759 research outputs found
Stability analysis and quasinormal modes of Reissner Nordstr{\o}m Space-time via Lyapunov exponent
We explicitly derive the proper time principal Lyapunov exponent
() and coordinate time () principal Lyapunov exponent
() for Reissner Nordstr{\o}m (RN) black hole (BH) . We also
compute their ratio. For RN space-time, it is shown that the ratio is
for
time-like circular geodesics and for Schwarzschild BH it is
. We
further show that their ratio may vary from
orbit to orbit. For instance, Schwarzschild BH at innermost stable circular
orbit(ISCO), the ratio is
and at marginally
bound circular orbit (MBCO) the ratio is calculated to be
. Similarly, for extremal RN
BH the ratio at ISCO is
.
We also further analyse the geodesic stability via this exponent. By evaluating
the Lyapunov exponent, it is shown that in the eikonal limit , the real and
imaginary parts of the quasi-normal modes of RN BH is given by the frequency
and instability time scale of the unstable null circular geodesics.Comment: Accepted in Pramana, 07/09/201
Beyond Logarithmic Corrections to Cardy Formula
As shown by Cardy modular invariance of the partition function of a given
unitary non-singular 2d CFT with left and right central charges c_L and c_R,
implies that the density of states in a microcanonical ensemble, at excitations
Delta and Delta-bar and in the saddle point approximation, is
\rho_0(\Delta,\bar\Delta;c_L, c_R)=c_L c_R
\exp(2\pi\sqrt{{c_L\Delta}/{6}})\exp(2\pi\sqrt{{c_R\bar\Delta}/{6}}). In this
paper, we extend Cardy's analysis and show that in the saddle point
approximation and up to contributions which are exponentially suppressed
compared to the leading Cardy's result, the density of states takes the form
\rho(\Delta,\bar\Delta; c_L,c_R)= f(c_L\Delta)
f(c_R\bar\Delta)\rho_0(\Delta,\bar\Delta; c_L, c_R), for a function f(x) which
we specify. In particular, we show that (i) \rho (\Delta,\bar\Delta; c_L, c_R)
is the product of contributions of left and right movers and hence, to this
approximation, the partition function of any modular invariant, non-singular
unitary 2d CFT is holomorphically factorizable and (ii) \rho(\Delta,\bar\Delta;
c_L, c_R)/(c_Lc_R) is only a function of and . In
addition, treating \rho(\Delta,\bar\Delta; c_L, c_R) as the density of states
of a microcanonical ensemble, we compute the entropy of the system in the
canonical counterpart and show that the function f(x) is such that the
canonical entropy, up to exponentially suppressed contributions, is simply
given by the Cardy's result \ln\rho_0(\Delta,\bar\Delta; c_L, c_R).Comment: 30 pages, no figures; v2: minor improvements, one reference added,
v3: minor corrections to match the published versio
Having a lot of a good thing: multiple important group memberships as a source of self-esteem.
Copyright: © 2015 Jetten et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedMembership in important social groups can promote a positive identity. We propose and test an identity resource model in which personal self-esteem is boosted by membership in additional important social groups. Belonging to multiple important group memberships predicts personal self-esteem in children (Study 1a), older adults (Study 1b), and former residents of a homeless shelter (Study 1c). Study 2 shows that the effects of multiple important group memberships on personal self-esteem are not reducible to number of interpersonal ties. Studies 3a and 3b provide longitudinal evidence that multiple important group memberships predict personal self-esteem over time. Studies 4 and 5 show that collective self-esteem mediates this effect, suggesting that membership in multiple important groups boosts personal self-esteem because people take pride in, and derive meaning from, important group memberships. Discussion focuses on when and why important group memberships act as a social resource that fuels personal self-esteem.This study was supported by 1. Australian Research Council Future Fellowship (FT110100238) awarded to Jolanda Jetten (see http://www.arc.gov.au) 2. Australian Research Council Linkage Grant (LP110200437) to Jolanda Jetten and Genevieve Dingle (see http://www.arc.gov.au) 3. support from the Canadian Institute for Advanced Research Social Interactions, Identity and Well-Being Program to Nyla Branscombe, S. Alexander Haslam, and Catherine Haslam (see http://www.cifar.ca)
String Theory on Warped AdS_3 and Virasoro Resonances
We investigate aspects of holographic duals to time-like warped AdS_3
space-times--which include G\"odel's universe--in string theory. Using
worldsheet techniques similar to those that have been applied to AdS_3
backgrounds, we are able to identify space-time symmetry algebras that act on
the dual boundary theory. In particular, we always find at least one Virasoro
algebra with computable central charge. Interestingly, there exists a dense set
of points in the moduli space of these models in which there is actually a
second commuting Virasoro algebra, typically with different central charge than
the first. We analyze the supersymmetry of the backgrounds, finding related
enhancements, and comment on possible interpretations of these results. We also
perform an asymptotic symmetry analysis at the level of supergravity, providing
additional support for the worldsheet analysis.Comment: 24 pages + appendice
The conserved C-terminus of the PcrA/UvrD helicase interacts directly with RNA polymerase
