Effects of armadin on hepatic transaminases in rats with acute generalized peritonitis on the background of diabetes mellitus

The article discusses the issues about the effect of the Armadin on the hepatic transaminase in rats with acute generalized peritonitis on the background of diabetes mellitus. The experiment was performed on 48 white male adult rats, which were divided into two groups. The experimental group – animals with simulated acute generalized peritonitis against the background of streptozotocin-induced diabetes with the drug “Armadin” (ethylmethylhydroxypyridine succinate) application (n=24). The control group – animals with simulated acute generalized peritonitis against the background of streptozotocin-induced diabetes without pharmacocorrection (n = 24). Diabetes mellitus was simulated by a single intraperitoneal injection of streptozotocin at the dose of 60 mg/kg. Acute generalized peritonitis was induced with 10% faecal suspension in a dose of 0.5 ml per 100 g of animal weight in the abdominal cavity of laboratory animals by puncture method. Every day for 6 days, rats of experimental group received the drug “Armadin” at the doses of 100 mg/kg. We found a probable decrease in aminotransferase activity on day 3 of the study in rats of the experimental group after administration of Armadin. Thus, ALT activity decreased by 26.7%, and AST activity – by 25.9% compared to the control group. On the 7th day of the study, the activity of ALT in the blood of rats of the experimental group decreased to 0.50 ± 0.03 mmol/l, which was 49.5% lower than the control group of rats in this period of the experiment. Similar changes are observed in the study of AST activity, where, accordingly, it decreased by 48 % relative to control. The positive effect of the drug "Armadin" on the body of rats, with AGP on the background of STZ-induced diabetes, is manifested by the restoration of the functional state of the liver

Machine learning technique for morphological classification of galaxies at z<0.1 from the SDSS

Methods. We used different galaxy classification techniques: human labeling, multi-photometry diagrams, Naive Bayes, Logistic Regression, Support Vector Machine, Random Forest, k-Nearest Neighbors, and k-fold validation. Results. We present results of a binary automated morphological classification of galaxies conducted by human labeling, multiphotometry, and supervised Machine Learning methods. We applied its to the sample of galaxies from the SDSS DR9 with redshifts of 0.02 < z < 0.1 and absolute stellar magnitudes of 24m < Mr < 19.4m. To study the classifier, we used absolute magnitudes: Mu, Mg, Mr , Mi, Mz, Mu-Mr , Mg-Mi, Mu-Mg, Mr-Mz, and inverse concentration index to the center R50/R90. Using the Support vector machine classifier and the data on color indices, absolute magnitudes, inverse concentration index of galaxies with visual morphological types, we were able to classify 316 031 galaxies from the SDSS DR9 with unknown morphological types. Conclusions. The methods of Support Vector Machine and Random Forest with Scikit-learn machine learning in Python provide the highest accuracy for the binary galaxy morphological classification: 96.4% correctly classified (96.1% early E and 96.9% late L types) and 95.5% correctly classified (96.7% early E and 92.8% late L types), respectively. Applying the Support Vector Machine for the sample of 316 031 galaxies from the SDSS DR9 at z < 0.1, we found 141 211 E and 174 820 L types among them.Comment: 10 pages, 5 figures. The presentation of these results was given during the EWASS-2017, Symposium "Astroinformatics: From Big Data to Understanding the Universe at Large". It is vailable through \url{http://space.asu.cas.cz/~ewass17-soc/Presentations/S14/Dobrycheva_987.pdf

The XXL Survey: XII. Optical spectroscopy of X-ray-selected clusters and the frequency of AGN in superclusters

