147 research outputs found
The ALTCRISS Project On Board the International Space Station
The Altcriss project aims to perform a long term survey of the radiation environment on board the International Space Station. Measurements are being performed with active and passive devices in different locations and orientations of the Russian segment of the station. The goal is perform a detailed evaluation of the differences in particle fluence and nuclear composition due to different shielding material and attitude of the station. The Sileye-3/Alteino detector is used to identify nuclei up to Iron in the energy range above approximately equal to 60 MeV/n; a number of passive dosimeters (TLDs, CR39) are also placed in the same location of Sileye-3 detector. Polyethylene shielding is periodically interposed in front of the detectors to evaluate the effectiveness of shielding on the nuclear component of the cosmic radiation. The project was submitted to ESA in reply to the AO the Life and Physical Science of 2004 and was begun in December 2005. Dosimeters and data cards are rotated every six months: up to now three launches of dosimeters and data cards have been performed and have been returned with the end expedition 12 and 13
The ALTCRISS project on board the International Space Station
The Altcriss project aims to perform a long term survey of the radiation
environment on board the International Space Station. Measurements are being
performed with active and passive devices in different locations and
orientations of the Russian segment of the station. The goal is to perform a
detailed evaluation of the differences in particle fluence and nuclear
composition due to different shielding material and attitude of the station.
The Sileye-3/Alteino detector is used to identify nuclei up to Iron in the
energy range above 60 MeV/n. Several passive dosimeters (TLDs, CR39) are also
placed in the same location of Sileye-3 detector. Polyethylene shielding is
periodically interposed in front of the detectors to evaluate the effectiveness
of shielding on the nuclear component of the cosmic radiation. The project was
submitted to ESA in reply to the AO in the Life and Physical Science of 2004
and data taking began in December 2005. Dosimeters and data cards are rotated
every six months: up to now three launches of dosimeters and data cards have
been performed and have been returned with the end of expedition 12 and 13.Comment: Accepted for publication on Advances in Space Research
http://dx.doi.org/10.1016/j.asr.2007.04.03
Two years of flight of the Pamela experiment: results and perspectives
PAMELA is a satellite borne experiment designed to study with great accuracy
cosmic rays of galactic, solar, and trapped nature in a wide energy range
(protons: 80 MeV-700 GeV, electrons 50 MeV-400 GeV). Main objective is the
study of the antimatter component: antiprotons (80 MeV-190 GeV), positrons (50
MeV-270 GeV) and search for antinuclei with a precision of the order of
). The experiment, housed on board the Russian Resurs-DK1 satellite,
was launched on June, 2006 in a orbit with an
inclination of 70 degrees. In this work we describe the scientific objectives
and the performance of PAMELA in its first two years of operation. Data on
protons of trapped, secondary and galactic nature - as well as measurements of
the December 2006 Solar Particle Event - are also provided.Comment: To appear on J. Phys. Soc. Jpn. as part of the proceedings of the
International Workshop on Advances in Cosmic Ray Science March, 17-19, 2008
Waseda University, Shinjuku, Tokyo, Japa
Silicon photomultipliers: On ground characterizations and modelling for use in front-end electronics aimed to space-borne experiments
Abstract Silicon Photomultipliers (Si-PM) consist of an array of semiconductor photodiodes joint on the common substrate and operating in limited geiger mode. A new generation of Si-PM is currently under test in INFN Rome Tor Vergata facilities: they consist of a 5625 element, 3 * 3 mm 2 array with an improved light response. These elements have been characterized. Furthermore, a functional model of the Si-PM has been developed to be used in a VLSI development of front-end electronics
A new measurement of the antiproton-to-proton flux ratio up to 100 GeV in the cosmic radiation
A new measurement of the cosmic ray antiproton-to-proton flux ratio between 1
and 100 GeV is presented. The results were obtained with the PAMELA experiment,
which was launched into low-earth orbit on-board the Resurs-DK1 satellite on
June 15th 2006. During 500 days of data collection a total of about 1000
antiprotons have been identified, including 100 above an energy of 20 GeV. The
high-energy results are a ten-fold improvement in statistics with respect to
all previously published data. The data follow the trend expected from
secondary production calculations and significantly constrain contributions
from exotic sources, e.g. dark matter particle annihilations.Comment: 10 pages, 4 figures, 1 tabl
PAMELA results on the cosmic-ray antiproton flux from 60 MeV to 180 GeV in kinetic energy
The satellite-borne experiment PAMELA has been used to make a new measurement
of the cosmic-ray antiproton flux and the antiproton-to-proton flux ratio which
extends previously published measurements down to 60 MeV and up to 180 GeV in
kinetic energy. During 850 days of data acquisition approximately 1500
antiprotons were observed. The measurements are consistent with purely
secondary production of antiprotons in the galaxy. More precise secondary
production models are required for a complete interpretation of the results.Comment: 11 pages, 3 figures, 1 table. Accepted for publication in Physical
Review Letter
Launch of the Space experiment PAMELA
PAMELA is a satellite borne experiment designed to study with great accuracy
cosmic rays of galactic, solar, and trapped nature in a wide energy range
protons: 80 MeV-700 GeV, electrons 50 MeV-400 GeV). Main objective is the study
of the antimatter component: antiprotons (80 MeV-190 GeV), positrons (50
MeV-270 GeV) and search for antimatter with a precision of the order of 10^-8).
