821 research outputs found

    Getting rights right: Explaining social rights constitutionalization in revolutionary Portugal

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    Constitutions are a key element of the normative script of the modern state. All constitutions lock in rights. Most include social provisions. Some are more generous than others in this regard. But none come close to the Portuguese Constitution of 1976 in the length and detail of its list of social and economic rights. Prevailing theories of institutional origins have generated hypotheses to account for the constitutionalization of second-generation rights. But they fall short of providing a full understanding of constitutionalization and the accompanying emergence of judicial review. Outlier cases, such as the Portuguese, are even more poorly explained by extant explanations. In this article, we test them against the Portuguese case, which, whenever appropriate, is compared with Spain. In doing this, we aim at two things: first, to identify shortcomings in the most familiar frameworks, theories, and hypotheses concerning the causal mechanisms leading to the inclusion of social and economic rights in constitutions; second, to propose alternative explanations where existing ones prove inadequate or insufficient.This is the author accepted manuscript. The final version is available from Oxford University Press via http://dx.doi.org/10.1093/icon/mot04

    Social representations of needlestick injuries

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    OBJECTIVES: understand the Social Representations about needlestick injuries elaborated by Nursing Technicians and analyze how these representations influence their conducts. METHOD: the data, obtained by interviews, were processed using ALCESTE software and their analysis was based on Serge Moscovici's Social Representations Theory. RESULTS: it was evidenced that, after the accident, these professionals take care of the affected area. Then, they report the accident, motivated by the fear of catching HIV and hepatitis. The different feelings experienced are due to this fear and the way they were forwarded by the institution, reflecting in the cause they attribute to their accident. CONCLUSIONS: it was verified that knowledge about the accident as a whole is very incipient in this professional group, demanding continuing education and greater emphasis on this subject in professional training. It is expected that this study draws public authorities and health institutions' attention to the problem and that it modifies Nursing Technicians' Social Representations about percutaneous exposure.OBJETIVOS: Comprender las Representaciones Sociales de los accidentes con materiales corto-punzantes, elaboradas por Técnicos de Enfermería, así como analizar de que modo esas representaciones influencian las conductas de eses profesionales. MÉTODO: Los datos, logrados por medio de entrevistas, fueron procesados por el software ALCESTE y el análisis de los mismos fue basado en la Teoría de las Representaciones Sociales de Serge Moscovici. RESULTADOS: se evidenció que, después de accidentarse, los Técnicos de Enfermería cuidan del área afectada. Enseguida, notifican el accidente, motivados por el miedo de que contraigan HIV y hepatitis. Los diversos sentimientos vividos son consecuentes de ese miedo y de la manera como fueron encaminados por la institución, reflejando en la causa que ellos atribuyen a su accidente. CONCLUSIONES: se constató que hay un conocimiento bastante incipiente por parte de esa clase profesional sobre el accidente como un todo, habiendo necesidad de una educación continuada y mayor énfasis en cuanto a ese asunto durante la formación profesional. Se espera que ese estudio llame la atención de los órganos gubernamentales e instituciones de salud sobre el problema y modifique las Representaciones Sociales de la exposición percutánea de los Técnicos de Enfermería.OBJETIVOS: compreender as representações sociais dos acidentes com materiais perfurocortantes, elaboradas por técnicos de enfermagem, bem como analisar de que modo essas representações influenciam as condutas desses profissionais. MÉTODO: os dados, obtidos por meio de entrevistas, foram processados pelo software Alceste e a análise dos mesmos foi baseada na Teoria das Representações Sociais de Serge Moscovici. RESULTADOS: evidenciou-se que, após se acidentarem, os técnicos de enfermagem cuidam da área afetada. Em seguida, notificam o acidente, motivados pelo medo de contraírem HIV e hepatite. Os diversos sentimentos vivenciados são decorrentes desse medo e da forma como foram encaminhados pela instituição, refletindo na causa que eles atribuem ao seu acidente. CONCLUSÕES: constatou-se que há conhecimento bastante incipiente por parte dessa classe profissional sobre o acidente, como um todo, havendo necessidade de educação continuada e maior ênfase quanto a esse assunto, durante a formação profissional. Espera-se que este estudo chame a atenção dos órgãos governamentais e instituições de saúde sobre o problema e modifique as representações sociais da exposição percutânea dos técnicos de enfermagem

