of the world, extracts from both regions
and local ones are commercialized, as in Mexico. Here, local experts developed a national AIT guideline (GUIMIT 2019) searching for compromises between both schools.
Methods: Using ADAPTE methodology for transculturizing guidelines and AGREE-II for evaluating guideline quality, GUIMIT selected 3 high-quality Main Reference Guidelines (MRGs): the European Academy of Allergy, Asthma and Immunology (EAACI) guideines, the S2k guideline of
various German-speaking medical societies (2014), and the US Practice Parameters on Allergen Immunotherapy 2011. We formulated clinical questions and based responses on the fused evidence available in the MRGs, combined with local possibilities, patient's preference, and costs. We
came across several issues on which the MRGs disagreed. These are presented here along with arguments of GUIMIT members to resolve them. GUIMIT (for a complete English version, see Supplementary data) concluded the following:
Results: Related to the diagnosis of IgE-mediated respiratory allergy, apart from skin prick testing
complementary tests (challenges, in vitro testing and molecular such as species-specific allergens) might be useful in selected cases to inform AIT composition. AIT is indicated in allergic rhinitis and suggested in allergic asthma (once controlled) and IgE-mediated atopic dermatitis. Concerning the correct subcutaneous AIT dose for compounding vials according to the US school: dosing tables and formula are given; up to 4 non-related allergens can be mixed, refraining from mixing high with low protease extracts. When using European extracts: the manufacturer's indications
should be followed; in multi-allergic patients 2 simultaneous injections can be given (100% consensus); mixing is discouraged. In Mexico only allergoid tablets are available; based on doses used in all sublingual immunotherapy (SLIT) publications referenced in MRGs, GUIMIT suggests a probable effective dose related to subcutaneous immunotherapy (SCIT) might be: 50â200% of the monthly SCIT dose given daily, maximum mixing 4 allergens. Also, a table with practical suggestions on non-evidence-existing issues, developed with a simplified Delphi method, is added.
Finally, dissemination and implementation of guidelines is briefly discussed, explaining how we used online tools for this in Mexico.
Conclusions: Countries where European and American AIT extracts are available should adjust AIT according to which school is followed
Non-motor symptom burden in patients with Parkinson's disease with impulse control disorders and compulsive behaviours : results from the COPPADIS cohort
The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson's disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose
Natural History of MYH7-Related Dilated Cardiomyopathy
BACKGROUND Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVES We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 +/- 19.2 years) recruited from 29 international centers. RESULTS At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% +/- 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of <= 35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality
Anales del III Congreso Internacional de Vivienda y Ciudad "Debate en torno a la nueva agenda urbana"
Acta de congresoEl III Congreso Internacional de Vivienda y Ciudad âDebates en torno a la NUEVa Agenda Urbanaâ, ha sido una apuesta de alto compromiso por acercar los debates centrales y urgentes que tensionan el pleno ejercicio del derecho a la ciudad. Para ello las instituciones organizadoras (INVIHAB âInstituto de InvestigaciĂłn de Vivienda y HĂĄbitat y MGyDH-MaestrĂa en GestiĂłn y Desarrollo Habitacional-1), hemos convidado un espacio que se concretĂł con potencia en un debate transdisciplinario. ConvocĂł a intelectuales de prestigio internacional, investigadores, acadĂ©micos y gestores estatales, y en una metodologĂa de innovaciĂłn articulĂł las voces acadĂ©micas con las de las organizaciones sociales y/o barriales en el Foro de las Organizaciones Sociales que tuvo su espacio propio para dar voz a quienes estĂĄn trabajando en los desafĂos para garantizar los derechos a la vivienda y los bienes urbanos en nuestras ciudades del Siglo XXI
I Congresso Ibero-Americano de Bibliotecas Escolares
Actas de la primera ediciĂłn del I Congreso Iberoamericano de Bibliotecas Escolares, CIBES 2015, organizado por la Universidad Carlos III de Madrid (España), la Universidad Estatal Paulista (Brasil) y el Ayuntamiento de Getafe (España). Celebrado: 21 - 23 de octubre de 2015 en la Universidad Estatal Paulista (MarĂlia) y 26 - 28 de octubre de 2015 en la Universidad Carlos III de Madrid (Getafe)Universidad Carlos III de Madrid (España)Universidad Estatal Paulista (Brasil)Ayuntamiento de Getafe (España)Dimensiones y visiones de la biblioteca escolar en una EducaciĂłn por competencias: la
necesidad de una polĂtica estratĂ©gica / Miguel Ăngel Marzal. -- Getafe ciudad educadora,
lectora y escritora: Bibliotecas escolares / Lourdes Muñoz Santiuste. -- Presente y
futuro: biblioteca escolar-CREA y proyectos interdisciplinares / Rosa PiquĂn. -- Cultura
en informaciĂłn: un reto esencial de la biblioteca escolar / MĂłnica BarĂł. -- Bibliotecas
escolares de Galicia: un mundo de oportunidades a favor de la EducaciĂłn / Cristina Novoa.
