Parallel Aligned Treebank Corpora at LDC: Methodology, Annotation and Integration

Proceedings of the Workshop on Annotation and Exploitation of Parallel Corpora AEPC 2010. Editors: Lars Ahrenberg, Jörg Tiedemann and Martin Volk. NEALT Proceedings Series, Vol. 10 (2010), 14-23. © 2010 The editors and contributors. Published by Northern European Association for Language Technology (NEALT) http://omilia.uio.no/nealt . Electronically published at Tartu University Library (Estonia) http://hdl.handle.net/10062/15893

A portable breast cancer detection system based on smartphone with infrared camera

The traditional detection methods have the disadvantages of radiation exposure, high cost, and shortage of medical resources, which restrict the popularity of early screening for breast cancer. An inexpensive, accessible, and friendly way to detect is urgently needed. Infrared thermography, an emerging means to breast cancer detection, is extremely sensitive to tissue abnormalities caused by inflammation and vascular proliferation. In this work, combined with the temperature and texture features, we designed a breast cancer detection system based on smart phone with infrared camera, achieving the accuracy of 99.21 % with the k-Nearest Neighbor classifier. We compared the diagnostic results of the low resolution, originated from the phone camera, with the high resolution of the conventional infrared camera. It was found that the accuracy and sensitivity decreased slightly, but both of them were over than 98 %. The proposed breast cancer detection system not only has excellent performance but also dramatically saves the detection cost, and its prospect will be fascinating

Panus tigrinus as a potential biomass source for Reactive Blue decolorization: Isotherm and kinetic study

Background: Textile and dye industries pose a serious threat to the environment. Conventional methods used for dye treatment are generally not always effective and environmentally friendly. This drove attention of scores of researchers to investigate alternative methods for the biodegradation of dyes using fungal strains. In this work, white-rot fungus (Panus tigrinus) was used as a biosorbent for the decolorization of Reactive Blue 19. The process parameters that were varied were initial concentration (50\u2013150 mg/L), contact time (30\u201390 min), and pH (2\u20136). In addition, to gain important data for the evaluation of a sorption process, the equilibrium and kinetics of the process were determined. Results: White-rot fungus showed great potential in decolorizing Azo dyes. The strain showed the maximum decolorization of 83.18% at pH 2, a contact time of 90 min, and an initial concentration of 50 mg/L. The Langmuir isotherm described the uptake of the Reactive Blue 19 dye better than the Freundlich isotherm. Analysis of the kinetic data showed that the dye uptake process followed the pseudo second-order rate expression. Conclusion: The biosorption process provided vital information on the process parameters required to obtain the optimum level of dye removal. The isotherm study indicated the homogeneous distribution of active sites on the biomass surface, and the kinetic study suggested that chemisorption is the rate-limiting step that controlled the biosorption process. According to the obtained results, P. tigrinus biomass can be used effectively to decolorize textile dyes and tackle the pollution problems in the environment

Molecular Signatures of Tumour and Its Microenvironment for Precise Quantitative Diagnosis of Oral Squamous Cell Carcinoma: An International Multi-Cohort Diagnostic Validation Study

Supplementary Materials: The following supporting information can be downloaded at: www.mdpi.com/xxx/s1, Table ST1 – qMIDSV2 Gene panel primer sequences; Figure S1 – qMIDSV1 vs qMIDSV2 384-well assay format and protocols; Figure S2. Individual target gene expression pattern in 1761 samples; Figure S3. Various statistical methods used for gene selection analysis on 1761 clinical samples; Figure S4. Diagnostic performance comparison between qMIDSV2 vs qMIDSV2* (with 4 less effective genes removed from the panel of 14 target genes of qMIDSV2); Figure S5. Effect of removing individual genes from the 14-target gene panel qMIDSV2 (qV2) on diagnostic test performance based on the UK patient cohort data

Evidence for Two Modes of Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia in Human Colon Cancer Cells

Colorectal cancer is the third leading cause of cancer-related mortality in the world-- the main cause of death from colorectal cancer is hepatic metastases, which can be treated with isolated hepatic perfusion (IHP). Searching for the most clinically relevant approaches for treating colorectal metastatic disease by isolated hepatic perfusion (IHP), we developed the application of oxaliplatin concomitantly with hyperthermia and humanized death receptor 4 (DR4) antibody mapatumumab (Mapa), and investigated the molecular mechanisms of this multimodality treatment in human colon cancer cell lines CX-1 and HCT116 as well as human colon cancer stem cells Tu-12, Tu-21 and Tu-22. We showed here, in this study, that the synergistic effect of the multimodality treatment-induced apoptosis was caspase dependent and activated death signaling via both the extrinsic apoptotic pathway and the intrinsic pathway. Death signaling was activated by c-Jun N-terminal kinase (JNK) signaling which led to Bcl-xL phosphorylation at serine 62, decreasing the anti-apoptotic activity of Bcl-xL, which contributed to the intrinsic pathway. The downregulation of cellular FLICE inhibitory protein long isoform (c-FLIPL) in the extrinsic pathway was accomplished through ubiquitination at lysine residue (K) 195 and protein synthesis inhibition. Overexpression of c-FLIPL mutant (K195R) and Bcl-xL mutant (S62A) completely abrogated the synergistic effect. The successful outcome of this study supports the application of multimodality strategy to patients with colorectal hepatic metastases who fail to respond to standard chemoradiotherapy that predominantly targets the mitochondrial apoptotic pathway. © 2013 Song et al

Periodontal status of rheumatoid arthritis patients in khartoum state

<p>Abstract</p> <p>Background</p> <p>Few studies have investigated the periodontal condition among Rheumatoid arthritis in Sudan. The present study described the periodontal condition among Sudanese patients suffering from rheumatoid arthritis and to compare them with those of non-rheumatic subjects.</p> <p>Methods</p> <p>A group of eighty rheumatoid arthritis patients was selected from Patient's Rheumatoid Clinics in Khartoum State during the period of January to May 2010. A control group of eighty patients with the same age and gender was selected for the study. Both Rheumatoid arthritis patients and the control group were examined for their plaque index, gingival index, and clinical attachment loss.</p> <p>Results</p> <p>The results revealed that there were no significant differences in plaque and gingival index among study and control groups, with mean plaque index of (1.25 ± 0.4) for patients and (1.17 ± 0.28) for the control group (p-value is 0.3597). The mean gingival index was (1.2 ± 0.24) for the patients and (1.2 ± 0.33) for the control (p = is 0.3049). The results showed statistically significant differences in clinical attachment loss between study and control groups, with mean clinical attachment loss of (1.03 ± 0.95) for the study group and (0.56 ± 0.63) for the control group (p = 0.0002). The study revealed that no association exists between the type of drug used to treat rheumatoid arthritis (NSAIDs & DMARDs) and the periodontal parameters (plaque index, gingival index, and clinical attachment loss).</p> <p>Conclusion</p> <p>A significant relationship between periodontal disease and Rheumatoid Arthritis does exist, but no difference between plaque and gingival index has been detected among study and control groups.</p