Effect of transmission setting and mixed species infections on clinical measures of malaria in Malawi

<p>Background: In malaria endemic regions people are commonly infected with multiple species of malaria parasites but the clinical impact of these Plasmodium co-infections is unclear. Differences in transmission seasonality and transmission intensity between endemic regions have been suggested as important factors in determining the effect of multiple species co-infections.</p> <p>Principal Findings: In order to investigate the impact of multiple-species infections on clinical measures of malaria we carried out a cross-sectional community survey in Malawi, in 2002. We collected clinical and parasitological data from 2918 participants aged >6 months, and applied a questionnaire to measure malaria morbidity. We examined the effect of transmission seasonality and intensity on fever, history of fever, haemoglobin concentration ([Hb]) and parasite density, by comparing three regions: perennial transmission (PT), high intensity seasonal transmission (HIST) and low intensity seasonal transmission (LIST). These regions were defined using multi-level modelling of PCR prevalence data and spatial and geo-climatic measures. The three Plasmodium species (P. falciparum, P. malariae and P. ovale) were randomly distributed amongst all children but not adults in the LIST and PT regions. Mean parasite density in children was lower in the HIST compared with the other two regions. Mixed species infections had lower mean parasite density compared with single species infections in the PT region. Fever rates were similar between transmission regions and were unaffected by mixed species infections. A history of fever was associated with single species infections but only in the HIST region. Reduced mean [Hb] and increased anaemia was associated with perennial transmission compared to seasonal transmission. Children with mixed species infections had higher [Hb] in the HIST region.</p> <p>Conclusions: Our study suggests that the interaction of Plasmodium co-infecting species can have protective effects against some clinical outcomes of malaria but that this is dependent on the seasonality and intensity of malaria transmission.</p&gt

Gender differences in biochemical markers and oxidative stress of rats after 28 days oral exposure to a mixture used for weight loss containing p-synephrine, ephedrine, salicin, and caffeine

The association of p-synephrine, ephedrine, salicin, and caffeine in dietary supplements and weight loss products is very common worldwide, even though ephedrine has been prohibited in many countries. The aim of this study was to evaluate a 28-day oral exposure toxicity profile of p-synephrine, ephedrine, salicin, and caffeine mixture (10:4:6:80 w/w respectively) in male and female Wistar rats. Body weight and signs of toxicity, morbidity, and mortality were observed daily. After 28 days, animals were euthanized and blood collected for hematological, biochemical, and oxidative stress evaluation. No clinical signs of toxicity, significant weight loss or deaths occurred, nor were there any significant alterations in hematological parameters. Biochemical and oxidative stress biomarkers showed lipid peroxidation, and hepatic and renal damage (p < 0.05; ANOVA/Bonferroni) in male rats (100 and 150 mg/kg) and a reduction (p < 0.05; ANOVA/Bonferroni) in glutathione (GSH) levels in all male groups. Female groups displayed no indications of oxidative stress or biochemical alterations. The different toxicity profile displayed by male and female rats suggests a hormonal influence on mixture effects. Results demonstrated that the tested mixture can alter oxidative status and promote renal and hepatic damages.A associação de p-sinefrina, efedrina, salicina, e cafeína em suplementos alimentares e produtos para perda de peso é muito utilizada em todo o mundo, embora a efedrina tenha sido proibida em muitos países. O objetivo deste estudo foi avaliar o perfil de toxicidade à exposição oral de 28 dias à associação de p-sinefrina, efedrina, salicina e cafeína (na proporção de 10:4:6:80 m/m respectivamente) em ratos Wistar machos e fêmeas. Diariamente, os animais foram observados quanto ao peso corporal, sinais de toxicidade, morbidade e mortalidade. Após 28 dias, os animais foram sacrificados e o sangue coletado para avaliações hematológicas, bioquímicas e de estresse oxidativo. Não se observaram sinais clínicos de toxicidade, tampouco perda significativa de peso, mortes, ou quaisquer alterações significativas nos parâmetros hematológicos. Biomarcadores do estresse oxidativo e bioquímicos mostraram peroxidação lipídica, danos renais e hepáticos (p < 0,05; ANOVA/Bonferroni) em ratos machos (100 e 150 mg/kg) e a redução (p < 0,05; ANOVA/Bonferroni) nos níveis de glutationa reduzida (GSH) em todos os grupos de machos tratados. Nas fêmeas, não houve indícios de estresse oxidativo, nem alterações bioquímicas. O diferente perfil de toxicidade entre os gêneros sugere influência hormonal nos efeitos de mistura administrada. A associação testada pode alterar o estado oxidativo e promover danos renais e hepáticos

