Crustal structure and Moho depth profile crossing the central Apennines (Italy) along the N42 degree parallel.

We present results from a teleseismic receiver-function study of the crustal structure in the central Apennines (Italy). Data from fifteen stations deployed in a linear transect running along the N42 degree parallel were used for the analysis. A total number of 364 receiver functions were analyzed. The crustal structure has been investigated using the neighborhood algorithm inversion scheme proposed by Sambridge [1999a], obtaining crustal thicknesses, bulk crustal VP/VS ratio and velocity-depth models. In each inversion, the degree of constraint of the different parameters has been appraised by the Bayesian inference algorithm by Sambridge [1999b]. The study region is characterized by crustal complexities and intense tectonic activity (recent volcanism, orogenesis, active extensional processes), and these complexities are reflected in the receiver functions. However, the relatively close spacing among the seismometers (about 20 km) helped us in the reconstruction of the crustal structure and Moho geometry along the transect. Crossing the Apennines from west to east, the Moho depth varies by more than 20 km, going from a relatively shallow depth (around 20 km) on the Tyrrhenian side, deepening down to about 45 km depth beneath the external front of the Apenninic orogen, and rising up again to about 30 km depth in correspondence of the Adriatic foreland. Despite the strong variability of the crustal thickness, the average crustal VS values show little variation along the transect, fluctuating around 3 km/s. The average VP values obtained from the VS and VP /VS are generally lower than 6 km/s

Preliminary realization of an electric-powered hydraulic pump system for a waste compactor truck and a techno-economic analysis

Most industrial trucks are equipped with hydraulic systems designed for specic operations, for which the required power is supplied by the internal combustion engine (ICE). The largest share of the power consumption is required by the hydraulic system during idling operations, and, consequently, the current literature focuses on energy saving strategies for the hydraulic system rather than making the vehicle traction more efficient. This study presents the preliminary realization of an electric-powered hydraulic pump system (e-HPS) that drives the lifting of the dumpster and the garbage compaction in a waste compactor truck, rather than traditional ICE-driven hydraulic pump systems (ICE-HPSs). The different components of the e-HPS are described and the battery pack was modelled using the kinetic battery model. The end-of-life of the battery pack was determined to assess the economic feasibility of the proposed e-HPS for the truck lifespan, using numerical simulations. The aim was twofold: To provide an implementation method to retrofit the e-HPS to a conventional waste compactor truck and to assess its economic feasibility, investigating fuel savings during the use phase and the consequent reduction of CO2 emissions. Results show that the total lifespan cost saving achieved a value of 65,000. Furthermore, total CO2 emissions for the e-HPS were about 80% lower than those of the ICE-HPS, highlighting that the e-HPS can provide significant environmental benefits in an urban context

Taking part in the community occupational therapy in dementia UK intervention from the perspective of people with dementia, family carers and occupational therapists: A qualitative study

AIM: Community Occupational Therapy in Dementia (COTiD-UK) is a manualised intervention delivered to the person with dementia and their identified family carer primarily in their own home. The focus is on enabling both the person with dementia and their family carer to engage in personally meaningful activities. This qualitative study examines the experiences of people with mild to moderate dementia, their family carers and occupational therapists, of taking part in the COTiD-UK intervention. METHOD: A purposive sample of 22 pairs of people with dementia and a family carer and seven occupational therapists took part in semi-structured interviews that were audio recorded, transcribed and inductively analysed using thematic analysis. FINDINGS: Themes from the occupational therapist interviews relate to the COTiD-UK intervention philosophy and content, aspects of delivering it in practice and thinking ahead to it becoming usual practice. Themes from the pair interviews relate to the focus of COTiD-UK sessions on meaningful occupation and working together and a sense of being able to plan to live well with dementia in the short- and longer-term as a result of the intervention. CONCLUSION: This person-centred occupation-focussed intervention was highly valued by people with dementia and their family carers and the occupational therapists delivering it

Global performance index for integrated management system: GPI-IMS

Background: The present work starts from a literature review of the evolution of Integrated Management Systems (IMSs), considering different points of view and standards: quality, environmental, occupational health and safety, sustainability and social issues. Even if the benefits are possible, there is not a common approach and a clear link between the integration of management systems and business performance, in particular considering safety performance. Methods: The present study analyzes the application of Risk Assessment in order to realize the integration of management systems. The main objective is to provide a tool for an integrated evaluation of all company performances, starting from the definition of some Key Performance Indicators—KPIs— proposed for a particular case study, even if their choice is not the core of the paper. The assessment team members on the basis of their knowledge, experience and useful literature, could choose the right KPIs for the specific application, able to take a picture of the current state and to suggest a possible recommended action of improving. The proposed Risk Assessment approach is an integration of modern management techniques: Integrated Management System and Improving Cycle DMAIC. Results: The new method, called the Global Performance Index for Integrated Management System—GPI-IMS, has been applied to a real case study in the logistic field in order to evaluate its goodness and possible generalization. Conclusions: The proposed method allows to define the requirements that any company must have to perform the best. The role of the assessment team is very important to evaluate the global performance of the company and to suggest the corrective actions to be adopted

