427 research outputs found
The first decade of oligotrophication of Lake Constance
In Lake Constance, after several decades of cutrophication, a decrease in phosphorus loading over the last decade has lead to a partial recovery from eutrophication. Here we analyse the shift in the taxonomic composition of phytoplankton during the first decade of oligotrophication in Lake Constance. During the 1980s, spring total P concentrations decreased from ca. 130 to less than 50 mgr·l–1. This decrease was reflected by an approximately proportional decrease in summer phytoplankton biomass while spring phytoplankton biomass seemed unresponsive. Major taxonomic changes occured during both growth seasons. In spring, the proportion of diatoms, green algae and Chrysophyta increased while the proportion of Cryptophyta decreased. The summer trend was very different: the relative importance of diatoms decreased and Cryptophyta and Chrysophyta increased, while Chlorophyta reached their peak around 1985. These trends are also analysed at the genus level. Comparison with taxonomic trends during the eutrophication period shows the expected reversals in most cases. Comparison with other lakes shows general similarities, with the notable exception that Planktothrix rubescens has never been important in Lake Constance. The increase of diatoms during spring is attributed to their improved competitive performance with increasing Si:P ratios. Their decrease during summer is explained by the increasing silicate removal from the epilimnion by increasing spring populations
Dynamical age differences among coeval star clusters as revealed by blue stragglers
Globular star clusters that formed at the same cosmic time may have evolved
rather differently from a dynamical point of view (because that evolution
depends on the internal environment) through a variety of processes that tend
progressively to segregate stars more massive than the average towards the
cluster centre. Therefore clusters with the same chronological age may have
reached quite different stages of their dynamical history (that is, they may
have different dynamical ages). Blue straggler stars have masses greater than
those at the turn-off point on the main sequence and therefore must be the
result of either a collision or a mass-transfer event. Because they are among
the most massive and luminous objects in old clusters, they can be used as test
particles with which to probe dynamical evolution. Here we report that globular
clusters can be grouped into a few distinct families on the basis of the radial
distribution of blue stragglers. This grouping corresponds well to an effective
ranking of the dynamical stage reached by stellar systems, thereby permitting a
direct measure of the cluster dynamical age purely from observed properties.Comment: Published on the 20 December 2012 issue of Natur
Examining a staging model for anorexia nervosa: empirical exploration of a four stage model of severity.
Background: An illness staging model for anorexia nervosa (AN) has received increasing attention, but assessing the merits of this concept is dependent on empirically examining a model in clinical samples. Building on preliminary findings regarding the reliability and validity of the Clinician Administered Staging Instrument for Anorexia Nervosa (CASIAN), the current study explores operationalising CASIAN severity scores into stages and assesses their relationship with other clinical features. Method: In women with DSM-IV-R AN and sub-threshold AN (all met AN criteria using DSM 5), receiver operating curve (ROC) analysis (n = 67) assessed the relationship between the sensitivity and specificity of each stage of the CASIAN. Thereafter chi-square and post-hoc adjusted residual analysis provided a preliminary assessment of the validity of the stages comparing the relationship between stage and treatment intensity and AN sub-types, and explored movement between stages after six months (Time 3) in a larger cohort (n = 171). Results: The CASIAN significantly distinguished between milder stages of illness (Stage 1 and 2) versus more severe stages of illness (Stages 3 and 4), and approached statistical significance in distinguishing each of the four stages from one other. CASIAN Stages were significantly associated with treatment modality and primary diagnosis, and CASIAN Stage at Time 1 was significantly associated with Stage at 6 month follow-up. Conclusions: Provisional support is provided for a staging model in AN. Larger studies with longer follow-up of cases are now needed to replicate and extend these findings and evaluate the overall utility of staging as well as optimal staging models
The periodicity of phytoplankton in Lake Constance (Bodensee) in comparison to other deep lakes of central Europe
Phytoplankton periodicity has been fairly regular during the years 1979 to 1982 in Lake Constance. Algal mass growth starts with the vernal onset of stratification; Cryptophyceae and small centric diatoms are the dominant algae of the spring bloom. In June grazing by zooplankton leads to a lsquoclear-water phasersquo dominated by Cryptophyceae. Algal summer growth starts under nutrient-saturated conditions with a dominance of Cryptomonas spp. and Pandorina morum. Depletion of soluble reactive phosphorus is followed by a dominance of pennate and filamentous centric diatoms, which are replaced by Ceratium hirundinella when dissolved silicate becomes depleted. Under calm conditions there is a diverse late-summer plankton dominated by Cyanophyceae and Dinobryon spp.; more turbulent conditions and silicon resupply enable a second summer diatom growth phase in August. The autumnal development leads from a Mougeotia — desmid assemblage to a diatom plankton in late autumn and winter.