The experiment, housed on board the Russian Resurs-DK1 satellite, was launched
on June, 15, 2006 in a 350*600 km orbit with an inclination of 70 degrees. The
detector is composed of a series of scintillator counters arranged at the
extremities of a permanent magnet spectrometer to provide charge,
Time-of-Flight and rigidity information. Lepton/hadron identification is
performed by a Silicon-Tungsten calorimeter and a Neutron detector placed at
the bottom of the device. An Anticounter system is used offline to reject false
triggers coming from the satellite. In self-trigger mode the Calorimeter, the
neutron detector and a shower tail catcher are capable of an independent
measure of the lepton component up to 2 TeV. In this work we describe the
experiment, its scientific objectives and the performance in the first months
after launch.Comment: Accepted for publication on Advances in Space Researc
PAMELA - A Payload for Antimatter Matter Exploration and Light-nuclei Astrophysics
The PAMELA experiment is a satellite-borne apparatus designed to study charged particles in the cosmic radiation with a particular focus on antiparticles. PAMELA is mounted on the Resurs DK1 satellite that was launched from the Baikonur cosmodrome on June 15th 2006. The PAMELA apparatus comprises a time-of-flight system, a magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail catcher scintillator and a neutron detector. The combination of these devices allows antiparticles to be reliably identified from a large background of other charged particles. This paper reviews the design, space qualification and on-ground performance of PAMELA. The in-orbit performance will be discussed in future publications.The PAMELA experiment is a satellite-borne apparatus designed to study charged particles in the cosmic radiation with a particular focus on antiparticles. PAMELA is mounted on the Resurs DK1 satellite that was launched from the Baikonur cosmodrome on June 15th 2006. The PAMELA apparatus comprises a time-of-flight system, a magnetic spectrometer, a silicon-tungsten electromagnetic calorimeter, an anticoincidence system, a shower tail catcher scintillator and a neutron detector. The combination of these devices allows antiparticles to be reliably identified from a large background of other charged particles. This paper reviews the design, space qualification and on-ground performance of PAMELA. The in-orbit performance will be discussed in future publications
LRRK2 Phosphorylates Tubulin-Associated Tau but Not the Free Molecule: LRRK2-Mediated Regulation of the Tau-Tubulin Association and Neurite Outgrowth
Leucine-rich repeat kinase 2 (LRRK2), a large protein kinase containing multi-functional domains, has been identified as the causal molecule for autosomal-dominant Parkinson's disease (PD). In the present study, we demonstrated for the first time that (i) LRRK2 interacts with tau in a tubulin-dependent manner; (ii) LRRK2 directly phosphorylates tubulin-associated tau, but not free tau; (iii) LRRK2 phosphorylates tau at Thr181 as one of the target sites; and (iv) The PD-associated LRRK2 mutations, G2019S and I2020T, elevated the degree of tau-phosphorylation. These results provide direct proof that tau is a physiological substrate for LRRK2. Furthermore, we revealed that LRRK2-mediated phosphorylation of tau reduces its tubulin-binding ability. Our results suggest that LRRK2 plays an important role as a physiological regulator for phosphorylation-mediated dissociation of tau from microtubules, which is an integral aspect of microtubule dynamics essential for neurite outgrowth and axonal transport
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