Assessing the potential of molten carbonate fuel cell-based schemes for carbon capture in natural gas-fired combined cycle power plants

Abstract This work explores two configurations of natural gas-fired combined cycles (NGCC) with molten carbonate fuel cells (MCFC) for CO2 capture. Special attention is devoted to the selection of MCFC operating conditions (trade-off between CO2 capture and voltage losses), heat integration scheme, fuel use and CO2 purification. Two schemes are considered: (i) in the first "integrated" scheme, MCFC modules are installed between the gas turbine and the heat recovery steam generator (HRSG) to maximize the efficiency of the integrated power plant; (ii) in the second "non-integrated" layout, the MCFC is located downstream of the HRSG and a regenerative heat exchanger is designed to preheat cathode reactants up to the MCFC working temperature. This study includes a full techno-economic analysis of the two layouts based on a preliminary sizing of the key-components, and a sensitivity analysis on the CO2 utilization factor. Compared to a benchmark amine scrubbing process, the "integrated" configuration shows considerably better performance (Specific Primary Energy Consumption for CO2 Avoided - SPECCA = 0.31 MJ kgCO2-1; Cost of CO2 avoided - CCA = 50 $tCO2−1), whereas the "non-integrated" solution shows higher energy penalties but similar CO2 avoidance cost (SPECCA = 2.4  MJ  kgCO2−1; CCA = 76$ tCO2−1)

Safety of measles, mumps, and rubella vaccine in egg allergy: in vivo and in vitro management

Background: Egg allergy is the second most prevalent form of food allergy in childhood. In spite of the evidence accumulated, inoculating egg allergy children with attenuated vaccines grown on chick embryo cell cultures, such as the measles, mumps, and rubella (MMR) vaccine, is regarded (erroneously) as potentially dangerous or even anaphylactogenic, by many. An issue perceived as particularly conflicting also by Health Professionals. Case presentation: A 15-year-old boy, with a history of severe egg allergy in early infancy, who was still sensitized to egg allergens, including baked egg, had never received MMR vaccination, in fear of possible anaphylaxis, in spite of the fact that this vaccination is mandatory in the first year of life, in Italy. Because of that, he was not allowed to attend school, longer, and was referred to us in order to assess the potential risk of MMR vaccination. Upon thorough allergologic workup, sensitization to MMR vaccine components was excluded by an in vivo approach, consisting in skin prick tests, intradermal tests, and subcutaneous injection test, corroborated by vaccine-specific B-lymphocyte proliferation assay, ex vivo. T-cell proliferation in response to MMR vaccine was also excluded. Eventually, the boy was inoculated with MMR vaccine and was readmitted to school. Conclusions: The diagnostic strategy adopted appears feasible and easy-to-perform and may be adopted in controversial cases (as the one reported), characterized by previous severe allergic reactions to egg. The B-lymphocyte proliferation assay we developed may represent a useful and reliable tool not only in research but also in clinical practice

Oxidative stress inhibits IFN-alpha-induced antiviral gene expression by blocking the JAK-STAT pathway.

Abstract BACKGROUND/AIMS: Unresponsiveness to IFN-alpha is common in chronic hepatitis C. Since conditions associated with an increased oxidative stress (advanced age, steatosis, fibrosis, iron overload, and alcohol consumption) reduce the likelihood of response, we hypothesized that oxidative stress may affect the antiviral actions of IFN-alpha. METHODS: We examined in a human hepatocellular carcinoma cell line (Huh-7) the effect of hydrogen peroxide (H2O2), as a generator of oxidative stress, on the IFN-alpha signaling pathway. RESULTS: Pretreatment of Huh-7 cells with 0.5-1 mM H2O2 resulted in the suppression of the IFN-alpha-induced antiviral protein MxA and of IRF-9 mRNA expression. The reduced expression of these genes was associated to H2O2 -mediated suppression of the IFN-alpha-induced assembly of signal transducer and activator of transcription (STAT) factors to specific promoter motifs on IFN-alpha-inducible genes. This was accomplished by preventing the IFN-alpha-induced tyrosine phosphorylation of STAT-1 and STAT-2 through the inactivation of the upstream receptor associated tyrosine kinases, JAK-1 and Tyk-2. The suppression was fast, occurring within 5mins of pretreatment with H2O2, and did not require protein synthesis. CONCLUSIONS: In conclusion, oxidative stress impairs IFN-alpha signaling and might cause resistance to the antiviral action of IFN-alpha in chronically HCV infected patients with high level of oxidative stress in the liver

