A 24-h helpline for access to expert management advice for food allergy-related anaphylaxis in children: protocol for a pragmatic randomised controlled trial

OBJECTIVES: Anaphylaxis is an important, potentially life-threatening paediatric emergency. It is responsible for considerable morbidity and, in some cases, death. Poor outcomes may be associated with an inability to differentiate between milder and potentially more severe reactions and an associated reluctance to administer self-injectable adrenaline. This study aims to assess the effectiveness of a 24-h telephone access to specialist paediatric allergy expert advice in improving the quality of life of children and their families with potentially life-threatening food allergy (ie, anaphylaxis) compared with usual clinical care. METHODS AND ANALYSIS: Children aged less than 16 years with food allergy and who carry an adrenaline autoinjector will be recruited from the Paediatric Allergy Clinic at Cork University Hospital, Ireland and baseline disease-specific quality of life will be ascertained using the validated Food Allergy Quality of Life Questionnaire (FAQLQ). Participants will be randomised for a period of 6 months to the 24-h telephone specialist support line or usual care. The primary outcome measure of interest is a change in FAQLQ scores, which will be assessed at 0, 1 and 6 months postrandomisation. Analysis will be on an intention-to-treat basis using a 2×3 repeated measures within-between analysis of variance. Although lacking power, we will in addition assess the impact of the intervention on a range of relevant process and clinical endpoints. ETHICS AND DISSEMINATION: This trial protocol has been approved by the Clinical Research Ethics Committee of the Cork Teaching Hospitals. The findings will be presented at international scientific conferences and will be reported on in the peer-reviewed literature in early 2013

Infant formula feeding practices in a prospective population based study

Background: It is recommended that formula-fed infants are given standard whey-based infant formula throughout the first year of life, unless otherwise advised by healthcare professionals. To our knowledge it has not yet been explored if parents are using a whey-based infant formula throughout the first 12 months of life. Reasons for parental choice of formula are also unknown. Therefore, the objective of this paper was to describe parental administration of whey-based and non whey-based infant formula in the first year of life. Methods: Data collected as part of the Cork BASELINE Birth Cohort Study examined infant feeding practices at 2, 6 and 12 months of age. Descriptive analysis explored infant feeding practices and parental reasons for changing from a whey-based to a non whey-based infant formula. Multiple logistic regression investigated parental and infant characteristics associated with the use of whey-based infant formula. Results: In total, 62.4%, 40.4% and 12.8% parent(s) at 2, 6 and 12 months, respectively, gave their infant whey-based infant formula. No parental or infant characteristic was found to consistently influence the use of whey-based infant formula. The most common reason reported by parent(s) for changing their infant’s formula to a non whey-based formula was that they perceived their baby as being hungry. Conclusion: The majority of parent(s) commence their infants on whey-based formula, but most change to non whey-based formula before 12 months of age. Parental perception of infant satiety and not healthcare advice was the most common reason for changing from a whey-based to a non whey-based infant formula. Additional research is now required to investigate the effect of whey-based and non whey-based infant formula on infant growth

The Gaia-ESO Survey: N-body modelling of the Gamma Velorum cluster

The Gaia-ESO Survey has recently unveiled the complex kinematic signature of the Gamma Velorum cluster: this cluster is composed of two kinematically distinct populations (hereafter, population A and B), showing two different velocity dispersions and a relative ~2 km s^-1 radial velocity (RV) shift. In this paper, we propose that the two populations of the Gamma Velorum cluster originate from two different sub-clusters, born from the same parent molecular cloud. We investigate this possibility by means of direct-summation N-body simulations. Our scenario is able to reproduce not only the RV shift and the different velocity dispersions, but also the different centroid (~0.5 pc), the different spatial concentration and the different line-of-sight distance (~5 pc) of the two populations. The observed 1-2 Myr age difference between the two populations is also naturally explained by our scenario, in which the two sub-clusters formed in two slightly different star formation episodes. Our simulations suggest that population B is strongly supervirial, while population A is close to virial equilibrium. We discuss the implications of our models for the formation of young star clusters and OB associations in the Milky Way.Comment: 12 pages, 7 figures, 2 tables, Astronomy and Astrophysics, in pres

