478 research outputs found

    Study of Indicators Initiatives

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    Framing Korean Complex–Coda Resolution with Optimality Theory

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    Fonotaktika korejskog jezika ne dozvoljava sloĆŸenu kodu, dakle korejski jezik rabi dvije strategije kako bi razbio suglasničke skupine i prilagodio se tom stanju. Prva je strategija ponovno povezivanje – “relinking” (termin koji rabe Choo&O’Grady 2003:58–9), tj. realizacija suglasničke skupine preko granice sloga, a druga je strategija brisanje. Teorija optimalnosti pogodna je da se njome objasni način na koji se rabe ove dvije strategije, ĆĄto je ujedno i tema ovoga rada. Koristeći se već ustanovljenim ograničenjima, ovaj rad nadopunjuje istraĆŸivanja unutar teorije optimalnosti o sličnim fonoloĆĄkim procesima u korejskome tako da se navedeni procesi mogu ujediniti pod jednim rangiranjem ograničenja.Korean phonotactics prohibits complex codas; therefore, the language employs two strategies that allow for the breakup of consonant clusters to conform to this prohibition. These strategies include “relinking” (as used by Choo & O’Grady 2003:58–9), that is, the realization of consonant clusters across syllable boundaries, and deletion. The preference of these strategies fits into an Optimality–Theoretic framework, which this paper explicates. By using well established constraints, this analysis complements OT research on similar phonological processes in Korean so that these processes can be unified under a single constraint ranking

    The self-care for people initiative: the outcome evaluation.

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    To determine the effects of a community-based training programme in self-care on the lay population

    The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing

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    Kinetoplastid parasites—trypanosomes and leishmanias—infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies. Benzoxaborole-based compounds are very promising potential novel anti-trypanosomal therapies, with candidates already in human and animal clinical trials. We investigated the mechanism of action of several benzoxaboroles, including AN7973, an early candidate for veterinary trypanosomosis. In all kinetoplastids, transcription is polycistronic. Individual mRNA 5'-ends are created by trans splicing of a short leader sequence, with coupled polyadenylation of the preceding mRNA. Treatment of Trypanosoma brucei with AN7973 inhibited trans splicing within 1h, as judged by loss of the Y-structure splicing intermediate, reduced levels of mRNA, and accumulation of peri-nuclear granules. Methylation of the spliced leader precursor RNA was not affected, but more prolonged AN7973 treatment caused an increase in S-adenosyl methionine and methylated lysine. Together, the results indicate that mRNA processing is a primary target of AN7973. Polyadenylation is required for kinetoplastid trans splicing, and the EC50 for AN7973 in T. brucei was increased three-fold by over-expression of the T. brucei cleavage and polyadenylation factor CPSF3, identifying CPSF3 as a potential molecular target. Molecular modeling results suggested that inhibition of CPSF3 by AN7973 is feasible. Our results thus chemically validate mRNA processing as a viable drug target in trypanosomes. Several other benzoxaboroles showed metabolomic and splicing effects that were similar to those of AN7973, identifying splicing inhibition as a common mode of action and suggesting that it might be linked to subsequent changes in methylated metabolites. Granule formation, splicing inhibition and resistance after CPSF3 expression did not, however, always correlate and prolonged selection of trypanosomes in AN7973 resulted in only 1.5-fold resistance. It is therefore possible that the modes of action of oxaboroles that target trypanosome mRNA processing might extend beyond CPSF3 inhibition

    Changes in the source and transport mechanism of terrigenous input to the Indian sector of southern ocean during the late quaternary and its palaeoceanographic implications

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    Changes in the terrigenous sediment source and transport mechanisms during the late Quaternary have been investigated using four sediment cores within the Indian sector of Southern Ocean, using the magnetic susceptibility (MS) and sedimentological records. Sediments deposited during the Holocene and other interglacial periods were characterised by low MS, low sand content, reduced ice-rafted detritus (IRD) input and increased illite possibly transported via hydrographic advection from the south. The glacial intervals are characterised by high MS, high sand content, increased IRD input and reduced illite clays, derived from both local as well as Antarctic sources. Significant reduction in clay fraction and illite content during glacials suggests that the erosive and transporting capabilities of the deep and bottom waters could have reduced compared to the interglacial times. The changes in terrigenous influx to this region were significantly influenced by the rhythmic glacial–interglacial fluctuations in bottom circulation and the position of the Polar Front

    Utilização de microeletrodos especĂ­ficos para oxigĂȘnio visando a detecção de sĂ­tios de FBN em plantas e culturas de bactĂ©rias diazotrĂłficas.

