La fondation du monastère Sainte-Catherine du Sinaï selon deux documents de sa bibliothèque: codex Arabe 692 et rouleau Arabe 955

In this paper we edit and translate the Arabic Codex n. 692 (1st part) and the Arabic scroll n. 955. We also comment on the main items mentioned in the two texts: their authenticity appears to be quite questionable. However, some of the facts, especially those in document 692-1, do not rule out the possibility that the documents drew inspiration from an ancient, unidentified source of the early history of the monastery. We therefore hypothesize, based on the known sources and the present documents, that theconstruction of the Sinai monastery was initiated towards the beginning of Justinian’s reign, and that the fortified tower mentioned by several sources represented the initial stage of the construction.En este artículo editamos y traducimos el Codex Arabe nº 692 (1.ª parte) y el Rollo Arabe nº 955. Comentamos, asimismo, los principales aspectos mencionados an ambos textos, en los cuales la autenticidad de muchos de esos elementos parecen ser cuestionables. Concretamente, en el documento 692-1, algunos hechos no descartan la posibilidad de que los documentos se inspirasen en una antigua fuente no identificada de la historia temprana del Monasterio. Planteamos, pues, la hipótesis basada en fuentes conocidas y documentos actuales, de que la construcción del Monasterio del Sinaí comenzó a comienzos del reinado de Justiniano y que la torre fortificada que mencionan varias fuentes fue el estadio inicial de la construcción

Un aperçu des descriptions grecques et arabes du Sinaï et du monastère Sainte-Catherine au XVIIIe siècle

This article overviews a number of manuscripts and printed books that constitute potential sources for the history of the monastery of Saint-Catherine, Sinai, in the 18th century. Firstly, the most likely source of this ensemble, the Épitomè written by Nectarios of Crete, is introduced. Then, the publication of the six editions of the Greek Périgraphè is discussed, starting from the first one, which was printed in 1710 in Wallachia, and ending with the sixth and the largest one, published in 1817 in Venice. This study indicates that a critical edition and translation of these texts, a sample of which we provide for the two Arabic versions, should be accompanied by a thorough examination of the differences they show with the Épitomè.El presente artículo revisa una serie de manuscritos y libros impresos que constituyen las fuentes potenciales para la historia del monasterio de Santa Catalina, en el Sinaí, durante el s. XVIII. En primer lugar, se presenta la fuente más probable de este conjunto, el Épitomè escrito por Nectarios de Creta. Luego, se estudia la publicación de las seis ediciones del Périgraphè griego, partiendo de la primera, impresa en Valaquia en 1710, y terminando con la sexta y la más extensa, publicada en Venecia en 1817. Este estudio señala que se debería acompañar una edición crítica y una traducción de estos textos de los que ofrecemos dos versiones árabes de un exhaustivo análisis de las diferencias entre ellas y el Épitomè

Health determinants of informal caregivers aged 65 years and over

peer reviewe

Building a Portuguese Coalition for Biodiversity Genomics

The diverse physiography of the Portuguese land and marine territory, spanning from continental Europe to the Atlantic archipelagos, has made it an important repository of biodiversity throughout the Pleistocene glacial cycles, leading to a remarkable diversity of species and ecosystems. This rich biodiversity is under threat from anthropogenic drivers, such as climate change, invasive species, land use changes, overexploitation or pathogen (re)emergence. The inventory, characterization and study of biodiversity at inter- and intra-specific levels using genomics is crucial to promote its preservation and recovery by informing biodiversity conservation policies, management measures and research. The participation of researchers from Portuguese institutions in the European Reference Genome Atlas (ERGA) initiative, and its pilot effort to generate reference genomes for European biodiversity, has reinforced the establishment of Biogenome Portugal. This nascent institutional network will connect the national community of researchers in genomics. Here, we describe the Portuguese contribution to ERGA’s pilot effort, which will generate high-quality reference genomes of six species from Portugal that are endemic, iconic and/or endangered, and include plants, insects and vertebrates (fish, birds and mammals) from mainland Portugal or the Azores islands. In addition, we outline the objectives of Biogenome Portugal, which aims to (i) promote scientific collaboration, (ii) contribute to advanced training, (iii) stimulate the participation of institutions and researchers based in Portugal in international biodiversity genomics initiatives, and (iv) contribute to the transfer of knowledge to stakeholders and engaging the public to preserve biodiversity. This initiative will strengthen biodiversity genomics research in Portugal and fuel the genomic inventory of Portuguese eukaryotic species. Such efforts will be critical to the conservation of the country’s rich biodiversity and will contribute to ERGA’s goal of generating reference genomes for European species.info:eu-repo/semantics/publishedVersio

Optimizing the design and analysis of clinical trials for antibacterials against multidrug-resistant organisms:a white paper from COMBACTE's STAT-Net

Innovations are urgently required for clinical development of antibacterials against multidrug-resistant organisms. Therefore, a European, public-private working group (STAT-Net; part of Combatting Bacterial Resistance in Europe [COMBACTE]), has reviewed and tested several innovative trials designs and analytical methods for randomized clinical trials, which has resulted in 8 recommendations. The first 3 focus on pharmacokinetic and pharmacodynamic modeling, emphasizing the pertinence of population-based pharmacokinetic models, regulatory procedures for the reassessment of old antibiotics, and rigorous quality improvement. Recommendations 4 and 5 address the need for more sensitive primary end points through the use of rank-based or time-dependent composite end points. Recommendation 6 relates to the applicability of hierarchical nested-trial designs, and the last 2 recommendations propose the incorporation of historical or concomitant trial data through Bayesian methods and/or platform trials. Although not all of these recommendations are directly applicable, they provide a solid, evidence-based approach to develop new, and established, antibacterials and address this public health challenge

The era of reference genomes in conservation genomics

Progress in genome sequencing now enables the large-scale generation of reference genomes. Various international initiatives aim to generate reference genomes representing global biodiversity. These genomes provide unique insights into genomic diversity and architecture, thereby enabling comprehensive analyses of population and functional genomics, and are expected to revolutionize conservation genomics

The era of reference genomes in conservation genomics

Progress in genome sequencing now enables the large-scale generation of reference genomes. Various international initiatives aim to generate reference genomes representing global biodiversity. These genomes provide unique insights into genomic diversity and architecture, thereby enabling comprehensive analyses of population and functional genomics, and are expected to revolutionize conservation genomics

The era of reference genomes in conservation genomics

info:eu-repo/semantics/publishedVersio