298 research outputs found

    Prognosis and clinical features of adult diagnosis CF

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    Peatland hydrology and carbon release: why small-scale process matters

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    Peatlands cover over 400 million hectares of the Earth's surface and store between one-third and one-half of the world's soil carbon pool. The long-term ability of peatlands to absorb carbon dioxide from the atmosphere means that they play a major role in moderating global climate. Peatlands can also either attenuate or accentuate flooding. Changing climate or management can alter peatland hydrological processes and pathways for water movement across and below the peat surface. It is the movement of water in peats that drives carbon storage and flux. These small-scale processes can have global impacts through exacerbated terrestrial carbon release. This paper will describe advances in understanding environmental processes operating in peatlands. Recent (and future) advances in high-resolution topographic data collection and hydrological modelling provide an insight into the spatial impacts of land management and climate change in peatlands. Nevertheless, there are still some major challenges for future research. These include the problem that impacts of disturbance in peat can be irreversible, at least on human time-scales. This has implications for the perceived success and understanding of peatland restoration strategies. In some circumstances, peatland restoration may lead to exacerbated carbon loss. This will also be important if we decide to start to create peatlands in order to counter the threat from enhanced atmospheric carbon

    Mechanically induced current and quantum evaporation from Luttinger liquids

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    We investigate transport through a tunnelling junction between an uncorrelated metallic lead and a Luttinger liquid when the latter is subjected to a time dependent perturbation. The tunnelling current as well as the electron energy distribution function are found to be strongly affected by the perturbation due to generation of harmonics in the density oscillations. Using a semiconducting lead instead of a metallic one results in electrons being injected into the lead even without applied voltage. Some applications to carbon nanotubes are discussed.Comment: 7 pages, 2 figures (eps files

    Pumping current of a Luttinger liquid with finite length

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    We study transport properties in a Tomonaga-Luttinger liquid in the presence of two time-dependent point like weak impurities, taking into account finite-length effects. By employing analytical methods and performing a perturbation theory, we compute the backscattering pumping current (I_bs) in different regimes which can be established in relation to the oscillatory frequency of the impurities and to the frequency related to the length and the renormalized velocity (by the electron-electron interactions) of the charge density modes. We investigate the role played by the spatial position of the impurity potentials. We also show how the previous infinite length results for I_bs are modified by the finite size of the system.Comment: 9 pages, 7 figure

    The K-turn motif in riboswitches and other RNA species

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    AbstractThe kink turn is a widespread structure motif that introduces a tight bend into the axis of duplex RNA. This generally functions to mediate tertiary interactions, and to serve as a specific protein binding site. K-turns or closely related structures are found in at least seven different riboswitch structures, where they function as key architectural elements that help generate the ligand binding pocket. This article is part of a Special Issue entitled: Riboswitches

    Single-molecule observation of the induction of k-turn RNA structure on binding L7Ae protein

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    AbstractThe k-turn is a commonly occurring structural motif that introduces a tight kink into duplex RNA. In free solution, it can exist in an extended form, or by folding into the kinked structure. Binding of proteins including the L7Ae family can induce the formation of the kinked geometry, raising the question of whether this occurs by passive selection of the kinked structure, or a more active process in which the protein manipulates the RNA structure. We have devised a single-molecule experiment whereby immobilized L7Ae protein binds Cy3-Cy5-labeled RNA from free solution. We find that all bound RNA is in the kinked geometry, with no evidence for transitions to an extended form at the millisecond timescale of the camera. Furthermore, real-time binding experiments provide no evidence for a more extended intermediate even at the earliest times, at a time resolution of 16 ms. The data support a passive conformational selection model by which the protein selects a fraction of RNA that is already in the kinked conformation, thereby drawing the equilibrium into this form

