Advanced detectors and signal processing

Continued progress is reported toward development of a silicon on garnet technology which would allow fabrication of advanced detection and signal processing circuits on bubble memories. The first integrated detectors and propagation patterns have been designed and incorporated on a new mask set. In addition, annealing studies on spacer layers are performed. Based on those studies, a new double layer spacer is proposed which should reduce contamination of the silicon originating in the substrate. Finally, the magnetic sensitivity of uncontaminated detectors from the last lot of wafers is measured. The measured sensitivity is lower than anticipated but still higher than present magnetoresistive detectors

The application of GIS based decision-tree models for generating the spatial distribution of hydromorphic organic landscapes in relation to digital terrain data

Accurate information about organic/mineral soil occurrence is a prerequisite for many land resources management applications (including climate change mitigation). This paper aims at investigating the potential of using geomorphometrical analysis and decision tree modeling to predict the geographic distribution of hydromorphic organic landscapes in unsampled area in Denmark. Nine primary (elevation, slope angle, slope aspect, plan curvature, profile curvature, tangent curvature, flow direction, flow accumulation, and specific catchment area) and one secondary (steady-state topographic wetness index) topographic parameters were generated from Digital Elevation Models (DEMs) acquired using airborne LIDAR (Light Detection and Ranging) systems. They were used along with existing digital data collected from other sources (soil type, geological substrate and landscape type) to explain organic/mineral field measurements in hydromorphic landscapes of the Danish area chosen. A large number of tree-based classification models (186) were developed using (1) all of the parameters, (2) the primary DEM-derived topographic (morphological/hydrological) parameters only, (3) selected pairs of parameters and (4) excluding each parameter one at a time from the potential pool of predictor parameters. The best classification tree model (with the lowest misclassification error and the smallest number of terminal nodes and predictor parameters) combined the steady-state topographic wetness index and soil type, and explained 68% of the variability in organic/mineral field measurements. The overall accuracy of the predictive organic/inorganic landscapes' map produced (at 1:50 000 cartographic scale) using the best tree was estimated to be ca. 75%. The proposed classification-tree model is relatively simple, quick, realistic and practical, and it can be applied to other areas, thereby providing a tool to facilitate the implementation of pedological/hydrological plans for conservation and sustainable management. It is particularly useful when information about soil properties from conventional field surveys is limited

Paragonimiasis In Iowa

The presence of the lung fluke, Paragonimus kelliocotti, was first recorded in the United States in a cat in 1894. It was first recognized in domesticated animals in Iowa in a dog from Blackhawk County in 1948. Subsequently, paragonimiasis has been diagnosed in dogs from Polk and Dallas counties. An additional case was found in a dog from an unrecorded county. Also, one cat from Story County has been found to harbor P. kellicotti

Boswellic acids show in vitro activity against Leishmania donovani

In continuation of our search for leads from medicinal plants against protozoal pathogens, we detected antileishmanial activity in polar fractions of a dichloromethane extract from Boswellia serrata resin. 11-keto-beta-boswellic acid (KBA) could be isolated from these fractions and was tested in vitro against Leishmania donovani axenic amastigotes along with five further boswellic acid derivatives. 3-O-acetyl-11-keto-beta-boswellic acid (AKBA) showed the strongest activity with an IC50 value of 0.88 microM against axenic amastigotes but was inactive against intracellular amastigotes in murine macrophages

From the Heart of The Ghoul: C and N Abundances in the Corona of Algol B

Chandra Low Energy Transmission Grating Spectrograph observations of Algol have been used to determine the abundances of C and N in the secondary star for the first time. The analysis was performed relative to similar observations of an adopted "standard" star HR 1099. It is demonstrated that HR 1099 and Algol are coronal twins in many respects and that their X-ray spectra are very similar in nearly all details, except for the observed strengths of C and N lines. The H-like transitions of C and N in the coronae of Algol and HR 1099 demonstrate that the surface abundances of Algol B have been strongly modified by CN-processing, as shown earlier by Schmitt & Ness (2002). It is found that N is enhanced in Algol B by a factor of 3 compared to HR 1099. No C lines are detected in the Algol spectrum, indicating a C depletion relative to HR 1099 by a factor of 10 or more. These C and N abundances indicate that Algol B must have lost at least half of its initial mass, and are consistent with predictions of evolutionary models that include non-conservative mass transfer and angular momentum loss through magnetic activity. Little or no dredge-up of material subjected to CN-processing has occurred on the subgiant component of HR 1099. It is concluded that Fe is very likely depleted in the coronae of both Algol and HR 1099 relative to their photospheres by 0.5 dex, and C, N and O by 0.3 dex. Instead, Ne is enhanced by up to 0.5 dex.Comment: 17 pages, 4 figures, ApJ accepte

