17 research outputs found
Measurement of charm production in neutrino charged-current interactions
The nuclear emulsion target of the CHORUS detector was exposed to the
wide-band neutrino beam of the CERN SPS of 27 GeV average neutrino energy from
1994 to 1997. In total about 100000 charged-current neutrino interactions with
at least one identified muon were located in the emulsion target and fully
reconstructed, using newly developed automated scanning systems. Charmed
particles were searched for by a program recognizing particle decays. The
observation of the decay in nuclear emulsion makes it possible to select a
sample with very low background and minimal kinematical bias. 2013
charged-current interactions with a charmed hadron candidate in the final state
were selected and confirmed through visual inspection. The charm production
rate induced by neutrinos relative to the charged-current cross-section is
measured to be sigma(nu_mu N -> mu- C X)/sigma(CC) = (5.75 +-0.32 stat +-0.30
syst)%. The charm production cross-section as a function of the neutrino energy
is also obtained. The results are in good agreement with previous measurements.
The charm-quark hadronization produces the following charmed hadrons with
relative fractions (in %): f_Dzero = 43.7+-4.5, f_Lambda_c^plus = 19.2+-4.2,
f_Dplus = 25.3+-4.2, and f_D_splus = 11.8+-4.7.Comment: 16 pages, 5 figure
Retroperitoneal fibrosis: a case report
Retroperitoneal fibrosis is characterized by development of extensive fibrosis, leading to entrapment and obstruction of retroperitoneal structures, notably the ureters. In most cases, the etiology is unknown. It is occasionally associated with autoimmune diseases. Response to corticosteroids and immunosuppressive therapy suggest it is probably immunologically mediated. The symptoms and signs associated with retroperitoneal fibrosis are non-specific, and diagnosis requires a high degree of suspicion. We should always have in mind retroperitoneal fibrosis in differential diagnosis of hydronephrosis
Performances of a resistive Micromegas module for the Time Projection Chambers of the T2K Near Detector upgrade
International audienceAn upgrade of the Near Detector of the T2K long baseline neutrino oscillation experiment, ND280, has been proposed. This upgrade will include two new Time Projection Chambers, each equipped with 16 resistive Micromegas modules for gas amplification. A first prototype of resistive Micromegas has been designed, built, installed in the HARP field cage, and exposed to a beam of charged particles at CERN. The data have been used to characterize the performances of the resistive Micromegas module. A spatial resolution of 300 μm and a deposited energy resolution of 9% were observed for horizontal electrons crossing the TPCs at 30 cm from the anode. Such performances fully satisfy the requirements for the upgrade of the ND280 TPC
Genotypic and phenotypic spectrum of infantile liver failure due to pathogenic TRMU variants.
Purpose: The study aimed to define the genotypic and phenotypic spectrum of reversible acute liver failure (ALF) of infancy resulting from biallelic pathogenic TRMU variants and to determine the role of cysteine supplementation in its treatment. Methods: Individuals with biallelic (likely) pathogenic variants in TRMU were studied through an international retrospective collection of de-identified patient data. Results: In 62 individuals, including 30 previously unreported cases, we described 48 (likely) pathogenic TRMU variants, of which, 18 were novel. Of these 62 individuals, 42 were alive at a median age of 6.8 (0.6-22) years after a median follow up of 3.6 (0.1-22) years. The most frequent finding, occurring in all but 2 individuals, was liver involvement. ALF occurred only in the first year of life and was reported in 43 of 62 individuals, 11 of whom received liver transplantation. Loss-of-function TRMU variants were associated with poor survival. Supplementation with at least 1 cysteine source, typically N-acetylcysteine, improved survival significantly. Neurodevelopmental delay was observed in 11 individuals and persisted in 4 of the survivors, but we were unable to determine whether this was a primary or a secondary consequence of TRMU deficiency. Conclusion: In most patients, TRMU-associated ALF is a transient, reversible disease and cysteine supplementation improved survival