The Gaia-ESO Survey: Tracing interstellar extinction

Large spectroscopic surveys have enabled in the recent years the computation of three-dimensional interstellar extinction maps thanks to accurate stellar atmospheric parameters and line-of-sight distances. Such maps are complementary to 3D maps extracted from photometry, allowing a more thorough study of the dust properties. Our goal is to use the high-resolution spectroscopic survey Gaia-ESO in order to obtain with a good distance resolution the interstellar extinction and its dependency as a function of the environment and the Galactocentric position. We use the stellar atmospheric parameters of more than 5000 stars, obtained from the Gaia-ESO survey second internal data release, and combine them with optical (SDSS) and near-infrared (VISTA) photometry as well as different sets of theoretical stellar isochrones, in order to calculate line-of-sight extinction and distances. The extinction coefficients are then compared with the literature to discuss their dependancy on the stellar parameters and position in the Galaxy. Within the errors of our method, our work does not show that there is any dependence of the interstellar extinction coefficient on the atmospheric parameters of the stars. We do not find any evidence of the variation of E(J-H)/E(J-K) with the angle from the Galactic centre nor with Galactocentric distance. This suggests that we are dealing with a uniform extinction law in the SDSS ugriz bands and the near-IR JHKs bands. Therefore, extinction maps using mean colour-excesses and assuming a constant extinction coefficient can be used without introducing any systematic errors.Comment: 13 pages, 14 figures, 1 Appendix accepted for publication in Astronomy&Astrophysic

The Gaia-ESO Survey: a quiescent Milky Way with no significant dark/stellar accreted disc

According to our current cosmological model, galaxies like the Milky Way are expected to experience many mergers over their lifetimes. The most massive of the merging galaxies will be dragged towards the disc-plane, depositing stars and dark matter into an accreted disc structure. In this work, we utilize the chemo-dynamical template developed in Ruchti et al. to hunt for accreted stars. We apply the template to a sample of 4,675 stars in the third internal data release from the Gaia-ESO Spectroscopic Survey. We find a significant component of accreted halo stars, but find no evidence of an accreted disc component. This suggests that the Milky Way has had a rather quiescent merger history since its disc formed some 8-10 billion years ago and therefore possesses no significant dark matter disc.Comment: 15 pages, 11 figures, accepted for publication in MNRA

Characterizing the efficacy of methods to subtract terrestrial transient noise near gravitational wave events and the effects on parameter estimation

We investigate the impact of transient noise artifacts, or {\it glitches}, on gravitational wave inference, and the efficacy of data cleaning procedures in recovering unbiased source properties. Due to their time-frequency morphology, broadband glitches demonstrate moderate to significant biasing of posterior distributions away from true values. In contrast, narrowband glitches have negligible biasing effects owing to distinct signal and glitch morphologies. We inject simulated binary black hole signals into data containing three common glitch types from past LIGO-Virgo observing runs, and reconstruct both signal and glitch waveforms using {\tt BayesWave}, a wavelet-based Bayesian analysis. We apply the standard LIGO-Virgo-KAGRA deglitching procedure to the detector data - we subtract the glitch waveform estimated by the joint {\tt BayesWave} inference before performing parameter estimation with detailed compact binary waveform models. We find that this deglitching effectively mitigates bias from broadband glitches, with posterior peaks aligning with true values post deglitching. This provides a baseline validation of existing techniques, while demonstrating waveform reconstruction improvements to the Bayesian algorithm for robust astrophysical characterization in glitch-prone detector data.Comment: 22 pages, 17 figure

