Pengaruh Ekstrak Tanaman Putri Malu (Mimosa Pudica Linn) terhadap Penurunan Kadar Glukosa Darah pada Mencit (Mus Musculus)

The research aim is to determine the effect of mimosa plant (mimosa pudica Linn) to reduce blood sugar levels in mice and determining the effective concentration of mimosa plant extracts as an alternative to decrease blood sugar levels. The extract is produced by the infusion method. The animal test used is male mice with amount 18 mice that induced by EDTA (ethylene diamine tetraacetic acid). Mice are divided into 6 groups randomly with different treatment. The group I, II, III and IV were given the mimosa plant extract with a concentration of 10, 20, 30, and 40% (w/v) respectively while group V is given glibenclamide suspension as positive control (+) and group VI is given Na-CMC 1% as negative control (-). Data were analyzed using the statistical test analysis of variance (ANOVA) and then followed by Duncan test. The results showed that the mimosa plant extract contains flavonoids, alkaloids, and tannins. In preclinical testing of mimosa plant extract proven to reduce blood sugar levels in mice and the most effective concentration is a concentration of 20% (w/v) with significantly α = 0.05

Curvature sensor utilizing evanescent field propagation via microfibers

In this study, we introduce curvature optical fiber sensor utilizing high sensitivity microfiber having a potential for pipeline monitoring system. The size of standard single mode fibers was narrowed down to different sizes with diameters of 10, 15 and 20 µm. Meanwhile, the up and down tapers were maintained at 2 mm, each, with waist lengths, were fixed at 15 mm, each. In this work, the microfibers with 15 and 20 µm of diameter sizes were able to detect a high bending sensitivity with the response of 3.4 nm/m−1 and 4.92 nm/m−1 by using an optical spectrum analyzer with 0.02 nm of optical resolution. This strategy is beneficial and practical in contrast to the ordinary system of utilizing a couple of hundred km ultrasonic long-range for pipeline monitoring. The proposed design can be permanently conceived in the pipeline to reduce the cost to achieve areas which require rehashed examinations

Analisis Kadar Glukosa pada Nasi Putih dan Nasi Jagung dengan Menggunakan Metode Spektronik 20

Study on the main content of carbohydrates in rice and corn has been done. This study aims to determine the glucose level in a mixture of corn and rice with a certain ratio prior and during storage in a rice cooker. Spectronic 20 was used in this study to measure the absorption wavelength of sample solutions. Samples used in this study were from rice and sweet corn (Zea mays L. Saccharata) in various ratios of 1:0, 0:1, 1:1, 1:2, 2:1, 3:1 and 1:3, and variations in storage of 0, 1, 6, 12, 18, 24, 30, and 36 hours. The results showed that the highest glucose level in corn were of 32.250 ppm within 12 hours storage, and 40.447 ppm in rice for 12 hours storage. The highest level of glucose in mixture of corn and rice for 12 hours storage was 67.546 ppm at a ratio of 1 : 3

Study of single mode tapered fiber-optic interferometer of different waist diameters and its application as a temperature sensor

We have proposed a study on single-mode tapered optical fiber for temperature sensing application. A theoretical analysis and its experimental validation were carried out to study the taper profile for highly sensitive temperature sensor. Experiments were performed to observe a wavelength shift of transmission spectra with different taper profiles. The effects of taper profiles on the sensitivity of the sensor were also investigated. Our results indicate that the tapered fiber-based temperature sensor has sensitivity in the range of 0.01143 to 0.03406 nm/C. The findings also demonstrate that the sensor sensitivity can be adjusted with variation to the taper profile

Passively mode-locked fiber laser by utilizing TTG film on a D-shaped fiber as a saturable absorber

