Modified Gravity on the Brane and Dark Energy

We analyze the dynamics of an AdS5 braneworld with matter fields when gravity is allowed to deviate from the Einstein form on the brane. We consider exact 5-dimensional warped solutions which are associated with conformal bulk fields of weight -4 and describe on the brane the following three dynamics: those of inhomogeneous dust, of generalized dark radiation, and of homogeneous polytropic dark energy. We show that, with modified gravity on the brane, the existence of such dynamical geometries requires the presence of non-conformal matter fields confined to the brane.Comment: Revised version published in Gen. Rel. Grav. Typos corrected, updated reference and some remarks added for clarity. 11 pages, latex, no figure

Assessment of disease progression in dysferlinopathy: A 1-year cohort study

ObjectiveTo assess the ability of functional measures to detect disease progression in dysferlinopathy over 6 months and 1 year.MethodsOne hundred ninety-three patients with dysferlinopathy were recruited to the Jain Foundation's International Clinical Outcome Study for Dysferlinopathy. Baseline, 6-month, and 1-year assessments included adapted North Star Ambulatory Assessment (a-NSAA), Motor Function Measure (MFM-20), timed function tests, 6-minute walk test (6MWT), Brooke scale, Jebsen test, manual muscle testing, and hand-held dynamometry. Patients also completed the ACTIVLIM questionnaire. Change in each measure over 6 months and 1 year was calculated and compared between disease severity (ambulant [mild, moderate, or severe based on a-NSAA score] or nonambulant [unable to complete a 10-meter walk]) and clinical diagnosis.ResultsThe functional a-NSAA test was the most sensitive to deterioration for ambulant patients overall. The a-NSAA score was the most sensitive test in the mild and moderate groups, while the 6MWT was most sensitive in the severe group. The 10-meter walk test was the only test showing significant change across all ambulant severity groups. In nonambulant patients, the MFM domain 3, wrist flexion strength, and pinch grip were most sensitive. Progression rates did not differ by clinical diagnosis. Power calculations determined that 46 moderately affected patients are required to determine clinical effectiveness for a hypothetical 1-year clinical trial based on the a-NSAA as a clinical endpoint.ConclusionCertain functional outcome measures can detect changes over 6 months and 1 year in dysferlinopathy and potentially be useful in monitoring progression in clinical trials.ClinicalTrials.gov identifier:NCT01676077

Assessing the relationship of patient reported outcome measures with functional status in dysferlinopathy: a Rasch analysis approach

Dysferlinopathy is a muscular dystrophy with a highly variable functional disease progression in which the relationship of function to some patient reported outcome measures (PROMs) has not been previously reported. This analysis aims to identify the suitability of PROMs and their association with motor performance.Two-hundred and four patients with dysferlinopathy were identified in the Jain Foundation's Clinical Outcome Study in Dysferlinopathy from 14 sites in 8 countries. All patients completed the following PROMs: Individualized Neuromuscular Quality of Life Questionnaire (INQoL), International Physical Activity Questionnaire (IPAQ), and activity limitations for patients with upper and/or lower limb impairments (ACTIVLIMs). In addition, nonambulant patients completed the Egen Klassifikation Scale (EK). Assessments were conducted annually at baseline, years 1, 2, 3, and 4. Data were also collected on the North Star Assessment for Limb Girdle Type Muscular Dystrophies (NSAD) and Performance of Upper Limb (PUL) at these time points from year 2. Data were analyzed using descriptive statistics and Rasch analysis was conducted on ACTIVLIM, EK, INQoL. For associations, graphs (NSAD with ACTIVLIM, IPAQ and INQoL and EK with PUL) were generated from generalized estimating equations (GEE). The ACTIVLIM appeared robust psychometrically and was strongly associated with the NSAD total score (Pseudo R(2) 0.68). The INQoL performed less well and was poorly associated with the NSAD total score (Pseudo R(2) 0.18). EK scores were strongly associated with PUL (Pseudo R(2) 0.69). IPAQ was poorly associated with NSAD scores (Pseudo R(2) 0.09). This study showed that several of the chosen PROMs demonstrated change over time and a good association with functional outcomes. An alternative quality of life measure and method of collecting data on physical activity may need to be selected for assessing dysferlinopathy

Measurements of the t(t)Overbar charge asymmetry using the dilepton decay channel in pp collisions at root s=7 TeV

