5,491 research outputs found
Selective-pivot sampling of radial distribution functions in asymmetric liquid mixtures
We present a Monte Carlo algorithm for selectively sampling radial
distribution functions and effective interaction potentials in asymmetric
liquid mixtures. We demonstrate its efficiency for hard-sphere mixtures, and
for model systems with more general interactions, and compare our simulations
with several analytical approximations. For interaction potentials containing a
hard-sphere contribution, the algorithm yields the contact value of the radial
distribution function.Comment: 5 pages, 5 figure
On the interplay between sedimentation and phase separation phenomena in two-dimensional colloidal fluids
Colloidal particles that are confined to an interface effectively form a
two-dimensional fluid. We examine the dynamics of such colloids when they are
subject to a constant external force, which drives them in a particular
direction over the surface. Such a situation occurs, for example, for colloidal
particles that have settled to the bottom of their container, when the
container is tilted at an angle, so that they `sediment' to the lower edge of
the surface. We focus in particular on the case when there are attractive
forces between the colloids which causes them to phase separate into regions of
high density and low density and we study the influence of this phase
separation on the sedimentation process. We model the colloids as Brownian
particles and use both Brownian dynamics computer simulations and dynamical
density functional theory (DDFT) to obtain the time evolution of the ensemble
average one-body density profiles of the colloids. We consider situations where
the external potential varies only in one direction so that the ensemble
average density profiles vary only in this direction. We solve the DDFT in
one-dimension, by assuming that the density profile only varies in one
direction. However, we also solve the DDFT in two-dimensions, allowing the
fluid density profile to vary in both the - and -directions. We find that
in certain situations the two-dimensional DDFT is clearly superior to its
one-dimensional counterpart when compared with the simulations and we discuss
this issue.Comment: 17 pages, 10 figures, submitted to Molecular Physic
Absence of renal hypoxia in the subacute phase of severe renal ischemia reperfusion injury
This is the author accepted manuscript. The final version is available from American Physiological Society via the DOI in this recordTissue hypoxia has been proposed as an important event in renal ischemia reperfusion injury (IRI) particularly during the period of ischemia and in the immediate hours following reperfusion. However, little is known about renal oxygenation during the subacute phase of IRI. We employed four different methods to assess the temporal and spatial changes in tissue oxygenation during the subacute phase (24 h and 5 days after reperfusion) of a severe form of renal IRI in rats. We hypothesized that the kidney is hypoxic 24 h and 5 days after an hour of bilateral renal ischemia, driven by a disturbed balance between renal oxygen delivery (DO2) and oxygen consumption (VO2). Renal DO2 was not significantly reduced in the subacute phase of IRI. In contrast, renal VO2 was 55% less 24 h, and 49% less 5 days after reperfusion than after sham-ischemia. Inner medullary tissue PO2, measured by radiotelemetry was 25 {plus minus} 12% greater 24 h after ischemia than after sham-ischemia. By 5 days after reperfusion, tissue PO2 was similar to that in rats subjected to sham-ischemia. Tissue PO2 measured by Clark electrode was consistently greater 24 h, but not 5 days, after ischemia than after sham-ischemia. Cellular hypoxia, assessed by pimonidazole adduct immunohistochemistry, was largely absent at both time-points and tissue levels of hypoxia inducible factors were downregulated following renal ischemia. Thus, in this model of severe IRI, tissue hypoxia does not appear to be an obligatory event during the subacute phase, likely due to the markedly reduced oxygen consumption.British Heart FoundationBritish Heart FoundationNational Health and Medical Research Council of AustraliaEuropean Union, Seventh Framework Programm
Dynamics of the chiral phase transition from AdS/CFT duality
We use Lorentzian signature AdS/CFT duality to study a first order phase
transition in strongly coupled gauge theories which is akin to the chiral phase
transition in QCD. We discuss the relation between the latent heat and the
energy (suitably defined) of the component of a D-brane which lies behind the
horizon at the critical temperature. A numerical simulation of a dynamical
phase transition in an expanding, cooling Quark-Gluon plasma produced in a
relativistic collision is carried out.Comment: 30 pages, 5 figure
Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations
Can the skin make you fat? A role for the skin in regulating adipose tissue function and whole-body glucose and lipid homeostasis