    Measurement of the residual stress tensor in a compact tension weld specimen

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    Neutron diffraction measurements have been performed to determine the full residual stress tensor along the expected crack path in an austenitic stainless steel (Esshete 1250) compact tension weld specimen. A destructive slitting method was then implemented on the same specimen to measure the stress intensity factor profile associated with the residual stress field as a function of crack length. Finally deformations of the cut surfaces were measured to determine a contour map of the residual stresses in the specimen prior to the cut. The distributions of transverse residual stress measured by the three techniques are in close agreement. A peak tensile stress in excess of 600 MPa was found to be associated with an electron beam weld used to attach an extension piece to the test sample, which had been extracted from a pipe manual metal arc butt weld. The neutron diffraction measurements show that exceptionally high residual stress triaxiality is present at crack depths likely to be used for creep crack growth testing and where a peak stress intensity factor of 35 MPa√m was measured (crack depth of 21 mm). The neutron diffraction measurements identified maximum values of shear stress in the order of 50 MPa and showed that the principal stress directions were aligned to within ~20° of the specimen orthogonal axes. Furthermore it was confirmed that measurement of strains by neutron diffraction in just the three specimen orthogonal directions would have been sufficient to provide a reasonably accurate characterisation of the stress state in welded CT specimens

    Capacidade para o trabalho e saúde: o que pensam as trabalhadoras da indústria de vestuário

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    Este estudo objetivou conhecer como as mulheres que atuam na indústria do vestuário em Divinópolis, Minas Gerais, entendem e relacionam os constructos capacidade para o trabalho e saúde. Utilizou-se metodologia qualitativa com análise dos depoimentos ancorada na teoria das representações sociais. Os resultados apontaram que a capacidade para o trabalho depende de fatores como capacitação, suporte social, exercício da profissão a domicilio, satisfação com o trabalho, saúde e envelhecimento. Além disso, ela sofre muitas influências externas ao trabalhador, que, por sua vez, precisa constantemente se adaptar às mudanças ocorridas. Os resultados evidenciaram a necessidade de reflexão sobre o papel das condições de trabalho e emprego, da rigidez organizacional e da perda de controle sobre o trabalho, na saúde e na capacidade para o trabalho das mulheres atuantes na indústria do vestuário

    Cross-species chromosome painting tracks the independent origin of multiple sex chromosomes in two cofamiliar Erythrinidae fishes

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    <p>Abstract</p> <p>Background</p> <p>The Erythrinidae fish family is characterized by a large variation with respect to diploid chromosome numbers and sex-determining systems among its species, including two multiple X<sub>1</sub>X<sub>2</sub>Y sex systems in <it>Hoplias malabaricus </it>and <it>Erythrinus erythrinus</it>. At first, the occurrence of a same sex chromosome system within a family suggests that the sex chromosomes are correlated and originated from ancestral XY chromosomes that were either homomorphic or at an early stage of differentiation. To identify the origin and evolution of these X<sub>1</sub>X<sub>2</sub>Y sex chromosomes, we performed reciprocal cross-species FISH experiments with two sex-chromosome-specific probes designed from microdissected X<sub>1 </sub>and Y chromosomes of <it>H. malabaricus </it>and <it>E. erythrinus</it>, respectively.</p> <p>Results</p> <p>Our results yield valuable information regarding the origin and evolution of these sex chromosome systems. Our data indicate that these sex chromosomes evolved independently in these two closed related Erythrinidae species. Different autosomes were first converted into a poorly differentiated XY sex pair in each species, and additional chromosomal rearrangements produced both X<sub>1</sub>X<sub>2</sub>Y sex systems that are currently present.</p> <p>Conclusions</p> <p>Our data provide new insights into the origin and evolution of sex chromosomes, which increases our knowledge about fish sex chromosome evolution.</p

