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Monitoring the chemistry of self-healing by vibrational spectroscopy - Current state and perspectives
Self-healing materials are designed to heal damage caused by, for example, mechanical stress or aging such that the original functionality of the material is at least partially restored. Thus, self-healing materials hold great promise for prolonging the lifetime of machines, particularly those in remote locations, as well as in increasing the reliability and safety associated with functional materials in, for example, aeronautics applications. Recent material science applications of self-healing have led to an increased interest in the field and, consequently, the spectroscopic characterization of a wide range of self-healing materials with respect to their mechanical properties such as stress and strain resistance and elasticity was in the focus. However, the characterization of the chemical mechanisms underlying various self-healing processes locally within the damaged region of materials still presents a major challenge. This requires experimental techniques that work non-destructively in situ and are capable of revealing the chemical composition of a sample with sufficient spatial and temporal resolution without disturbing the healing process. Along these lines, vibrational spectroscopy and, in particular Raman spectroscopy, holds great promise, largely due to the high spatial resolution in the order of several hundreds of nanometers that can be obtained. This article aims to summarize the state of the art and prospective of Raman spectroscopy to contribute significant insights to the research on self-healing materials - in particular focusing on polymer and biopolymer materials
Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine : A Prospective Study of Phase 3 Clinical Trial Participants
Funding Information: This work was funded by TauRx Therapeutics Ltd., Singapore.Peer reviewedPublisher PD
HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine
Funding: This study was sponsored by WisTa Laboratories Ltd., Singapore. (grant PAR1577).Peer reviewedPublisher PD
Identification and mitigation of a vibrational telescope systematic with application to spitzer
We observed Proxima Centauri with the Spitzer Space Telescope Infrared Array Camera five times in 2016 and 2017 to search for transits of Proxima Centauri b. Following standard analysis procedures, we found three asymmetric, transit-like events that are now understood to be vibrational systematics. This systematic is correlated with the width of the point-response function (PRF), which we measure with rotated and nonrotated-Gaussian fits with respect to the detector array. We show that the systematic can be removed with a novel application of an adaptive elliptical-aperture photometry technique, and compare the performance of this technique with fixed and variable circular-aperture photometry, using both BiLinearly Interpolated Subpixel Sensitivity (BLISS) maps and nonbinned Pixel-Level Decorrelation (PLD). With BLISS maps, elliptical photometry results in a lower standard deviation of normalized residuals, and reduced or similar correlated noise when compared to circular apertures. PLD prefers variable, circular apertures, but generally results in more correlated noise than BLISS. This vibrational effect is likely present in other telescopes and Spitzer observations, where correction could improve results. Our elliptical apertures can be applied to any photometry observations, and may be even more effective when applied to more circular PRFs than Spitzer's.The authors acknowledge support from the following: CATA-Basal/Chile PB06 Conicyt and Fondecyt/Chile project #1161218 (J.S.J.). Spanish MINECO programs AYA2016-79245-C03-03-P, ESP2017-87676-C05-02-R (E.R.), ESP2016-80435-C2-2-R (E.P.) and through the “Centre of Excellence Severo Ochoa” award SEV-2017-0709 (P.J.A.,C.R.-L., E.R.). STFC Consolidated Grant ST/P000592/1 (G.A.E.). NASA Planetary Atmospheres Program grant
NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G (R.C., J.H., K.M., M.H.). Spanish Ministry of Science, Innovation and Universities and the Fondo
Europeo de Desarrollo Regional (FEDER) through grant ESP2016-80435-C2-1-R and PGC2018-098153-B-C33 (I.R.)
Evidence of Final-State Suppression of High-p_T Hadrons in Au + Au Collisions Using d + Au Measurements at RHIC
Transverse momentum spectra of charged hadrons with 6 GeV/c have
been measured near mid-rapidity (0.2 1.4) by the PHOBOS experiment
at RHIC in Au + Au and d + Au collisions at . The spectra for different collision centralities are compared to collisions at the same energy. The resulting nuclear modification
factor for central Au + Au collisions shows evidence of strong suppression of
charged hadrons in the high- region ( GeV/c). In contrast, the d +
Au nuclear modification factor exhibits no suppression of the high-
yields. These measurements suggest a large energy loss of the high-
particles in the highly interacting medium created in the central Au + Au
collisions. The lack of suppression in d + Au collisions suggests that it is
unlikely that initial state effects can explain the suppression in the central
Au + Au collisions.Comment: 3 pages, 4 figures, International Europhysics Conference on High
Energy Physics EPS (July 17th-23rd 2003) in Aachen, German
PATRIOT: A phase I study to assess the tolerability, safety and biological effects of a specific ataxia telangiectasia and Rad3-related (ATR) inhibitor (AZD6738) as a single agent and in combination with palliative radiation therapy in patients with solid tumours.
