790 research outputs found
OSETI with STACEE: A Search for Nanosecond Optical Transients from Nearby Stars
We have used the STACEE high-energy gamma-ray detector to look for fast
blue-green laser pulses from the vicinity of 187 stars. The STACEE detector
offers unprecedented light-collecting capability for the detection of
nanosecond pulses from such lasers. We estimate STACEE's sensitivity to be
approximately 10 photons per square meter at a wavelength of 420 nm. The stars
have been chosen because their characteristics are such that they may harbor
habitable planets and they are relatively close to Earth. Each star was
observed for 10 minutes and we found no evidence for laser pulses in any of the
data sets.Comment: 38 pages, 12 figures. Accepted for publication in Astrobiolog
Perfluorinated alkyl acids in the serum and follicular fluid of UK women with and without polycystic ovarian syndrome undergoing fertility treatment and associations with hormonal and metabolic parameters
© 2018 Women with polycystic ovarian syndrome (PCOS) undergoing treatment for infertility could be a sensitive subpopulation for endocrine effects of exposure to perfluorinated alkyl acids (PFAAs), persistent organic pollutants with potential endocrine activity. Women with, PCOS (n = 30) and age- and BMI-matched controls (n = 29) were recruited from a UK fertility clinic in 2015. Paired serum and follicular fluid samples were collected and analysed for 13 PFAAs. Sex steroid and thyroid hormones, and metabolic markers were measured and assessed for associations with serum PFAAs. Four PFAAs were detected in all serum and follicular fluid samples and concentrations in the two matrices were highly correlated (R2 > 0.95): perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorononanoic acid (PFNA). Serum PFOS was positively associated with age (1 ng/mL per yr, p < 0.05) and was higher in PCOS cases than controls (geometric mean [GM] 3.9 vs. 3.1 ng/mL, p < 0.05) and in women with irregular vs. regular menstrual cycles (GM 3.9 vs. 3.0 ng/mL, p = 0.01). After adjustment for confounders, serum testosterone was significantly associated with PFOA, PFHxS, PFNA, and the molar sum of the four frequently detected serum PFAAs (approximately 50 percent increase per ln-unit) among controls but not PCOS cases. HbA1c in PCOS cases was inversely associated with serum PFOA, PFHxs, and sum of PFAAs (2–3 mmol/mol per ln-unit). In controls, fasting glucose was positively associated with serum PFOA and sum of PFAAs (0.25 nmol/L per ln-unit increase in PFAAs). Few other associations were observed. The analyses and findings here should be considered exploratory in light of the relatively small sample sizes and large number of statistical comparisons conducted. However, the data do not suggest increased sensitivity to potential endocrine effects of PFAAs in PCOS patients
Members of the fatty acid binding protein family are differentiation factors for the mammary gland
Mammary gland development is controlled by systemic hormones and by growth factors that might complement or mediate hormonal action. Peptides that locally signal growth cessation and stimulate differentiation of the developing epithelium have not been described. Here, we report that recombinant and wild-type forms of mammary-derived growth inhibitor (MDGI) and heart-fatty acid binding protein (FABP), which belong to the FABP family, specifically inhibit growth of normal mouse mammary epithelial cells (MEC), while growth of stromal cells is not suppressed. In mammary gland organ culture, inhibition of ductal growth is associated with the appearance of bulbous alveolar end buds and formation of fully developed lobuloalveolar structures. In parallel, MDGI stimulates its own expression and promotes milk protein synthesis. Selective inhibition of endogenous MDGI expression in MEC by antisense phosphorothioate oligonucleotides suppresses appearance of alveolar end buds and lowers the beta-casein level in organ cultures. Furthermore, MDGI suppresses the mitogenic effects of epidermal growth factor, and epidermal growth factor antagonizes the activities of MDGI. Finally, the regulatory properties of MDGI can be fully mimicked by an 11-amino acid sequence, represented in the COOH terminus of MDGI and a subfamily of structurally related FABPs. This peptide does not bind fatty acids. To our knowledge, this is the first report about a growth inhibitor promoting mammary gland differentiation
Nonlinear Optical studies of the Transient Coherence in the Quantum Hall System
We review recent investigations of the femtosecond non-linear optical
response of the two-dimensional electron gas (2DEG) in a strong magnetic field.
We probe the Quantum Hall (QH) regime for filling factors . Our
focus is on the transient coherence induced via optical excitation and on its
time evolution during early femtosecond timescales. We simultaneously study the
interband and intraband coherence in this system by using a nonlinear
spectroscopic technique, transient three-pulse four wave mixing optical
spectroscopy, and a many-body theory. We observe striking differences in the
temporal and spectral profile of the nonlinear optical signal between a
modulation doped quantum well system (with the 2DEG) and a similar undoped
quantum well (without a 2DEG). We attribute these qualitative differences to
Coulomb correlations between the photoexcited electron-hole pairs and the 2DEG.
