Tanto Ella Assume Novitate al Fianco. Lisboa, Turim e o intercâmbio cultural do século das luzes

This volume provides an interdisciplinary, multifaceted view of a key period of the making and remaking of the European artistic, cultural and political landscape at the turn from the eighteenth to the nineteenth century. It focus on the relationships between Lisbon and Turin as a prime analyzer of the main forms of sociability and circulation of objects, knowledge, tastes, styles of government and public policies upon which a new European geopolitical panorama was erected, extending as well to the overseas territories. The variety of approaches deployed in the volume are unified by a broad notion of cultural history which includes on an equal footing the visual and the scientific, the material and the political culture. The studies in this volume underline the crucial importance of the transfer of tastes and habitus, and the associated emergence of new forms of sensibility, in shaping the transition from Enlightenment to the Post-Napoleonic Europe

Seasonal precipitation in eastern Amazon during rainy season: regional observations and RegCM3 simulations

This paper presents a contribution on the climate modelling studies with emphasis on seasonal rainfall variability in eastern Amazonia, during the austral summer and autumn seasons (DJF and MAM). Based on RegCM3 regional climate simulations for a 26 years period (1982/83 to 2007/08) using high resolution domain scale (30 km) and two different convection schemes (Grell and MIT), it was investigated the model performance to simulate the regional pluviometric distribution in eastern Amazon, with reference to a new observational data base containing regional aspects extracted from a dense rain gauge station network. The quantitative analysis showed that RegCM3 presents systematic errors, especially those related to the dry bias in the Amapá and north/northeast of Pará using both schemes Grell and MIT, which indicate that the model does not reproduce ITCZ characteristics over equatorial Atlantic. The simulations using MIT also indicated wet bias in the southwest/south/southeast of Pará and north of Tocantins. Moreover, through composites technique, it was also investigated RegCM3 response to reproduce the anomalous spatial rainfall patterns in association with ENSO episodes and interhemispheric SSTa gradient phases across the intertropical Atlantic. The results showed that the model represented realistically well the spatial pattern related to the rainfall anomalies above (below) than normal in most of eastern Amazonia, during the known favourable scenarios, i.e., La Niña and south Atlantic SSTa gradient (unfavourable, i.e., El Niño and north Atlantic SSTa gradient).O presente trabalho apresenta uma contribuição aos estudos de modelagem climática com ênfase na variabilidade pluviométrica sazonal da Amazônia oriental, durante as estações de verão e outono (DJF e MAM). Baseado nos resultados das simulações regionais do RegCM3 para um período de 26 anos (1982/83 a 2007/08) e usando domínio em alta resolução espacial (30 Km) e dois diferentes esquemas de convecção (Grell e MIT), foi investigado o desempenho do modelo em simular a distribuição regional de precipitação sazonal na Amazônia oriental, com referência a um novo conjunto de dados observacional compilado com informações de uma ampla rede integrada de estações pluviométricas. As análises quantitativas evidenciaram que o RegCM3 apresenta erros sistemáticos, sobretudo aqueles relacionados com viés seco no Amapá e norte/nordeste do Pará usando ambos os esquemas Grell e MIT, os quais apontam que o modelo não reproduz as características da ZCIT sobre o Atlântico equatorial. As simulações usando MIT, também apresentaram viés úmido no sudoeste/sul/sudeste do Pará e norte do Tocantins. Além disso, através da técnica de composições, também foi investigado o desempenho do RegCM3 em reproduzir os padrões espaciais anômalos de precipitação sazonal em associação aos episódios ENOS, e as fases do gradiente térmico sobre o Atlântico intertropical. Os resultados demonstraram que o modelo conseguiu representar realisticamente bem o padrão espacial das anomalias pluviométricas acima (abaixo) do normal em grande parte da Amazônia oriental, durante os conhecidos cenários favoráveis, i.e., condições de La Niña e gradiente de aTSM para o Atlântico sul (desfavoráveis, i.e., El Niño e gradiente de aTSM para o Atlântico norte

One More Piece in the VACV Ecological Puzzle: Could Peridomestic Rodents Be the Link between Wildlife and Bovine Vaccinia Outbreaks in Brazil?

