Triplet Leptogenesis in Left-Right Symmetric Seesaw Models

We discuss scalar triplet leptogenesis in a specific left-right symmetric seesaw model. We show that the Majorana phases that are present in the model can be effectively used to saturate the existing upper limit on the CP-asymmetry of the triplets. We solve the relevant Boltzmann equations and analyze the viability of triplet leptogenesis. It is known for this kind of scenario that the efficiency of leptogenesis is maximal if there exists a hierarchy between the branching ratios of the triplet decays into leptons and Higgs particles. We show that triplet leptogenesis typically favors branching ratios with not too strong hierarchies, since maximal efficiency can only be obtained at the expense of suppressed CP-asymmetries.Comment: 16 pages, 5 figures, published versio

Stability and leptogenesis in the left-right symmetric seesaw mechanism

We analyze the left-right symmetric type I+II seesaw mechanism, where an eight-fold degeneracy among the mass matrices of heavy right-handed neutrinos M_R is known to exist. Using the stability property of the solutions and their ability to lead to successful baryogenesis via leptogenesis as additional criteria, we discriminate among these eight solutions and partially lift their eight-fold degeneracy. In particular, we find that viable leptogenesis is generically possible for four out of the eight solutions.Comment: 25 pages, 11 figures, latex; minor changes, published versio

Mortality trends in external causes of death in people with mental health disorders in Sweden, 1987-2010

AIM: We investigated mortality from external causes in Swedish people who had been hospitalised with a severe mental disorder.METHODS: Hospitalisations in people aged 15 years or older admitted to hospital with a main diagnosis of schizophrenia, bipolar mood disorder or unipolar mood disorder between 1987 and 2010 were linked to their causes of death.RESULTS: The mortality rate from all external causes was 20-fold higher in those with unipolar mood disorder, 15-fold higher in those with bipolar disorder and 12-fold higher in those with schizophrenia than in the general population. Over the study periods, the mortality rate declined more for people with unipolar mood disorder (-35%) and schizophrenia (-29%) than the total population (-25%) and those with bipolar mood disorder (-15%). The suicide rate declined most for those with unipolar mood disorder and schizophrenia (-42% for both) and less for the general population (-37%) and those with bipolar mood disorder (-21%). For external causes other than suicide, the mortality rate declined in the general population (-17%) but increased in people with schizophrenia (14%), bipolar mood disorder (30%) and unipolar mood disorder (52%).CONCLUSIONS: People with mental disorders have high but declining excess mortality from suicide. Mortality from other external causes has increased, as has the gap in mortality rates between psychiatric patients and the general population.</div

Damping signatures in future neutrino oscillation experiments

We discuss the phenomenology of damping signatures in the neutrino oscillation probabilities, where either the oscillating terms or the probabilities can be damped. This approach is a possibility for tests of non-oscillation effects in future neutrino oscillation experiments, where we mainly focus on reactor and long-baseline experiments. We extensively motivate different damping signatures due to small corrections by neutrino decoherence, neutrino decay, oscillations into sterile neutrinos, or other mechanisms, and classify these signatures according to their energy (spectral) dependencies. We demonstrate, at the example of short baseline reactor experiments, that damping can severely alter the interpretation of results, e.g., it could fake a value of $\sin(2\theta_{13})$ smaller than the one provided by Nature. In addition, we demonstrate how a neutrino factory could constrain different damping models with emphasis on how these different models could be distinguished, i.e., how easily the actual non-oscillation effects could be identified. We find that the damping models cluster in different categories, which can be much better distinguished from each other than models within the same cluster.Comment: 33 pages, 5 figures, LaTeX. Final version published in JHE

Indirect Detection of Kaluza-Klein Dark Matter from Latticized Universal Dimensions

We consider Kaluza-Klein dark matter from latticized universal dimensions. We motivate and investigate two different lattice models, where the models differ in the choice of boundary conditions. The models reproduce relevant features of the continuum model for Kaluza-Klein dark matter. For the model with simple boundary conditions, this is the case even for a model with only a few lattice sites. We study the effects of the latticization on the differential flux of positrons from Kaluza-Klein dark matter annihilation in the galactic halo. We find that for different choices of the compactification radius, the differential positron flux rapidly converges to the continuum model results as a function of the number of lattice sites. In addition, we consider the prospects for upcoming space-based experiments such as PAMELA and AMS-02 to probe the latticization effect.Comment: 25 pages, 9 figures, LaTeX. Final version published in JCA

Comparison of Training, Anthropometric, Physiological and Psychological Variables of Ultra-Endurance Cyclists and Runners

AbstractWe compared training, anthropometric, physiological and psychological characteristics between 14 cyclists, participants in a 24-hour mountain bike race and 12 runners, participants in a 7-day running ultra-marathon. Methods: Questionnaires and physiological measurements. Results: The differences in ages between cyclists and runners were significant (p << 0.01). The pre-race minus post-race differences (Δ) in body mass (from 76.5 ± 13.1kg to 72.0 ± 12.0kg) and (Δ) in value of hematocrit (6.1 ± 3.5%) were significant only in runners. The post-race minus pre-race difference (Δ) in the rating of perceived exertion was significant in both groups