-- 10 años de la Red de Bibliotecas Escolares de Extremadura (REBEX) / Casildo MacĂas
Pereira. -- Biblioteca Escolar y uso Ă©tico de la informaciĂłn para una Cultura de Paz / Ana
Barrero TĂscar. -- DinamizaciĂłn de la Biblioteca Escolar Plumita durante el curso escolar
2014/15 / MarĂa Antonia Cano Cañada. -- Experiencia de la creaciĂłn de una biblioteca
escolar / Susana Santos MartĂn. -- Grupo cooperativo Bibliotecas escolares en Red-Albacete
/ José Manuel Garrido Argandoña y Eva Leal Scasso. -- La BCREA "Juan Leiva". El fomento de
la lectura desde la web social / Andrés Pulido Villar. -- Proceso de implantación de una
herramienta de autoevaluaciĂłn en la red de bibliotecas escolares de Extremadura (REBEX) /
Casildo MacĂas Pereira. -- La biblioteca escolar: abriendo fronteras / Lorena VerĂłnica
Cabrera Orellana. -- O programa RBE e a avaliaçao das bibliotecas escolares: melhoria,
desenvolvimiento e innovaçao / Elsa Conde. -- Profesional de BiblioteconomĂa y
DocumentaciĂłn: esencial en la plantilla de la escuela / Pilar del Campo Puerta. -- Una
mirada activa al proceso educativo desde la biblioteca escolar / MarĂa JesĂșs Fontela
FernĂĄndez . -- Con otra mirada "La ilustraciĂłn como vehĂculo de comunicaciĂłn y aprendizaje
en las bibliotecas escolares" / Pablo Jurado SĂĄnchez-GalĂĄn. -- Fingertips. Recriar a
biblioteca escolar na sala de aula / Rui Alfonso Mateus. -- Hablemos de libros. CĂłmo
transformar una clase de literatura en una comunidad de interpretaciĂłn de textos /
Francisco CĂ©sar DĂaz Rey. -- InclusiĂłn social de familias inmigrantes a travĂ©s de un
programa de aprendizaje de la lengua castellana / Ana Carmen Tolino FernĂĄndez-Henarejos.
-- O desenvolvimento de atividades de mediação de leitura em biblioteca escolar: o caso da
biblioteca da Escola Sesc de Ensino MĂ©dio / Vagner Amaro. -- La biblioteca escolar.