We show, in particular, that intraband many-particle coherences assisted by the
inter-Landau-level magnetoplasmon excitations of the 2DEG dominate the
femtosecond nonlinear optical responce. The most striking effect of these
exciton-magnetoplasmon coherences is a large off-resonant four-wave-mixing
signal in the case of very low photoexcited carrier densities, not observed in
the undoped system, with strong temporal oscillations and unusually symmetric
temporal profile.Comment: 22 pages, 9 figures; review article to be published in Solid State
Communication
Very high energy observations of the BL Lac objects 3C 66A and OJ 287
Using the Solar Tower Atmospheric Cherenkov Effect Experiment (STACEE), we
have observed the BL Lac objects 3C 66A and OJ 287. These are members of the
class of low-frequency-peaked BL Lac objects (LBLs) and are two of the three
LBLs predicted by Costamante and Ghisellini to be potential sources of very
high energy (>100 GeV) gamma-ray emission. The third candidate, BL Lacertae,
has recently been detected by the MAGIC collaboration. Our observations have
not produced detections; we calculate a 99% CL upper limit of flux from 3C 66A
of 0.15 Crab flux units and from OJ 287 our limit is 0.52 Crab. These limits
assume a Crab-like energy spectrum with an effective energy threshold of 185
GeV.Comment: 24 pages, 15 figures, Accepted for publication in Astroparticle
Physic
Stationary solutions of the one-dimensional nonlinear Schroedinger equation: I. Case of repulsive nonlinearity
All stationary solutions to the one-dimensional nonlinear Schroedinger
equation under box and periodic boundary conditions are presented in analytic
form. We consider the case of repulsive nonlinearity; in a companion paper we
treat the attractive case. Our solutions take the form of stationary trains of
dark or grey density-notch solitons. Real stationary states are in one-to-one
correspondence with those of the linear Schr\"odinger equation. Complex
stationary states are uniquely nonlinear, nodeless, and symmetry-breaking. Our
solutions apply to many physical contexts, including the Bose-Einstein
condensate and optical pulses in fibers.Comment: 11 pages, 7 figures -- revised versio
Electron Dephasing in Mesoscopic Metal Wires
The low-temperature behavior of the electron phase coherence time,
, in mesoscopic metal wires has been a subject of controversy
recently. Whereas theory predicts that in narrow wires should
increase as as the temperature is lowered, many samples exhibit
a saturation of below about 1 K. We review here the experiments
we have performed recently to address this issue. In particular we emphasize
that in sufficiently pure Ag and Au samples we observe no saturation of
down to our base temperature of 40 mK. In addition, the measured
magnitude of is in excellent quantitative agreement with the
prediction of the perturbative theory of Altshuler, Aronov and Khmelnitskii. We
discuss possible explanations why saturation of is observed in
many other samples measured in our laboratory and elsewhere, and answer the
criticisms raised recently by Mohanty and Webb regarding our work.Comment: 14 pages, 3 figures; to appear in proceedings of conference
"Fundamental Problems of Mesoscopic Physics", Granada, Spain, 6-11 September,
200
Specific Heat of Liquid Helium in Zero Gravity very near the Lambda Point
We report the details and revised analysis of an experiment to measure the
specific heat of helium with subnanokelvin temperature resolution near the
lambda point. The measurements were made at the vapor pressure spanning the
region from 22 mK below the superfluid transition to 4 uK above. The experiment
was performed in earth orbit to reduce the rounding of the transition caused by
gravitationally induced pressure gradients on earth. Specific heat measurements
were made deep in the asymptotic region to within 2 nK of the transition. No
evidence of rounding was found to this resolution. The optimum value of the
critical exponent describing the specific heat singularity was found to be a =
-0.0127+ - 0.0003. This is bracketed by two recent estimates based on
renormalization group techniques, but is slightly outside the range of the
error of the most recent result. The ratio of the coefficients of the leading
order singularity on the two sides of the transition is A+/A- =1.053+ - 0.002,
which agrees well with a recent estimate. By combining the specific heat and
superfluid density exponents a test of the Josephson scaling relation can be
made. Excellent agreement is found based on high precision measurements of the
superfluid density made elsewhere. These results represent the most precise
tests of theoretical predictions for critical phenomena to date.Comment: 27 Pages, 20 Figure
Universal Behavior of Charged Particle Production in Heavy Ion Collisions
The PHOBOS experiment at RHIC has measured the multiplicity of primary
charged particles as a function of centrality and pseudorapidity in Au+Au
collisions at sqrt(s_NN) = 19.6, 130 and 200 GeV. Two kinds of universal
behavior are observed in charged particle production in heavy ion collisions.
The first is that forward particle production, over a range of energies,
follows a universal limiting curve with a non-trivial centrality dependence.
The second arises from comparisons with pp/pbar-p and e+e- data.
N_tot/(N_part/2) in nuclear collisions at high energy scales with sqrt(s) in a
similar way as N_tot in e+e- collisions and has a very weak centrality
dependence. This feature may be related to a reduction in the leading particle
effect due to the multiple collisions suffered per participant in heavy ion
collisions.Comment: 4 Pages, 5 Figures, contributed to the Proceedings of Quark Matter
2002, Nantes, France, 18-24 July 200
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