    New organizational forms in emerging economies: bridging the gap between agribusiness management and international development

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    This is the author accepted manuscript. The final version is available from Emerald via the DOI in this recordPurpose: This editorial article introduces and analyzes a variety of new organizational forms that rapidly emerged in Africa, Asia, Latin America and Eastern Europe in the latest two decades. Among the others, these include: business model partnerships, business platforms, incubators and hubs, public–private partnerships, agribusiness companies' foundations and spin-offs, short supply chains, community-supported agriculture and other community self-organizing experiences. Building upon the recent literature and the five selected papers in this special issue, the authors discuss what is novel in these organizations and why, when and how they emerge and evolve over time. Design/methodology/approach: The authors identify three elements that, when considered together, explain and predict the emergence and evolution of these new organizational forms: institutions, strategies and learning processes. Findings: The authors demonstrate that societal actors seeking to (re)design these new organizational forms need to consider these three elements to combine the pursuit of their interests of their own constituencies with the sustainable development goals (SDGs). Originality/value: Taking stock from the literature, the authors invite future research on new organizational forms to take explicitly the pursuit of the SDGs into consideration; to build upon a process ontology; and to deeply reflect on our positionality of scientists studying and sometimes engaging in these organizations

    Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes

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    The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models of disrupted CNP and GC-B indicate a potential role in growth hormone secretion. In the current study, we investigate the molecular and pharmacological properties of the CNP/GC-B system in somatotrope lineage cells. Primary rat pituitary and GH3 somatolactotropes expressed functional GC-A and GC-B receptors that had similar EC50 properties in terms of cGMP production. Interestingly, GC-B signaling underwent rapid homologous desensitization in a protein phosphatase 2A (PP2A)-dependent manner. Chronic exposure to either CNP or ANP caused a significant down-regulation of both GC-A- and GC-B-dependent cGMP accumulation in a ligand-specific manner. However, this down-regulation was not accompanied by alterations in the sub-cellular localization of these receptors. Heterologous desensitization of GC-B signaling occurred in GH3 cells following exposure to either sphingosine-1-phosphate or thyrotrophin-releasing hormone (TRH). This heterologous desensitization was protein kinase C (PKC)-dependent, as pre-treatment with GF109203X prevented the effect of TRH on CNP/GC-B signaling. Collectively, these data indicate common and distinct properties of particulate guanylyl cyclase receptors in somatotropes and reveal that independent mechanisms of homologous and heterologous desensitization occur involving either PP2A or PKC. Guanylyl cyclase receptors thus represent potential novel therapeutic targets for treating growth-hormone-associated disorders

    Expression of Drosophila virilis Retroelements and Role of Small RNAs in Their Intrastrain Transposition

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    Transposition of two retroelements (Ulysses and Penelope) mobilized in the course of hybrid dysgenesis in Drosophila virilis has been investigated by in situ hybridization on polytene chromosomes in two D. virilis strains of different cytotypes routinely used to get dysgenic progeny. The analysis has been repeatedly performed over the last two decades, and has revealed transpositions of Penelope in one of the strains, while, in the other strain, the LTR-containing element Ulysses was found to be transpositionally active. The gypsy retroelement, which has been previously shown to be transpositionally inactive in D. virilis strains, was also included in the analysis. Whole mount is situ hybridization with the ovaries revealed different subcellular distribution of the transposable elements transcripts in the strains studied. Ulysses transpositions occur only in the strain where antisense piRNAs homologous to this TE are virtually absent and the ping-pong amplification loop apparently does not take place. On the other hand small RNAs homologous to Penelope found in the other strain, belong predominantly to the siRNA category (21nt), and consist of sense and antisense species observed in approximately equal proportion. The number of Penelope copies in the latter strain has significantly increased during the last decades, probably because Penelope-derived siRNAs are not maternally inherited, while the low level of Penelope-piRNAs, which are faithfully transmitted from mother to the embryo, is not sufficient to silence this element completely. Therefore, we speculate that intrastrain transposition of the three retroelements studied is controlled predominantly at the post-transcriptional level
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