4,285 research outputs found
Dynamical scaling analysis of the optical Hall conductivity in the quantum Hall regime
Dynamical scaling analysis is theoretically performed for the ac (optical)
Hall conductivity as a function of Fermi
energy and frequency for the two-dimensional electron
gas and for graphene. In both systems, results based on exact diagonalization
show that displays a well-defined dynamical
scaling, for which the dynamical critical exponent as well as the localization
exponent are fitted and plugged in. A crossover from the dc-like bahavior to
the ac regime is identified. The dynamical scaling analysis has enabled us to
quantify the plateau in the ac Hall conductivity previously obtained, and to
predict that the plateaux structure in ac is robust enough to be observed in
the THz regime.Comment: 5 pages, 3 figure
Regularizing effect and local existence for non-cutoff Boltzmann equation
The Boltzmann equation without Grad's angular cutoff assumption is believed
to have regularizing effect on the solution because of the non-integrable
angular singularity of the cross-section. However, even though so far this has
been justified satisfactorily for the spatially homogeneous Boltzmann equation,
it is still basically unsolved for the spatially inhomogeneous Boltzmann
equation. In this paper, by sharpening the coercivity and upper bound estimates
for the collision operator, establishing the hypo-ellipticity of the Boltzmann
operator based on a generalized version of the uncertainty principle, and
analyzing the commutators between the collision operator and some weighted
pseudo differential operators, we prove the regularizing effect in all (time,
space and velocity) variables on solutions when some mild regularity is imposed
on these solutions. For completeness, we also show that when the initial data
has this mild regularity and Maxwellian type decay in velocity variable, there
exists a unique local solution with the same regularity, so that this solution
enjoys the regularity for positive time
Unusual Low-Temperature Phase in VO Nanoparticles
We present a systematic investigation of the crystal and electronic structure
and the magnetic properties above and below the metal-insulator transition of
ball-milled VO nanoparticles and VO microparticles. For this research,
we performed a Rietveld analysis of synchrotron radiation x-ray diffraction
data, O x-ray absorption spectroscopy, V resonant inelastic x-ray
scattering, and magnetic susceptibility measurements. This study reveals an
unusual low-temperature phase that involves the formation of an elongated and
less-tilted V-V pair, a narrowed energy gap, and an induced paramagnetic
contribution from the nanoparticles. We show that the change in the crystal
structure is consistent with the change in the electronic states around the
Fermi level, which leads us to suggest that the Peierls mechanism contributes
to the energy splitting of the state. Furthermore, we find that the
high-temperature rutile structure of the nanoparticles is almost identical to
that of the microparticles.Comment: 7 pages, 8 figures, 2 table
Global existence and full regularity of the Boltzmann equation without angular cutoff
We prove the global existence and uniqueness of classical solutions around an
equilibrium to the Boltzmann equation without angular cutoff in some Sobolev
spaces. In addition, the solutions thus obtained are shown to be non-negative
and in all variables for any positive time. In this paper, we study
the Maxwellian molecule type collision operator with mild singularity. One of
the key observations is the introduction of a new important norm related to the
singular behavior of the cross section in the collision operator. This norm
captures the essential properties of the singularity and yields precisely the
dissipation of the linearized collision operator through the celebrated
H-theorem
Ascaris suum: cDNA microarray analysis of 4th stage larvae (L4) during self-cure from the intestine
There is spontaneous cure of a large portion of Ascaris suum 4th-stage larvae (L4) from the jejunum of infected pigs between 14 and 21 days after inoculation (DAI). Those L4 that remain in the jejunum continue to develop while those that have moved to the ileum are eventually expelled from the intestines. Although increases in intestinal mucosal mast cells and changes in localhost immunity are coincidental with spontaneous cure, the population of L4 that continue to develop in the jejunum may counteract host protective mechanisms by the differential production of factors related to parasitism. To this end, a cDNA library was constructed from L4 isolated from pig jejunum at 21 DAI, and 93% of 1920 original clones containing a single amplicon in the range 400– 1500 bp were verified by gel electrophoresis and printed onto glass slides for microarray analysis. Fluorescent probes were prepared from total RNA isolated from: (1) 3rd stage-larvae from lung at 7 DAI, (L3); (2) L4 from jejunum at 14 DAI (L4-14-J); (3) L4 from jejunum at 21 DAI (L4-21-J); (4) L4 from ileum at 21 DAI (L4-21-I, and; (5) adults (L5). Cy3-labeled L3, L4-14-J, L4-21-I and L5 cDNA, and Cy5-labeled L4-21-J cDNA were simultaneously used to screen the printed arrays containing the L4-21-J-derived cDNA library. Several clones showed consistent differential gene expression over two separate experiments and were grouped into 3 distinct transcription patterns. The data showed that sequences from muscle actin and myosin, ribosomal protein L11, glyceraldehyde-3- phosphate dehydrogenase and the flavoprotein subunit of succinate dehydrogenase were highly expressed in L4-21-J, but not in L4- 21-I; as were a collection of unannotated genes derived from a worm body wall-hypodermis library, and a testes germinal zone tissue library. These results suggest that only actively developing A. suum L4 are destined to parasitize the host and successfully neutralize host protective responses
Symmetries and conservation laws in the Gunther k-symplectic formalism of field theory
This paper is devoted to studying symmetries of k-symplectic Hamiltonian and
Lagrangian first-order classical field theories. In particular, we define
symmetries and Cartan symmetries and study the problem of associating
conservation laws to these symmetries, stating and proving Noether's theorem in
different situations for the Hamiltonian and Lagrangian cases. We also
characterize equivalent Lagrangians, which lead to an introduction of
Lagrangian gauge symmetries, as well as analyzing their relation with Cartan
symmetries.Comment: 29 page
Lipschitz shadowing implies structural stability
We show that the Lipschitz shadowing property of a diffeomorphism is
equivalent to structural stability. As a corollary, we show that an expansive
diffeomorphism having the Lipschitz shadowing property is Anosov.Comment: 11 page
Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose:analysis of individual patient data from randomised trials
Background
A one-dose-fits-all approach to use of aspirin has yielded only modest benefits in long-term prevention of cardiovascular events, possibly due to underdosing in patients of large body size and excess dosing in patients of small body size, which might also affect other outcomes.
