Analisis Pengaruh Motivasi Kerja, Pengendalian Internal, Dan Komitmen Organisasi Terhadap Kinerja Karyawan (Studi Empiris Pada AJB Bumi Putera 1912 Kantor Cabang Solo Gladag)

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh motivasi kerja, pengendalian internal, dan komitmen organisasi terhadap kinerja karyawan. Penelitian ini merupakan penelitian dengan data primer dengan metode survey kuisioner pada AJB Bumi Putera 1912 Kantor Cabang Solo Gladag. Teknik pengambilan sampel pada penelitian ini menggunakan metode covinience sampling berdasarkan kemudahan. Jumlah kuisioner yang terkumpul sebanyak 52. Alat analisis yang digunakan adalah regresi linier berganda, Uji F, Uji t (ttest), dan Uji Koefisien determinasi (R2), Uji asumsi klasik juga digunakan dalam penelitian ini, antara lain: uji normalitas, uji multikolinearitas, uji heteroskedastisitas. Data diolah dengan bantuan software SPSS 16.0 Hasil penelitian menunjukkan bahwa pertama, motivasi kerja berpengaruh positif dan signifikan terhadap kinerja karyawan, dengan nilai signifikansi 0,002 < 0,05. Kedua pengendalian internal berpengaruh positif dan signifikan terhadap kinerja karyawan, dengan nilai signifikansi 0,009 < 0,05. Ketiga komitmen organisasi berpengaruh positif dan signifikan terhadap kinerja karyawan, dengan nilai signifikansi 0,000 < 0,05

Faktor Faktor Yang Berpengaruh Terhadap Tingkat Resiko Kredit Pada Perusahaan Perbankan Yang Terdaftar Di Bursa Efek Indonesia Tahun 2009-2013

This study aims to: 1) To determine the effect of the Capital Adequacy Ratio (CAR) on the level of credit risk in banking companies listed in Indonesia Stock Exchange 2009-2013 period. 2) To determine the effect of the Loan to Deposit Ratio (LDR) to the level of credit risk in banking companies listed in Indonesia Stock Exchange 2009-2013 period. 3) To determine the effect of firm size (Size) of the level of credit risk in banking companies listed in Indonesia Stock Exchange 2009-2013 period. 4) To determine the effect of Operating Expenses to Operating Income (BOPO) on the level of credit risk in banking companies listed in Indonesia Stock Exchange 2009-2013 period. 5) To determine the effect of CAR, LDR, company size and BOPO imultaneously on the level of credit risk in banking companies listed in Indonesia Stock Exchange 2009-2013 period. The hypothesis in this study were: 1) Anticipated Capital Adequacy Ratio (CAR) significantly affects the level of credit risk in banking companies listed in Indonesia Stock Exchange 2009-2013 period. 2) Loan to Deposit Ratio (LDR) significantly affects the level of credit risk in banking companies listed in Indonesia Stock Exchange 2009-2013 period. 3) The size of the company (Size) significantly affects the level of credit risk in banking companies listed in Indonesia Stock Exchange 2009-2013 period. 4) Operating Expenses to Operating Income (BOPO) significantly affects the level of credit risk in banking companies listed in Indonesia Stock Exchange 2009-2013 period. 5) CAR, LDR, company size and BOPO simultaneously significant effect on the level of credit risk in banking companies listed in Indonesia Stock Exchange 2009-2013 period. Data needed in this research is secondary data obtained from the banking company's financial statements obtained from BEI. The amount of data in this study were 140 data. Analysis of the data used in this research is multiple linear regression, t test, F test and coefficient of determination. The results of data analysis in this study can be concluded that: 1) Capital Adequacy Ratio (CAR) significantly affects the level of credit risk (NPL). 2) Loan to Deposit Ratio (LDR) significantly affects the level of credit risk (NPL). 3) The size of the company (Size) significantly affects the level of credit risk (NPL). 4) Operating Expenses to Operating Income (BOPO) had no significant effect on the level of credit risk (NPL). 5) CAR, LDR, company size and BOPO simultaneously significant effect on the level of credit risk (NPL)