Copyright: © 2013 Gwynn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was supported by a Wellcome Trust project grant to MD (Reference: 077368), an ERC starting grant to MD (Acronym: SM-DNA-REPAIR) and a BBSRC project grant to PM, NS and MD (Reference: BB/I003142/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD
The role of temperature and frequency on fretting wear of a like-on-like stainless steel contact
The influences of environmental temperature and fretting frequency on the mechanisms and rates of wear in a like-on-like 304 stainless steel contact were examined, and mainly attributed to changes in the mechanical response of the bulk material and to changes in the behaviour of the oxide debris formed in the fretting process. At low temperatures, wear proceeds by continual oxide formation and egress from the contact, whilst at high temperatures, the rate of wear is much reduced, associated with the development of oxide formed into a protective bed within the contact. The temperature at which the change between these two behaviours took place was dependent upon the fretting frequency, with evidence that, at this transition temperature, changes in behaviour can occur as the fretting test proceeds under a fixed set of conditions. An interaction diagram has been developed which provides a coherent framework by which the complex effects of these two parameters can be rationalised in terms of widely accepted physical principles
Nuclear Pore Proteins Nup153 and Megator Define Transcriptionally Active Regions in the Drosophila Genome
Transcriptional regulation is one of the most important processes for modulating gene expression. Though much of this control is attributed to transcription factors, histones, and associated enzymes, it is increasingly apparent that the spatial organization of chromosomes within the nucleus has a profound effect on transcriptional activity. Studies in yeast indicate that the nuclear pore complex might promote transcription by recruiting chromatin to the nuclear periphery. In higher eukaryotes, however, it is not known whether such regulation has global significance. Here we establish nucleoporins as a major class of global regulators for gene expression in Drosophila melanogaster. Using chromatin-immunoprecipitation combined with microarray hybridisation, we show that Nup153 and Megator (Mtor) bind to 25% of the genome in continuous domains extending 10 kb to 500 kb. These Nucleoporin-Associated Regions (NARs) are dominated by markers for active transcription, including high RNA polymerase II occupancy and histone H4K16 acetylation. RNAi–mediated knock-down of Nup153 alters the expression of ∼5,700 genes, with a pronounced down-regulatory effect within NARs. We find that nucleoporins play a central role in coordinating dosage compensation—an organism-wide process involving the doubling of expression of the male X chromosome. NARs are enriched on the male X chromosome and occupy 75% of this chromosome. Furthermore, Nup153-depletion abolishes the normal function of the male-specific dosage compensation complex. Finally, by extensive 3D imaging, we demonstrate that NARs contribute to gene expression control irrespective of their sub-nuclear localization. Therefore, we suggest that NAR–binding is used for chromosomal organization that enables gene expression control
High quality RNA isolation from Aedes aegypti midguts using laser microdissection microscopy
Background: Laser microdissection microscopy (LMM) has potential as a research tool because it allows precise excision of target tissues or cells from a complex biological specimen, and facilitates tissue-specific sample preparation. However, this method has not been used in mosquito vectors to date. To this end, we have developed an LMM method to isolate midgut RNA using Aedes aegypti
Clonogenic growth of human breast cancer cells co-cultured in direct contact with serum-activated fibroblasts
INTRODUCTION: Accumulating evidence suggests that fibroblasts play a pivotal role in promoting the growth of breast cancer cells. The objective of the present study was to characterize and validate an in vitro model of the interaction between small numbers of human breast cancer cells and human fibroblasts. METHODS: We measured the clonogenic growth of small numbers of human breast cancer cells co-cultured in direct contact with serum-activated, normal human fibroblasts. Using DNA microarrays, we also characterized the gene expression profile of the serum-activated fibroblasts. In order to validate the in vivo relevance of our experiments, we then analyzed clinical samples of metastatic breast cancer for the presence of myofibroblasts expressing α-smooth muscle actin. RESULTS: Clonogenic growth of human breast cancer cells obtained directly from in situ and invasive tumors was dramatically and consistently enhanced when the tumor cells were co-cultured in direct contact with serum-activated fibroblasts. This effect was abolished when the cells were co-cultured in transwells separated by permeable inserts. The fibroblasts in our experimental model exhibited a gene expression signature characteristic of 'serum response' (i.e. myofibroblasts). Immunostaining of human samples of metastatic breast cancer tissue confirmed that myofibroblasts are in direct contact with breast cancer cells. CONCLUSION: Serum-activated fibroblasts promote the clonogenic growth of human breast cancer cells in vitro through a mechanism that involves direct physical contact between the cells. This model shares many important molecular and phenotypic similarities with the fibroblasts that are naturally found in breast cancers
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