Benzimidazolil-kinolinil-merkaptotriazoli kao potencijalni antimikrobni i antivirusni agensi

Condensation of ethylaceto acetate (EAA) with resorcinol in concentrated H2SO4 afforded 7-hydroxy-4-methyl coumarin (1) which on reaction with thiosemicarbazide in anhydrous pyridine yielded 7-hydroxy-4-methyl-quinolinyl [1,5-c]-mercaptotriazole (2). Reaction of 2 with formaldehyde solution and amino acid in ethanol yielded 7-hydroxy-4-methyl-8-(N-methyl-aminoacid)-quinolinyl [1,5-c]-2"-mercaptotriazole (3). Interaction of 3 with o-phenylenediamine in pyridine yielded 7-hydroxy-4-methyl-8-(aminobenzimidazolyl)-quinolinyl [1,5-c]-2"-mercaptotriazole derivatives (4a-e). The latter compounds were evaluated for their antiviral and antimicrobial activities.Kondenzacijom etilacetoacetata (EAA) s rezorciolom u koncentriranoj H2SO4 dobiven je 7-hidroksi-4-metil kumarin (1) koji u reakciji s tiosemikarbazidom u bezvodnom piridinu daje 7-hidroksi-4-metil-kinolinil [1,5-c]-merkaptotriazol (2). Reakcijom spoja 2 s otopinom formaldehida i aminokiselinom u etanolu nastao je 7-hidroksi-4-metil-8-(N-metil-aminokiselina)-kinolinil [1,5-c]-2"-merkaptotriazol (3), koji je s o-fenilendiaminom u piridinu dao 7-hidroksi-4-metil-8-(aminobenzimidazolil)-kinolinil [1,5-c]-2\u27\u27-merkaptotriazol derivate (4a-e). Ispitano je antivirusno i antimikrobno djelovanje spojeva 4

Benzimidazolil-kinolinil-merkaptotriazoli kao potencijalni antimikrobni i antivirusni agensi

Condensation of ethylaceto acetate (EAA) with resorcinol in concentrated H2SO4 afforded 7-hydroxy-4-methyl coumarin (1) which on reaction with thiosemicarbazide in anhydrous pyridine yielded 7-hydroxy-4-methyl-quinolinyl [1,5-c]-mercaptotriazole (2). Reaction of 2 with formaldehyde solution and amino acid in ethanol yielded 7-hydroxy-4-methyl-8-(N-methyl-aminoacid)-quinolinyl [1,5-c]-2"-mercaptotriazole (3). Interaction of 3 with o-phenylenediamine in pyridine yielded 7-hydroxy-4-methyl-8-(aminobenzimidazolyl)-quinolinyl [1,5-c]-2"-mercaptotriazole derivatives (4a-e). The latter compounds were evaluated for their antiviral and antimicrobial activities.Kondenzacijom etilacetoacetata (EAA) s rezorciolom u koncentriranoj H2SO4 dobiven je 7-hidroksi-4-metil kumarin (1) koji u reakciji s tiosemikarbazidom u bezvodnom piridinu daje 7-hidroksi-4-metil-kinolinil [1,5-c]-merkaptotriazol (2). Reakcijom spoja 2 s otopinom formaldehida i aminokiselinom u etanolu nastao je 7-hidroksi-4-metil-8-(N-metil-aminokiselina)-kinolinil [1,5-c]-2"-merkaptotriazol (3), koji je s o-fenilendiaminom u piridinu dao 7-hidroksi-4-metil-8-(aminobenzimidazolil)-kinolinil [1,5-c]-2\u27\u27-merkaptotriazol derivate (4a-e). Ispitano je antivirusno i antimikrobno djelovanje spojeva 4

Production of solar hydrogen energy by nanostructured semiconductor photoelectrode

75-78The present paper describes the modification and solar hydrogen production studies employing a new semiconductor-septum (SC-SEP) photoelectrode ns-TiO2-In2O3 admixed/Ti based photoelectrochemical solar cell. The current-voltage characteristics of the above SC-SEP cell revealed that an enhancement in short-circuit current (ISC) up to three times (5~14.6 mAcm-2). The optimum hydrogen production rate was found to be 11.8 lh-1m-2 for 5 M H2SO4 and with a further increase in H2SO4 concentration, the hydrogen production rate was found to be invariant. In yet another part of our study instead of using new SC-SEP solar cell design, we used a new material form such as ns-TiO2-WO3. The WO3 admixed ns-TiO2 exhibited a high photo-current and photo-voltage of 15.6 mAcm-2, 960 mV, respectively. The ns-TiO2-WO3 electrode exhibited a higher hydrogen gas evolution rate of 13.8 lh-1m-2

Synthesis, characterization and biological activity of 1,3,4-substituted 2-azetidinones

158-162Amido/imido alcohol/2-phenyl-3-hydroxyethylquinazolin-4 (3H) -one 1 on treatment with benzoic acid in the presence of conc. H2SO4 yields m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxoquinazolinyl) benzoic acids 2. The acid chloride of 2 on reaction with hydrazine hydrate affords m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl) benzoic acid hydrazides 4 which on condensation with an aromatic aldehyde in acetic acid gives m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl) benzoic acid hydrazones 5. Compounds 5 undergo cyclization with phenoxy acetic acid in the presence of thionyl chloride in dry benzene to furnish 1-[m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl-benzamido)]-3-phenoxy-4-phenyl-2-azetidinones 6. The antiviral and antifungal activities of 6 have been reported

Structural and dielectric studies of [PVA –LiAc] : TiO₂ polymer nano-composite system

70-74An attempt has been made in the present work to prepare Poly Vinyl Alcohol (PVA) based proton conducting gel electrolyte that characterizes them. Nano composite polymer electrolyte consisting of Poly Vinyl Alcohol (PVA), Lithium acetate with TiO2 filler, is synthesized by the combination of solution cast technique and sol-gel process. Electrically conducting polymer have been most widely accomplished using chemical and electrochemical processing techniques. The composite electrolyte films were characterized by different experimental techniques. The average particle sizes of composite electrolytes were in between 20-30 nm and this system is essentially ionic with maximum conductivity of polymer electrolyte 90[80PVA-20LiAc]:10TiO2 is [~4.5x10-6 S/cm] at room temperature. </sub