PATRIOT is a phase I study of the ATR inhibitor, AZD6738, as monotherapy, and in combination with palliative radiotherapy. Here, we describe the protocol for this study, which opened in 2014 and is currently recruiting and comprises dose escalation of both drug and radiotherapy, and expansion cohorts
Scaling ozone responses of forest trees to the ecosystem level in a changing climate
Many uncertainties remain regarding how climate change will alter the structure and function of forest ecosystems. At the Aspen FACE experiment in northern Wisconsin, we are attempting to understand how an aspen/birch/maple forest ecosystem responds to long-term exposure to elevated carbon dioxide (CO 2 ) and ozone (O 3 ), alone and in combination, from establishment onward. We examine how O 3 affects the flow of carbon through the ecosystem from the leaf level through to the roots and into the soil micro-organisms in present and future atmospheric CO 2 conditions. We provide evidence of adverse effects of O 3 , with or without co-occurring elevated CO 2 , that cascade through the entire ecosystem impacting complex trophic interactions and food webs on all three species in the study: trembling aspen ( Populus tremuloides Michx . ), paper birch ( Betula papyrifera Marsh), and sugar maple ( Acer saccharum Marsh). Interestingly, the negative effect of O 3 on the growth of sugar maple did not become evident until 3 years into the study. The negative effect of O 3 effect was most noticeable on paper birch trees growing under elevated CO 2 . Our results demonstrate the importance of long-term studies to detect subtle effects of atmospheric change and of the need for studies of interacting stresses whose responses could not be predicted by studies of single factors. In biologically complex forest ecosystems, effects at one scale can be very different from those at another scale. For scaling purposes, then, linking process with canopy level models is essential if O 3 impacts are to be accurately predicted. Finally, we describe how outputs from our long-term multispecies Aspen FACE experiment are being used to develop simple, coupled models to estimate productivity gain/loss from changing O 3 .Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72464/1/j.1365-3040.2005.01362.x.pd
Measurement of the p-pbar -> Wgamma + X cross section at sqrt(s) = 1.96 TeV and WWgamma anomalous coupling limits
The WWgamma triple gauge boson coupling parameters are studied using p-pbar
-> l nu gamma + X (l = e,mu) events at sqrt(s) = 1.96 TeV. The data were
collected with the DO detector from an integrated luminosity of 162 pb^{-1}
delivered by the Fermilab Tevatron Collider. The cross section times branching
fraction for p-pbar -> W(gamma) + X -> l nu gamma + X with E_T^{gamma} > 8 GeV
and Delta R_{l gamma} > 0.7 is 14.8 +/- 1.6 (stat) +/- 1.0 (syst) +/- 1.0 (lum)
pb. The one-dimensional 95% confidence level limits on anomalous couplings are
-0.88 < Delta kappa_{gamma} < 0.96 and -0.20 < lambda_{gamma} < 0.20.Comment: Submitted to Phys. Rev. D Rapid Communication
Measurement of the ttbar Production Cross Section in ppbar Collisions at sqrt{s} = 1.96 TeV using Kinematic Characteristics of Lepton + Jets Events
We present a measurement of the top quark pair ttbar production cross section
in ppbar collisions at a center-of-mass energy of 1.96 TeV using 230 pb**{-1}
of data collected by the DO detector at the Fermilab Tevatron Collider. We
select events with one charged lepton (electron or muon), large missing
transverse energy, and at least four jets, and extract the ttbar content of the
sample based on the kinematic characteristics of the events. For a top quark
mass of 175 GeV, we measure sigma(ttbar) = 6.7 {+1.4-1.3} (stat) {+1.6- 1.1}
(syst) +/-0.4 (lumi) pb, in good agreement with the standard model prediction.Comment: submitted to Phys.Rev.Let
Measurement of the ttbar Production Cross Section in ppbar Collisions at sqrt(s)=1.96 TeV using Lepton + Jets Events with Lifetime b-tagging
We present a measurement of the top quark pair () production cross
section () in collisions at TeV
using 230 pb of data collected by the D0 experiment at the Fermilab
Tevatron Collider. We select events with one charged lepton (electron or muon),
missing transverse energy, and jets in the final state. We employ
lifetime-based b-jet identification techniques to further enhance the
purity of the selected sample. For a top quark mass of 175 GeV, we
measure pb, in
agreement with the standard model expectation.Comment: 7 pages, 2 figures, 3 tables Submitted to Phys.Rev.Let
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