871 research outputs found
Acute stress affects peripersonal space representation in cortisol stress responders.
Peripersonal space is the representation of the space near the body. It is implemented by a dedicated multisensory-motor network, whose purpose is to predict and plan interactions with the environment, and which can vary depending on environmental circumstances. Here, we investigated the effect on the PPS representation of an experimentally induced stress response and compared it to a control, non-stressful, manipulation. We assessed PPS representation in healthy humans, before and after a stressful manipulation, by quantifying visuotactile interactions as a function of the distance from the body, while monitoring salivary cortisol concentration. While PPS representation was not significantly different between the control and experimental group, a relation between cortisol response and changes in PPS emerged within the experimental group. Participants who showed a cortisol stress response presented enhanced visuotactile integration for stimuli close to the body and reduced for far stimuli. Conversely, individuals with a less pronounced cortisol response showed a reduced difference in visuotactile integration between the near and the far space. In our interpretation, physiological stress resulted in a freezing-like response, where multisensory-motor resources are allocated only to the area immediately surrounding the body
Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists.
N-methyl-D-aspartate receptors (NMDARs) are located in neuronal cell membranes at synaptic and extrasynaptic locations, where they are believed to mediate distinct physiological and pathological processes. Activation of NMDARs requires glutamate and a coagonist whose nature and impact on NMDAR physiology remain elusive. We report that synaptic and extrasynaptic NMDARs are gated by different endogenous coagonists, D-serine and glycine, respectively. The regionalized availability of the coagonists matches the preferential affinity of synaptic NMDARs for D-serine and extrasynaptic NMDARs for glycine. Furthermore, glycine and D-serine inhibit NMDAR surface trafficking in a subunit-dependent manner, which is likely to influence NMDARs subcellular location. Taking advantage of this coagonist segregation, we demonstrate that long-term potentiation and NMDA-induced neurotoxicity rely on synaptic NMDARs only. Conversely, long-term depression requires both synaptic and extrasynaptic receptors. Our observations provide key insights into the operating mode of NMDARs, emphasizing functional distinctions between synaptic and extrasynaptic NMDARs in brain physiology
Results of the minimally invasive coronary artery bypass grafting angiographic patency study
ObjectiveMinimally invasive coronary artery bypass grafting is safe and widely applicable, and may be associated with fewer transfusions and infections, and better recovery than standard coronary artery bypass grafting. However, graft patency rates remain unknown. The Minimally Invasive Coronary Artery Bypass Grafting Patency Study prospectively evaluated angiographic graft patency 6 months after minimally invasive coronary artery bypass grafting.MethodsIn this dual-center study, 91 patients were prospectively enrolled to undergo minimally invasive coronary artery bypass grafting via a 4- to 7-cm left thoracotomy approach. The left internal thoracic artery, the ascending aorta for proximal anastomoses, and all coronary targets were directly accessed without endoscopic or robotic assistance. The study primary outcome was graft patency at 6 months, using 64-slice computed tomography angiography. Secondary outcomes included conversions to sternotomy and major adverse cardiovascular events (Clinical Trial Registration Unique identifier: NCT01334866).ResultsThe mean age of patients was 64 ± 8 years, the mean ejection fraction was 51% ± 11%, and there were 10 female patients (11%) in the study. Surgeries were performed entirely off-pump in 68 patients (76%). Complete revascularization was achieved in all patients, and the median number of grafts was 3. There was no perioperative mortality, no conversion to sternotomy, and 2 reopenings for bleeding. Transfusion occurred in 24 patients (26%). The median length of hospital stay was 4 days, and all patients were followed to 6 months, with no mortality or major adverse cardiovascular events. Six-month computed tomography angiographic graft patency was 92% for all grafts and 100% for left internal thoracic artery grafts.ConclusionsMinimally invasive coronary artery bypass grafting is safe, feasible, and associated with excellent outcomes and graft patency at 6 months post-surgery
Ring closing reaction in diarylethene captured by femtosecond electron crystallography
The photoinduced ring-closing reaction in diarylethene, which serves as a model system for understanding reactive crossings through conical intersections, was directly observed with atomic resolution using femtosecond electron diffraction. Complementary ab initio calculations were also performed. Immediately following photoexcitation, subpicosecond structural changes associated with the formation of an open-ring excited-state intermediate were resolved. The key motion is the rotation of the thiophene rings, which significantly decreases the distance between the reactive carbon atoms prior to ring closing. Subsequently, on the few picosecond time scale, localized torsional motions of the carbon atoms lead to the formation of the closed-ring photoproduct. These direct observations of the molecular motions driving an organic chemical reaction were only made possible through the development of an ultrabright electron source to capture the atomic motions within the limited number of sampling frames and the low data acquisition rate dictated by the intrinsically poor thermal conductivity and limited photoreversibility of organic materials
Exposure to Mass Media and Interpersonal Counseling Has Additive Effects on Exclusive Breastfeeding and Its Psychosocial Determinants Among Vietnamese Mothers