Methods
Using individual patient data, we analysed the modifying effects of bodyweight (10 kg bands) and height (10 cm bands) on the effects of low doses (≤100 mg) and higher doses (300–325 mg or ≥500 mg) of aspirin in randomised trials of aspirin in primary prevention of cardiovascular events. We stratified the findings by age, sex, and vascular risk factors, and validated them in trials of aspirin in secondary prevention of stroke. Additionally, we assessed whether any weight or height dependence was evident for the effect of aspirin on 20-year risk of colorectal cancer or any in-trial cancer.
Results
Among ten eligible trials of aspirin in primary prevention (including 117 279 participants), bodyweight varied four-fold and trial median weight ranged from 60·0 kg to 81·2 kg (pand#60;0·0001). The ability of 75–100 mg aspirin to reduce cardiovascular events decreased with increasing weight (pinteraction=0·0072), with benefit seen in people weighing 50–69 kg (hazard ratio [HR] 0·75 [95% CI 0·65–0·85]) but not in those weighing 70 kg or more (0·95 [0·86–1·04]; 1·09 [0·93–1·29] for vascular death). Furthermore, the case fatality of a first cardiovascular event was increased by low-dose aspirin in people weighing 70 kg or more (odds ratio 1·33 [95% CI 1·08–1·64], p=0·0082). Higher doses of aspirin (≥325 mg) had the opposite interaction with bodyweight (difference pinteraction=0·0013), reducing cardiovascular events only at higher weight (pinteraction=0·017). Findings were similar in men and women, in people with diabetes, in trials of aspirin in secondary prevention, and in relation to height (pinteraction=0·0025 for cardiovascular events). Aspirin-mediated reductions in long-term risk of colorectal cancer were also weight dependent (pinteraction=0·038). Stratification by body size also revealed harms due to excess dosing: risk of sudden death was increased by aspirin in people at low weight for dose (pinteraction=0·0018) and risk of all-cause death was increased in people weighing less than 50 kg who were receiving 75–100 mg aspirin (HR 1·52 [95% CI 1·04–2·21], p=0·031). In participants aged 70 years or older, the 3-year risk of cancer was also increased by aspirin (1·20 [1·03–1·47], p=0·02), particularly in those weighing less than 70 kg (1·31 [1·07–1·61], p=0·009) and consequently in women (1·44 [1·11–1·87], p=0·0069).
Interpretation
Low doses of aspirin (75–100 mg) were only effective in preventing vascular events in patients weighing less than 70 kg, and had no benefit in the 80% of men and nearly 50% of all women weighing 70 kg or more. By contrast, higher doses of aspirin were only effective in patients weighing 70 kg or more. Given that aspirin's effects on other outcomes, including cancer, also showed interactions with body size, a one-dose-fits-all approach to aspirin is unlikely to be optimal, and a more tailored strategy is required
Anti-Human CD9 Antibody Fab Fragment Impairs the Internalization of Extracellular Vesicles and the Nuclear Transfer of their Cargo Proteins.
The intercellular communication mediated by extracellular vesicles (EVs) has gained international interest during the last decade. Interfering with the mechanisms regulating this cellular process might find application particularly in oncology where cancer cell-derived EVs play a role in tumour microenvironment transformation. Although several mechanisms were ascribed to explain the internalization of EVs, little is our knowledge about the fate of their cargos, which are crucial to mediate their function. We recently demonstrated a new intracellular pathway in which a fraction of endocytosed EV-associated proteins is transported into the nucleoplasm of the host cell via a subpopulation of late endosomes penetrating into the nucleoplasmic reticulum. Silencing tetraspanin CD9 both in EVs and recipient cells strongly decreased the endocytosis of EVs and abolished the nuclear transfer of their cargos. Here, we investigated whether monovalent Fab fragments derived from 5H9 anti-CD9 monoclonal antibody (referred hereafter as CD9 Fab) interfered with these cellular processes. To monitor the intracellular transport of proteins, we used fluorescent EVs containing CD9-green fluorescent protein fusion protein and various melanoma cell lines and bone marrow-derived mesenchymal stromal cells as recipient cells. Interestingly, CD9 Fab considerably reduced EV uptake and the nuclear transfer of their proteins in all examined cells. In contrast, the divalent CD9 antibody stimulated both events. By impeding intercellular communication in the tumour microenvironment, CD9 Fab-mediated inhibition of EV uptake, combined with direct targeting of cancerous cells could lead to the development of novel anti-melanoma therapeutic strategies
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