    The Kink Turn, a Key Architectural Element in RNA Structure

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    AbstractKink turns (k-turns) are widespread structural elements that introduce an axial bend into duplex RNA with an included angle of 50°. These mediate key tertiary interactions and bind specific proteins including members of the L7Ae family. The standard k-turn comprises a three-nucleotide bulge followed by G·A and A·G pairs. The RNA kinks by an association of the two minor grooves, stabilized by the formation of a number of key cross-strand hydrogen bonds mostly involving the adenine bases of the G·A and A·G pairs. The k-turns may be divided into two conformational classes, depending on the receptor for one of these hydrogen bonds. k-turns become folded by one of three different processes. Some, but not all, k-turns become folded in the presence of metal ions. Whether or not a given k-turn is folded under these conditions is determined by its sequence. We present a set of rules for the prediction of folding properties and the structure adopted on local sequence

    Flight Development for Cryogenic Fluid Management in Support of Exploration Missions

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    This paper describes the results of the "Experimentation for the Maturation of Deep Space Cryogenic Refueling Technology" study. The purposes of this study were to identify cryogenic fluids management technologies requiring low gravity flight experiments to bring to technology readiness level (TRL) 5-6; to study many possible flight experiment options; and to develop near-term low-cost flight experiment concepts to mature core technologies of refueling. A total of twenty-five white papers were prepared in the course of this study. Each white paper is briefly summarized and relevant references cited. A total of 90 references are cited

    Measurement of the Charged Multiplicities in b, c and Light Quark Events from Z0 Decays

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    Average charged multiplicities have been measured separately in bb, cc and light quark (u,d,su,d,s) events from Z0Z^0 decays measured in the SLD experiment. Impact parameters of charged tracks were used to select enriched samples of bb and light quark events, and reconstructed charmed mesons were used to select cc quark events. We measured the charged multiplicities: nˉuds=20.21±0.10(stat.)±0.22(syst.)\bar{n}_{uds} = 20.21 \pm 0.10 (\rm{stat.})\pm 0.22(\rm{syst.}), nˉc=21.28±0.46(stat.)0.36+0.41(syst.)\bar{n}_{c} = 21.28 \pm 0.46(\rm{stat.}) ^{+0.41}_{-0.36}(\rm{syst.}) nˉb=23.14±0.10(stat.)0.37+0.38(syst.)\bar{n}_{b} = 23.14 \pm 0.10(\rm{stat.}) ^{+0.38}_{-0.37}(\rm{syst.}), from which we derived the differences between the total average charged multiplicities of cc or bb quark events and light quark events: Δnˉc=1.07±0.47(stat.)0.30+0.36(syst.)\Delta \bar{n}_c = 1.07 \pm 0.47(\rm{stat.})^{+0.36}_{-0.30}(\rm{syst.}) and Δnˉb=2.93±0.14(stat.)0.29+0.30(syst.)\Delta \bar{n}_b = 2.93 \pm 0.14(\rm{stat.})^{+0.30}_{-0.29}(\rm{syst.}). We compared these measurements with those at lower center-of-mass energies and with perturbative QCD predictions. These combined results are in agreement with the QCD expectations and disfavor the hypothesis of flavor-independent fragmentation.Comment: 19 pages LaTex, 4 EPS figures, to appear in Physics Letters

    Surface state atoms and their contribution to the surface tension of quantum liquids

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    We investigate the new type of excitations on the surface of liquid helium. These excitations, called surfons, appear because helium atoms have discrete energy level at the liquid surface, being attracted to the surface by the van der Waals force and repulsed at a hard-core interatomic distance. The concentration of the surfons increases with temperature. The surfons propagate along the surface and form a two-dimensional gas. Basing on the simple model of the surfon microscopic structure, we estimate the surfon activation energy and effective mass for both helium isotopes. We also calculate the contribution of the surfons to the temperature dependence of the surface tension. This contribution explains the great and long-standing discrepancy between theory and experiment on this temperature dependence in both helium isotopes. The achieved agreement between our theory and experiment is extremely high. The comparison with experiment allows to extract the surfon activation energy and effective mass. The values of these surfon microscopic parameters are in a reasonable agreement with the calculated from the proposed simple model of surfon structure.Comment: 10 pages, 6 figure
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