A MODEST review

We present an account of the state of the art in the fields explored by the research community invested in 'Modeling and Observing DEnse STellar systems'. For this purpose, we take as a basis the activities of the MODEST-17 conference, which was held at Charles University, Prague, in September 2017. Reviewed topics include recent advances in fundamental stellar dynamics, numerical methods for the solution of the gravitational N-body problem, formation and evolution of young and old star clusters and galactic nuclei, their elusive stellar populations, planetary systems, and exotic compact objects, with timely attention to black holes of different classes of mass and their role as sources of gravitational waves. Such a breadth of topics reflects the growing role played by collisional stellar dynamics in numerous areas of modern astrophysics. Indeed, in the next decade, many revolutionary instruments will enable the derivation of positions and velocities of individual stars in the Milky Way and its satellites and will detect signals from a range of astrophysical sources in different portions of the electromagnetic and gravitational spectrum, with an unprecedented sensitivity. On the one hand, this wealth of data will allow us to address a number of long-standing open questions in star cluster studies; on the other hand, many unexpected properties of these systems will come to light, stimulating further progress of our understanding of their formation and evolution.Comment: 42 pages; accepted for publication in 'Computational Astrophysics and Cosmology'. We are much grateful to the organisers of the MODEST-17 conference (Charles University, Prague, September 2017). We acknowledge the input provided by all MODEST-17 participants, and, more generally, by the members of the MODEST communit

The Next Generation Virgo Cluster Survey (NGVS). I. Introduction to the survey

The Next Generation Virgo Cluster Survey (NGVS) is a program that uses the 1 deg 2 MegaCam instrument on the Canada-France-Hawaii Telescope to carry out a comprehensive optical imaging survey of the Virgo cluster, from its core to its virial radius - covering a total area of 104 deg 2 - in the u*griz bandpasses. Thanks to a dedicated data acquisition strategy and processing pipeline, the NGVS reaches a point-source depth of g 25.9 mag (10\u3c3) and a surface brightness limit of \u3bc g 29 mag arcsec -2 (2\u3c3 above the mean sky level), thus superseding all previous optical studies of this benchmark galaxy cluster. In this paper, we give an overview of the technical aspects of the survey, such as areal coverage, field placement, choice of filters, limiting magnitudes, observing strategies, data processing and calibration pipelines, survey timeline, and data products. We also describe the primary scientific topics of the NGVS, which include: the galaxy luminosity and mass functions; the color-magnitude relation; galaxy scaling relations; compact stellar systems; galactic nuclei; the extragalactic distance scale; the large-scale environment of the cluster and its relationship to the Local Supercluster; diffuse light and the intracluster medium; galaxy interactions and evolutionary processes; and extragalactic star clusters. In addition, we describe a number of ancillary programs dealing with "foreground" and "background" science topics, including the study of high-inclination trans-Neptunian objects; the structure of the Galactic halo in the direction of the Virgo Overdensity and Sagittarius Stream; the measurement of cosmic shear, galaxy-galaxy, and cluster lensing; and the identification of distant galaxy clusters, and strong-lensing events. \ua9 2012. The American Astronomical Society. All rights reserved..Peer reviewed: YesNRC publication: Ye

Euclid: Early Release Observations -- Deep anatomy of nearby galaxies

International audienceEuclid is poised to make significant advances in the study of nearby galaxies in the local Universe. Here we present a first look at 6 galaxies observed for the Nearby Galaxy Showcase as part of the Euclid Early Release Observations acquired between August and November, 2023. These targets, 3 dwarf galaxies (HolmbergII, IC10, NGC6822) and 3 spirals (IC342, NGC2403, NGC6744), range in distance from about 0.5 Mpc to 8.8 Mpc. Our assessment of the surface brightness depths in the stacked Euclid images confirms previous estimates in 100 arcsec^2 regions of 1sigma=30.5 mag/arcsec^2 for VIS, but slightly deeper than previous estimates for NISP with 1sigma=29.2-29.4 mag/arcsec^2. By combining Euclid HE, YE, and IE into RGB images, we illustrate the large field-of-view covered by a single Reference Observing Sequence, together with exquisite detail on parsec scales in these nearby galaxies. Radial surface brightness and color profiles demonstrate galaxy colors in agreement with stellar population synthesis models. Standard stellar photometry selection techniques find approximately 1.3 million stars across the 6 galaxy fields. Euclid's resolved stellar photometry allows us to constrain the star-formation histories of these galaxies, by disentangling the distributions of young stars, as well as asymptotic giant branch and red giant branch stellar populations. We finally examine 2 galaxies individually for surrounding satellite systems. Our analysis of the ensemble of dwarf satellites around NGC6744 reveals a new galaxy, EDwC1, a nucleated dwarf spheroidal at the end of a spiral arm. Our new census of the globular clusters around NGC2403 yields 9 new star-cluster candidates, 8 of which with colors indicative of evolved stellar populations. In summary, our investigation of the 6 Showcase galaxies demonstrates that Euclid is a powerful probe of the anatomy of nearby galaxies [abridged]