In this paper, we propose a mode-locked fiber laser by utilizing single layer Trivial Transfer Graphene film (TTGF) as a saturable absorber (SA). The SA was deposited on the top of a side-polished D-shaped fiber. The SA was then integrated in the ring cavity configuration, with a clockwise light propagation. Three distinctive 2 m erbium doped fibers (EDFs) those are Metro-Gain15 EDF, Iso-Gain6 EDF and Iso-Gain12 EDF were used as gain media, interchangeable in the experiment. From the results, the Metro-Gain15 EDF gives the most proficient gain medium on generating a passively mode-locked fiber laser. The Metro-Gain15 Erbium doped mode-locked Laser was successfully producing ultrashort pulse with 8 nm spectral band-width, 13 MHz of repetition rate and 915 fs pulse duration. These outcomes demonstrated that TTGF deposited on the D-shaped fiber is a suitable component as an SA to produce a stable output passively mode-locked fiber laser for many optical fiber applications

The discovery and enhanced properties of trichain lipids in lipopolyplex gene delivery systems

The formation of a novel trichain (TC) lipid was discovered when a cationic lipid possessing a terminal hydroxyl group and the helper lipid dioleoyl l-α-phosphatidylethanolamine (DOPE) were formulated as vesicles and stored. Importantly, the transfection efficacies of lipopolyplexes comprised of the TC lipid, a targeting peptide and DNA (LPDs) were found to be higher than when the corresponding dichain (DC) lipid was used. To explore this interesting discovery and determine if this concept can be more generally applied to improve gene delivery efficiencies, the design and synthesis of a series of novel TC cationic lipids and the corresponding DC lipids was undertaken. Transfection efficacies of the LPDs were found to be higher when using the TC lipids compared to the DC analogues, so experiments were carried out to investigate the reasons for this enhancement. Sizing experiments and transmission electron microscopy indicated that there were no major differences in the size and shape of the LPDs prepared using the TC and DC lipids, while circular dichroism spectroscopy showed that the presence of the third acyl chain did not influence the conformation of the DNA within the LPD. In contrast, small angle neutron scattering studies showed a considerable re-arrangement of lipid conformation upon formulation as LPDs, particularly of the TC lipids, while gel electrophoresis studies revealed that the use of a TC lipid in the LPD formulation resulted in enhanced DNA protection properties. Thus, the major enhancement in transfection performance of these novel TC lipids can be attributed to their ability to protect and subsequently release DNA. Importantly, the TC lipids described here highlight a valuable structural template for the generation of gene delivery vectors, based on the use of lipids with three hydrophobic chains

British Association of dermatologists guidelines for biologic therapy for psoriasis 2020 – a rapid update

The overall aim of the guideline is to provide up‐to‐date, evidence‐based recommendations on the use of biologic therapies targeting TNF (adalimumab, etanercept, certolizumab pegol, infliximab), IL12/23p40 (ustekinumab), IL17A (ixekizumab, secukinumab), IL17RA (brodalumab) and IL23p19 (guselkumab, risankizumab, tildrakizumab) in adults, children and young people for the treatment of psoriasis; consideration is given to the specific needs of people with psoriasis and psoriatic arthritis

Microwave-assisted extraction of lipid from fish waste

Processing fish waste for extraction of value added products such as protein, lipid, gelatin, amino acids, collagen and oil has become one of the most intriguing researches due to its valuable properties. In this study the extraction of lipid from sardine fish waste was carried out using microwave-assisted extraction (MAE) and compared with Soxhlets and Hara and Radin methods. A mixture of two organic solvents isopropanol/hexane and distilled water were used for MAE and Hara and Radin methods. Meanwhile, Soxhlet method utilized only hexane as solvent. The results show that the higher yield of lipid 80.5 mg/g was achieved using distilled water in MAE method at 10 min extraction time. Soxhlet extraction method only produced 46.6 mg/g of lipid after 4 hours of extraction time. Lowest yield of lipid was found at 15.8 mg/g using Hara and Radin method. Based on aforementioned results, it can be concluded MAE method is superior compared to the Soxhlet and Hara and Radin methods which make it an attractive route to extract lipid from fish waste