Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Patellar luxation in dogs: a retrospective study

Submitted by Guilherme Lemeszenski ([email protected]) on 2013-08-22T18:56:14Z No. of bitstreams: 1 S0102-09352009000200035.pdf: 151214 bytes, checksum: 3a419a048a5508aecdde4c468a2e9d5f (MD5)Made available in DSpace on 2013-08-22T18:56:14Z (GMT). No. of bitstreams: 1 S0102-09352009000200035.pdf: 151214 bytes, checksum: 3a419a048a5508aecdde4c468a2e9d5f (MD5) Previous issue date: 2009-04-01Made available in DSpace on 2013-09-30T19:49:57Z (GMT). No. of bitstreams: 2 S0102-09352009000200035.pdf: 151214 bytes, checksum: 3a419a048a5508aecdde4c468a2e9d5f (MD5) S0102-09352009000200035.pdf.txt: 17158 bytes, checksum: 600eaaa16aa49e42de9ebec8926c8217 (MD5) Previous issue date: 2009-04-01Submitted by Vitor Silverio Rodrigues ([email protected]) on 2014-05-20T15:13:07Z No. of bitstreams: 2 S0102-09352009000200035.pdf: 151214 bytes, checksum: 3a419a048a5508aecdde4c468a2e9d5f (MD5) S0102-09352009000200035.pdf.txt: 17158 bytes, checksum: 600eaaa16aa49e42de9ebec8926c8217 (MD5)Made available in DSpace on 2014-05-20T15:13:07Z (GMT). No. of bitstreams: 2 S0102-09352009000200035.pdf: 151214 bytes, checksum: 3a419a048a5508aecdde4c468a2e9d5f (MD5) S0102-09352009000200035.pdf.txt: 17158 bytes, checksum: 600eaaa16aa49e42de9ebec8926c8217 (MD5) Previous issue date: 2009-04-01Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)UNESP Faculdade de Medicina Veterinária e ZootecniaUNESP Faculdade de Medicina Veterinária e Zootecni

Efeito da densidade de estocagem no desempenho de rã-touro (Rana catesbeiana) em recria Effects of stocking density on performance of bullfrog (Rana catesbeiana) in the post-metamorphic phase

Este trabalho foi realizado com o objetivo de avaliar quatro densidades de estocagem na recria de rã-touro em mini-baias. As densidades estudadas foram: D1: 75 rãs/m&sup2; (inicial) e 35 rãs/m&sup2; (final); D2: 105 rãs/m&sup2; (inicial) e 50 rãs/m&sup2; (final); D3: 125 rãs/m&sup2; (inicial) e 60 rãs/m&sup2; (final); e D4: 160 rãs/m&sup2; (inicial) e 75 rãs/m&sup2; (final). No ensaio de desempenho, foram utilizadas 558 rãs com peso médio de 26,80 g durante 56 dias, distribuídas em um delineamento em blocos casualizados, com seis repetições. Houve efeito das densidades sobre o ganho de peso, que foram inversamente proporcionais. Menores densidades resultaram em maior consumo de alimento, de modo que, com o uso das densidades iniciais de 75 e 105 rãs/m&sup2;, obteve-se maior consumo de alimento que o uso de 125 e 160 rãs/m&sup2;. A conversão alimentar aparente também variou; a densidade inicial de 160 rãs/m&sup2; proporcionou a pior média desse parâmetro. Os tratamentos foram avaliados economicamente, segundo os custos com alimentação, a receita bruta e a receita líquida parcial proporcionados. Concluiu-se que a densidade final de 50 rãs/m&sup2; aumentou a receita líquida parcial, proporcionando resultados mais adequados para produção de rãs.<br>This work was carried out with the objective of evaluate four stocking densities of bullfrog (post-metamorphic) in mini-stalls. The densities studied were D1: 75 bullfrogs/m&sup2; (initial) and 35 bullfrogs/m&sup2; (finishing); D2: 105 bullfrogs/m&sup2; (initial) and 50 bullfrogs/m&sup2; (finishing); D3: 125 bullfrogs/m&sup2; (initial) and 60 bullfrogs/m&sup2; (finishing); and D4: 160 bullfrogs/m&sup2; (initial) and 75 bullfrogs/m&sup2; (finishing). The performance trial was carried out with 558 bullfrogs averaging initial weight of 26.80 g, during 56 days, according to a completely randomized blocks design with six replicates. Inversely proportional effects of densities on weight gain were observed. Smaller densities resulted in greater values of feed intake, and the initial densities of 75 and 105 bullfrogs/m&sup2; resulted in higher values of feed intake than 125 and 160 bullfrogs/m&sup2;. The apparent feed conversion also varied , showing the worst average on initial density of 160 bullfrogs/m&sup2;. Economic analysis was performed with the costs with feeding, gross income and partial net income. It was concluded that the final density of 50 bullfrogs/m&sup2; increased the partial net income and was indicated for production of bullfrogs

First joint Gravitational Waves search by the AURIGA-EXPLORER-NAUTILUS-Virgo collaboration

We present results of the search for coincident burst excitations over a 24 hours long data set collected by AURIGA, EXPLORER, NAUTILUS and Virgo detectors during September 2005. The search of candidate triggers was performed independently on each of the data sets from single detectors. We looked for two-fold time coincidences between these candidates using an algorithm optimized for a given population of sources and we calculated the efficiency of detection through injections of templated signal waveforms into the streams of data. To this purpose we have considered the case of signals shaped as damped sinusoids coming from the galactic center direction. In this framework our method targets an optimal balance between high efficiency and low false alarm rate, aiming at setting confidence intervals as stringent as possible in terms of the rate of the selected source models.We present results of the search for coincident burst excitations over a 24 hours long data set collected by AURIGA, EXPLORER, NAUTILUS and Virgo detectors during September 2005. The search of candidate triggers was performed independently on each of the data sets from single detectors. We looked for two-fold time coincidences between these candidates using an algorithm optimized for a given population of sources and we calculated the efficiency of detection through injections of templated signal waveforms into the streams of data. To this purpose we have considered the case of signals shaped as damped sinusoids coming from the galactic center direction. In this framework our method targets an optimal balance between high efficiency and low false alarm rate, aiming at setting confidence intervals as stringent as possible in terms of the rate of the selected source models