Pengaruh Struktur dan Mekanisme Corporate Governance Terhadap Tingkat Kepatuhan Mandatory Disclosure (Studi Empiris pada Perusahaan Manufaktur yang Terdaftar di BEI yang Tergabung pada LQ45 Periode 2011-2015)

The purpose of this study was to determine the level of mandatory disclosure to determine the effect of structure and mechanism corporate governance that identified as managerial ownership, institusional ownership, the number of audit committee, the number of audit committee meetings, the proportion of independent commissioner and the number of meeting of the board of commissioner. This research uses a sample of manufacturing companies that are listed in the Indonesia Stock Exchange registered of Indeks LQ45 from the 2011-2015 research period. The sample is chosen using a purposive sampling method, and 141 companies are used for the sample. Data analysis with classic assumption and hypothesis test is used multiple regression method in SPSS 21.0 software. The result of multiple regression showed that corporate governance structure and mechanism affects the level of mandatory disclosure. Independent variables that affect the level of mandatory disclosure are managerial ownership, number of audit committee meetings and number of meeting of the board of commissioner. Other variable namely are institusional ownership, the number of audit committee and the proportion of independent commissioner do not affect the level of mandatory disclosure. Keywords: managerial ownership, institutional ownership, audit committee number, audit committee meeting number, independent commissioner proportion, and commissioner board meeting number, mandatory disclosure compliance level

Analisis Keuangan Untuk Mengukur Kinerja Keuangan Pada Perusahaan Semen Yang Terdaftar Di Bursa Efek Indonesia Periode 2010-2015

This research was aimed to find out financial performance of cement companies listed at Indonesia stock exchange in period 2010-2015 if seen from financial ratio analysis, to find out financial performance progress of cement companies listed at Indonesia stock Exchange in period 2010-2015 if seen cross-section and time-series technique, and to find out financial performance progress of PT Semen Indonesia (Persero)Tbk in period 2010-2015 if seen from commonsize analysis and indeks/trend analysis. This research used a sample cement companies listed at Indonesia stock exchange in period 2010-2015. Sample selection using purposive sampling technique and the criteria (1) cement companies listed atIndonesia stock exchange in period 2010-2015 (2) release an annual report for research period by cement companies. From a sample selection, obtainable three cement companies as a sample. This research use secondary data, an annual report from www.idx.co.id and download from each cement companies profile. Result of this research indicate the best financial performance than other cement companies is PT Indocement Tunggal Prakarsa Tbk if seen from financial ratio analysis and cross-section technique. Based from time-series technique, the best financial performance PT Semen Indonesia (Persero) Tbk in 2010, the best financial performance PT Holcim Indonesia Tbk in 2012, and the best financial performance PT Indocement Tunggal Prakarsa Tbk in 2011. Based from commonsize analysis PT Semen Indonesia (Persero) Tbk can push a cost, manage an asset and add a weath, and have a good financial performance. Last, based from indeks/trend analysis PT Semen Indonesia (Persero) Tbk can push a cost, manage a credit and stock, and have a good financial performance. Keyword: Financial performance, Financial ratio analysis, Cross-section technique, Time-series technique, Commonsize analysis, Indeks/trend analysi