This article belongs to the first series of XXL publications. It presents multifibre spectroscopic observations of three 0.55 sq.deg. fields in the XXL Survey, which were selected on the basis of their high density of X-ray-detected clusters. The observations were obtained with the AutoFib2+WYFFOS (AF2) wide-field fibre spectrograph mounted on the 4.2m William Herschel Telescope. The paper first describes the scientific rationale, the preparation, the data reduction, and the results of the observations, and then presents a study of active galactic nuclei (AGN) within three superclusters. We obtained redshifts for 455 galaxies in total, 56 of which are counterparts of X-ray point-like sources. We were able to determine the redshift of the merging supercluster XLSSC-e, which consists of six individual clusters at z~0.43, and we confirmed the redshift of supercluster XLSSC-d at z~0.3. More importantly, we discovered a new supercluster, XLSSC-f, that comprises three galaxy clusters also at z~0.3. We find a significant 2D overdensity of X-ray point-like sources only around the supercluster XLSSC-f. This result is also supported by the spatial (3D) analysis of XLSSC-f, where we find four AGN with compatible spectroscopic redshifts and possibly one more with compatible photometric redshift. In addition, we find two AGN (3D analysis) at the redshift of XLSSC-e, but no AGN in XLSSC-d. Comparing these findings with the optical galaxy overdensity we conclude that the total number of AGN in the area of the three superclusters significantly exceeds the field expectations. The difference in the AGN frequency between the three superclusters cannot be explained by the present study because of small number statistics. Further analysis of a larger number of superclusters within the 50 sq. deg. of the XXL is needed before any conclusions on the effect of the supercluster environment on AGN can be reached.Comment: 11 pages, published by A&

Charge distribution in two-dimensional electrostatics

We examine the stability of ringlike configurations of N charges on a plane interacting through the potential $V(z_1,...,z_N)=\sum_i |z_i|^2-\sum_{i<j} ln|z_i-z_j|^2$. We interpret the equilibrium distributions in terms of a shell model and compare predictions of the model with the results of numerical simulations for systems with up to 100 particles.Comment: LaTe

ВИБІР СТАБІЛІЗАТОРА ЕКСТЕМПОРАЛЬНОЇ СУСПЕНЗІЇ З ВІСМУТУ НІТРАТОМ ОСНОВНИМ

The aim of the work. The choice of stabilizer of extemporaneous suspension with bismuth nitrate basic, followed by the creation of a drug for use in gastroenterology. Materials and Methods. The object of the study were samples of extemporal suspension of bismuth nitrate basic made according to traditional rules of preparation of suspensions. Sedimentation stability and resuspendability studies were studied for suspension samples using different stabilizers. Microscopic analysis was performed to determine the particle size and homogeneity of the dispersed phase distribution. Results and Discussion. The results of the study show that samples of nonstabilized suspension and suspension with the adding of sodium alginate, NaCMC and xanthan gum during storage worsen their resuspension and are characterized by aggregative instability after 14 days of storage. The suspension sample with aerosil is a readily suspended and has satisfactory uniformity characteristics of the active pharmaceutical ingredient particles in the dispersion medium. Conclusions. The aggregative stability and appearance of suspension samples depending on stabilizers and their shelf life have been studied. A study of the resuspension of stabilized suspension samples was performed and aerosil was selected as a stabilizer of suspension with bismuth nitrate basic for a further research on the development of extemporaneous drug.Мета роботи. Вибір стабілізатора екстемпоральної суспензії з вісмуту нітратом основним з наступним створенням лікарського засобу для застосування у гастроентерології. Матеріали і методи. Об’єктом дослідження слугували зразки екстемпоральної суспензії з вісмуту нітратом основним виготовлені за традиційними правилами приготування суспензій. Дослідження седиментаційної стабільності та ресуспендованості вивчали для зразків суспензії із використанням різних стабілізаторів. Мікроскопічний аналіз проводили для визначення розміру часток та однорідності розподілу дисперсної фази. Результати й обговорення. Результати проведеного дослідження свідчать, що зразки нестабілізованої суспензії та суспензії з додаванням натрію альгінату, NaКМЦ та ксантанової камеді при зберіганні погіршують свою ресуспендованість та характеризуються агрегативною нестійкістю після 14 діб зберігання. Зразок суспензії із аеросилом відноситься до легкоресуспендованих суспензій і має задовільні характеристики однорідності розподілу часток активного фармацевтичного інгредієнта у дисперсійному середовищі. Висновки. Вивчена агрегативна стійкість та зовнішній вигляд зразків суспензії в залежності від стабілізаторів та терміну їх зберігання. Проведено вивчення ресуспендованості стабілізованих зразків суспензії та обрано аеросил у якості стабілізатора суспензії з вісмуту нітратом основним для подальших досліджень з розробки екстемпорального лікарського засобу

Forming Student Platforms to Commercialize Business Ideas and to Formalize Social Initiatives