Proceso de enseñanza-aprendizaje de padres a hijos / Ana Carmen Tolino Fernåndez-
Henarejos. -- Leo con y para los demĂĄs / Ismael FernĂĄndez FernĂĄndez, Ana MarĂa Moreno
Vicente y Ana Beatriz Vicente PĂ©rez. -- Nanas y arrullo. PoesĂa a la deriva / Bernardo
Fuentes Navarrete y Carlos GarcĂa-Romeral PĂ©rez. -- GestiĂłn y evaluaciĂłn de servicios
bibliotecarios para personas con dislexia: una biblioteca escolar inclusiva desde una
perspectiva internacional / Carmen Jorge GarcĂa-Reyes. -- Sueños lectores compartidos
hechos realidad: la biblioteca escolar del C.E.I.P-S.E.S-A.A âLA PAZâ de Albacete / Ana
Rosa Cabañero Tobarra, Juan Manuel HerrĂĄez, Eva Leal Scasso, MarĂa MarĂn SĂĄnchez, Ana
BelĂ©n Medrano MartĂnez y MarĂa JosĂ© Nortes RuipĂ©rez. -- El programa biblioteca escuela en
Civican. La literatura como elemento motivador para la alfabetizaciĂłn informacional /
Villar Arellano Yanguas. -- La competencia digital en el diseño curricular: desde la
biblioteca al aula / Felicidad Campal GarcĂa. -- O deselvomimento da pesquisa escolar por
meio da competĂȘncia em informaçao / Luciane de FĂĄtima Cavalcante Beckman y Marta Leandro
da Mata. -- Proyecto escolar de investigación documental "Te pillé leyendo" / José Manuel
Garrido Argandoña. -- Aprender com a Biblioteca Escolar: formar para as literacias / Paula
Correia y Isabel Mendinhos. -- SucediĂł en el siglo XX / MarĂa Antonia Becerra MontalbĂĄn,
Ăngel BernabĂ© Muñoz y SofĂa Vaz Romero. -- El Club de lectura en la nube / BelĂ©n Benito
BlĂĄzquez y Ana OrdĂĄs GarcĂa. -- Promover a leitura e a escrita na era digital:
prĂĄcticas nas bibliotecas escolares / MarĂa Raquel Ramos. -- A biblioteca escolar e o
desafĂo da interculturalidade: o projeto Ser + cidadao / MarĂa da Conceição TomĂ©. --
Cuando la competencia digital encontrĂł a la alfabetizaciĂłn informacional o Mucho ruido y
pocas nueces / Felicidad Campal GarcĂa. -- Hora de ler, un programa para el fomento de la
lectura en contexto educativo / Cristina Novoa. -- HĂĄbitos de lectura para las
competencias en informaciĂłn y alfabetizaciĂłn en informaciĂłn en bibliotecas escolares de
Puerto Rico / Karen Denise Centeno Casillas. -- Repositorios digitales en las bibliotecas
escolares andaluzas: situaciĂłn, modelos y herramientas para su creaciĂłn / Dolores Olmos
Olmos y Andrés Pulido Villar. -- Trabajando las competencias clave con las aventuras de
Mozarito en Extremadura / MarĂa Teresa Carballosa GonzĂĄlez y MarĂa Esther Nieto Vidal. --
AnĂĄlisis de modelos de evaluaciĂłn de la web de la biblioteca escolar / RaĂșl Cremades
GarcĂa. -- EmociĂłnate con las historias: El bosque de las emociones e historias con mucho
teatro / Esther Luis PĂ©rez y Ana MarĂa Peromingo FernĂĄndez. -- Biblioteca escolar de
innovaciĂłn y continuaciĂłn / E. MarĂa Guerrero Palacios y Silvia Mora RamĂrez. -- Uso de
estĂĄndares y licencias para la creaciĂłn y difusiĂłn de contenidos en las bibliotecas
escolares / José Luis Barreiro Cebey. -- La biblioteca escolar digital móvil / Javier
FernĂĄndez Delgado. -- Uso de aplicaciones mĂłviles para el desarrollo de
la competencia lingĂŒĂstica. Proyecto Hansel App Gretel / Dolores Olmos Olmos. -- A memĂłria
e a mediação segundo Vigotski / Leda Maria AraĂșjo, Patricia Celia Santana, Sueli Bortolin
y Leticia Gorri Molina. -- Bibliotecas escolares como tema de estudo dos alunos de
graduação em blioteconomia do Instituto de Ensino Superior da FUNLEC: estado da arte /
Tiago Pereira Nocera y Rodrigo Pereira. -- AçÔes de mediação da leitura e da informação
em bibliotecas escolares: um olhar sobre as bibliotecas dos Colégios de Aplicação /
Tatyanne Christina Gonçalves Ferreira Valdez y Alberto Calil JĂșnior. -- Mediação
pedagĂłgica numa biblioteca de escola pĂșblica em Londrina / Rovilson JosĂ© da Silva, Teba
Silva Yllana y Sueli Bortolin. -- Utilização de categorias por cores em sistema de