Inter-lake comparison of algal seasonality includes in ascending order of P-richness Königsee, Attersee, Walensee, Lake Lucerne, Lago Maggiore, Ammersee, Lake Zürich, Lake Geneva, Lake Constance. The oligotrophic lakes have one or two annual maxima of biomass; after the vernal maximum there is a slowly developing summer depression and sometimes a second maximum in autumn. The more eutrophic lakes have an additional maximum in summer. The number of floristically determined successional stages increases with increasing eutrophy, from three in Königsee and Attersee to eight in Lake Geneva and Lake Constance
The impact of point mutations in the human androgen receptor : classification of mutations on the basis of transcriptional activity
Peer reviewedPublisher PD
The use of sodium thiosulfate as an otoprotectant in cancer patients treated with platinum compounds: a review of the literature
Non-standard interactions versus non-unitary lepton flavor mixing at a neutrino factory
The impact of heavy mediators on neutrino oscillations is typically described
by non-standard four-fermion interactions (NSIs) or non-unitarity (NU). We
focus on leptonic dimension-six effective operators which do not produce
charged lepton flavor violation. These operators lead to particular
correlations among neutrino production, propagation, and detection non-standard
effects. We point out that these NSIs and NU phenomenologically lead, in fact,
to very similar effects for a neutrino factory, for completely different
fundamental reasons. We discuss how the parameters and probabilities are
related in this case, and compare the sensitivities. We demonstrate that the
NSIs and NU can, in principle, be distinguished for large enough effects at the
example of non-standard effects in the --sector, which basically
corresponds to differentiating between scalars and fermions as heavy mediators
as leading order effect. However, we find that a near detector at superbeams
could provide very synergistic information, since the correlation between
source and matter NSIs is broken for hadronic neutrino production, while NU is
a fundamental effect present at any experiment.Comment: 32 pages, 5 figures. Final version published in JHEP. v3: Typo in Eq.
(27) correcte
Altered monocyte activation markers in Tourette's syndrome: a case-control study
Background: Infections and immunological processes are likely to be involved in the pathogenesis of Tourette's syndrome (TS). To determine possible common underlying immunological mechanisms, we focused on innate immunity and studied markers of inflammation, monocytes, and monocyte-derived cytokines. Methods: In a cross-sectional study, we used current methods to determine the number of monocytes and levels of C-reactive protein (CRP) in 46 children, adolescents, and adult patients suffering from TS and in 43 healthy controls matched for age and sex. Tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), soluble CD14 (sCD14), IL1-receptor antagonist (IL1-ra), and serum neopterin were detected by immunoassays. Results: We found that CRP and neopterin levels and the number of monocytes were significantly higher in TS patients than in healthy controls. Serum concentrations of TNF-alpha, sIL1-ra, and sCD14 were significantly lower in TS patients. All measured values were within normal ranges and often close to detection limits. Conclusions: The present results point to a monocyte dysregulation in TS. This possible dysbalance in innate immunity could predispose to infections or autoimmune reactions
Quantum Process Tomography of a Universal Entangling Gate Implemented with Josephson Phase Qubits
Quantum logic gates must perform properly when operating on their standard
input basis states, as well as when operating on complex superpositions of
these states. Experiments using superconducting qubits have validated the truth
table for particular implementations of e.g. the controlled-NOT gate [1,2], but
have not fully characterized gate operation for arbitrary superpositions of
input states. Here we demonstrate the use of quantum process tomography (QPT)
[3,4] to fully characterize the performance of a universal entangling gate
between two superconducting quantum bits. Process tomography permits complete
gate analysis, but requires precise preparation of arbitrary input states,
control over the subsequent qubit interaction, and simultaneous single-shot
measurement of the output states. We use QPT to measure the fidelity of the
entangling gate and to quantify the decoherence mechanisms affecting the gate
performance. In addition to demonstrating a promising fidelity, our entangling
gate has a on/off ratio of 300, a level of adjustable coupling that will become
a requirement for future high-fidelity devices. This is the first solid-state
demonstration of QPT in a two-qubit system, as solid-state process tomography
has previously only been demonstrated with single qubits [5,6]
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