The tt¯ charge asymmetry in proton-proton collisions at s√ = 7 TeV is measured using the dilepton decay channel (ee, e μ , or μμ ). The data correspond to a total integrated luminosity of 5.0 fb −1 , collected by the CMS experiment at the LHC. The tt and lepton charge asymmetries, defined as the differences in absolute values of the rapidities between the reconstructed top quarks and antiquarks and of the pseudorapidities between the positive and negative leptons, respectively, are measured to be A C = −0 . 010 ± 0 . 017 (stat . ) ± 0 . 008 (syst . ) and AlepC = 0 . 009 ± 0 . 010 (stat . ) ± 0 . 006 (syst . ). The lepton charge asymmetry is also measured as a function of the invariant mass, rapidity, and transverse momentum of the tt¯ system. All measurements are consistent with the expectations of the standard model

Aktivizem v etnomuzikologiji jugovzhodne Azije

Začenši s kratkim pregledom strategij in aktivnosti aplikativne etnomuzikologije se pričujoči prispevek osredotoča na razvoj socialno angažiranega pristopa k omogočanju mladih Malezijcev, da se lotijo dveh vprašanj: oživljanja tradicij in preseganja kulturnih pregrad v multietnični in multikulturni družbi, v kateri so nestrpnosti često prisotne.Beginning with a short overview of the strategies and activities in applied ethnomusicology in Southeast Asia, this paper focuses on the development of a socially engaged approach to empower young people in Malaysia to address two concerns: revitalizing traditions and bridging cultural barriers in a multiethnic and multireligious society where tensions often occur

Determinants of persistent organic pollutant (POP) concentrations in human breast milk of a cross-sectional sample of primiparous mothers in Belgium

Background Bio-accumulation of persistent organic pollutants (POPs) in the environment and in the food chain can lead to high pollutant concentrations in human fat-containing tissues and breast&nbsp;milk. Objectives We aimed to identify the maternal characteristics that determined POP concentrations in breast milk of primiparous mothers in&nbsp;Belgium. Methods Breast milk samples were obtained from a cross-sectional sample of 206 primiparous mothers in 2014. POP concentrations in breast milk samples were determined by GC-ECNI-MS and GC-EI-MS/MS depending on the analytes’ sensitivity. Associations between POP concentrations in breast milk and potential determinants were investigated using two-way contingency tables and multivariable generalized linear&nbsp;models. Results Fifteen of the 23 screened POPs were detected in the breast milk samples. Four organochlorine compounds (p,p′-DDT, p,p′-DDE, HCB and β-HCH) and two brominated flame retardant congeners (BDE-47, BDE-153) were detected at concentrations above the limit of quantification in &gt;50% of the breast milk samples. Maternal age and BMI were usually associated with higher POP concentrations. Rural residency and consumption of home-produced eggs, fatty fish and fish oil supplements were associated with higher concentrations of DDT and DDE. Consumption of fatty fish and being breastfed during childhood were associated with higher concentrations of HCB and β-HCH. Fish oil supplements and home-produced eggs were associated with higher concentrations of BDEs, but for BDE congeners exposure routes other than diet require further&nbsp;investigation. Conclusions Dietary and non-dietary determinants predict individual POP concentrations in breast&nbsp;milk.</p

Determinants of persistent organic pollutant (POP) concentrations in human breast milk of a cross-sectional sample of primiparous mothers in Belgium

Background: Bio-accumulation of persistent organic pollutants (POPs) in the environment and in the food&nbsp;chain can lead to high pollutant concentrations in human fat-containing tissues and breast&nbsp;milk. Objectives: We aimed to identify the maternal characteristics that determined POP concentrations in breast&nbsp;milk of primiparous mothers in&nbsp;Belgium. Methods: Breast milk samples were obtained from a cross-sectional sample of 206 primiparous mothers in&nbsp;2014. POP concentrations in breast milk samples were determined by GC-ECNI-MS and GC-EI-MS/MS depending&nbsp;on the analytes’ sensitivity. Associations between POP concentrations in breast milk and potential&nbsp;determinants were investigated using two-way contingency tables and multivariable generalized linear&nbsp;models. Results: Fifteen of the 23 screened POPs were detected in the breast milk samples. Four organochlorine&nbsp;compounds (p,p′-DDT, p,p′-DDE, HCB and β-HCH) and two brominated flame retardant congeners (BDE-47, BDE- 153) were detected at concentrations above the limit of quantification in&gt;50% of the breast milk&nbsp;samples. Maternal age and BMI were usually associated with higher POP concentrations. Rural residency and&nbsp;consumption of home-produced eggs, fatty fish and fish oil supplements were associated with higher&nbsp;concentrations of DDT and DDE. Consumption of fatty fish and being breastfed during childhood were associated with&nbsp;higher concentrations of HCB and β-HCH. Fish oil supplements and home-produced eggs were associated with&nbsp;higher concentrations of BDEs, but for BDE congeners exposure routes other than diet require further&nbsp;investigation. Conclusions: Dietary and non-dietary determinants predict individual POP concentrations in breast&nbsp;milk.</p