237 research outputs found
Tsunami Resonance in Palma Bay and Harbor, Majorca Island, as induced by the 2003 Western Mediterranean Earthquake
ABSTRACT: he tsunami induced by the May 21, 2003, Algerian Boumerde`s-Zemmouri earthquake (moment magnitude Mw=6.9) propagated across the western Mediterranean Basin, thereby causing material damages in some harbors and coastal areas. This was the case in the Balearic Islands and particularly the Palma harbor. Attempts to simulate the 2003 tsunami event found discrepancies between tsunami arrival times and wave amplitude when comparing tide gauge records with results from numerical models. To date, all published model results of the amplitude of the tsunami are underestimations, attributed to numerical limitations due to the lack of high-resolution bathymetry and poor definition of harbor geometry. Other views suggest the nappropriateness of the available seismic source parameterizations and the possible occurrence of submarine landsliding triggered by the earthquake that has not been included in the numerical simulations. In this article we present the results of a numerical study aimed at better understanding the response of the interacting Palma bay and harbor under the impact of the 2003 western Mediterranean tsunami. The transference of the tsunami energy from the generation area to the continental shelf, the bay, and the harbor has been studied and compared with the natural oscillation modes of the bay and harbor water bodies. Our work includes a sensitivity analysis of the source parameterization and the bathymetry grid size for the bay and harbor as a way to explain the discrepancies between simulations and observations. The Palma harbor tide gauge shows that energy from the tsunami concentrated mainly in periods that fitted to the natural modes of oscillations of the bay. Therefore, the significant wave amplification observed inside the harbor, mainly in its northern basin, was generated by a resonance effect induced by Palma bay. The improvement of the bathymetry grid resolution in the bay and harbor domains and the inclusion in the simulations of the exact harbor geometry and internal configuration result in a slight wave-high increment that is much below the wave height recorded in the tide gauge. Our results strongly point to a necessary revision of the tsunami seismic source parameters
N-[3-(2,6-Dimethylanilino)-1-methylbut-2-enylidene]-2,6-dimethylanilinium chloride1
The title salt, C21H27N2
+·Cl− resulted from the condensation between 2,6-dimethylaniline and acetylacetone in acidified ethanol. The bulky cation is stabilized in a β-iminoenamine tautomeric form, and presents a W-shaped conformation. The benzene rings are arranged almost parallel, with a dihedral angle of 6.58 (4)° between the mean planes. Both N—H groups in the cation form strong hydrogen bonds with two symmetry-related chloride anions. The resulting supramolecular structure is a one dimensional polymer running along [001], alternating cations and anions. The π–π interaction observed in the molecule, characterized by a centroid–centroid separation of 4.298 (4) Å, is thus extended to the chains, with separations of 5.222 (4) Å between benzene rings of neighbouring cations in the crystal
Supporting data for the MS identification of distinct transferrin glycopeptide glycoforms and citrullinated peptides associated with inflammation or autoimmunity
This data article presents the results of all the statistical analyses applied to the relative intensities of the detected 2D-DiGE protein spots for each of the 3 performed DiGE experiments. The data reveals specific subsets of protein spots with significant differences between WT and CD38-deficient mice with either Collagen-induced arthritis (CIA), or with chronic inflammation induced by CFA, or under steady-state conditions. This article also shows the MS data analyses that allowed the identification of the protein species which serve to discriminate the different experimental groups used in this study. Moreover, the article presents MS data on the citrullinated peptides linked to specific protein species that were generated in CIA(+) or CFA-treated mice. Lastly, this data article provides MS data on the efficiency of the analyses of the transferrin (Tf) glycopeptide glycosylation pattern in spleen and serum from CIA(+) mice and normal controls. The data supplied in this work is related to the research article entitled "identification of multiple transferrin species in spleen and serum from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with disease activity: the role of CD38" [1]. All mass spectrometry data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with identifiers PRIDE: PXD002644, PRIDE: PXD002643, PRIDE: PXD003183 and PRIDE: PXD003163
A simple but complex enough -SIR type model to be used with COVID-19 real data. Application to the case of Italy
Since the start of the COVID-19 pandemic in China many models have appeared in the literature, trying to simulate its dynamics. Focusing on modeling the biological and sociological mechanisms which influence the disease spread, the basic reference example is the SIR model. However, it is too simple to be able to model those mechanisms (including the three main types of control measures: social distancing, contact tracing and health system measures) to fit real data and to simulate possible future scenarios. A question, then, arises: how much and how do we need to complexify a SIR model? We develop a -SEIHQRD model, which may be the simplest one satisfying the mentioned requirements for arbitrary territories and can be simplified in particular cases. We show its very good performance in the Italian case and study different future scenarios
