41 research outputs found
Thermal stability of copper nitride thin films: The role of nitrogen migration
The atomic composition, structural, morphological, and optical properties of N-rich copper nitride thin films have been investigated prior to and after annealing them in vacuum at temperatures up to 300 °C. Films were characterized by means of ion-beam analysis (IBMA), X-ray diffraction (XRD), atomic force microscopy (AFM), and spectroscopic ellipsometry techniques (SE). The data reveal that even when the total (integrated over the whole thickness) atomic composition of the films remains constant, nitrogen starts to migrate from the bulk to the film surface, without out-diffusing, at temperatures as low as 100 °C. This migration leads to two chemical phases with different atomic concentration of nitrogen, lattice parameters, and crystallographic orientation but with the same crystal structure. XRD experimental and Rietveld refined data seem to confirm that nitrogen excess accommodates in interstitial locations within the anti-ReO3 crystal lattice forming a solid solution. The influence of nitrogen migration on the optical (electronic) properties of the films will be discusse
Potential common radiation problems for components and diagnostics in future magnetic and inertial confinement fusion devices
This work aims at identifying common potential problems that future fusion devices will encounter for both magnetic (MC) and inertial (IC) confinement approaches in order to promote joint efforts and to avoid duplication of research
High thyrotropin is critical for cardiac electrical remodeling and arrhythmia vulnerability in hypothyroidism
Background: Hypothyroidism, the most common endocrine disease, induces cardiac electrical remodeling that creates a substrate for ventricular arrhythmias. Recent studies report that high thyrotropin (TSH) levels are related to cardiac electrical abnormalities and increased mortality rates. The aim of the present work was to investigate the direct effects of TSH on the heart and its possible causative role in the increased incidence of arrhythmia in hypothyroidism. Methods: A new rat model of central hypothyroidism (low TSH levels) was created and characterized together with the classical propylthiouracil-induced primary hypothyroidism model (high TSH levels). Electrocardiograms were recorded in vivo, and ionic currents were recorded from isolated ventricular myocytes in vitro by the patch-clamp technique. Protein and mRNA were measured by Western blot and quantitative reverse transcription polymerase chain reaction in rat and human cardiac myocytes. Adult human action potentials were simulated in silico to incorporate the experimentally observed changes. Results: Both primary and central hypothyroidism models increased the L-type Ca2+ current (ICa-L) and decreased the ultra-rapid delayed rectifier K+ current (IKur) densities. However, only primary but not central hypothyroidism showed electrocardiographic repolarization abnormalities and increased ventricular arrhythmia incidence during caffeine/dobutamine challenge. These changes were paralleled by a decrease in the density of the transient outward K+ current (Ito) in cardiomyocytes from animals with primary but not central hypothyroidism. In vitro treatment with TSH for 24 hours enhanced isoproterenol-induced spontaneous activity in control ventricular cells and diminished Ito density in cardiomyocytes from control and central but not primary hypothyroidism animals. In human myocytes, TSH decreased the expression of KCND3 and KCNQ1, Ito, and the delayed rectifier K+ current (IKs) encoding proteins in a protein kinase A–dependent way. Transposing the changes produced by hypothyroidism and TSH to a computer model of human ventricular action potential resulted in enhanced occurrence of early afterdepolarizations and arrhythmia mostly in primary hypothyroidism, especially under b-adrenergic stimulation. Conclusions: The results suggest that suppression of repolarizing K+ currents by TSH underlies most of the electrical remodeling observed in hypothyroidism. This work demonstrates that the activation of the TSHreceptor/protein kinase A pathway in the heart is responsible for the cardiac electrical remodeling and arrhythmia generation seen in hypothyroidism.Fil: Fernandez Ruocco, Maria Julieta. Universidade Federal do Rio de Janeiro; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; ArgentinaFil: Gallego, Monica. Universidad del País Vasco; EspañaFil: Rodriguez de Yurre, Ainhoa. Universidade Federal do Rio de Janeiro; Brasil. Universidad del País Vasco; EspañaFil: Zayas Arrabal, Julian. Universidad del País Vasco; EspañaFil: Echeazarra, Leyre. Universidade Federal do Rio de Janeiro; BrasilFil: Alquiza, Amaia. Universidad del País Vasco; EspañaFil: Fernández López, Victor. Universidad del País Vasco; EspañaFil: Rodriguez Robledo, Juan M.. Universidad del País Vasco; EspañaFil: Brito, Oscar. Instituto Nacional de Cardiologia; BrasilFil: Schleier, Ygor. Universidade Federal do Rio de Janeiro; BrasilFil: Sepúlveda, Marisa Noemí. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; ArgentinaFil: Oshiyama, Natalia F.. University of Campinas. Center for Biomedical Engineering; BrasilFil: Vila Petroff, Martin Gerarde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani". Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Cardiovasculares "Dr. Horacio Eugenio Cingolani"; ArgentinaFil: Bassani, Rosana A.. University of Campinas. Center for Biomedical Engineering; BrasilFil: Medei, Emiliano H.. Universidade Federal do Rio de Janeiro; BrasilFil: Casis, Oscar. Universidad del País Vasco; Españ
Galaxies Going Bananas: Inferring the 3D Geometry of High-Redshift Galaxies with JWST-CEERS
The 3D geometry of high-redshift galaxies remains poorly understood. We build
a differentiable Bayesian model and use Hamiltonian Monte Carlo to efficiently
and robustly infer the 3D shapes of star-forming galaxies in JWST-CEERS
observations with at . We reproduce
previous results from HST-CANDELS in a fraction of the computing time and
constrain the mean ellipticity, triaxiality, size and covariances with samples
as small as galaxies. We find high 3D ellipticities for all
mass-redshift bins suggesting oblate (disky) or prolate (elongated) geometries.
