An increased weaning age and liquid feed enhances weight gain compared to piglets fed dry feed pre-weaning

Increasing age and providing liquid creep feed could potentially increase the solid feed intake in pre-weaning piglets, which may in turn promote gut maturation and post-weaning feed intake, possibly lessening the severity of the growth-check associated with the suckling-to-weaning transition. Therefore, this study aimed to investigate if feeding dry- versus liquid creep feed (DF vs. LF) and weaning in week 4 or 5 (4W or 5W) could accelerate maturational changes to the small intestines of pre-weaning piglets by increasing digestive and absorptive capacity. In a 2 × 2 factorial study the effect of weaning age (WA) and feeding strategy (FS) on weaning weight, pre-weaning accumulated gain (AG), and average daily gain was measured for 12 923 piglets. A subpopulation of 15 piglets from each treatment group (4WDF, 4WLF, 5WDF and 5WLF; n = 60) were sacrificed to assess the effects of WA and FS on weight of digestive organs, activity of maltase, lactase and sucrase, and gene expression level of sodium-glucose linked transporter 1 (SGLT-1), glucose transporter 2 (GLUT2) and peptide transporter 1 (PepT1) in the proximal part of the small intestine (SI). No interactions were found but average weaning weight was affected by WA (P < 0.001) and FS (P < 0.001), where 5W were heavier than 4W and LF were heavier than DF. Correspondingly, the average daily gain (ADG) was affected by both WA (P = 0.003) and FS (P < 0.001). Only WA affected the relative weight of the digestive organs, where stomach weight, weight of SI and colon weight were heavier in 5W piglets compared to 4W. Lactase activity tended to decrease with age (P = 0.061), but there was no difference in the activity of maltase or sucrase between any of the treatment groups. Similarly, there was no differences in gene expression level of SGLT1, GLUT2 or PepT1 between neither the two ages nor feeding strategies. In conclusion, both WA and FS affect weaning weight and weight gain of piglets in the pre-weaning period

New technologies for DNA analysis – a review of the READNA Project

International audienceThe REvolutionary Approaches and Devices for Nucleic Acid analysis (READNA) project received 12 million s funding under the European Union Framework Programme 7 from 1st June 2008 to 30th November 2012. The 19 project partners from both academia and industry from in total 7 countries had a project budget of 16 Ms with which they have discovered, created and developed a huge body of insights into nucleic acid analysis. Results have been presented widely in publications and in innumerous public presentations. Results have been moved to spin-offs such as the Olink enrichment kits (now sold by Agilent as Haloplex) and are findingtheir way to the market, such as the Oxford Nanopore MinIon sequencer that was first released to early-access user sites in 2014

Euclid: Early Release Observations -- Deep anatomy of nearby galaxies

International audienceEuclid is poised to make significant advances in the study of nearby galaxies in the local Universe. Here we present a first look at 6 galaxies observed for the Nearby Galaxy Showcase as part of the Euclid Early Release Observations acquired between August and November, 2023. These targets, 3 dwarf galaxies (HolmbergII, IC10, NGC6822) and 3 spirals (IC342, NGC2403, NGC6744), range in distance from about 0.5 Mpc to 8.8 Mpc. Our assessment of the surface brightness depths in the stacked Euclid images confirms previous estimates in 100 arcsec^2 regions of 1sigma=30.5 mag/arcsec^2 for VIS, but slightly deeper than previous estimates for NISP with 1sigma=29.2-29.4 mag/arcsec^2. By combining Euclid HE, YE, and IE into RGB images, we illustrate the large field-of-view covered by a single Reference Observing Sequence, together with exquisite detail on parsec scales in these nearby galaxies. Radial surface brightness and color profiles demonstrate galaxy colors in agreement with stellar population synthesis models. Standard stellar photometry selection techniques find approximately 1.3 million stars across the 6 galaxy fields. Euclid's resolved stellar photometry allows us to constrain the star-formation histories of these galaxies, by disentangling the distributions of young stars, as well as asymptotic giant branch and red giant branch stellar populations. We finally examine 2 galaxies individually for surrounding satellite systems. Our analysis of the ensemble of dwarf satellites around NGC6744 reveals a new galaxy, EDwC1, a nucleated dwarf spheroidal at the end of a spiral arm. Our new census of the globular clusters around NGC2403 yields 9 new star-cluster candidates, 8 of which with colors indicative of evolved stellar populations. In summary, our investigation of the 6 Showcase galaxies demonstrates that Euclid is a powerful probe of the anatomy of nearby galaxies [abridged]

Euclid: Early Release Observations -- Programme overview and pipeline for compact- and diffuse-emission photometry

International audienceThe Euclid ERO showcase Euclid's capabilities in advance of its main mission, targeting 17 astronomical objects, from galaxy clusters, nearby galaxies, globular clusters, to star-forming regions. A total of 24 hours observing time was allocated in the early months of operation, engaging the scientific community through an early public data release. We describe the development of the ERO pipeline to create visually compelling images while simultaneously meeting the scientific demands within months of launch, leveraging a pragmatic, data-driven development strategy. The pipeline's key requirements are to preserve the image quality and to provide flux calibration and photometry for compact and extended sources. The pipeline's five pillars are: removal of instrumental signatures; astrometric calibration; photometric calibration; image stacking; and the production of science-ready catalogues for both the VIS and NISP instruments. We report a PSF with a full width at half maximum of 0.16" in the optical and 0.49" in the three NIR bands. Our VIS mean absolute flux calibration is accurate to about 1%, and 10% for NISP due to a limited calibration set; both instruments have considerable colour terms. The median depth is 25.3 and 23.2 AB mag with a SNR of 10 for galaxies, and 27.1 and 24.5 AB mag at an SNR of 5 for point sources for VIS and NISP, respectively. Euclid's ability to observe diffuse emission is exceptional due to its extended PSF nearly matching a pure diffraction halo, the best ever achieved by a wide-field, high-resolution imaging telescope. Euclid offers unparalleled capabilities for exploring the LSB Universe across all scales, also opening a new observational window in the NIR. Median surface-brightness levels of 29.9 and 28.3 AB mag per square arcsec are achieved for VIS and NISP, respectively, for detecting a 10 arcsec x 10 arcsec extended feature at the 1 sigma level