Poorest countries experience earlier anthropogenic emergence of daily temperature extremes

Understanding how the emergence of the anthropogenic warming signal from the noise of internal variability translates to changes in extreme event occurrence is of crucial societal importance. By utilising simulations of cumulative carbon dioxide (CO2) emissions and temperature changes from eleven earth system models, we demonstrate that the inherently lower internal variability found at tropical latitudes results in large increases in the frequency of extreme daily temperatures (exceedances of the 99.9th percentile derived from pre-industrial climate simulations) occurring much earlier than for mid-to-high latitude regions. Most of the world's poorest people live at low latitudes, when considering 2010 GDP-PPP per capita; conversely the wealthiest population quintile disproportionately inhabit more variable mid-latitude climates. Consequently, the fraction of the global population in the lowest socio-economic quintile is exposed to substantially more frequent daily temperature extremes after much lower increases in both mean global warming and cumulative CO2 emissions

Remote monitoring of off-grid renewable energy case studies in rural Malawi, Zambia, and Gambia

Increased understanding of off-grid renewable energy technology (RET) performance can assist in improving sustainability of such systems. The technologies for remote monitoring of RET deployments in developing countries are promising with various configurations and usages being tested. Recent applications of remote monitoring technologies in Malawi, Gambia, and Zambia are presented along with their respective strengths and weaknesses. The potential for remote monitoring applications to improve sustainability of off-grid RET is explored along with some theoretical directions of the technologies

Instability and Spatiotemporal Dynamics of Alternans in Paced Cardiac Tissue

We derive an equation that governs the spatiotemporal dynamics of small amplitude alternans in paced cardiac tissue. We show that a pattern-forming linear instability leads to the spontaneous formation of stationary or traveling waves whose nodes divide the tissue into regions with opposite phase of oscillation of action potential duration. This instability is important because it creates dynamically an heterogeneous electrical substrate for inducing fibrillation if the tissue size exceeds a fraction of the pattern wavelength. We compute this wavelength analytically as a function of three basic length scales characterizing dispersion and inter-cellular electrical coupling.Comment: 4 pages, 3 figures, submitted to PR

'Respect me: respect self' - the key to improved global relationships.

This paper examines the definitions of respect in a 21st century globally inclusive environment, with a view to exploring the implications for nurturing harmonious working relationships in, and between culturally diverse economically active groups. It is based on research conducted since 2005 which explores the meanings attached to, and experience of, respect from the perspective of undergraduate students in a UK university business school, who worked together on a consulting to business module. The research methodology consisted of tracking via focus group interactions and video records of two culturally diverse groups, comprising seven students each, over a two year period, with approximately eight focus group – video sessions per group. Significantly, our findings suggest that respect is an important shared value, and one that all students acknowledge as having an impact on their behaviour, attitudes and emotions. We argue that in our case, respect develops as an awareness of difference and is based on systematically produced data of the actors’ life experience, rather than, fictions or stereotypes. We suggest that this process encourages a positive approach to respect as it facilitates a shift in behaviours, attitudes, and ‘mental models’, (the latter, as described by Senge et al 1994). The significance of respect to the development and maintenance of both an economic democracy and for transnational relations between such democracies, is therefore crucial if there is to be equal access for all, regardless of their diversity, to the benefits which should accrue to all those who participate in the wealth creation activity of their society and the global economy

FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells

Receptor Tyrosine Kinases (RTKs) and Focal Adhesion Kinase (FAK) regulate multiple signalling pathways, including mitogen-activated protein (MAP) kinase pathway. FAK interacts with several RTKs but little is known about how FAK regulates their downstream signalling. Here we investigated how FAK regulates signalling resulting from the overexpression of the RTKs RET and EGFR. FAK suppressed RTKs signalling in Drosophila melanogaster epithelia by impairing MAPK pathway. This regulation was also observed in MDA-MB-231 human breast cancer cells, suggesting it is a conserved phenomenon in humans. Mechanistically, FAK reduced receptor recycling into the plasma membrane, which resulted in lower MAPK activation. Conversely, increasing the membrane pool of the receptor increased MAPK pathway signalling. FAK is widely considered as a therapeutic target in cancer biology; however, it also has tumour suppressor properties in some contexts. Therefore, the FAK-mediated negative regulation of RTK/MAPK signalling described here may have potential implications in the designing of therapy strategies for RTK-driven tumours

Patente in der europäischen Finanzindustrie: terra incognita?

