Trend-based analysis of a population model of the AKAP scaffold protein

We formalise a continuous-time Markov chain with multi-dimensional discrete state space model of the AKAP scaffold protein as a crosstalk mediator between two biochemical signalling pathways. The analysis by temporal properties of the AKAP model requires reasoning about whether the counts of individuals of the same type (species) are increasing or decreasing. For this purpose we propose the concept of stochastic trends based on formulating the probabilities of transitions that increase (resp. decrease) the counts of individuals of the same type, and express these probabilities as formulae such that the state space of the model is not altered. We define a number of stochastic trend formulae (e.g. weakly increasing, strictly increasing, weakly decreasing, etc.) and use them to extend the set of state formulae of Continuous Stochastic Logic. We show how stochastic trends can be implemented in a guarded-command style specification language for transition systems. We illustrate the application of stochastic trends with numerous small examples and then we analyse the AKAP model in order to characterise and show causality and pulsating behaviours in this biochemical system

Asteroseismic diagrams from a survey of solar-like oscillations with Kepler

Photometric observations made by the NASA Kepler Mission have led to a dramatic increase in the number of main-sequence and subgiant stars with detected solar-like oscillations. We present an ensemble asteroseismic analysis of 76 solar-type stars. Using frequencies determined from the Kepler time-series photometry, we have measured three asteroseismic parameters that characterize the oscillations: the large frequency separation (\Delta \nu), the small frequency separation between modes of l=0 and l=2 (\delta \nu_02), and the dimensionless offset (\epsilon). These measurements allow us to construct asteroseismic diagrams, namely the so-called C-D diagram of \delta \nu_02 versus \Delta \nu, and the recently re-introduced {\epsilon} diagram. We compare the Kepler results with previously observed solar-type stars and with theoretical models. The positions of stars in these diagrams places constraints on their masses and ages. Additionally, we confirm the observational relationship between {\epsilon} and T_eff that allows for the unambiguous determination of radial order and should help resolve the problem of mode identification in F stars.Comment: 6 pages, 5 figures, accepted for publication in The Astrophysical Journal Letter

A História da Alimentação: balizas historiográficas

Os M. pretenderam traçar um quadro da História da Alimentação, não como um novo ramo epistemológico da disciplina, mas como um campo em desenvolvimento de práticas e atividades especializadas, incluindo pesquisa, formação, publicações, associações, encontros acadêmicos, etc. Um breve relato das condições em que tal campo se assentou faz-se preceder de um panorama dos estudos de alimentação e temas correia tos, em geral, segundo cinco abardagens Ia biológica, a econômica, a social, a cultural e a filosófica!, assim como da identificação das contribuições mais relevantes da Antropologia, Arqueologia, Sociologia e Geografia. A fim de comentar a multiforme e volumosa bibliografia histórica, foi ela organizada segundo critérios morfológicos. A seguir, alguns tópicos importantes mereceram tratamento à parte: a fome, o alimento e o domínio religioso, as descobertas européias e a difusão mundial de alimentos, gosto e gastronomia. O artigo se encerra com um rápido balanço crítico da historiografia brasileira sobre o tema

A Meta-Analysis of Geographical Indication Food Valuation Studies: What Drives the Premium for Origin Labels?”

We conduct a meta-analysis of studies estimating price premiums for agricultural products differentiated by Geographical Indication (GI). Models accounting for differences across product characteristics (food categories) and institutions (PDO, PGI, trademarks) explain a large portion of the variance in estimated premiums. Specifically, GIs capture the highest percentage premium in markets for products with short supply chains and relatively low added value (e.g., agricultural commodities). The premium is lower for wine and olive oil, where alternative means of product differentiation (e.g., branding) exist. Controlling for product characteristics, GIs adopting stricter regulations (PDO) yield larger premiums than less regulated ones (PGI)

Viral Hepatitis In Patients Infected With Human Immunodeficiency Virus.

From 1992 to 1995 we studied 232 (69% male, 87% Caucasian) anti-human immunodeficiency virus (anti-HIV) positive Brazilian patients, through a questionnaire; HIV had been acquired sexually by 50%, from blood by 32%, sexually and/or from blood by 16.4% and by an unknown route by 1.7%. Intravenous drug use was reported by 29%; it was the most important risk factor for HIV transmission. The alanine aminotransferase quotient (qALT) was >1 for 40% of the patients, 93.6% had anti-hepatitis A virus antibody, 5.3% presented hepatitis B surface antigen, 44% were anti-hepatitis B core antigen positive and 53.8% were anti-hepatitis C virus (anti-HCV) positive. The anti-HCV test showed a significant association with qALT>1. Patients for whom the probable HIV transmission route was blood had a 10.8 times greater risk of being anti-HCV positive than patients infected by other routes. Among 30 patients submitted to liver biopsy, 18 presented chronic hepatitis.7425326

Concrete as low-cost catalyst to improve gas quality during biomass gasification in a pilot-scale gasifier

Concrete was evaluated as low-cost catalyst for in-situ application in an autothermal 80 kWth pilot-scale bubbling fluidized bed direct (air) biomass gasifier. To improve the understanding of the observed phenomena, the process was also evaluated in smaller-scale reactive system, namely an externally heated 3 kWth bench-scale bubbling fluidized bed. Concrete application showed promising results regarding the relative increase of H2 concentration and H2/CO molar ratio in the producer gas (up to 99.2 and 77.4%, respectively), indicating that this material can promote the water-gas shift reaction. However, this effect was dependent on the gas-solid contact time and catalyst temperature, being that it was only relevant when these parameters were at least 5.2 s and 746 °C, respectively. A maximum lower heating value of 7.5 MJ/Nm3 of the producer gas was found with concrete application (23.8% relative increase), which is higher than commonly found in the literature. Relative increases of up to 25.1, 55.3 and 47.0% for the specific dry gas production, cold gas efficiency and carbon conversion efficiency, respectively, were also found, consequently suggesting that, in addition to the promotion of the water-gas shift reaction, this material has potential to promote tar reforming/cracking and carbon gasification reactions.publishe