When the path is never shortest: a reality check on shortest path biocomputation
Shortest path problems are a touchstone for evaluating the computing
performance and functional range of novel computing substrates. Much has been
published in recent years regarding the use of biocomputers to solve minimal
path problems such as route optimisation and labyrinth navigation, but their
outputs are typically difficult to reproduce and somewhat abstract in nature,
suggesting that both experimental design and analysis in the field require
standardising. This chapter details laboratory experimental data which probe
the path finding process in two single-celled protistic model organisms,
Physarum polycephalum and Paramecium caudatum, comprising a shortest path
problem and labyrinth navigation, respectively. The results presented
illustrate several of the key difficulties that are encountered in categorising
biological behaviours in the language of computing, including biological
variability, non-halting operations and adverse reactions to experimental
stimuli. It is concluded that neither organism examined are able to efficiently
or reproducibly solve shortest path problems in the specific experimental
conditions that were tested. Data presented are contextualised with biological
theory and design principles for maximising the usefulness of experimental
biocomputer prototypes.Comment: To appear in: Adamatzky, A (Ed.) Shortest path solvers. From software
to wetware. Springer, 201
Oxidative phosphorylation dysfunction modifies the cell secretome
Mitochondrial oxidative phosphorylation disorders are extremely heterogeneous conditions. Their clinical and genetic variability makes the identification of reliable and specific biomarkers very challenging. Until now, only a few studies have focused on the effect of a defective oxidative phosphorylation functioning on the cell’s secretome, although it could be a promising approach for the identification and pre-selection of potential circulating biomarkers for mitochondrial diseases. Here, we review the insights obtained from secretome studies with regard to oxidative phosphorylation dysfunction, and the biomarkers that appear, so far, to be promising to identify mitochondrial diseases. We propose two new biomarkers to be taken into account in future diagnostic trials
Influence of age on the occurrence of adverse events in rheumatic patients at the onset of biological treatment : Data from the BIOBADASER III register
To assess whether age, at the beginning of biologic treatment, is associated with the time a first adverse event (AE) appears in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), or psoriatic arthritis (PsA). All patients in the BIOBADASER registry diagnosed with RA, AS, and PsA, and classified as young ( 75 years old) at start of biological treatment were included. Factors associated with the appearance of a first AE using adjusted incidence rate ratios (IRR) (Poisson regression) were analyzed. Survival to first AE was studied by Kaplan-Meier analysis and hazard ratios (HR) by Cox regression. 2483 patients were included: 1126 RA, 680 PsA, and 677 AS. Age group stratification was as follows: 63 young, 2127 adults, 237 elderly, and 56 very elderly. Regression model revealed an increased probability of suffering a first AE at age 65 years or older [IRR elderly: 1.42 (CI95% 1.13-1.77)]. Other characteristics associated with AE were female gender, the use of DMARDs, including methotrexate, the presence of comorbidities, and the time of disease duration. Factors that had the greatest impact on survival over a first AE were age > 75 years [HR 1.50 (1.01-2.24)] and female gender [HR 1.42 (1.22-1.64)]. Age at the start of treatment and female gender are key factors associated with the appearance of a first AE with biologics. Other factors related to patient status and treatment were also associated with a first AE in rheumatic patients treated with biologics
TOX3 rs3803662 Polymorphism Is Associated With Breast Cancer Protection In Northeastern Mexican Woman
Introduction: Low penetrance genes are involved in breast cancer (BC) and confer risk for the development of this neoplasia. Different single nucleotide polymorphisms (SNPs) associated with BC have been identified, such as rs3803662 (TOX3), which is related to estrogen receptors in European and African-American women. The contribution of this variant in the Mexican population is unknown. The objective of this study was to evaluate, through a case-control design, the association of the SNP rs3803662 (TOX3), with the risk of BC in women from northeastern Mexico.
Methods: We included 434 cases and 228 controls. Genotyping was carried out using RFLPs. The SPSS 7.0 statistical program was used to determine the gene frequencies, the estimation of the relative risk (Odds ratio [OR]), and the Hardy-Weinberg equilibrium (EHW).
Results: The homocygote (T/T) genotype of the SNP TOX3 rs3803662 was identified as a protective allele for BC (OR: 0.47, 95% CI: 0.29 - 0.78).
Conclusions; The T allele of the SNP rs3803662 can be considered as a protective factor for BC from northeastern Mexico women
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