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    Microeletrodo. EspĂ©cies vegetais. Micropropagação. BactĂ©rias utilizadas. DifusĂŁo de oxigĂȘnio. Resultados e discussĂŁo. Taxa de difusĂŁo do oxigĂȘnio na ausĂȘncia de membranas biolĂłgicas. Verificação do padrĂŁo de difusĂŁo de oxigĂȘnio em nĂłdulos de soja e feijĂŁo. Concentração de oxigĂȘnio em rtaĂ­zes de cana-de-açĂșcar. Concentração de oxigĂȘnio em raĂ­zes de arroz. Concentração de oxigĂȘnio em pelĂ­culas bacterianas formadas em meios de cultura semi-sĂłlidos.bitstream/CNPAB-2010/27349/1/doc111.pd

    Effectiveness of a community football programme on improving physiological markers of health in a hard-to-reach male population: the role of exercise intensity

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    © 2015 Taylor & Francis. The present study evaluated the effectiveness of participation in recreational football during a community health programme, on physiological markers of health within a hard to reach population. Nine men (Age: 33 ± 9 years, Mass: 75.4 ± 13.7 kg, Height: 1.74 ± 0.07 m and Body Fat: 19 ± 2%) were recruited to participate in the study in collaboration with an English Premier League Football Club. Participants completed the 12-week football-based programme which included two coached football sessions each week. Physiological tests for blood pressure, resting heart rate, cholesterol and an anthropometrical test for body composition were completed at three time points during the study (Weeks – 1, 6 and 12) in an attempt to evaluate the impact of the intervention on health. During each training session, measurements of intensity (%HRmax, identified from the yoyo intermittent level 1 test), duration and rating of perceived exertion were made. The 12-week programme (mean HRmax throughout programme = 75 ± 4% beats min−1; mean RPE throughout programme = 6 ± 1) elicited few changes in physiological markers of health with the only significant change been a decrease in resting heart rate from weeks 6 to 12 (87 ± 22 beats min−1 at week-6, to 72 ± 17 beats min−1; p < 0.05). These data would suggest that the current community football-related health project was not effective in improving physiological markers of health, but was able to maintain their level of health. A lack of improvement may be due to the low intensity of sessions and a lack of coach education for the promotion of sessions that aim to improve health

    Male frequent attenders of general practice and their help seeking preferences

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    Background: Low rates of health service usage by men are commonly linked to masculine values and traditional male gender roles. However, not all men conform to these stereotypical notions of masculinity, with some men choosing to attend health services on a frequent basis, for a variety of different reasons. This study draws upon the accounts of male frequent attenders of the General Practitioner's (GP) surgery, examining their help-seeking preferences and their reasons for choosing services within general practice over other sources of support. Methods: The study extends thematic analysis of interview data from the Self Care in Primary Care study (SCinPC), a large scale multi-method evaluation study of a self care programme delivered to frequent attenders of general practice. Data were collected from 34 semi-structured interviews conducted with men prior to their exposure to the intervention. Results: The ages of interviewed men ranged from 16 to 72 years, and 91% of the sample (n= 31) stated that they had a current health condition. The thematic analysis exposed diverse perspectives within male help-seeking preferences and the decision-making behind men's choice of services. The study also draws attention to the large variation in men's knowledge of available health services, particularly alternatives to general practice. Furthermore, the data revealed some men's lack of confidence in existing alternatives to general practice. Conclusions: The study highlights the complex nature of male help-seeking preferences, and provides evidence that there should be no 'one size fits all' approach to male service provision. It also provides impetus for conducting further studies into this under researched area of interest. © 2011 WPMH GmbH
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