The pathways through which behavior change interventions impact breastfeeding practices have not been well studied. This study aimed to examine: (1) the effects of exposure to mass media and interpersonal counseling on exclusive breastfeeding (EBF) and hypothesized psychosocial determinants (i.e. knowledge, intention, beliefs, social norms, and self-efficacy); and (2) the pathways through which exposure to mass media and interpersonal counseling are associated with EBF. We used survey data from mothers with children\u3c 2 year (n = 2045) from the 2013 process evaluation of Alive & Thrive’s program in Viet Nam. Multiple linear regression analyses and structural equation modeling were used to estimate effects. Exposure to mass media only, interpersonal counseling only, both or neither was 51%, 5%, 19% and 25%, respectively. Exposure to both mass media and interpersonal counseling had additive effects on EBF as well as on related psychosocial factors, compared with no exposure. For example, EBF prevalence was 26.1 percentage points (pp) higher in the group that received interpersonal counseling only, 3.9 pp higher in the mass media group and 31.8 pp higher in the group that received both interventions. As hypothesized, more than 90% of the total effect of the two interventions on EBF was explained by the psychosocial factors measured. Our findings suggest that combining different behavior change interventions leads to greater changes in psychosocial factors, which in turn positively affects breastfeeding behaviors
South Pole Telescope Detections of the Previously Unconfirmed Planck Early SZ Clusters in the Southern Hemisphere
We present South Pole Telescope (SPT) observations of the five galaxy cluster
candidates in the southern hemisphere which were reported as unconfirmed in the
Planck Early Sunyaev-Zel'dovich (ESZ) sample. One cluster candidate, PLCKESZ
G255.62-46.16, is located in the 2500-square-degree SPT SZ survey region and
was reported previously as SPT-CL J0411-4819. For the remaining four
candidates, which are located outside of the SPT SZ survey region, we performed
short, dedicated SPT observations. Each of these four candidates was strongly
detected in maps made from these observations, with signal-to-noise ratios
ranging from 6.3 to 13.8. We have observed these four candidates on the
Magellan-Baade telescope and used these data to estimate cluster redshifts from
the red sequence. Resulting redshifts range from 0.24 to 0.46. We report
measurements of Y_0.75', the integrated Comptonization within a 0.75' radius,
for all five candidates. We also report X-ray luminosities calculated from
ROSAT All-Sky Survey catalog counts, as well as optical and improved SZ
coordinates for each candidate. The combination of SPT SZ measurements, optical
red-sequence measurements, and X-ray luminosity estimates demonstrates that
these five Planck ESZ cluster candidates do indeed correspond to real galaxy
clusters with redshifts and observable properties consistent with the rest of
the ESZ sample.Comment: 7 emulateapj pages, 4 figures, 1 table. Revised to match published
versio
Mass Calibration and Cosmological Analysis of the SPT-SZ Galaxy Cluster Sample Using Velocity Dispersion and X-ray Measurements
We present a velocity dispersion-based mass calibration of the South Pole
Telescope Sunyaev-Zel'dovich effect survey (SPT-SZ) galaxy cluster sample.
Using a homogeneously selected sample of 100 cluster candidates from 720 deg2
of the survey along with 63 velocity dispersion () and 16 X-ray Yx
measurements of sample clusters, we simultaneously calibrate the
mass-observable relation and constrain cosmological parameters. The
calibrations using and Yx are consistent at the level,
with the calibration preferring ~16% higher masses. We use the full
cluster dataset to measure . The
SPT cluster abundance is lower than preferred by either the WMAP9 or
Planck+WMAP9 polarization (WP) data, but assuming the sum of the neutrino
masses is eV, we find the datasets to be consistent at the
1.0 level for WMAP9 and 1.5 for Planck+WP. Allowing for larger
further reconciles the results. When we combine the cluster and
Planck+WP datasets with BAO and SNIa, the preferred cluster masses are
higher than the Yx calibration and higher than the
calibration. Given the scale of these shifts (~44% and ~23% in mass,
respectively), we execute a goodness of fit test; it reveals no tension,
indicating that the best-fit model provides an adequate description of the
data. Using the multi-probe dataset, we measure and
. Within a CDM model we find eV. We present a consistency test of the cosmic growth rate.
Allowing both the growth index and the dark energy equation of state
parameter to vary, we find and ,
demonstrating that the expansion and the growth histories are consistent with a
LCDM model ().Comment: Accepted by ApJ (v2 is accepted version); 17 pages, 6 figure
Optical Spectroscopy and Velocity Dispersions of Galaxy Clusters from the SPT-SZ Survey
We present optical spectroscopy of galaxies in clusters detected through the
Sunyaev-Zel'dovich (SZ) effect with the South Pole Telescope (SPT). We report
our own measurements of spectroscopic cluster redshifts, and velocity
dispersions each calculated with more than member galaxies. This catalog
also includes dispersions of SPT-observed clusters previously reported in
the literature. The majority of the clusters in this paper are SPT-discovered;
of these, most have been previously reported in other SPT cluster catalogs, and
five are reported here as SPT discoveries for the first time. By performing a
resampling analysis of galaxy velocities, we find that unbiased velocity
dispersions can be obtained from a relatively small number of member galaxies
(), but with increased systematic scatter. We use this analysis to
determine statistical confidence intervals that include the effect of
membership selection. We fit scaling relations between the observed cluster
velocity dispersions and mass estimates from SZ and X-ray observables. In both
cases, the results are consistent with the scaling relation between velocity
dispersion and mass expected from dark-matter simulations. We measure a
30% log-normal scatter in dispersion at fixed mass, and a 10%
offset in the normalization of the dispersion-mass relation when compared to
the expectation from simulations, which is within the expected level of
systematic uncertainty.Comment: Accepted to ApJ. 20 pages, 6 figure
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