Sebaceous Carcinoma of the Eyelid

Sebaceous gland carcinoma of the eyelid is a very rare, slow growing tumor arising from the meibomian glands. In contrast to squamous cell carcinoma and basal cell carcinoma which arise frequently from the lower lid, sebaceous carcinoma arises from the upper lid where meibomian glands are more numerous. We present a case of sebaceous carcinoma in an elderly lady who presented with a slow growing tumor in the lateral third of the lower lid, without any lymph node metastasis. The tumor was treated by wide excision and the eyelid was reconstructed by Tenzel semilunar flap

Compressor Performance Comparison of R454A and R454C for Refrigeration

The intent of this paper is to compare compressor performance of two low GWP refrigerants that are mildly flammable. Since there are limited test capabilities for compressors with flammable refrigerants, the compressor tests in this paper are based on a non-flammable refrigerant, in this case R513A. The tested compressor is an open type screw compressor that is driven by an external motor and is vapor injected. A physical compressor model is created from test data. This compressor model is not based on maps for efficiencies, capacity, or power consumption, but rather a basis of physical bulk elements, such as pressure drop from orifices (at suction, discharge and vapor injection), leakage orifices, volume ratio between the suction port and the vapor injection port as well as volume ratio between the suction port and the discharge port. The compressor displacement and speeds are the most fundamental inputs for both the model and the tests. For mechanical losses a friction coefficient and friction exponent, relative to the speed, are obtained from the developed compressor model. This model can predict the actual compressor operation with different refrigerants. This compressor model developed based on R513A testing is applied to predict the performance of R454A and R454C refrigerants that are potential candidates for low GWP transport refrigeration. R454A always gives higher capacity than R454C. For COP, R454A outperforms R454C in some conditions while R454C outperforms R454A in others

Spin-Flip Interactions and the Puzzle of psi's Polarization at Tevatron

Nonrelativistic QCD provides a systematic approach for inclusive decays and productions of a quarkonium. By taking color-octet components into account, the approach can explain the $\psi'$-anomaly at Tevatron, where the measured production rate at large transverse momentum $p_\perp$ is in order of magnitude larger than the predicted with color-singlet components only. With the approach one can predict that the produced $J/\psi$ and $\psi'$ at large $p_\perp$ will be transversely polarized. But the prediction fails in confronting with experimental measurements and this generates a puzzle. We examine the role of spin-flip interactions in the spin density matrix of the transition of a color-octet charm quark pair into $J/\psi$ and $\psi'$. These interactions will introduce new nonperturbative parameters in the spin density matrix. Our result shows that the impact of the interactions is always to dilute the polarization and can be very significant. Taking the impact into account, predictions for the polarization are more close to the measured than the previous predicted. The same can also be expected for the polarization of $J/\psi$.Comment: match the published version Phys.Lett.B645:180-184,200

Renormalization Group Approach to Low Temperature Properties of a Non-Fermi Liquid Metal

We expand upon on an earlier renormalization group analysis of a non-Fermi liquid fixed point that plausibly govers the two dimensional electron liquid in a magnetic field near filling fraction $\nu=1/2$. We give a more complete description of our somewhat unorthodox renormalization group transformation by relating both our field-theoretic approach to a direct mode elimination and our anisotropic scaling to the general problem of incorporating curvature of the Fermi surface. We derive physical consequences of the fixed point by showing how they follow from renormalization group equations for finite-size scaling, where the size may be set by the temperature or by the frequency of interest. In order fully to exploit this approach, it is necessary to take into account composite operators, including in some cases dangerous ``irrelevant'' operators. We devote special attention to gauge invariance, both as a formal requirement and in its positive role providing Ward identities constraining the renormalization of composite operators. We emphasize that new considerations arise in describing properties of the physical electrons (as opposed to the quasiparticles.) We propose an experiment which, if feasible, will allow the most characteristic feature of our results, that isComment: 42 pages, 5 figures upon request, uses Phyzzx, IASSNS-HEP 94/6

Stellar spectroscopy: Fermions and holographic Lifshitz criticality

Electron stars are fluids of charged fermions in Anti-de Sitter spacetime. They are candidate holographic duals for gauge theories at finite charge density and exhibit emergent Lifshitz scaling at low energies. This paper computes in detail the field theory Green's function G^R(w,k) of the gauge-invariant fermionic operators making up the star. The Green's function contains a large number of closely spaced Fermi surfaces, the volumes of which add up to the total charge density in accordance with the Luttinger count. Excitations of the Fermi surfaces are long lived for w <~ k^z. Beyond w ~ k^z the fermionic quasiparticles dissipate strongly into the critical Lifshitz sector. Fermions near this critical dispersion relation give interesting contributions to the optical conductivity.Comment: 38 pages + appendices. 9 figure

Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies

The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas sections. Surprisingly, they all recognized the 64 kDa autoantigen glutamate decarboxylase. In this study we investigated which typical features of cytoplasmic islet cell antibodies are represented by these monoclonals. We show by double immunofluorescence testing that MICA 1-6 stain pancreatic beta cells which is in agreement with the beta-cell specific expression of glutamate decarboxylase. In contrast an islet-reactive IgM monoclonal antibody obtained from a pre-diabetic individual stained all islet cells but lacked the tissue specificity of MICA 1-6 and must therefore be considered as a polyreactive IgM-antibody. We further demonstrate that MICA 1-6 revealed typical features of epitope sensitivity to biochemical treatment of the target tissue which has been demonstrated for islet cell antibodies, and which has been used to argue for a lipid rather than a protein nature of target antigens. Our results provide direct evidence that the epitopes recognized by the MICA are destroyed by methanol/chloroform treatment but reveal a high stability to Pronase digestion compared to proinsulin epitopes. Conformational protein epitopes in glutamate decarboxylase therefore show a sensitivity to biochemical treatment of sections such as ganglioside epitopes. MICA 1-6 share typical features of islet cell and 64 kDa antibodies and reveal that glutamate decarboxylase-reactive islet cell antibodies represent a subgroup of islet cell antibodies present in islet cell antibody-positive sera

qqqbar to qqqbar and qqbarqbar to qqbarqbar Elastic Scatterings and Thermalization of Quark Matter and Antiquark Matter

Thermalization of quark matter and antiquark matter is studied with quark-quark-antiquark as well as quark-antiquark-antiquark elastic scatterings. Squared amplitudes of qqqbar to qqqbar and qqbarqbar to qqbarqbar at order alpha_s^4 are derived in perturbative QCD. Solved by a new technique, solutions of transport equations with the squared amplitudes indicate that the scatterings qqqbar to qqqbar and qqbarqbar to qqbarqbar shorten the thermalization time of quark matter and antiquark matter. It is emphasized that three-parton and other multi-parton scatterings become important at the high parton number density achieved in RHIC Au-Au collisions.Comment: 14 pages, 5 figures, Late

A 2-D π–π dimer model system to investigate structure-charge transfer relationships in rubrene

© The Royal Society of Chemistry 2019Rubrene (5,6,11,12-tetraphenyltetracene) is undoubtedly one of the best performing organic charge transfer mediating materials, with experimentally determined mobilities up to 40 cm2 V−1 s−1. Consequently, there has been increasing interest by means of crystal engineering in trying to generate rubrene-based materials with analogous or even superior conducting properties. Often, experimental measurements are carried out in thin film architectures of these materials, where measured properties can be detrimentally impacted by device manufacture rather than intrinsic charge transfer properties of the material. The latter results in discarding potential good performers. To address these concerns, we report a two-dimensional model system that will allow researchers to predict charge transfer properties of their materials solely requiring the coordinates of the π–π stacking motifs. We envisaged this study to be of significant interest to the increasingly large community of materials scientists devoted to the realisation of improved organic charge mediating materials and particularly to those engaged in exploiting rubrene-based architectures.Peer reviewedFinal Accepted Versio

Plant-expressed Fc-fusion protein tetravalent dengue vaccine with inherent adjuvant properties.

Dengue is a major global disease requiring improved treatment and prevention strategies. The recently licensed Sanofi-Pasteur Denvaxia vaccine does not protect children under the age of nine and additional vaccine strategies are thus needed to halt this expanding global epidemic. Here, we employed a molecular engineering approach and plant-expression to produce a humanised and highly immunogenic Poly-Immunoglobulin G Scaffold (PIGS) fused to the consensus dengue envelope protein III domain (cEDIII). The immunogenicity of this IgG Fc receptor targeted vaccine candidate was demonstrated in transgenic mice expressing human FcγRI/CD64, by induction of neutralising antibodies and evidence of cell-mediated immunity. Furthermore, these molecules were able to prime immune cells from human adenoid/tonsillar tissue ex vivo as evidenced by antigen-specific CD4+ and CD8+ T cell proliferation, IFN-γ and antibody production. The purified polymeric fraction of dengue PIGS (D-PIGS) induced stronger immune activation than the monomeric form, suggesting a more efficient interaction with the low affinity Fcγ receptors on antigen-presenting cells. These results show that the plant-expressed D-PIGS have the potential for translation towards a safe and easily scalable single antigen based tetravalent dengue vaccine. This article is protected by copyright. All rights reserved

Immunolocalization of angiogenic growth factors in the ovine uterus during the oestrus cycle and in response to Steroids

The vascular changes associated with endometrial maturation in preparation for embryo implantation depend on numerous growth factors, known to regulate key angiogenic events. Primarily, the vascular endothelial growth factor (VEGF) family promotes vascular growth, whilst the angiopoietins maintain blood vessel integrity. The aim was to analyse protein levels of VEGFA ligand and receptors, Angiopoietin‐1 and 2 (ANG1/2) and endothelial cell receptor tyrosine kinase (TIE‐2) in the ovine endometrium in the follicular and luteal phases of the oestrus cycle and in response to ovarian steroids. VEGFA and its receptors were localized in both vascular cells and non‐vascular epithelium (glandular and luminal epithelium) and stroma cells. VEGFA and VEGFR2 proteins were elevated in vascular cells in follicular phase endometrium, compared to luteal phase, most significantly in response to oestradiol. VEGFR1 was expressed by epithelial cells and endothelial cells and was stimulated in response to oestradiol. In contrast, Ang‐1 and Ang‐2 proteins were elevated in luteal phase endometrium compared to follicular phase, and in response to progesterone, evident in vascular smooth muscle cells and glands which surround TIE‐2‐expressing blood vessels. Our findings indicate that VEGFA is stimulated by oestradiol, most predominantly in follicular phase endometrium, and Ang‐1 and 2 are stimulated by progesterone and were increased during the luteal phase of the oestrus cycle, during the time of vascular maturation