BACKGROUND: Despite the fact that smallpox eradication was declared by the World Health Organization (WHO) in 1980, other poxviruses have emerged and re-emerged, with significant public health and economic impacts. Vaccinia virus (VACV), a poxvirus used during the WHO smallpox vaccination campaign, has been involved in zoonotic infections in Brazilian rural areas (Bovine Vaccinia outbreaks - BV), affecting dairy cattle and milkers. Little is known about VACV's natural hosts and its epidemiological and ecological characteristics. Although VACV was isolated and/or serologically detected in Brazilian wild animals, the link between wildlife and farms has not yet been elucidated. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we describe for the first time, to our knowledge, the isolation of a VACV (Mariana virus - MARV) from a mouse during a BV outbreak. Genetic data, in association with biological assays, showed that this isolate was the same etiological agent causing exanthematic lesions observed in the cattle and human inhabitants of a particular BV-affected area. Phylogenetic analysis grouped MARV with other VACV isolated during BV outbreaks. CONCLUSION/SIGNIFICANCE: These data provide new biological and epidemiological information on VACV and lead to an interesting question: could peridomestic rodents be the link between wildlife and BV outbreaks

Testagem, Quarentena e Telemonitoramento Da Covid-19 na Atenção Básica: Reflexões das Experiências da Gestão e Assistência

The initial cases of Covid-19, originating in China, triggered a pandemic, exposing deficiencies in the healthcare system. The project "Expansion of Testing, Quarantine, and Telemonitoring Strategies to Contribute to Confronting the Covid-19 Pandemic in Brazil" emerged in response to this crisis. This article aims to recount the project's experience in tackling the Covid-19 pandemic in primary healthcare. Monitors operated between June 2022 and February 2023 in Family Health Units and Basic Health Units in Salvador, Bahia. Their activities included supporting the implementation of the strategy, resource organization, conducting sociobehavioral research, and providing guidance to healthcare workers and users. The participation of monitors as intermediaries between healthcare professionals, bureaucratic demands, and users facilitated communication, testing, and research. Outreach strategies, such as meetings, local radio broadcasts, social media, and the distribution of pamphlets, resulted in increased community adherence to testing and participation in the research. However, challenges emerged due to insecurity in certain neighborhoods, impacting access to healthcare services. The contribution of monitors to the expansion of the strategy strengthened the research, enabling the systematization of care, dynamic operations, and ensuring qualified and safe attention.Los primeros casos de Covid-19, originados en China, desencadenaron una pandemia, evidenciando deficiencias en el sistema de salud. El proyecto "Expansión de Estrategias de Pruebas, Cuarentena y Telemonitoreo para Contribuir en la Enfrentamiento de la Pandemia de Covid-19 en Brasil" surgió como respuesta a esta crisis. Este artículo busca relatar la experiencia del proyecto en la lucha contra la pandemia de Covid-19 en la atención primaria de la salud. Los monitores trabajaron entre junio de 2022 y febrero de 2023 en Unidades de Salud de la Familia y Unidades Básicas de Salud en Salvador, Bahía. Sus actividades incluyeron apoyo a la implementación de la estrategia, organización de recursos, aplicación de investigaciones sociocomportamentales y orientación a trabajadores de la salud y usuarios. La participación de los monitores como mediadores entre profesionales de la salud, demandas burocráticas y usuarios facilitó la comunicación, la realización de pruebas y la investigación. Estrategias de divulgación, como reuniones, radios locales, redes sociales y distribución de folletos, resultaron en una mayor adhesión comunitaria a las pruebas y en la participación en la investigación. Sin embargo, surgieron desafíos debido a la inseguridad en ciertos barrios, afectando el acceso a los servicios de salud. La contribución de los monitores en la expansión de la estrategia fortaleció la investigación, permitiendo la sistematización de la asistencia, operaciones dinámicas y garantizando atención calificada y segura.Os primeiros casos de Covid-19, originados na China, desencadearam uma pandemia, evidenciando deficiências no sistema de saúde. O projeto "Expansão das Estratégias de Testagem, Quarentena e Telemonitoramento para Contribuir no Enfrentamento da Pandemia de Covid-19 no Brasil" surgiu como resposta a essa crise. Este artigo busca relatar a experiência dos de projeto no enfrentamento da pandemia de Covid-19 na atenção básica à saúde. Os monitores atuaram entre junho de 2022 e fevereiro de 2023 em Unidades de Saúde da Família e Unidades Básicas de Saúde em Salvador, Bahia. Suas atividades incluíram apoio à implementação da estratégia, organização de recursos, aplicação de pesquisas sociocomportamentais e orientação a trabalhadores da saúde e usuários. A participação dos monitores como mediadores entre profissionais de saúde, demandas burocráticas e usuários facilitou a comunicação, a realização de testes e a pesquisa. Estratégias de divulgação, como reuniões, rádios locais, redes sociais e distribuição de folhetos, resultaram em maior adesão comunitária aos testes e na participação na pesquisa. Contudo, desafios surgiram devido à insegurança em determinados bairros, impactando o acesso aos serviços de saúde. A contribuição dos monitores na expansão da estratégia fortaleceu a pesquisa, permitindo a sistematização da assistência, operações dinâmicas e garantindo atenção qualificada e segura