The Effect of Auditory Distraction on the Useful Field of View in Hearing Impaired Individuals and its implications for driving

This study assessed whether the increased demand of listening in hearing impaired individuals exacerbates the detrimental impact of auditory distraction on a visual task (useful field of view test), relative to normally hearing listeners. Auditory distraction negatively affects this visual task, which is linked with various driving performance outcomes. Hearing impaired and normally hearing participants performed useful field of view testing with and without a simultaneous listening task. They also undertook a cognitive test battery. For all participants, performing the visual and auditory tasks together reduced performance on each respective test. For a number of subtests, hearing impaired participants showed poorer visual task performance, though not to a statistically significant extent. Hearing impaired participants were significantly poorer at a reading span task than normally hearing participants and tended to score lower on the most visually complex subtest of the visual task in the absence of auditory task engagement. Useful field of view performance is negatively affected by auditory distraction, and hearing loss may present further problems, given the reductions in visual and cognitive task performance suggested in this study. Suggestions are made for future work to extend this study, given the practical importance of the findings

Antioxidant Protects against Increases in Low Molecular Weight Hyaluronan and Inflammation in Asphyxiated Newborn Pigs Resuscitated with 100% Oxygen

BACKGROUND: Newborn resuscitation with 100% oxygen is associated with oxidative-nitrative stresses and inflammation. The mechanisms are unclear. Hyaluronan (HA) is fragmented to low molecular weight (LMW) by oxidative-nitrative stresses and can promote inflammation. We examined the effects of 100% oxygen resuscitation and treatment with the antioxidant, N-acetylcysteine (NAC), on lung 3-nitrotyrosine (3-NT), LMW HA, inflammation, TNFα and IL1ß in a newborn pig model of resuscitation. METHODS & PRINCIPAL FINDINGS: Newborn pigs (n = 40) were subjected to severe asphyxia, followed by 30 min ventilation with either 21% or 100% oxygen, and were observed for the subsequent 150 minutes in 21% oxygen. One 100% oxygen group was treated with NAC. Serum, bronchoalveolar lavage (BAL), lung sections, and lung tissue were obtained. Asphyxia resulted in profound hypoxia, hypercarbia and metabolic acidosis. In controls, HA staining was in airway subepithelial matrix and no 3-NT staining was seen. At the end of asphyxia, lavage HA decreased, whereas serum HA increased. At 150 minutes after resuscitation, exposure to 100% oxygen was associated with significantly higher BAL HA, increased 3NT staining, and increased fragmentation of lung HA. Lung neutrophil and macrophage contents, and serum TNFα and IL1ß were higher in animals with LMW than those with HMW HA in the lung. Treatment of 100% oxygen animals with NAC blocked nitrative stress, preserved HMW HA, and decreased inflammation. In vitro, peroxynitrite was able to fragment HA, and macrophages stimulated with LMW HA increased TNFα and IL1ß expression. CONCLUSIONS & SIGNIFICANCE: Compared to 21%, resuscitation with 100% oxygen resulted in increased peroxynitrite, fragmentation of HA, inflammation, as well as TNFα and IL1ß expression. Antioxidant treatment prevented the expression of peroxynitrite, the degradation of HA, and also blocked increases in inflammation and inflammatory cytokines. These findings provide insight into potential mechanisms by which exposure to hyperoxia results in systemic inflammation

Non-typeable Haemophilus Influenzae detection in the lower airways of patients with lung cancer and chronic obstructive pulmonary disease

Background: Chronic airway inflammation and hypersensitivity to bacterial infection may contribute to lung cancer pathogenesis. Previous studies have demonstrated that nontypeable Haemophilus influenzae (NTHi) is the most common colonizing bacteria in the lower airways of patients with COPD. The objective of this study was to determine the presence of NTHi and immunoglobulin concentrations in patients with lung cancer, COPD and controls. Methods: Serum and bronchial wash samples were collected from patients undergoing diagnostic bronchoscopy. Total IgE, IgG and specific NTHi IgG were measured by enzyme linked immunosorbent assay. Bronchial wash samples were examined for the presence of NTHi via PCR. Results: Out of the 60 patients: 20 had confirmed Lung Cancer, 27 had COPD only and 13 were used as Controls. NTHi was detected in the lower airways of all three groups (Lung Cancer 20%; COPD 22% and Controls 15%). Total IgE was highest in Lung Cancer subjects followed by COPD and control subjects (mean ± SD: 870 ± 944, 381 ± 442, 159 ± 115). Likewise total IgG was higher in Lung cancer (Mean ± SD: 6.99 ± 1.8) patients compared to COPD (Mean ± SD: 5.43 ± 2). Conclusions: The lack of difference in NTHi and specific antibodies between the three groups makes it less likely that NTHi has an important pathogenetic role in subjects with Lung Cancer. However the detection of higher IgE antibody in Lung Cancer subjects identifies a possible mechanism for carcinogenesis in these subjects and warrants further study.Griffith Health, School of MedicineFull Tex