PENGARUH KUALITAS KERJA DAN DISIPLIN KERJA TERHADAP KINERJA KARYAWAN DI PT AINNA PUTRI SENJAYA KABUPATEN SUBANG

ABSTRAK Pada saat ini jasa pertambangan merupakan sektor ekonomi yang sangat besar dan tumbuh pesat, hal ini menuntut PT. Ainna Putri Senjaya Kabupaten Subang juga harus mempunyai pengelolaan sumber daya manusia yang berkualitas agar menciptakan kinerja yang unggul. Setelah peneliti melakukan penelitian pada PT. Ainna Putri Senjaya Kabupaten Subang, terdapat permasalahan yang dihadapi perusahaan yaitu penurunan kinerja karyawan sebesar 5,05%, dilihat pada tahun 2021 kinerja karyawan memperoleh nilai sebesar 81,15% dengan kategori baik dan pada tahun 2022 kinerja karyawan mengalami penurunan dengan memperoleh nilai sebesar 76,01% dengan kategori kurang baik. Hasil penelitian ini diharapkan dapat memberikan informasi sebagai dasar pendukung dan sumbangan pemikiran kepada perusahaan untuk dapat meningkatkan evaluasi kinerja karyawan. Hasil penelitian ini berkaitan erat dengan kualitas kerja dan disiplin kerja yang sangat dibutuhkan perusahaan dalam mengontrol kinerja karyawannya. Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh kualitas kerja, disiplin kerja dan kinerja karyawan pada PT. Ainna Putri Senjaya Kabupaten Subang. Penelitian ini menggunakan metode deskriptif dan verifikatif. Metode analisis data yang digunakan adalah analisis regresi linier berganda, analisis korelasi berganda dan koefisien determinasi. Teknik sampling yang digunakan adalah sampling jenuh dengan jumlah populasi dan sampel sebanyak 40 responden. Teknik yang digunakan adalah observasi, wawancara dan menyebarkan kuesioner. Berdasarkan dari hasil analisis deskriptif kualitas kerja mendapatkan nilai rata-rata sebesar 3,35 dengan kategori kurang baik, disiplin kerja mendapatkan nilai rata-rata sebesar 3,34 dengan kategori kurang baik dan kinerja karyawan mendapatkan nilai rata-rata sebesar 3,32 dengan kategori kurang baik. Berdasarkan dari hasil analisis verifikatif yaitu koefisien determinasi secara simultan pengaruh kualitas kerja dan disiplin kerja terhadap kinerja karyawan yaitu sebesar 86,6%. Sedangkan dilihat dari koefisien determinasi secara parsial kualitas kerja memberikan pengaruh terhadap kinerja karyawan sebesar 40,7% dan disiplin kerja memberikan pengaruh terhadap kinerja karyawan sebesar 45,9%. Sehingga dapat disimpulkan bahwa disiplin kerja memberikan pengaruh yang lebih besar terhadap kinerja karyawan. Kata kunci : Kualitas Kerja, Disiplin Kerja, Kinerja Karyawa

The catalytic subunit of the system L1 amino acid transporter (S<i>lc7a5</i>) facilitates nutrient signalling in mouse skeletal muscle

The System L1-type amino acid transporter mediates transport of large neutral amino acids (LNAA) in many mammalian cell-types. LNAA such as leucine are required for full activation of the mTOR-S6K signalling pathway promoting protein synthesis and cell growth. The SLC7A5 (LAT1) catalytic subunit of high-affinity System L1 functions as a glycoprotein-associated heterodimer with the multifunctional protein SLC3A2 (CD98). We generated a floxed Slc7a5 mouse strain which, when crossed with mice expressing Cre driven by a global promoter, produced Slc7a5 heterozygous knockout (Slc7a5+/-) animals with no overt phenotype, although homozygous global knockout of Slc7a5 was embryonically lethal. Muscle-specific (MCK Cre-mediated) Slc7a5 knockout (MS-Slc7a5-KO) mice were used to study the role of intracellular LNAA delivery by the SLC7A5 transporter for mTOR-S6K pathway activation in skeletal muscle. Activation of muscle mTOR-S6K (Thr389 phosphorylation) in vivo by intraperitoneal leucine injection was blunted in homozygous MS-Slc7a5-KO mice relative to wild-type animals. Dietary intake and growth rate were similar for MS-Slc7a5-KO mice and wild-type littermates fed for 10 weeks (to age 120 days) with diets containing 10%, 20% or 30% of protein. In MS-Slc7a5-KO mice, Leu and Ile concentrations in gastrocnemius muscle were reduced by ∼40% as dietary protein content was reduced from 30 to 10%. These changes were associated with >50% decrease in S6K Thr389 phosphorylation in muscles from MS-Slc7a5-KO mice, indicating reduced mTOR-S6K pathway activation, despite no significant differences in lean tissue mass between groups on the same diet. MS-Slc7a5-KO mice on 30% protein diet exhibited mild insulin resistance (e.g. reduced glucose clearance, larger gonadal adipose depots) relative to control animals. Thus, SLC7A5 modulates LNAA-dependent muscle mTOR-S6K signalling in mice, although it appears non-essential (or is sufficiently compensated by e.g. SLC7A8 (LAT2)) for maintenance of normal muscle mass

Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice

Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is a congenital visceral myopathy characterized by severe dilation of the urinary bladder and defective intestinal motility. The genetic basis of MMIHS has been ascribed to spontaneous and autosomal dominant mutations in actin gamma 2 (ACTG2), a smooth muscle contractile gene. However, evidence suggesting a recessive origin of the disease also exists. Using combined homozygosity mapping and whole exome sequencing, a genetically isolated family was found to carry a premature termination codon in Leiomodin1 (LMOD1), a gene preferentially expressed in vascular and visceral smooth muscle cells. Parents heterozygous for the mutation exhibited no abnormalities, but a child homozygous for the premature termination codon displayed symptoms consistent with MMIHS. We used CRISPR-Cas9 (CRISPR-associated protein) genome editing of Lmod1 to generate a similar premature termination codon. Mice homozygous for the mutation showed loss of LMOD1 protein and pathology consistent with MMIHS, including late gestation expansion of the bladder, hydronephrosis, and rapid demise after parturition. Loss of LMOD1 resulted in a reduction of filamentous actin, elongated cytoskeletal dense bodies, and impaired intestinal smooth muscle contractility. These results define LMOD1 as a disease gene for MMIHS and suggest its role in establishing normal smooth muscle cytoskeletal-contractile coupling

Early invasive vulvar squamous cell carcinoma arising in a woman with vulvar pemphigus vulgaris and systemic lupus erythematosus

Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. Genital involvement occurs when most other common sites are concurrently affected or are in remission. Systemic lupus erythematosus (SLE) is an autoimmune disease that may affect many parts of the body and the skin with occasional bullous lesions. Pemphigus vulgaris and SLE may be associated, albeit rarely. Here, we report the first case of a woman affected with SLE presenting with early invasive squamous cell carcinoma (SCC) arising from Pemphigus Vulgaris of the vulva

Partial volume correction strategies for quantitative FDG PET in oncology

Purpose: Quantitative accuracy of positron emission tomography (PET) is affected by partial volume effects resulting in increased underestimation of the standardized uptake value (SUV) with decreasing tumour volume. The purpose of the present study was to assess accuracy and precision of different partial volume correction (PVC) methods. Methods: Three methods for PVC were evaluated: (1) inclusion of the point spread function (PSF) within the reconstruction, (2) iterative deconvolution of PET images and (3) calculation of spill-in and spill-out factors based on tumour masks. Simulations were based on a mathematical phantom with tumours of different sizes and shapes. Phantom experiments were performed in 2-D mode using the National Electrical Manufacturers Association (NEMA) NU2 image quality phantom containing six differently sized spheres. Clinical studies (2-D mode) included a test-retest study consisting of 10 patients with stage IIIB and IV non-small cell lung cancer and a response monitoring study consisting of 15 female breast cancer patients. In all studies tumour or sphere volumes of interest (VOI) were generated using VOI based on adaptive relative thresholds. Results: Simulations and experiments provided similar results. All methods were able to accurately recover true SUV within 10% for spheres equal to and larger than 1 ml. Reconstruction-based recovery, however, provided up to twofold better precision than image-based methods. Cl