The authors have shown the role of youth initiatives in the development of society and solving crisis situations in the economy. The theory and practice of youth entrepreneurship in the university environment based on the study of domestic and international publications is researched. We have defined the features of functioning of such domestic and world-famous business schools as Tech StartUp School, Youth &amp; Business, Business School at Kyiv-Mohyla Academy, Lviv Business School (LvBS), Insead (France), Harvard Business School (USA), London Business School (UK/OAU), Stanford Business School (USA), etc. The necessity of solving the problem of building effective communication and business relations between the student, the teacher, the entrepreneur, the university and local authorities in realization of their own social initiatives and business ideas of students is determined. The problems of formalization of social student initiatives and attraction of international donor organizations to their financing are highlighted. The model of stage-by-stage creation of a student's platform, infrastructure construction on the basis of universities, vocational schools, colleges, public organizations and technoparks and a system of communication between a student, a teacher, an entrepreneur, an educational institution and local authorities is offered. The direction of further research aimed at improving the site infrastructure, on the mechanisms of formation and interaction of centres, offices and laboratories with the proper technical, technological and informational support is determined. The necessity of reorientation of university curriculum for business needs, of preparation specialists with well-defined competencies, in accordance with the branch direction and potential opportunities of the region is established.Висвітлено проблеми молодіжного підприємництва, показано роль та особливості функціонування вітчизняних і міжнародних структур університетського середовища, які працюють у сфері надання консультацій у створенні і веденні власного бізнесу. Показано, що попри безсумнівну ефективність цих структур у підготовці студентів до роботи у сучасних міжнародних та вітчизняних компаніях та наданні глибоких теоретичних знань з формування бізнесу, є неможливим, у рамках таких шкіл, прищеплення студентам вузькоспеціалізованих практичних навичок для ведення чітко визначеного бізнесу. Висвітлено проблеми реалізації соціальних студентських ініціатив та залучення міжнародних донорських організацій до їх фінансування. Обґрунтовано доцільність створення студентських майданчиків, як складової частини молодіжного і університетського підприємництва, на якому будуть створені умови для: студентів, щодо реалізації власних соціальних і бізнес-ідей; підприємців, які хочуть розвивати бізнес; освітян, науковців, фахівців, що прагнуть "інвестувати" власні знання, навики і досвід у реалізацію студентських ідей; університетів, що отримуватимуть замовлення від бізнесу на підготовку фахівців з чітко визначеними компетентностями. Запропоновано модель поетапного створення студентського майданчика з побудовою інфраструктури на базі вишів, профтехучилищ, коледжів, громадських організацій та технопарків і системою комунікаційних зв'язків між студентом, викладачем, підприємцем, освітнім закладом і місцевою владою, які в процесі комерціалізації бізнес-ідеї або формалізації соціальної ініціативи переростатимуть у партнерські або ділові

Hamstring stretch reflex:could it be a reproducible objective measure of functional knee stability?"

Background: The anterior cruciate ligament (ACL) plays an important role in anterior knee stability by preventing anterior translation of the tibia on the femur. Rapid translation of the tibia with respect to the femur produces an ACL-hamstring stretch reflex which may provide an object measure of neuromuscular function following ACL injury or reconstruction. The aim of this study was to determine if the ACL-hamstring stretch reflex could be reliably and consistently obtained using the KT-2000 arthrometer.  Methods: A KT-2000 arthrometer was used to translate the tibia on the femur while recording the electromyography over the biceps femoris muscle in 20 participants, all with intact ACLs. In addition, a sub-group comprising 4 patients undergoing a knee arthroscopy for meniscal pathology, were tested before and after anaesthetic and with direct traction on the ACL during arthroscopy. The remaining 16 participants underwent testing to elicit the reflex using the KT-2000 only.  Results: A total number of 182 trials were performed from which 70 trials elicited stretch reflex (38.5 %). The mean onset latency of the hamstring stretch reflexes was 58.9 ± 17.9 ms. The average pull force was 195 ± 47 N, stretch velocity 48 ± 35 mm/s and rate of force 19.7 ± 6.4 N/s. Conclusions Based on these results, we concluded that the response rate of the anterior cruciate ligament-hamstring reflex is too low for it to be reliably used in a clinical setting, and thus would have limited value in assessing the return of neuromuscular function following ACL injuries