The cosmic evolution of radio-AGN feedback to z=1

This paper presents the first measurement of the radio luminosity function of 'jet-mode' (radiatively-inefficient) radio-AGN out to z=1, in order to investigate the cosmic evolution of radio-AGN feedback. Eight radio source samples are combined to produce a catalogue of 211 radio-loud AGN with 0.5<z<1.0, which are spectroscopically classified into jet-mode and radiative-mode (radiatively-efficient) AGN classes. Comparing with large samples of local radio-AGN from the Sloan Digital Sky Survey, the cosmic evolution of the radio luminosity function of each radio-AGN class is independently derived. Radiative-mode radio-AGN show an order of magnitude increase in space density out to z~1 at all luminosities, consistent with these AGN being fuelled by cold gas. In contrast, the space density of jet-mode radio-AGN decreases with increasing redshift at low radio luminosities (L_1.4 < 1e24 W/Hz) but increases at higher radio luminosities. Simple models are developed to explain the observed evolution. In the best-fitting models, the characteristic space density of jet-mode AGN declines with redshift in accordance with the declining space density of massive quiescent galaxies, which fuel them via cooling of gas in their hot haloes. A time delay of 1.5-2 Gyr may be present between the quenching of star formation and the onset of jet-mode radio-AGN activity. The behaviour at higher radio luminosities can be explained either by an increasing characteristic luminosity of jet-mode radio-AGN activity with redshift (roughly as (1+z) cubed) or if the jet-mode radio-AGN population also includes some contribution of cold-gas-fuelled sources seen at a time when their accretion rate was low. Higher redshifts measurements would distinguish between these possibilities.Comment: Accepted for publication in MNRA

Reaching older people with PA delivered in football clubs: the reach, adoption and implementation characteristics of the Extra Time Programme.

Background Older adults (OA) represent a core priority group for physical activity and Public Health policy. As a result, significant interest is placed on how to optimise adherence to interventions promoting these approaches. Extra Time (ET) is an example of a national programme of physical activity interventions delivered in professional football clubs for OA aged 55+ years. This paper aims to examine the outcomes from ET, and unpick the processes by which these outcomes were achieved. Methods This paper represents a secondary analysis of data collected during the evaluation of ET. From the 985 OA reached by ET, n=486 adopted the programme and completed post-intervention surveys (typically 12 weeks). We also draw on interview data with 18 ET participants, and 7 staff who delivered the programme. Data were subject to thematic analysis to generate overarching and sub themes. Results Of the 486 participants, the majority 95%, (n= 462) were White British and 59.7% (n=290) were female. Most adopters (65.4%/n=318) had not participated in previous interventions in the host clubs. Social interaction was the most frequently reported benefit of participation (77.2%, n=375). While the reach of the club badge was important in letting people know about the programme, further work enhanced adoption and satisfaction. These factors included (i) listening to participants, (ii) delivering a flexible age-appropriate programme of diverse physical and social activities, (iii) offering activities which satisfy energy drives and needs for learning and (iv) extensive opportunities for social engagement. Conclusions Findings emerging from this study indicate that physical activity and health interventions delivered through professional football clubs can be effective for engaging OA

Development of a composite model derived from cardiopulmonary exercise tests to predict mortality risk in patients with mild-to-moderate heart failure

