Conceptually plausible Bayesian inference in interval timing

In a world that is uncertain and noisy, perception makes use of optimization procedures that rely on the statistical properties of previous experiences. A well-known example of this phenomenon is the central tendency effect observed in many psychophysical modalities. For example, in interval timing tasks, previous experiences influence the current percept, pulling behavioural responses towards the mean. In Bayesian observer models, these previous experiences are typically modelled by unimodal statistical distributions, referred to as the prior. Here, we critically assess the validity of the assumptions underlying these models and propose a model that allows for more flexible, yet conceptually more plausible, modelling of empirical distributions. By representing previous experiences as a mixture of lognormal distributions, this model can be parametrized to mimic different unimodal distributions and thus extends previous instantiations of Bayesian observer models. We fit the mixture lognormal model to published interval timing data of healthy young adults and a clinical population of aged mild cognitive impairment patients and age-matched controls, and demonstrate that this model better explains behavioural data and provides new insights into the mechanisms that underlie the behaviour of a memory-affected clinical population

Bodyspace at the pub: sexual orientations and organizational space

In this article we argue that sexuality is not only an undercurrent of service environments, but is integral to the way that these workspaces are experienced and negotiated. Through drawing on Sara Ahmed’s (2006a) ‘orientation’ thesis, we develop a concept of ‘bodyspace’ to suggest that individuals understand, shape and make meaning of work spaces through complex sexually-orientated negotiations. Presenting analysis from a study of UK pubs, we explore bodyspace in the lived experience of workplace sexuality through three elements of orientation: background; bodily dwelling; and lines of directionality. Our findings show how organizational spaces afford or mitigate possibilities for particular bodies, which simultaneously shape expectations and experiences of sexuality at work. Bodyspace therefore provides one way of exposing the connection between sexual ‘orientation’ and the lived experience of service sector work

Luchtweginfecties bij paarden

Bij paarden vormen aandoeningen van de luchtwegen na kreupelheden het belangrijkste probleem op het gebied van de gezondheid

The impact of MRI scanner environment on perceptual decision-making

Despite the widespread use of functional magnetic resonance imaging (fMRI), few studies have addressed scanner effects on performance. The studies that have examined this question show a wide variety of results. In this article we report analyses of three experiments in which participants performed a perceptual decision-making task both in a traditional setting as well as inside an MRI scanner. The results consistently show that response times increase inside the scanner. Error rates also increase, but to a lesser extent. To reveal the underlying mechanisms that drive the behavioral changes when performing a task inside the MRI scanner, the data were analyzed using the linear ballistic accumulator model of decision-making. These analyses show that, in the scanner, participants exhibit a slow down of the motor component of the response and have less attentional focus on the task. However, the balance between focus and motor slowing depends on the specific task requirements

Конференции

Background Polypharmacy poses threats to patients’ health. The Systematic Tool to Reduce Inappropriate Prescribing (STRIP) is a drug optimization process for conducting medication reviews in primary care. To effectively and efficiently incorporate this method into daily practice, the STRIP Assistant—a decision support system that aims to assist physicians with the pharmacotherapeutic analysis of patients’ medical records—has been developed. It generates context-specific advice based on clinical guidelines. Objective The aim of this study was to validate the STRIP Assistant’s usability as a tool for physicians to optimize medical records for polypharmacy patients. Methods In an online experiment, 42 physicians were asked to optimize medical records for two comparable polypharmacy patients, one in their usual manner and one using the STRIP Assistant. Changes in effectiveness were measured by comparing respondents’ optimized medicine prescriptions with medication prepared by an expert panel of two geriatrician-pharmacologists. Efficiency was operationalized by recording the time the respondents took to optimize the two cases. User satisfaction was measured with the System Usability Scale (SUS). Independent and paired t tests were used for analysis. Results Medication optimization significantly improved with the STRIP Assistant. Appropriate decisions increased from 58 % without the STRIP Assistant to 76 % with it (p < 0.0001). Inappropriate decisions decreased from 42 % without the STRIP Assistant to 24 % with it (p < 0.0001). Participants spent significantly more time optimizing medication with the STRIP Assistant (24 min) than without it (13 min; p < 0.0001). They assigned it a below-average SUS score of 63.25. Conclusion The STRIP Assistant improves the effectiveness of medication reviews for polypharmacy patients