This work was supported by the following funding: BBSRC-LIDO Studentship (PWC, MPP and EE); Diabetes UK project grant (15/0005154) (PWC); British Skin Foundation (RFH, MP); MedCity (RFH)
Melting mud in Earth's mantle
Melting of subducted sediment remains controversial, as direct observation of sediment melt generation at mantle depths is not possible. Geochemical fingerprints provide indirect evidence for subduction delivery of sediment to the mantle; however, sediment abundance in mantle-derived melt is generally low (0%–2%), and difficult to detect. Here we provide evidence for melting of subducted sediment in granite sampled from an exhumed mantle section. Peraluminous granite dikes that intrude peridotite in the Oman–United Arab Emirates ophiolite have U-Pb ages of 99.8 ± 3.3 Ma that predate obduction. The dikes have unusually high oxygen isotope (δ18O) values for whole rock (14–23‰) and quartz (20–22‰), and yield the highest δ18O zircon values known (14–28‰; values relative to Vienna standard mean ocean water [VSMOW]). The extremely high oxygen isotope ratios uniquely identify the melt source as high-δ18O marine sediment (pelitic and/or siliciceous mud), as no other source could produce granite with such anomalously high δ18O. Formation of high-δ18O sediment-derived (S-type) granite within peridotite requires subduction of sediment to the mantle, where it melted and intruded overlying mantle wedge. The granite suite described here contains the highest oxygen isotope ratios reported for igneous rocks, yet intruded mantle peridotite below the Mohorovičić seismic discontinuity, the most primitive oxygen isotope reservoir in the silicate Earth. Identifying the presence and quantifying the extent of sediment melting within the mantle has important implications for understanding subduction recycling of supracrustal material and effects on mantle heterogeneity over time.National Geographi
Homeostasis of metabolites in Escherichia coli on transition from anaerobic to aerobic conditions and the transient secretion of pyruvate
We have developed a method for rapid quenching of samples
taken from chemostat cultures of Escherichia coli that gives
reproducible and reliable measurements of extracellular and
intracellular metabolites by 1H NMR and have applied it
to study the major central metabolites during the transition
from anaerobic to aerobic growth. Almost all metabolites
showed a gradual change after perturbation with air, consistent
with immediate inhibition of pyruvate formate-lyase, dilution
of overflow metabolites and induction of aerobic enzymes.
Surprisingly, although pyruvate showed almost no change
in intracellular concentration, the extracellular concentration
transiently increased. The absence of intracellular accumulation
of pyruvate suggested that one or more glycolytic enzymes
might relocate to the cell membrane. To test this hypothesis,
chromosomal pyruvate kinase (pykF) was modified to express
either PykF-green fluorescent protein or PykF-FLAG fusion
proteins. Measurements showed that PykF-FLAG relocates to
the cell membrane within 5 min of aeration and then slowly
returns to the cytoplasm, suggesting that on aeration, PykF
associates with the membrane to facilitate secretion of pyruvate
to maintain constant intracellular levels
Sunglass Filter Transmission and Its Operational Effect in Solar Protection for Civilian Pilots.
INTRODUCTION: The ocular effects of excess solar radiation exposure are well documented. Recent evidence suggests that ocular ultraviolet radiation (UVR) exposure to professional pilots may fall outside international guideline limits unless eye protection is used. Nonprescription sunglasses should be manufactured to meet either international or national standards. The mean increase in UVR and blue light hazards at altitude has been quantified and the aim of this research was to assess the effectiveness of typical pilot sunglasses in reducing UVR and blue light hazard exposure in flight. METHOD: A series of sunglass filter transmittance measurements were taken from personal sunglasses (N = 20) used by pilots together with a series of new sunglasses (N = 18). RESULTS: All nonprescription sunglasses measured conformed to international standards for UVR transmittance and offered sufficient UVR protection for pilots. There was no difference between right and left lenses or between new and used sunglasses. All sunglasses offered sufficient attenuation to counter the mean increase in blue light exposure that pilots experience at altitude, although used sunglasses with scratched lenses were marginally less effective. One pair of prescription sunglasses offered insufficient UVR attenuation for some flights, but would have met requirements of international and national standards for UV-A transmittance. This was likely due to insufficient UVR blocking properties of the lens material. CONCLUSIONS: Lenses manufactured to minimally comply with standards for UVR transmittance could result in excess UVR exposure to a pilot based on in-flight irradiance data; an additional requirement of less than 10% transmittance at 380 nm is recommended
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