Objective: Cardiopulmonary exercise testing (CPET) is used to predict outcome in patients with mild-to-moderate heart failure (HF). Single CPET-derived variables are often used, but we wanted to see if a composite score achieved better predictive power. Methods: Retrospective analysis of patient records at the Department of Cardiology, Castle Hill Hospital, Kingston-upon-Hull. 387 patients [median (25th-75th percentile)] [age 65 (56-72) years; 79% males; LVEF 34 (31-37) %] were included. Patients underwent a symptomlimited, maximal CPET on a treadmill. During a median follow up of 8.6 ± 2.1 years in survivors, 107 patients died. Survival models were built and validated using a hybrid approach between the bootstrap and Cox regression. Nine CPET-derived variables were included. Z-score defined each variable's predictive strength. Model coefficients were converted to a risk score. Results: Four CPET-related variables were independent predictors of all-cause mortality in the survival model: the presence of exertional oscillatory ventilation (EOV), increasing slope of the relation between ventilation and carbon dioxide production (VE/VCO2 slope), decreasing oxygen uptake efficiency slope (OUES), and an increase in the lowest ventilatory equivalent for carbon dioxide (VEqCO2 nadir). Individual predictors of mortality ranged from 0.60 to 0.71 using Harrell’s C-statistic, but the optimal combination of EOV + VE/VCO2 slope + OUES + VEqCO2 nadir reached 0.75. The Hull CPET risk score had a significantly higher area under the curve (0.78) when compared to the Heart Failure Survival Score (AUC=0.70;

The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study

Context: There is concern whether soy phytoestrogens may affect thyroid function. If true, soy phytoestrogens may be expected to have a greater impact in subjects with subclinical hypothyroidism. Objective: The primary aim was to determine the effect of soy phytoestrogen supplementation on thyroid function, with a secondary aim of assessing the effects on cardiovascular risk indices in patients with subclinical hypothyroidism. Design and Setting: We conducted a randomized, double-blind, crossover study in a tertiary care setting. Participants: Sixty patients with subclinical hypothyroidism participated in the study. Intervention: Patients were randomly assigned to either low-dose phytoestrogen (30 g soy protein with 2 mg phytoestrogens, representative of a Western diet) or high-dose phytoestrogen (30 g soy protein with 16 mg phytoestrogens, representative of a vegetarian diet) supplementation for 8 wk, then crossed over after an 8-wk washout period. Main Outcome Measures: The primary outcome was progression to overt hypothyroidism, with secondary outcome measures of blood pressure, insulin resistance, lipids, and highly sensitive C-reactive protein (hsCRP). Results: Six female patients in the study progressed into overt hypothyroidism with a standardized rate ratio of 3.6 (95% confidence interval, 1.9, 6.2) after 16-mg phytoestrogen supplementation. Both systolic and diastolic blood pressure decreased with 16 mg phytoestrogens, whereas systolic pressure alone decreased with 2 mg phytoestrogens. Insulin resistance (homeostasis model assessment of insulin resistance, 3.5 ± 0.09 vs. 2.6 ± 0.08; P < 0.02) and hsCRP (4.9 ± 0.04 vs. 3.9 ± 0.03; P < 0.01) decreased with 16 mg phytoestrogens. Lipid profile remained unchanged. Conclusion: There is a 3-fold increased risk of developing overt hypothyroidism with dietary supplementation of 16 mg soy phytoestrogens with subclinical hypothyroidism. However, 16-mg soy phytoestrogen supplementation significantly reduces the insulin resistance, hsCRP, and blood pressure in these patients. Copyright © 2011 by The Endocrine Society

Experimental Study of an Inclined Jet-In-Cross-Flow Interacting with a Vortex Generator

An experiment is conducted on the effectiveness of a vortex generator (VG) in preventing lift-off of a jet-in-cross-flow (JICF), with film-cooling application in mind. The jet issues into the boundary layer at an angle of 20 to the free-stream. The effect of a triangular ramp-shaped VG is studied while varying its geometry and location. Detailed flow-field properties are documented for a specific case in which the height of the VG and the diameter of the orifice are comparable to the approach boundary layer thickness. This combination of VG and JICF produce a streamwise vortex pair with vorticity magnitude three times larger (and of opposite sense) than that found in the JICF alone. Such a VG appears to be most effective in keeping the jet attached to the wall. While most of the data are taken at a jet-to-freestream momentum flux ratio (J) of 2, limited surveys are done for varying J. The VG is found to have a significant effect even at the highest J (=11) covered in the experiment. Effect of parametric variation is studied mostly from surveys ten diameters downstream from the orifice. When the VG height is halved there is a lift-off of the jet. On the other hand, when the height is doubled, the jet core is dissipated due to larger turbulence intensities. Varying the location of the VG, over a distance of three diameters from the orifice, is found to have little impact. Rounding off the edges of the VG with increasing radius of curvature progressively diminishes the effect. However, a small radius of curvature may be quite tolerable in practice