biblioteca voltado ao pĂșblico infanto-juvenil / Liliana Giusti Serra. -- Atividades de
ensino dos atos de leitura com crianças em risco social / Adriana Naomi Fukushima da Silva
y Dagoberto Buim Arena. -- Biblioteca escolar: espaço de significados entre
alunos, professores e bibliotecĂĄrios / Rodrigo Barbosa Paulo, Marisa Xavier, Helen Castro
Casarin y Creuza Barbaroto. -- A Biblioteca Escolar no Contexto da Legislação e
do Processo Educativo / Eliane Lourdes da Silva Moro, Francisca Rosaline Leite Mota y
Raimundo Martins de Lima. -- O jornal impresso como fonte de informação: a importùncia da
formação de leitores crĂticos / Mariana PĂcaro Cerigatto. -- Bibliotecas escolares no
estado do Rio Grande do Sul: a trajetĂłria de realização dos fĂłruns gaĂșchos pela melhoria
das bibliotecas escolares / Eliane Lourdes da Silva Moro y Lizandra Brasil Estabel. -- O
acesso Ă informação dos usuĂĄrios surdos na biblioteca escolar / AndrĂ© LuĂs OnĂłrio
Coneglian y Mayara Melo Santana. -- Aprendizagem coletiva de bibliotecĂĄrios e a
competĂȘncia de pesquisa dos docentes: o caso do Instituto Federal do EspĂrito Santo /
Maristela Almeida Mercandeli Rodrigues y Beatriz Quiroz Villardi. -- Biblioteca escolar:
atores, parĂąmetros e competĂȘncias / Mavi Galante Mancera DallÂŽAcqua Carvalho y Claudio
Marcondes de Castro Filho. -- Estratégias de aprendizagem de escrita no
Ensino Fundamental II / Ărika Christina Kohle. -- BebĂȘs e livros: leitura nas bebetecas.
Kenia Adriana de Aquino Modesto Silva, Juliane Francischeti Martins Motoyama y Renata
Junqueira de Souza. -- Pråticas alternativas para organização de acervos nos espaços de
leitura em ambientes escolares / Luciana Souza Gracioso, Ariovaldo Alves,
DĂ©bora Nascimento, Suelen Redondo, Tainara Torika Kiri de Castro, Elizabete Angelon y
Eduardo Barbosa. -- ReflexÔes sobre a modelagem e criação de uma Rede Virtual de Leitores
para Bibliotecas Escolares / Carla Floriana Martins y Raoni Guerra RajĂŁo. -- Biblioteca
escolar: espaço de formação leitora? / Silvana Ferreira de Souza Balsan y Renata
Junqueira de Souza. -- âSe a Biblioteca Escolar Ă© minha mĂŁe, o Google Ă© meu paiâ:
representaçÔes da relação entre Biblioteca Escolar e Google no imaginårio de
alunos do ensino técnico / Adriana Bogliolo Sirihal-Duarte, Maria L. Amorim Antunes y
Raquel Miranda Vilela Paiva. -- Desafios e propostas para a universalização das
bibliotecas escolares no Brasil e na Espanha / Rodrigo Pereira, Daniela Spudeit y Fernanda
de Sales. -- Bibliotecårio educador: possibilidades de atuação no contexto da biblioteca
escolar / André Carlos da Silva, Valéria Martin Valls y Mariana de Paula Silva. -- Uma ONG
para Bibliotecas Escolares : estratégia para ampliar a igualdade e capacidade de acesso
e uso da informação e educação escolar de qualidade / Suelen Camilo Ferreira y Luciana de
Souza Gracioso. -- O aluno com deficĂȘncia: o papel do bibliotecĂĄrio na disponibilidade de
recursos acessĂveis na biblioteca escolar / Adriano de Sales Coelho, Rosilene de Melo
Oliveira y Marcos Pastana Santos. -- Biblioteca digital virtual e o uso do tablete: uma
possibilidade de construção de novas pråticas de leitura na escola / Barbara Cibelli da
Silva Monteagudo y Dagoberto Buim Arena. -- A importùncia da biblioteca na educação de
crianças de 0 a 3 anos / Yngrid Karolline Mendonça Costa y Cyntia Graziella Guizelim
SimÔes Girotto. -- Comportamento Informacional de adolescentes: a relação com bibliotecas
e escolas / Nelson Sebastian Silva-Jerez y Helen de Castro S. Casarin
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and lowâmiddle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of âsingle-useâ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for lowâmiddle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both highâ and lowâmiddleâincome countries
- âŠ