Virulence in Murine Model Shows the Existence of Two Distinct Populations of Brazilian Vaccinia virus Strains

Brazilian Vaccinia virus had been isolated from sentinel mice, rodents and recently from humans, cows and calves during outbreaks on dairy farms in several rural areas in Brazil, leading to high economic and social impact. Some phylogenetic studies have demonstrated the existence of two different populations of Brazilian Vaccinia virus strains circulating in nature, but little is known about their biological characteristics. Therefore, our goal was to study the virulence pattern of seven Brazilian Vaccinia virus strains. Infected BALB/c mice were monitored for morbidity, mortality and viral replication in organs as trachea, lungs, heart, kidneys, liver, brain and spleen. Based on the virulence potential, the Brazilian Vaccinia virus strains were grouped into two groups. One group contained GP1V, VBH, SAV and BAV which caused disease and death in infected mice and the second one included ARAV, GP2V and PSTV which did not cause any clinical signals or death in infected BALB/c mice. The subdivision of Brazilian Vaccinia virus strains into two groups is in agreement with previous genetic studies. Those data reinforce the existence of different populations circulating in Brazil regarding the genetic and virulence characteristics

SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. Methods By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARSCoV-2 introductions and early dissemination in Portugal. Results We detected at least 277 independent SARS-CoV-2 introductions, mostly from European countries (namely the United Kingdom, Spain, France, Italy, and Switzerland), which were consistent with the countries with the highest connectivity with Portugal. Although most introductions were estimated to have occurred during early March 2020, it is likely that SARS-CoV-2 was silently circulating in Portugal throughout February, before the first cases were confirmed. Conclusions Here we conclude that the earlier implementation of measures could have minimized the number of introductions and subsequent virus expansion in Portugal. This study lays the foundation for genomic epidemiology of SARS-CoV-2 in Portugal, and highlights the need for systematic and geographically-representative genomic surveillance.We gratefully acknowledge to Sara Hill and Nuno Faria (University of Oxford) and Joshua Quick and Nick Loman (University of Birmingham) for kindly providing us with the initial sets of Artic Network primers for NGS; Rafael Mamede (MRamirez team, IMM, Lisbon) for developing and sharing a bioinformatics script for sequence curation (https://github.com/rfm-targa/BioinfUtils); Philippe Lemey (KU Leuven) for providing guidance on the implementation of the phylodynamic models; Joshua L. Cherry (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health) for providing guidance with the subsampling strategies; and all authors, originating and submitting laboratories who have contributed genome data on GISAID (https://www.gisaid.org/) on which part of this research is based. The opinions expressed in this article are those of the authors and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government. This study is co-funded by Fundação para a Ciência e Tecnologia and Agência de Investigação Clínica e Inovação Biomédica (234_596874175) on behalf of the Research 4 COVID-19 call. Some infrastructural resources used in this study come from the GenomePT project (POCI-01-0145-FEDER-022184), supported by COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Programme (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and by Fundação para a Ciência e a Tecnologia (FCT).info:eu-repo/semantics/publishedVersio