XMM Follow-Up Observations of Three Swift BAT-Selected Active Galactic Nuclei

We present XMM-Newton observations of three AGN taken as part of a hunt to find very heavily obscured Compton-thick AGN. For obscuring columns greater than 10^25 cm^-2, AGN are only visible at energies below 10 keV via reflected/scattered radiation, characterized by a flat power-law. We therefore selected three objects (ESO 417-G006, IRAS 05218-1212, and MCG -01-05-047) from the Swift BAT hard X-ray survey catalog with Swift X-ray Telescope XRT 0.5-10 keV spectra with flat power-law indices as candidate Compton-thick sources for follow-up observations with the more sensitive instruments on XMM-Newton. The XMM spectra, however, rule out reflection-dominated models based on the weakness of the observed Fe K-alpha lines. Instead, the spectra are well-fit by a model of a power-law continuum obscured by a Compton-thin absorber, plus a soft excess. This result is consistent with previous follow-up observations of two other flat-spectrum BAT-detected AGN. Thus, out of the six AGN in the 22-month BAT catalog with apparently flat Swift XRT spectra, all five that have had follow-up observations are not likely Compton-thick. We also present new optical spectra of two of these objects, IRAS 05218-1212 and MCG -01-05-047. Interestingly, though both these AGN have similar X-ray spectra, their optical spectra are completely different, adding evidence against the simplest form of the geometric unified model of AGN. IRAS 05218-1212 appears in the optical as a Seyfert 1, despite the ~8.5x10^22 cm^-2 line-of-sight absorbing column indicated by its X-ray spectrum. MCG -01-05-047's optical spectrum shows no sign of AGN activity; it appears as a normal galaxy.Comment: 18 pages including 4 figures, accepted by Ap

MgII absorption systems with W_0 > 0.1 \AA for a radio selected sample of 77 QSOs and their associated magnetic fields at high redshifts

We present a catalogue of MgII absorption systems obtained from high resolution UVES/VLT data of 77 QSOs in the redshift range 0.6 < z < 2.0, and down to an equivalent width W_0 > 0.1 \AA. The statistical properties of our sample are found to be in agreement with those from previous work in the literature. However, we point out that the previously observed increase with redshift of dN/dz for weak absorbers, pertains exclusively to very weak absorbers with W_0 < 0.1 \AA. Instead, dN/dz for absorbers with W_0 in the range 0.1-0.3 \AA actually decreases with redshift, similarly to the case of strong absorbers. We then use this catalogue to extend our earlier analysis of the links between the Faraday Rotation Measure of the quasars and the presence of intervening MgII absorbing systems in their spectra. In contrast to the case with strong MgII absorption systems W_0 > 0.3 \AA, the weaker systems do not contribute significantly to the observed Rotation Measure of the background quasars. This is possibly due to the higher impact parameters of the weak systems compared to strong ones, suggesting that the high column density magnetized material that is responsible for the Faraday Rotation is located within about 50 kpc of the galaxies. Finally, we show that this result also rules out the possibility that some unexpected secondary correlation between the quasar redshift and its intrinsic Rotation Measure is responsible for the association of high Rotation Measure and strong intervening MgII absorption that we have presented elsewhere, since this would have produced an equal effect for the weak absorption line systems, which exhibit a very similar distribution of quasar redshifts.Comment: Accepted for publication in ApJ. 12 pages, 8 figure