ALMA observations of atomic carbon in z~4 dusty star-forming galaxies

We present ALMA [CI]($1-0$) (rest frequency 492 GHz) observations for a sample of 13 strongly-lensed dusty star-forming galaxies originally discovered at 1.4mm in a blank-field survey by the South Pole Telescope. We compare these new data with available [CI] observations from the literature, allowing a study of the ISM properties of $\sim 30$ extreme dusty star-forming galaxies spanning a redshift range $2 < z < 5$. Using the [CI] line as a tracer of the molecular ISM, we find a mean molecular gas mass for SPT-DSFGs of $6.6 \times 10^{10}$ M$_{\odot}$. This is in tension with gas masses derived via low-$J$ $^{12}$CO and dust masses; bringing the estimates into accordance requires either (a) an elevated CO-to-H$_2$ conversion factor for our sample of $\alpha_{\rm CO} \sim 2.5$ and a gas-to-dust ratio $\sim200$, or (b) an high carbon abundance $X_{\rm CI} \sim 7\times10^{-5}$. Using observations of a range of additional atomic and molecular lines (including [CI], [CII], and multiple transitions of CO), we use a modern Photodissociation Region code (3D-PDR) to assess the physical conditions (including the density, UV radiation field strength, and gas temperature) within the ISM of the DSFGs in our sample. We find that the ISM within our DSFGs is characterised by dense gas permeated by strong UV fields. We note that previous efforts to characterise PDR regions in DSFGs may have significantly underestimated the density of the ISM. Combined, our analysis suggests that the ISM of extreme dusty starbursts at high redshift consists of dense, carbon-rich gas not directly comparable to the ISM of starbursts in the local Universe.Comment: 21 pages, 12 figures. Accepted for publication in MNRA

Long-Term Results of Bariatric Restrictive Procedures: A Prospective Study

Laparoscopic adjustable gastric banding (LAGB) and vertical-banded gastroplasty (VBG) are surgical treatment modalities for morbid obesity. This prospective study describes the long-term results of LAGB and VBG. One hundred patients were included in the study. Fifty patients underwent LAGB and 50 patients, open VBG. Study parameters were weight loss, changes in obesity-related comorbidities, long-term complications, re-operations including conversions to other bariatric procedures and laboratory parameters including vitamin status. From 91 patients (91%), data were obtained with a mean follow-up duration of 84 months (7 years). Weight loss [percent excess weight loss (EWL)] was significantly more after VBG compared with LAGB, 66% versus 54%, respectively. All comorbidities significantly decreased in both groups. Long-term complications after VBG were mainly staple line disruption (54%) and incisional hernia (27%). After LAGB, the most frequent complications were pouch dilatation (21%) and anterior slippage (17%). Major re-operations after VBG were performed in 60% of patients. All re-operations following were conversions to Roux-en-Y gastric bypass (RYGB). In the LAGB group, 33% of patients had a refixation or replacement of the band, and 11% underwent conversion to another bariatric procedure. There were no significant differences in weight loss between patients with or without re-interventions. No vitamin deficiencies were present after 7 years, although supplement usage was inconsistent. This long-term follow-up study confirms the high occurrence of late complications after restrictive bariatric surgery. The failure rate of 65% after VBG is too high, and this procedure is not performed anymore in our institution. The re-operation rate after LAGB is decreasing as a result of new techniques and materials. Results of the re-operations are good with sustained weight loss and reduction in comorbidities. However, in order to achieve these results, a durable and complete follow-up after restrictive procedures is imperative

Quasars in the MAMBO blank field survey

Our MAMBO 1.2 mm blank field imaging survey of ~0.75 sqd has uncovered four unusually bright sources, with flux densities between 10 and 90 mJy, all located in the Abell 2125 field. The three brightest are flat spectrum radio sources with bright optical and X-ray counterparts. Their mm and radio flux densities are variable on timescales of months. Their X-ray luminosities classify them as quasars. The faintest of the four mm bright sources appears to be a bright, radio-quiet starburst at z~3, similar to the sources seen at lower flux densities in the MAMBO and SCUBA surveys. It may also host a mildly obscured AGN of quasar-like X-ray luminosity. The three non-thermal mm sources imply an areal density of flat spectrum radio sources higher by at least 7 compared with that expected from an extrapolation of the lower frequency radio number counts.Comment: 8 pages, 7 figures. Accepted for publication by A&

A behavioral theory of alliance portfolio reconfiguration: Evidence from pharmaceutical biotechnology

Research summary: Extant research suggests that firms rationally evaluate external and/or internal contingencies when deciding how to reconfigure their alliance portfolios. We advance a behavioral perspective which assumes that managers are boundedly rational and thus rely on behavioral heuristics when making alliance portfolio reconfiguration decisions. In panel data on U.S.-listed biotechnology firms, we find that below-aspiration performance motivates a firm to form alliances with novel partners within the resource scope of its existing alliance portfolio. This effect is weakened by equity ties with existing partners and strengthened by firm-specific uncertainty. Conversely, above-aspiration performance leads to new alliances with existing partners but outside the resource scope of the firm’s existing alliance portfolio. Finally, as organizational slack increases, a firm forms alliances with novel partners focusing on new-to-the-portfolio resources. Managerial summary: We study why and how firms change the configuration of their alliance portfolios over time. We find that actual performance relative to performance objectives, and firms’ excess resources, are important drivers of such change. The more firms fail to meet their performance objectives, the more likely they are to form alliances with novel partners focusing on areas in which they already have one or more alliances with other partners. The more firms exceed their performance objectives, the greater their inclination to form alliances with their existing partners in areas in which they do not yet have alliances. The greater the stock of excess resources, the greater firms’ propensities to form alliances with novel partners focusing on areas in which they do not yet have alliances