Die unklare Formulierung des Artikels 52 des Europäischen Patentübereinkommens hat zu einer Unsicherheit bezüglich der Patentierbarkeit von Erfindungen mit finanzwirtschaftlichem Hintergrund am Europäischen Patentamt (EPA) geführt. Der vorliegende Artikel gibt einen Überblick über die geltende Rechtslage in Europa und stellt sie den relevanten Regelungen in den USA gegenüber. In einer empirischen Erhebung werden 1761 Patentanmeldungen am EPA identifiziert, denen eine Erfindung mit finanzwirtschaftlichem Hintergrund zu Grunde liegt. Die Analyse dieser Patente zeigt, dass nur lediglich circa 20 Prozent aller bisher abgeschlossenen Anmeldeverfahren zu einer Patentgewährung geführt haben. Verglichen mit einer durchschnittlichen langfristigen Gewährungsrate von rund 68 Prozent scheint das EPA restriktiv bei der Gewährung von "Finanzpatenten" zu sein. Dieses Ergebnis ist für die Bemühungen um einen neuen regulativen Rahmen zur Vermeidung zukünftiger Finanzmarktkrisen relevant. Eine umfassende Patentierung könnte einer schnellen Verbreitung von aus regulatorischen Gründen gewünschten Methoden im Wege stehen.The imprecise wording of article 52 of the European Patent Convention lead to uncertainty with regard to the patentability of inventions related to financial methods and processes at the European Patent Office (EPO). This article summarizes the relevant legislation in Europe and contrasts it with the legislation in the US. In the empirical part of the paper, 1,761 EPO patent applications based on inventions related to financial methods and processes are identified. The analysis of those patent applications demonstrates that only 20 Prozent of the completed application procedures led to a final patent grant. Compared to an overall grant rate of about 68 Prozent at the EPO this finding highlights that the EPO pursues a restrictive approach towards the award of "financial patents". This finding bears relevance for the future design of a regulatory framework for the financial industry: Widespread patenting could hinder fast diffusion of financial innovation and hamper regulators' efforts to implement them

Search for Electroweak Production of Single Top Quarks in ppbar Collisions

We present a search for electroweak production of single top quarks in the electron+jets and muon+jets decay channels. The measurements use ~90 pb^-1 of data from Run 1 of the Fermilab Tevatron collider, collected at 1.8 TeV with the DZero detector between 1992 and 1995. We use events that include a tagging muon, implying the presence of a b jet, to set an upper limit at the 95% confidence level on the cross section for the s-channel process ppbar->tb+X of 39 pb. The upper limit for the t-channel process ppbar->tqb+X is 58 pb.Comment: 11 pages, 2 figures. This is the published versio

Search for Top Squark Pair Production in the Dielectron Channel

This report describes the first search for top squark pair production in the channel stop_1 stopbar_1 -> b bbar chargino_1 chargino_1 -> ee+jets+MEt using 74.9 +- 8.9 pb^-1 of data collected using the D0 detector. A 95% confidence level upper limit on sigma*B is presented. The limit is above the theoretical expectation for sigma*B for this process, but does show the sensitivity of the current D0 data set to a particular topology for new physics.Comment: Five pages, including three figures, submitted to PRD Brief Report

Limits on Anomalous WWgamma and WWZ Couplings

Limits on the anomalous WWgamma and WWZ couplings are presented from a simultaneous fit to the data samples of three gauge boson pair final states in pbar-p collisions at sqrt(s)=1.8 TeV: Wgamma production with the W boson decaying to enu or munu, W boson pair production with both of the W bosons decaying to enu or munu, and WW or WZ production with one W boson decaying to enu and the other W boson or the Z boson decaying to two jets. Assuming identical WWgamma and WWZ couplings, 95 % C.L. limits on the anomalous couplings of -0.30<Delta kappa<0.43 (lambda = 0) and -0.20<lambda<0.20 (Delta kappa = 0) are obtained using a form factor scale Lambda = 2.0 TeV. Limits found under other assumptions on the relationship between the WWgamma and WWZ couplings are also presented.Comment: 13 pages, 3 figures, submitted to Physical Review