Characterization of chenopodin isoforms from quinoa seeds and assessment of their potential anti-inflammatory activity in Caco-2 cells

Several food-derived molecules, including proteins and peptides, can show bioactivities toward the promotion of well-being and disease prevention in humans. There is still a lack of information about the potential effects on immune and inflammatory responses in mammalian cells following the ingestion of seed storage proteins. This study, for the first time, describes the potential immunomodulation capacity of chenopodin, the major protein component of quinoa seeds. After characterizing the molecular features of the purified protein, we were able to separate two different forms of chenopodin, indicated as LcC (Low charge Chenopodin, 30% of total chenopodin) and HcC (High charge Chenopodin, 70% of total chenopodin). The biological effects of LcC and HcC were investigated by measuring NF-\u3baB activation and IL-8 expression studies in undifferentiated Caco-2 cells. Inflammation was elicited using IL-1\u3b2. The results indicate that LcC and HcC show potential anti-inflammatory activities in an intestinal cell model, and that the proteins can act differently, depending on their structural features. Furthermore, the molecular mechanisms of action and the structural/functional relationships of the protein at the basis of the observed bioactivity were investigated using in silico analyses and structural predictions

A microseismic study in a low seismicity area of Italy: the Città di Castello 2000-2001 experiment

Recent seismological studies contribute to better understand the first order characteristics of earthquake occurrence in Italy, identifying the potential sites for moderate to large size earthquakes. Ad hoc passive seismic experiments performed in these areas provide information to focus on the location and geometry of the active faults more closely. This information is relevant for assessing seismic hazard and for accurately constraining possible ground shaking scenarios. The area around the Città di Castello Basin, in the Northern Apennines (Central Italy), is characterized by the absence of instrumental seismicity (M > 2.5), it is adjacent to faults ruptured by recent and historical earthquakes. To better understand the tectonics of the area, we installed a dense network of seismic stations equipped with broadband and short period seismometers collecting data continuously for 8 months (October 2000-May 2001). The processing of ~ 900 Gbyte of data revealed a consistent background seismicity consisting of very low magnitude earthquakes (ML < 3.2). Preliminary locations of about 2200 local earthquakes show that the area can be divided into two regions with different seismic behaviour: an area to the NW, in between Sansepolcro and Città di Castello, where seismicity is not present. An area toward the SE, in between Città di Castello, Umbertide and Gubbio, where we detected a high microseismicity activity. These findings suggest a probable different mechanical behaviour of the two regions. In the latter area, the seismicity is confined between 0 and 8 km of depth revealing a rather well defined east-dipping, low angle fault 35 km wide that cuts through the entire upper crust down to 12-15 km depth. Beside an apparent structural complexity, fault plane solutions of background seismicity reveal a homogeneous pattern of deformation with a clear NE-SW extension

Surveillance study of hepatitis E virus (HEV) in domestic and wild ruminants in northwestern Italy

In industrialized countries, increasing autochthonous infections of hepatitis E virus (HEV) are caused by zoonotic transmission of genotypes (Gts) 3 and 4, mainly through consumption of contaminated raw or undercooked pork meat. Although swine and wild boar are recognized as the main reservoir for Gt3 and Gt4, accumulating evidence indicates that other animal species, including domestic and wild ruminants, may harbor HEV. Herein, we screened molecularly and serologically serum and fecal samples from two domestic and four wild ruminant species collected in Valle d’Aosta and Piemonte regions (northwestern Italy. HEV antibodies were found in sheep (21.6%), goats (11.4%), red deer (2.6%), roe deer (3.1%), and in Alpine ibex (6.3%). Molecular screening was performed using different primer sets targeting highly conserved regions of hepeviruses and HEV RNA, although at low viral loads, was detected in four fecal specimens (3.0%, 4/134) collected from two HEV seropositive sheep herds. Taken together, the data obtained document the circulation of HEV in the geographical area assessed both in wild and domestic ruminants, but with the highest seroprevalence in sheep and goats. Consistently with results from other studies conducted in southern Italy, circulation of HEV among small domestic ruminants seems to occur more frequently than expected