Euclid: Early Release Observations -- Deep anatomy of nearby galaxies

International audienceEuclid is poised to make significant advances in the study of nearby galaxies in the local Universe. Here we present a first look at 6 galaxies observed for the Nearby Galaxy Showcase as part of the Euclid Early Release Observations acquired between August and November, 2023. These targets, 3 dwarf galaxies (HolmbergII, IC10, NGC6822) and 3 spirals (IC342, NGC2403, NGC6744), range in distance from about 0.5 Mpc to 8.8 Mpc. Our assessment of the surface brightness depths in the stacked Euclid images confirms previous estimates in 100 arcsec^2 regions of 1sigma=30.5 mag/arcsec^2 for VIS, but slightly deeper than previous estimates for NISP with 1sigma=29.2-29.4 mag/arcsec^2. By combining Euclid HE, YE, and IE into RGB images, we illustrate the large field-of-view covered by a single Reference Observing Sequence, together with exquisite detail on parsec scales in these nearby galaxies. Radial surface brightness and color profiles demonstrate galaxy colors in agreement with stellar population synthesis models. Standard stellar photometry selection techniques find approximately 1.3 million stars across the 6 galaxy fields. Euclid's resolved stellar photometry allows us to constrain the star-formation histories of these galaxies, by disentangling the distributions of young stars, as well as asymptotic giant branch and red giant branch stellar populations. We finally examine 2 galaxies individually for surrounding satellite systems. Our analysis of the ensemble of dwarf satellites around NGC6744 reveals a new galaxy, EDwC1, a nucleated dwarf spheroidal at the end of a spiral arm. Our new census of the globular clusters around NGC2403 yields 9 new star-cluster candidates, 8 of which with colors indicative of evolved stellar populations. In summary, our investigation of the 6 Showcase galaxies demonstrates that Euclid is a powerful probe of the anatomy of nearby galaxies [abridged]

Euclid: Early Release Observations -- Deep anatomy of nearby galaxies

International audienceEuclid is poised to make significant advances in the study of nearby galaxies in the local Universe. Here we present a first look at 6 galaxies observed for the Nearby Galaxy Showcase as part of the Euclid Early Release Observations acquired between August and November, 2023. These targets, 3 dwarf galaxies (HolmbergII, IC10, NGC6822) and 3 spirals (IC342, NGC2403, NGC6744), range in distance from about 0.5 Mpc to 8.8 Mpc. Our assessment of the surface brightness depths in the stacked Euclid images confirms previous estimates in 100 arcsec^2 regions of 1sigma=30.5 mag/arcsec^2 for VIS, but slightly deeper than previous estimates for NISP with 1sigma=29.2-29.4 mag/arcsec^2. By combining Euclid HE, YE, and IE into RGB images, we illustrate the large field-of-view covered by a single Reference Observing Sequence, together with exquisite detail on parsec scales in these nearby galaxies. Radial surface brightness and color profiles demonstrate galaxy colors in agreement with stellar population synthesis models. Standard stellar photometry selection techniques find approximately 1.3 million stars across the 6 galaxy fields. Euclid's resolved stellar photometry allows us to constrain the star-formation histories of these galaxies, by disentangling the distributions of young stars, as well as asymptotic giant branch and red giant branch stellar populations. We finally examine 2 galaxies individually for surrounding satellite systems. Our analysis of the ensemble of dwarf satellites around NGC6744 reveals a new galaxy, EDwC1, a nucleated dwarf spheroidal at the end of a spiral arm. Our new census of the globular clusters around NGC2403 yields 9 new star-cluster candidates, 8 of which with colors indicative of evolved stellar populations. In summary, our investigation of the 6 Showcase galaxies demonstrates that Euclid is a powerful probe of the anatomy of nearby galaxies [abridged]

