Beyond the Economic: The Freedoms, Capabilities, and Social Capital of Latin American Women Entrepreneurs in San Francisco

In light of the scholarly debate surrounding the goals and mixed effects of development programs, particularly in recent years in relation to microfinance, this study investigates the effects of economic development programs on Latin American women entrepreneurs in San Francisco’s Mission District. It demonstrates that microfinance, when combined with education, can provide important non-economic benefits that contribute to increased freedoms and capabilities for immigrant women entrepreneurs. Drawing on qualitative interviews with ten business owners, as well as a review of the existing literature surrounding development, immigration, and gender, this research argues that owning a business in the US can produce enhanced freedoms and capabilities for Latin American immigrant women, including changing identities and family dynamics and increased social opportunities like education and healthcare. This study also expands the notion of capital beyond the economic by considering how the shared cultural capital of the Latino community can contribute to a strong network of social capital among immigrant women entrepreneurs, which in turn helps to sustain their businesses and ensure their continued economic success. Several potential barriers to success that this group of immigrant women faces are the challenges of renegotiating gender norms upon transition to a new culture and joining the work force, as well as the obstacles and social stigmas associated with immigration status and citizenship rights. This study concludes that these barriers can prevent the enjoyment of other freedoms like political participation and that displacement of immigrants through gentrification also threatens economic success by devaluing established immigrant networks of social capital

Allen Linear (Interval) Temporal Logic --Translation to LTL and Monitor Synthesis--

The relationship between two well established formalisms for temporal reasoning is first investigated, namely between Allen's interval algebra (or Allen's temporal logic, abbreviated \ATL) and linear temporal logic (\LTL). A discrete variant of \ATL is defined, called Allen linear temporal logic (\ALTL), whose models are \omega-sequences of timepoints, like in \LTL. It is shown that any \ALTL formula can be linearly translated into an equivalent \LTL formula, thus enabling the use of \LTL techniques and tools when requirements are expressed in \ALTL. %This translation also implies the NP-completeness of \ATL satisfiability. Then the monitoring problem for \ALTL is discussed, showing that it is NP-complete despite the fact that the similar problem for \LTL is EXPSPACE-complete. An effective monitoring algorithm for \ALTL is given, which has been implemented and experimented with in the context of planning applications

Modulation of drug sensitivity in yeast cells by the ATP‐binding domain of human DNA topoisomerase IIα

Epipodophyllotoxins are effective antitumour drugs that trap eukaryotic DNA topoisomerase II in a covalent complex with DNA. Based on DNA cleavage assays, the mode of interaction of these drugs was proposed to involve amino acid residues of the catalytic site. An in vitro binding study, however, revealed two potential binding sites for etoposide within human DNA topoisomerase IIα (htopoIIα), one in the catalytic core of the enzyme and one in the ATP‐binding N‐terminal domain. Here we have tested how N‐terminal mutations that reduce the affinity of the site for etoposide or ATP affect the sensitivity of yeast cells to etoposide. Surprisingly, when introduced into full‐length enzymes, mutations that lower the drug binding capacity of the N‐terminal domain in vitro render yeast more sensitive to epipodophyllotoxins. Consistently, when the htopoIIα N‐terminal domain alone is overexpressed in the presence of yeast topoII, cells become more resistant to etoposide. Point mutations that weaken etoposide binding eliminate this resistance phenotype. We argue that the N‐terminal ATP‐binding pocket competes with the active site of the holoenzyme for binding etoposide both in cis and in trans with different outcomes, suggesting that each topoisomerase II monomer has two non‐equivalent drug‐binding site

Le concept de maladies virales émergentes : quel risque de zoonose pour La Réunion ?

A La Réunion, le risque d'émergence de maladies virales est constitué par plusieurs zoonoses virales qu'il convient de surveiller: infections à virus Sindbis, virus de l'encéphalite japonaise, virus Wesselsbron, virus Nipah, virus Zika, virus West Nile, virus de la fièvre de la vallée du Rift. La lutte contre ces maladies virales émergentes (MVE) passe par une détection précoce des cas et donc un système de surveillance doté d'un véritable réseau d'information, d'alerte et de prévention international. (Résumé d'auteur

Insulin-like growth factor 1 receptors in human breast tumour: localisation and quantification by histo-autoradiographic analysis.

To assess the precise role of IGF1 in benign and malignant breast diseases, we analysed the tissular localisation, characterised, and quantified specific insulin-like growth factor 1 (IGF1) binding sites in these heterogenous tissues, using histo-autoradiographic analysis (HAA). The 125I-IGF1 binding was performed on frozen tissue sections and analysed using 3H Ultrofilm autoradiography coupled to computerised image analysis. Competitive binding experiments using unlabelled IGF1, IGF2 and insulin showed that the tissues exhibited typical type I IGF binding sites. This specificity was confirmed by the use of alpha IR-3 monoclonal antibody, as inhibitor of 125I-IGF1 binding. IGF1 binding sites were detected in 18 human primary breast cancers, 12 benign breast tumours and two normal breast tissues. Using HAA we found that the human breast carcinomas studied exhibit a specific and high binding capacity for 125I-IGF1 exclusively localised on the proliferative epithelial component. The 125I-IGF1 binding activity of benign breast tumours or normal breast tissue was significantly lower than in cancerous tissues. There was a significant correlation between IGF1-R concentrations detected with HAA and those detected with a classical biochemical method. Moreover, HAA could be useful in further detailing whether a tumour is IGF1-R positive or negative HAA appears to be a useful method for the detection of growth factor receptors, specially in small biopsy specimens

Invisible Z-Boson Decays at e+e- Colliders

The measurement of the invisible Z-boson decay width at e+e- colliders can be done "indirectly", by subtracting the Z-boson visible partial widths from the Z-boson total width, or "directly", from the process e+e- -> \gamma \nu \bar{\nu}. Both procedures are sensitive to different types of new physics and provide information about the couplings of the neutrinos to the Z-boson. At present, measurements at LEP and CHARM II are capable of constraining the left-handed Z\nu\nu-coupling, 0.45 <~ g_L <~ 0.5, while the right-handed one is only mildly bounded, |g_R| <= 0.2. We show that measurements at a future e+e- linear collider at different center-of-mass energies, \sqrt{s} = MZ and \sqrt{s}s ~ 170 GeV, would translate into a markedly more precise measurement of the Z\nu\nu-couplings. A statistically significant deviation from Standard Model predictions will point toward different new physics mechanisms, depending on whether the discrepancy appears in the direct or the indirect measurement of the invisible Z-width. We discuss some scenarios which illustrate the ability of different invisible Z-boson decay measurements to constrain new physics beyond the Standard Model

Characterising Deadlines in Temporal Modal Defeasible Logic

We provide a conceptual analysis of several kinds of deadlines, represented in Temporal Modal Defeasible Logic. The paper presents a typology of deadlines, based on the following parameters: deontic operator, maintenance or achievement, presence or absence of sanctions, and persistence after the deadline. The deadline types are illustrated by a set of examples