We break that degeneracy by constraining the mean triaxiality to be for
dwarfs at (favoring the prolate scenario),
with significantly lower triaxialities for higher masses and lower redshifts
indicating the emergence of disks. The prolate population traces out a
``banana'' in the projected diagram with an excess of low ,
large galaxies. The dwarf prolate fraction rises from at
to at . If these are disks, they cannot be
axisymmetric but instead must be unusually oval (triaxial) unlike local
circular disks. We simultaneously constrain the 3D size-mass relation and its
dependence on 3D geometry. High-probability prolate and oblate candidates show
remarkably similar S\'ersic indices (), non-parametric morphological
properties and specific star formation rates. Both tend to be visually
classified as disks or irregular but edge-on oblate candidates show more dust
attenuation. We discuss selection effects, follow-up prospects and theoretical
implications.Comment: Submitted to ApJ, main body is 35 pages of which ~half are full-page
figures, comments welcom
The Lyman Continuum Escape Fraction of Star-forming Galaxies at from UVCANDELS
The UltraViolet Imaging of the Cosmic Assembly Near-infrared Deep
Extragalactic Legacy Survey Fields (UVCANDELS) survey is a Hubble Space
Telescope (HST) Cycle-26 Treasury Program, allocated in total 164 orbits of
primary Wide-Field Camera 3 Ultraviolet and Visible light F275W imaging with
coordinated parallel Advanced Camera for Surveys F435W imaging, on four of the
five premier extragalactic survey fields: GOODS-N, GOODS-S, EGS, and COSMOS. We
introduce this survey by presenting a thorough search for galaxies at
that leak significant Lyman continuum (LyC) radiation, as well as
a stringent constraint on the LyC escape fraction () from stacking
the UV images of a population of star-forming galaxies with secure redshifts.
Our extensive search for LyC emission and stacking analysis benefit from the
catalogs of high-quality spectroscopic redshifts compiled from archival
ground-based data and HST slitless spectroscopy, carefully vetted by dedicated
visual inspection efforts. We report a sample of five galaxies as individual
LyC leaker candidates, showing estimated
using detailed Monte Carlo analysis of intergalactic medium attenuation. We
develop a robust stacking method to apply to five samples of in total 85
non-detection galaxies in the redshift range of . Most stacks
give tight 2- upper limits below . A stack
for a subset of 32 emission-line galaxies shows tentative LyC leakage detected
at 2.9-, indicating at ,
supporting the key role of such galaxies in contributing to the cosmic
reionization and maintaining the UV ionization background. These new F275W and
F435W imaging mosaics from UVCANDELS have been made publicly available on the
Barbara A. Mikulski Archive for Space Telescopes.Comment: 33 pages, 21 figures, and 5 tables. Resubmitted after addressing the
referee repor
Nephrocalcinosis in a patient with complete distal renal tubular acidosis.
Sección: Image en MedicineA 35-year-old patient, diagnosed with distal renal tubular
acidosis (dRTA), presented with metabolic acidosis (pH =7.1)
together with hypokalaemia (2.8 meq/l), hyperlipidaemia and
renal insuffi ciency (creatinine clearance = 60.8 ml/min). A 24 h
urine examination showed an alkaline pH (7.5), hypercalciuria,
hyperkaliuria hypocitraturia (1, 2 ,3). The patient was treated
with potassium, citrate supplements and simvastatin . A typical
renal colic occurred and an image study revealed considerable
bilateral nephrocalcinosis, radio-opaque lithiasis in the left distal
lumbar ureter and the right mid lumbar ureter with severe left
ureter-hydronephrosis. Ureteroscopy and laser lithotripsy of left
lumbar fragments were performed, continuing with the medical
treatment (4).Ye