Mitochondrial DNA Haplogroup JT is Related to Impaired Glycaemic Control and Renal Function in Type 2 Diabetic Patients

The association between mitochondrial DNA (mtDNA) haplogroup and risk of type 2 diabetes (T2D) is undetermined and controversial. This study aims to evaluate the impact of the main mtDNA haplogroups on glycaemic control and renal function in a Spanish population of 303 T2D patients and 153 healthy controls. Anthropometrical and metabolic parameters were assessed and mtDNA haplogroup was determined in each individual. Distribution of the different haplogroups was similar in diabetic and healthy populations and, as expected, T2D patients showed poorer glycaemic control and renal function than controls. T2D patients belonging to the JT haplogroup (polymorphism m.4216T>C) displayed statistically significant higher levels of fasting glucose and HbA(1c) than those of the other haplogroups, suggesting a poorer glycaemic control. Furthermore, diabetic patients with the JT haplogroup showed a worse kidney function than those with other haplogroups, evident by higher levels of serum creatinine, lower estimated glomerular filtration rate (eGFR), and slightly higher (although not statistically significant) urinary albumin-to-creatinine ratio. Our results suggest that JT haplogroup (in particular, change at position 4216 of the mtDNA) is associated with poorer glycaemic control in T2D, which can trigger the development of diabetic nephropathy

GIADA performance during Rosetta mission scientific operations at comet 67P

The Grain Impact Analyser and Dust Accumulator (GIADA) instrument onboard Rosetta studied the dust environment of comet 67P/Churyumov–Gerasimenko from 3.7 au inbound, through perihelion, to 3.8 au outbound, measuring the dust flow and the dynamic properties of individual particles. GIADA is composed of three subsystems: 1) Grain Detection System (GDS); 2) Impact Sensor (IS); and 3) Micro-Balances System (MBS). Monitoring the subsystems’ performance during operations is an important element for the correct calibration of scientific measurements. In this paper, we analyse the GIADA inflight calibration data obtained by internal calibration devices for the three subsystems during the period from 1 August 2014 to 31 October 2015. The calibration data testify a nominal behaviour of the instrument during these fifteen months of mission; the only exception is a minor loss of sensitivity for one of the two GDS receivers, attributed to dust contamination

Discovery of a bright eclipsing cataclysmic variable

We report on the discovery of J0644+3344, a bright deeply eclipsing cataclysmic variable (CV) binary. Spectral signatures of both binary components and an accretion disk can be seen at optical wavelengths. The optical spectrum shows broad H I, He I, and He II accretion disk emission lines with deep narrow absorption components from H I, He I, Mg II and Ca II. The absorption lines are seen throughout the orbital period, disappearing only during primary eclipse. These absorption lines are either the the result of an optically-thick inner accretion disk or from the photosphere of the primary star. Radial velocity measurements show that the H I, He I, and Mg II absorption lines phase with the the primary star, while weak absorption features in the continuum phase with the secondary star. Radial velocity solutions give a 150+/-4 km/s semi-amplitude for the primary star and 192.8+/-5.6 km/s for the secondary. The individual stellar masses are 0.63-0.69 Mdot for the primary and 0.49-0.54 Mdot for the secondary. The bright eclipsing nature of this binary has helped provide masses for both components with an accuracy rarely achieved for CVs. This binary most closely resembles a nova-like UX UMa or SW Sex type of CV. J0644+3344, however, has a longer orbital period than most UX UMa or SW Sex stars. Assuming an evolution toward shorter orbital periods, J0644+3344 is therefore likely to be a young interacting binary. The secondary star is consistent with the size and spectral type of a K8 star, but has an M0 mass.Comment: 10 pages, 13 figure, accepted for publication in A&

Lethal Concentration of Carbonate OF Ca as a Function of the Osmotic Potential of the Solution in Sunflower (Heliantusannuus L.)

In order to know the effect of CaCO3 in solution, sunflower seedlings cv. Victoria, an experiment was completely randomized, where five concentrations of calcium carbonate were evaluated to determine the lethal concentration (LC50), pH and EC of the solution under laboratory conditions in the Universidad Tecnologica de Tehuacan, to simulate of excess Ca++ in the soils or nutrient solution. The results indicate, the LC50 was 62.8 mg CaCO3 L-1, so maximum values for pH, EC and calcium absorption, They were achieved at concentrations of 120 and 160 mg L-1 of CaCO3. This work can be concluded, Sunflower can absorb the high levels of calcium and used as an alternative, for remediation of agricultural soils affected hard water and Ca++ salts

The EBLM project. II. A very hot, low-mass M dwarf in an eccentric and long period eclipsing binary system from SuperWASP

In this paper, we derive the fundamental properties of 1SWASPJ011351.29+314909.7 (J0113+31), a metal-poor (-0.40 +/- 0.04 dex), eclipsing binary in an eccentric orbit (~0.3) with an orbital period of ~14.277 d. Eclipsing M dwarfs orbiting solar-type stars (EBLMs), like J0113+31, have been identified from WASP light curves and follow-up spectroscopy in the course of the transiting planet search. We present the first binary of the EBLM sample to be fully analysed, and thus, define here the methodology. The primary component with a mass of 0.945 +/- 0.045 Msun has a large radius (1.378 +/- 0.058 Rsun) indicating that the system is quite old, ~9.5 Gyr. The M-dwarf secondary mass of 0.186 +/- 0.010 Msun and radius of 0.209 +/- 0.011 Rsun are fully consistent with stellar evolutionary models. However, from the near-infrared secondary eclipse light curve, the M dwarf is found to have an effective temperature of 3922 +/- 42 K, which is ~600 K hotter than predicted by theoretical models. We discuss different scenarios to explain this temperature discrepancy. The case of J0113+31 for which we can measure mass, radius, temperature and metallicity, highlights the importance of deriving mass, radius and temperature as a function of metallicity for M dwarfs to better understand the lowest mass stars. The EBLM Project will define the relationship between mass, radius, temperature and metallicity for M dwarfs providing important empirical constraints at the bottom of the main sequence.Comment: 13 pages, 7 figures. Accepted for publication in A&

GU Boo: A New 0.6 Msun Detached Eclipsing Binary

We have found a new low-mass, double-lined, detached eclipsing binary, GU Boo, among a sample of new variables from the ROTSE-I database. The binary has an orbital period of 0.488728 +/- 0.000002 days, and estimated apparent magnitudes Vrotse = 13.7 and I = 11.8. Our analysis of the light and radial velocity curves of the system yields individual masses and radii of M1= 0.610 +/- 0.007 Msun, M2 = 0.599 +/- 0.006 Msun, R1= 0.623 +/- 0.016 Rsun, R2= 0.620 +/- 0.020 Rsun. The stars in GU Boo are therefore very similar to the components of the eclipsing binary YY Gem. For this study we have adopted a mean effective temperature for the binary of Teff = 3870 +/- 130 K. Based on its space velocities we suggest that GU Boo is a main sequence binary, possibly with an age of several Gyr. The metallicity of the binary is not well constrained at this point but we speculate that it should not be very different from solar. We have compared the physical parameters of GU Boo with current low-mass stellar models, where we accounted for uncertainties in age and metallicity by considering a wide range of values for those parameters. Our comparisons reveal that all the models underestimate the radii of the components of GU Boo by at least 10-15%. This result is in agreement with the recent studies of YY Gem and CU Cnc.Comment: 41 pages, 10 figures, 11 tables; accepted by Ap