Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

PCR MÚLTIPLE ANIDADA PARA DETECCIÓN DE FITOPLASMAS Y RICKETTSIA ASOCIADOS CON LOS SÍNTOMAS DEL COGOLLO ARREPOLLADO (BTS) EN PAPAYO

Recientemente, los grupos fitoplasmas 16SrI «Candidatus Phytoplasma asteris»,16SrII «Candidatus Phytoplasma aurantifolia» y rickettsia se asociaron a síntomas del cogollo arrepollado (BTS) del papayo en Cuba. El ADN de muestras de plantas de papayo positivas a fitoplasmas y rickettsia se empleó para optimizar y evaluar un ensayo de PCR múltiple anidada. Se usaron los iniciadores de PCR genéricos para fitoplamas R16mF2/R16mR1en la primera amplificación y en la segunda amplificación una mezcla PBTF1/PBTR1 (específicos para rickettsia) y R16F2n/BPVNr/ p86r (específicos para los grupos de fitoplasmas 16SrI y 16SrII). El ensayo de diagnóstico por PCR múltiple anidado permitió la detección simultánea de fitoplasmas y rickettsia en muestras de plantasde papayo de condiciones de campo

PCR MÚLTIPLE ANIDADA PARA DETECCIÓN DE FITOPLASMAS Y RICKETTSIA ASOCIADOS CON LOS SÍNTOMAS DEL COGOLLO ARREPOLLADO (BTS) EN PAPAYO

Recientemente, los grupos fitoplasmas 16SrI «Candidatus Phytoplasma asteris»,16SrII «Candidatus Phytoplasma aurantifolia» y rickettsia se asociaron a síntomas del cogollo arrepollado (BTS) del papayo en Cuba. El ADN de muestras de plantas de papayo positivas a fitoplasmas y rickettsia se empleó para optimizar y evaluar un ensayo de PCR múltiple anidada. Se usaron los iniciadores de PCR genéricos para fitoplamas R16mF2/R16mR1en la primera amplificación y en la segunda amplificación una mezcla PBTF1/PBTR1 (específicos para rickettsia) y R16F2n/BPVNr/ p86r (específicos para los grupos de fitoplasmas 16SrI y 16SrII). El ensayo de diagnóstico por PCR múltiple anidado permitió la detección simultánea de fitoplasmas y rickettsia en muestras de plantasde papayo de condiciones de campo

Redescription of the poorly known planktonic copepod Pontellopsis lubbockii (Giesbrecht, 1889) (Pontellidae) from the Eastern Tropical Pacific with a key to species

A system for imaging magnetic surfaces using a magnetoresistive sensor array is developed. The experimental setup is composed of a linear array of 12 sensors uniformly spaced, with sensitivity of 150 pT*Hz -1/2 at 1 Hz, and it is able to scan an area of (16 × 18) cm2 from a separation of 0.8 cm of the sources with a resolution of 0.3 cm. Moreover, the point spread function of the multi-sensor system is also studied, in order to characterize its transference function and to improve the quality in the restoration of images. Furthermore, the images are generated by mapping the response of the sensors due to the presence of phantoms constructed of iron oxide, which are magnetized by a pulse of 80 mT. The magnetized phantoms are linearly scanned through the sensor array and the remanent magnetic field is acquired and displayed in gray levels using a PC. The images of the magnetic sources are reconstructed using two-dimensional generalized parametric Wiener filtering. Our results exhibit a very good capability to determine the spatial distribution of magnetic field sources, which produce magnetic fields of low intensity. " 2014 AIP Publishing LLC.",,,,,,"10.1063/1.4884641",,,"http://hdl.handle.net/20.500.12104/44114","http://www.scopus.com/inward/record.url?eid=2-s2.0-84903834733&partnerID=40&md5=65f8edb2b8ef4cdb659ba2f843959b4

Reconstruction of magnetic source images using the Wiener filter and a multichannel magnetic imaging system

A system for imaging magnetic surfaces using a magnetoresistive sensor array is developed. The experimental setup is composed of a linear array of 12 sensors uniformly spaced, with sensitivity of 150 pT*Hz -1/2 at 1 Hz, and it is able to scan an area of (16 × 18) cm2 from a separation of 0.8 cm of the sources with a resolution of 0.3 cm. Moreover, the point spread function of the multi-sensor system is also studied, in order to characterize its transference function and to improve the quality in the restoration of images. Furthermore, the images are generated by mapping the response of the sensors due to the presence of phantoms constructed of iron oxide, which are magnetized by a pulse of 80 mT. The magnetized phantoms are linearly scanned through the sensor array and the remanent magnetic field is acquired and displayed in gray levels using a PC. The images of the magnetic sources are reconstructed using two-dimensional generalized parametric Wiener filtering. Our results exhibit a very good capability to determine the spatial distribution of magnetic field sources, which produce magnetic fields of low intensity. © 2014 AIP Publishing LLC