Estimation of the basic reproduction number for Streptococcus equi spp. equi outbreaks by meta-analysis of strangles outbreak reports

Background Streptococcus equi spp. equi (S. equi), the cause of strangles in horses, is considered a highly contagious pathogen affecting equines and the equine industry worldwide. Fundamental epidemiological characteristics of outbreaks, such as the basic reproduction number (R-0), are not well described. Objectives Estimate R-0 for S. equi in equine populations from outbreak data. Study design Systematic review and meta-analysis of published and unpublished data. Methods A literature search for outbreak reports was carried out. Depending on data available in the reports, the early epidemic growth rate or final attack rate (AR) approach was used to estimate the basic reproduction number for that outbreak. Other recorded outbreak characteristics were the type of housing (group vs. individual). An overall estimate for R-0 was computed by meta-analysis. Results Data from eight outbreaks were extracted from peer-reviewed publications. Data from two additional, non-published outbreaks was also included in the meta-analysis. A conservative estimate for R-0 was 2.2 (95% confidence interval [CI] 1.9-2.5). A less conservative estimate, including outbreaks with a 100% AR for which a lower limit R-0 was estimated, was 2.7 (95% CI 2.1-3.3). Main limitations Few papers describing longitudinal incidence data were found so most estimates were based on the outbreaks' final size. Several outbreaks had a 100% attack rate and could therefore only be included as a lower limit estimate in the meta-analysis. The reported result therefore may be an underestimation. Conclusions This estimate for R-0 for S. equi informs parameters for future mathematical modelling, quantifies desired preventive vaccine coverage and helps evaluate the effect of prevention strategies through future modelling studies

Salt marshes create more extensive channel networks than mangroves.

This is the final version. Available from Nature Research via the DOI in this record. Data availability: The data generated in this study have been deposited in the Zenodo database under accession code (https://doi.org/10.5281/zenodo.6331067).Coastal wetlands fulfil important functions for biodiversity conservation and coastal protection, which are inextricably linked to typical morphological features like tidal channels. Channel network configurations in turn are shaped by bio-geomorphological feedbacks between vegetation, hydrodynamics and sediment transport. This study investigates the impact of two starkly different recruitment strategies between mangroves (fast/homogenous) and salt marshes (slow/patchy) on channel network properties. We first compare channel networks found in salt marshes and mangroves around the world and then demonstrate how observed channel patterns can be explained by vegetation establishment strategies using controlled experimental conditions. We find that salt marshes are dissected by more extensive channel networks and have shorter over-marsh flow paths than mangrove systems, while their branching patterns remain similar. This finding is supported by our laboratory experiments, which reveal that different recruitment strategies of mangroves and salt marshes hamper or facilitate channel development, respectively. Insights of our study are crucial to understand wetland resilience with rising sea-levels especially under climate-driven ecotone shifts

Mattress and pillow for prone positioning for treatment of obstructive sleep apnoea

Conclusion: The new mattress and pillow for prone positioning (MPP) is efficient in reducing the apnoea-hypopnoea index (AHI) and oxygen desaturation index (ODI) in most patients with obstructive sleep apnoea (OSA), with satisfactory compliance. Objective: The aim of the present study was to evaluate the effect of the prone body and head sleep position on severity of disease in patients with OSA after 4 weeks of adaptation to a mattress and pillow facilitating prone positioning. Methods: Fourteen patients with mild to severe OSA, 11 men and 3 women with a mean AHI of 26 (min, 6; max, 53) and mean ODI of 21 (min, 6; max, 51) were evaluated. Two polysomnographic (PSG) studies were performed. The first PSG study was without any treatment and the second was after 4 weeks of adaptation to the MPP for prone positioning of the body and the head. Results: Mean AHI and ODI decreased from 26 and 21 to 8 and 7, respectively (p 4 h per night during the 4-week study.Acta Otolaryngologica Foundation, Swede