Evaluation of the contribution of fisheries and aquaculture to food security in developing countries

Fish contain important nutrients such as essential fatty acids, iron, zinc, calcium, vitamin A and vitamin C. Production of freshwater fish depends on the strategic application of various management techniques. The demand for fish products has increased beyond the natural supply, resulting in a high pressure on fisheries. Development of aquaculture is necessary for a rapid growth in fish production. A number of constraints hamper the development of aquaculture. Introduction of polyculture technologies in some countries is a way of maximizing production from different levels of the food chain. The roles of women in making fish products available to consumers is frequently over-looked by policy makers. Gender equity in policy-making and management of fisheries and in capacity building is an important issue. Fish production from inland waters and coastal areas can be increased by adopting cage and pen culture systems. Input subsidies and loans to resource poor farmers can boost fish production

On a notion of maps between orbifolds, I. function spaces

This is the first of a series of papers which are devoted to a comprehensive theory of maps between orbifolds. In this paper, we define the maps in the more general context of orbispaces, and establish several basic results concerning the topological structure of the space of such maps. In particular, we show that the space of such maps of C^r-class between smooth orbifolds has a natural Banach orbifold structure if the domain of the map is compact, generalizing the corresponding result in the manifold case. Motivations and applications of the theory come from string theory and the theory of pseudoholomorphic curves in symplectic orbifolds.Comment: Final version, 46 pages. Accepted for publication in Communications in Contemporary Mathematics. A preliminary version of this work is under a different title "A homotopy theory of orbispaces", arXiv: math. AT/010202

Journal Staff

The aluminum–zinc-vacancy (Al Zn −V Zn ) complex is identified as one of the dominant defects in Al-containing n -type ZnO after electron irradiation at room temperature with energies above 0.8 MeV. The complex is energetically favorable over the isolated V Zn , binding more than 90% of the stable V Zn ’s generated by the irradiation. It acts as a deep acceptor with the (0/− ) energy level located at approximately 1 eV above the valence band. Such a complex is concluded to be a defect of crucial and general importance that limits the n -type doping efficiency by complex formation with donors, thereby literally removing the donors, as well as by charge compensation

Variability of Low-ionization Broad Absorption Line Quasars Based on Multi-epoch Spectra from The Sloan Digital Sky Survey

We present absorption variability results for 134 bona fide \mgii\ broad absorption line (BAL) quasars at 0.46~$\lesssim z \lesssim$~2.3 covering days to $\sim$ 10 yr in the rest frame. We use multiple-epoch spectra from the Sloan Digital Sky Survey, which has delivered the largest such BAL-variability sample ever studied. \mgii-BAL identifications and related measurements are compiled and presented in a catalog. We find a remarkable time-dependent asymmetry in EW variation from the sample, such that weakening troughs outnumber strengthening troughs, the first report of such a phenomenon in BAL variability. Our investigations of the sample further reveal that (i) the frequency of BAL variability is significantly lower (typically by a factor of 2) than that from high-ionization BALQSO samples; (ii) \mgii\ BAL absorbers tend to have relatively high optical depths and small covering factors along our line of sight; (iii) there is no significant EW-variability correlation between \mgii\ troughs at different velocities in the same quasar; and (iv) the EW-variability correlation between \mgii\ and \aliii\ BALs is significantly stronger than that between \mgii\ and \civ\ BALs at the same velocities. These observational results can be explained by a combined transverse-motion/ionization-change scenario, where transverse motions likely dominate the strengthening BALs while ionization changes and/or other mechanisms dominate the weakening BALs.Comment: 24 pages, accepted for publication in ApJ

An analytic relation for the thickness of accretion flows

We take the vertical distribution of the radial and azimuthal velocity into account in spherical coordinates, and find that the analytic relation c_{s0}/(v_K \Theta) = [(\gamma -1)/(2\gamma)]^{1/2} is valid for both geometrically thin and thick accretion flows, where c_{s0} is the sound speed on the equatorial plane, v_K is the Keplerian velocity, \Theta is the half-opening angle of the flow, and \gamma is the adiabatic index.Comment: 4 pages, 2 figures, accepted by Science in China Series

Epigallocatechin-3-Gallate Enhances the Therapeutic Effects of Leptomycin B on Human Lung Cancer A549 Cells

Our previous studies have shown Leptomycin B (LMB) is a promising antilung cancer drug. Epigallocatechin-3-gallate (EGCG) has antitumor properties but a debatable clinical application. The objective of this study is to evaluate the combination therapeutic effect of LMB and EGCG and its molecular mechanisms in human lung cancer A549 cells. Increased cytotoxicity was observed in LMB+EGCG-treated cells compared to LMB-treated cells. Elevated ROS was maximized 2 h after treatment, and LMB+EGCG-treated cells had higher ROS levels compared to LMB. N-Acetyl-L-cysteine (NAC) studies confirmed the oxidative role of LMB and/or EGCG treatment. In comparison to the control, CYP3A4, SOD, GPX1, and p21 mRNA expression levels were increased 7.1-, 2.0-, 4.6-, and 13.1-fold in LMB-treated cells, respectively, while survivin was decreased 42.6-fold. Additionally, these increases of CYP3A4, SOD, and GPX1 were significantly reduced, while p21 was significantly increased in LMB+EGCG-treated cells compared to LMB-treated cells. The qRT-PCR results for p21 and survivin were further confirmed by Western blot. Our study first shows that LMB produces ROS and is possibly metabolized by CYP3A4, GPX1, and SOD in A549 cells, and combination treatment of LMB and EGCG augments LMB-induced cytotoxicity through enhanced ROS production and the modulation of drug metabolism and p21/survivin pathways

Prostaglandin E2 Inhibition of IL-27 Production in Murine Dendritic Cells: A Novel Mechanism That Involves IRF1

IL-27, a multifunctional cytokine produced by APCs, antagonizes inflammation by affecting conventional dendritic cells (cDC), inducing IL-10, and promoting development of regulatory Tr1 cells. Although the mechanisms involved in IL-27 induction are well studied, much less is known about the factors that negatively impact IL-27 expression. PGE2, a major immunomodulatory prostanoid, acts as a proinflammatory agent in several models of inflammatory/autoimmune disease, promoting primarily Th17 development and function. In this study, we report on a novel mechanism that promotes the proinflammatory function of PGE2 We showed previously that PGE2 inhibits IL-27 production in murine bone marrow-derived DCs. In this study, we show that, in addition to bone marrow-derived DCs, PGE2 inhibits IL-27 production in macrophages and in splenic cDC, and we identify a novel pathway consisting of signaling through EP2/EP4→induction of cAMP→downregulation of IFN regulatory factor 1 expression and binding to the p28 IFN-stimulated response element site. The inhibitory effect of PGE2 on p28 and irf1 expression does not involve endogenous IFN-β, STAT1, or STAT2, and inhibition of IL-27 does not appear to be mediated through PKA, exchange protein activated by cAMP, PI3K, or MAPKs. We observed similar inhibition of il27p28 expression in vivo in splenic DC following administration of dimethyl PGE2 in conjunction with LPS. Based on the anti-inflammatory role of IL-27 in cDC and through the generation of Tr1 cells, we propose that the PGE2-induced inhibition of IL-27 in activated cDC represents an important additional mechanism for its in vivo proinflammatory functions