The Gaia-ESO Survey: Separating disk chemical substructures with cluster models

(Abridged) Recent spectroscopic surveys have begun to explore the Galactic disk system outside the solar neighborhood on the basis of large data samples. In this way, they provide valuable information for testing spatial and temporal variations of disk structure kinematics and chemical evolution. We used a Gaussian mixture model algorithm, as a rigurous mathematical approach, to separate in the [Mg/Fe] vs. [Fe/H] plane a clean disk star subsample from the Gaia-ESO survey internal data release 2. We find that the sample is separated into five groups associated with major Galactic components; the metal-rich end of the halo, the thick disk, and three subgroups for the thin disk sequence. This is confirmed with a sample of red clump stars from the Apache Point Observatory Galactic Evolution Experiment (APOGEE) survey. The two metal-intermediate and metal-rich groups of the thin disk decomposition ([Fe/H]>-0.25 dex) highlight a change in the slope at solar metallicity. This holds true at different radial regions. The distribution of Galactocentric radial distances of the metal-poor part of the thin disk ([Fe/H]<-0.25 dex) is shifted to larger distances than those of the more metal-rich parts. Moreover, the metal-poor part of the thin disk presents indications of a scale height intermediate between those of the thick and the rest of the thin disk, and it displays higher azimuthal velocities than the latter. These stars might have formed and evolved in parallel and/or dissociated from the inside-out formation taking place in the internal thin disk. Their enhancement levels might be due to their origin from gas pre-enriched by outflows from the thick disk or the inner halo. The smooth trends of their properties (their spatial distribution with respect to the plane, in particular) with [Fe/H] and [Mg/Fe] suggested by the data indicates a quiet dynamical evolution, with no relevant merger events

The Gaia-ESO Survey: the selection function of the Milky Way field stars

The Gaia-ESO Survey was designed to target all major Galactic components (i.e., bulge, thin and thick discs, halo and clusters), with the goal of constraining the chemical and dynamical evolution of the Milky Way. This paper presents the methodology and considerations that drive the selection of the targeted, allocated and successfully observed Milky Way field stars. The detailed understanding of the survey construction, specifically the influence of target selection criteria on observed Milky Way field stars is required in order to analyse and interpret the survey data correctly. We present the target selection process for the Milky Way field stars observed with VLT/FLAMES and provide the weights that characterise the survey target selection. The weights can be used to account for the selection effects in the Gaia-ESO Survey data for scientific studies. We provide a couple of simple examples to highlight the necessity of including such information in studies of the stellar populations in the Milky Way.Comment: 18 pages, 19 figures, Accepted for publication in MNRAS (April 25, 2016

The Gaia-ESO Survey: the most metal-poor stars in the Galactic bulge

We present the first results of the EMBLA survey (Extremely Metal-poor BuLge stars with AAOmega), aimed at finding metal-poor stars in the Milky Way bulge, where the oldest stars should now preferentially reside. EMBLA utilises SkyMapper photometry to pre-select metal-poor candidates, which are subsequently confirmed using AAOmega spectroscopy. We describe the discovery and analysis of four bulge giants with -2.72<=[Fe/H]<=-2.48, the lowest metallicity bulge stars studied with high-resolution spectroscopy to date. Using FLAMES/UVES spectra through the Gaia-ESO Survey we have derived abundances of twelve elements. Given the uncertainties, we find a chemical similarity between these bulge stars and halo stars of the same metallicity, although the abundance scatter may be larger, with some of the stars showing unusual [{\alpha}/Fe] ratios.Comment: 7 pages, 5 figures. Accepted for publication by MNRA

The Gaia-ESO Survey: Detailed Abundances in the Metal-poor Globular Cluster NGC 4372

We present the abundance analysis for a sample of 7 red giant branch stars in the metal-poor globular cluster NGC 4372 based on UVES spectra acquired as part of the Gaia-ESO Survey. This is the first extensive study of this cluster from high resolution spectroscopy. We derive abundances of O, Na, Mg, Al, Si, Ca, Sc, Ti, Fe, Cr, Ni, Y, Ba, and La. We find a metallicity of [Fe/H] = -2.19 $\pm$ 0.03 and find no evidence for a metallicity spread. This metallicity makes NGC 4372 one of the most metal-poor galactic globular clusters. We also find an {\alpha}-enhancement typical of halo globular clusters at this metallicity. Significant spreads are observed in the abundances of light elements. In particular we find a Na-O anti-correlation. Abundances of O are relatively high compared with other globular clusters. This could indicate that NGC 4372 was formed in an environment with high O for its metallicity. A Mg-Al spread is also present which spans a range of more than 0.5 dex in Al abundances. Na is correlated with Al and Mg abundances at a lower significance level. This pattern suggests that the Mg-Al burning cycle is active. This behavior can also be seen in giant stars of other massive, metal-poor clusters. A relation between light and heavy s-process elements has been identified.Comment: 14 pages, 14 figures, accepted for publication in A&