Euclid: Early Release Observations -- Deep anatomy of nearby galaxies

International audienceEuclid is poised to make significant advances in the study of nearby galaxies in the local Universe. Here we present a first look at 6 galaxies observed for the Nearby Galaxy Showcase as part of the Euclid Early Release Observations acquired between August and November, 2023. These targets, 3 dwarf galaxies (HolmbergII, IC10, NGC6822) and 3 spirals (IC342, NGC2403, NGC6744), range in distance from about 0.5 Mpc to 8.8 Mpc. Our assessment of the surface brightness depths in the stacked Euclid images confirms previous estimates in 100 arcsec^2 regions of 1sigma=30.5 mag/arcsec^2 for VIS, but slightly deeper than previous estimates for NISP with 1sigma=29.2-29.4 mag/arcsec^2. By combining Euclid HE, YE, and IE into RGB images, we illustrate the large field-of-view covered by a single Reference Observing Sequence, together with exquisite detail on parsec scales in these nearby galaxies. Radial surface brightness and color profiles demonstrate galaxy colors in agreement with stellar population synthesis models. Standard stellar photometry selection techniques find approximately 1.3 million stars across the 6 galaxy fields. Euclid's resolved stellar photometry allows us to constrain the star-formation histories of these galaxies, by disentangling the distributions of young stars, as well as asymptotic giant branch and red giant branch stellar populations. We finally examine 2 galaxies individually for surrounding satellite systems. Our analysis of the ensemble of dwarf satellites around NGC6744 reveals a new galaxy, EDwC1, a nucleated dwarf spheroidal at the end of a spiral arm. Our new census of the globular clusters around NGC2403 yields 9 new star-cluster candidates, 8 of which with colors indicative of evolved stellar populations. In summary, our investigation of the 6 Showcase galaxies demonstrates that Euclid is a powerful probe of the anatomy of nearby galaxies [abridged]

Euclid: Early Release Observations -- Deep anatomy of nearby galaxies

International audienceEuclid is poised to make significant advances in the study of nearby galaxies in the local Universe. Here we present a first look at 6 galaxies observed for the Nearby Galaxy Showcase as part of the Euclid Early Release Observations acquired between August and November, 2023. These targets, 3 dwarf galaxies (HolmbergII, IC10, NGC6822) and 3 spirals (IC342, NGC2403, NGC6744), range in distance from about 0.5 Mpc to 8.8 Mpc. Our assessment of the surface brightness depths in the stacked Euclid images confirms previous estimates in 100 arcsec^2 regions of 1sigma=30.5 mag/arcsec^2 for VIS, but slightly deeper than previous estimates for NISP with 1sigma=29.2-29.4 mag/arcsec^2. By combining Euclid HE, YE, and IE into RGB images, we illustrate the large field-of-view covered by a single Reference Observing Sequence, together with exquisite detail on parsec scales in these nearby galaxies. Radial surface brightness and color profiles demonstrate galaxy colors in agreement with stellar population synthesis models. Standard stellar photometry selection techniques find approximately 1.3 million stars across the 6 galaxy fields. Euclid's resolved stellar photometry allows us to constrain the star-formation histories of these galaxies, by disentangling the distributions of young stars, as well as asymptotic giant branch and red giant branch stellar populations. We finally examine 2 galaxies individually for surrounding satellite systems. Our analysis of the ensemble of dwarf satellites around NGC6744 reveals a new galaxy, EDwC1, a nucleated dwarf spheroidal at the end of a spiral arm. Our new census of the globular clusters around NGC2403 yields 9 new star-cluster candidates, 8 of which with colors indicative of evolved stellar populations. In summary, our investigation of the 6 Showcase galaxies demonstrates that Euclid is a powerful probe of the anatomy of nearby galaxies [abridged]

Euclid: Early Release Observations -- Programme overview and pipeline for compact- and diffuse-emission photometry

International audienceThe Euclid ERO showcase Euclid's capabilities in advance of its main mission, targeting 17 astronomical objects, from galaxy clusters, nearby galaxies, globular clusters, to star-forming regions. A total of 24 hours observing time was allocated in the early months of operation, engaging the scientific community through an early public data release. We describe the development of the ERO pipeline to create visually compelling images while simultaneously meeting the scientific demands within months of launch, leveraging a pragmatic, data-driven development strategy. The pipeline's key requirements are to preserve the image quality and to provide flux calibration and photometry for compact and extended sources. The pipeline's five pillars are: removal of instrumental signatures; astrometric calibration; photometric calibration; image stacking; and the production of science-ready catalogues for both the VIS and NISP instruments. We report a PSF with a full width at half maximum of 0.16" in the optical and 0.49" in the three NIR bands. Our VIS mean absolute flux calibration is accurate to about 1%, and 10% for NISP due to a limited calibration set; both instruments have considerable colour terms. The median depth is 25.3 and 23.2 AB mag with a SNR of 10 for galaxies, and 27.1 and 24.5 AB mag at an SNR of 5 for point sources for VIS and NISP, respectively. Euclid's ability to observe diffuse emission is exceptional due to its extended PSF nearly matching a pure diffraction halo, the best ever achieved by a wide-field, high-resolution imaging telescope. Euclid offers unparalleled capabilities for exploring the LSB Universe across all scales, also opening a new observational window in the NIR. Median surface-brightness levels of 29.9 and 28.3 AB mag per square arcsec are achieved for VIS and NISP, respectively, for detecting a 10 arcsec x 10 arcsec extended feature at the 1 sigma level