ETHNOMEDICINAL PLANTS USED BY RAJGOND TRIBES OF HALADKERI VILLAGE IN BIDAR DISTRICT, KARNATAKA, INDIA

Objective: Present work deals with the studies on Ethnomedicinal plants used by Rajgond Tribes of Haladkeri village in Bidar District, Karnataka, IndiaMethods: Field trips were conducted from March to December, 2014 to collect the information on the medicinal plants used in the treatment of different ailments by Rajgond Tribe using the methodology suggested by Jain and Goel.Results: A total of 12 Vaidyas or healers were interviewed and 60 ethno medicinal plants species belonging to 37 families were recorded along with their scientific names, vernacular names, botanical family, parts used and their ethno medicinal significance.Conclusion: Rajgond Tribe of Haladkeri Village in Bidar District is far away from modern medicine even in 21st Century and is known for their unique way of life and disease management. As the majority of people in modern days is much conscious about their health and aware of the side effects of modern drugs, such study of ethnic drugs may turn a useful base in finding out new drug molecules

Nanotechnology and diabetes

Nanotechnology offers sensing technologies that provide more accurate and timely medical information for diagnosing disease, and miniature devices that can administer treatment automatically if required. Some tests such as diabetes blood sugar levels require patients to administer the test themselves to avoid the risk of their blood glucose falling to dangerous levels. Certain users such as children and the elderly may not be able to perform the test properly, timely or without considerable pain. Nanotechnology can now offers new implantable and/or wearable sensing technologies that provide continuous and extremely accurate medical information. In the long run, nanotechnology will clearly open up many routes to treatments and cures for diabetes, as it will for many of the diseases and conditions that currently plague mankind. Nanotechnology offers some new solutions in treating diabetes mellitus. Boxes with nanopores that protect transplanted beta cells from the immune system attack, artificial pancreas and artificial beta cell instead of pancreas transplantation, nanospheres as biodegradable polymeric carriers for oral delivery of insulin are just some of them. The abilities of nanomedicine are huge, and nanotechnology could give medicine an entirely new outlook. Whilst some of these technologies are quite far-fetched, there is evidence that we will see significant advances in the treatment and management of diabetes quite soon. The purpose of this review is to throw more light on the recent advances and impact of nanotechnology on biomedical sciences to cure diabetes

A reliable micro-grid with seamless transition between grid connected and islanded mode for residential community with enhanced power quality

This paper presents a reliable micro-grid for residential community with modified control techniques to achieve enhanced operation during grid connected, islanded and resynchronization mode. The proposed micro-grid is a combination of solar photo-voltaic (PV), battery storage system and locally distributed DG systems with residential local loads. A modified power control technique is developed such that, local load reactive power demand, harmonic currents and load unbalance is compensated by respective residential local DG. However, active power demand of all local residential load is shared between the micro-grid and respective local DG. This control technique also achieves constant active power loading on the micro-grid by supporting additional active power local load demand of respective residential DG. Hence, proposed modified power control technique achieves transient free operation of the micro-grid during residential load disturbances. An additional modified control technique is also developed to achieve seamless transition of micro-grid between grid connected mode and islanded mode. The dynamic performance of this micro-grid during grid connected, islanded and re-synchronization mode under linear and non-linear load variations is verified using real time simulator (RTS)

A Non-catalytic Deep Desulphurization Process using Hydrodynamic Cavitation

A novel approach is developed for desulphurization of fuels or organics without use of catalyst. In this process, organic and aqueous phases are mixed in a predefined manner under ambient conditions and passed through a cavitating device. Vapor cavities formed in the cavitating device are then collapsed which generate (in-situ) oxidizing species which react with the sulphur moiety resulting in the removal of sulphur from the organic phase. In this work, vortex diode was used as a cavitating device. Three organic solvents (n-octane, toluene and n-octanol) containing known amount of a model sulphur compound (thiophene) up to initial concentrations of 500 ppm were used to verify the proposed method. A very high removal of sulphur content to the extent of 100% was demonstrated. The nature of organic phase and the ratio of aqueous to organic phase were found to be the most important process parameters. The results were also verified and substantiated using commercial diesel as a solvent. The developed process has great potential for deep of various organics, in general, and for transportation fuels, in particular

Once weekly alendronate produces a greater decrease in bone resorption than daily risedronate

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Impact of wild prey availability on livestock predation by snow leopards

The fieldwork was supported by Fondation Segré-Whitley Fund for Nature, Conservation Leadership Programme and National Geographic Young Explorer fund. These grants supported K.R.S., Y.V.B. and C.M. Laboratory analysis was supported by the Department of Science and Technology, Government of India. This grant supported U.R., V.C., Y.V.B., K.R.S. and C.M. Data Dryad Repository. (http://dx.doi.org/10.5061/dryad.8p689)An increasing proportion of the world’s poor is rearing livestock today, and the global livestock population is growing. Livestock predation by large carnivores and their retaliatory killing is becoming an economic and conservation concern. A common recommendation for carnivore conservation and for reducing predation on livestock is to increase wild prey populations based on the assumption that the carnivores will consume this alternative food. Livestock predation, however, could either reduce or intensify with increases in wild prey depending on prey choice and trends in carnivore abundance. We show that the extent of livestock predation by the endangered snow leopard Panthera uncia intensifies with increases in the density of wild ungulate prey, and subsequently stabilizes. We found that snow leopard density, estimated at seven sites, was a positive linear function of the density of wild ungulates—the preferred prey—and showed no discernible relationship with livestock density. We also found that modelled livestock predation increased with livestock density. Our results suggest that snow leopard conservation would benefit from an increase in wild ungulates, but that would intensify the problem of livestock predation for pastoralists. The potential benefits of increased wild prey abundance in reducing livestock predation can be overwhelmed by a resultant increase in snow leopard populations. Snow leopard conservation efforts aimed at facilitating increases in wild prey must be accompanied by greater assistance for better livestock protection and offsetting the economic damage caused by carnivores.Publisher PDFPeer reviewe

Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc. The molecular and cellular processes that lead to renal damage and to the heterogeneity of lupus nephritis (LN) are not well understood. We applied single-cell RNA sequencing (scRNA-seq) to renal biopsies from patients with LN and evaluated skin biopsies as a potential source of diagnostic and prognostic markers of renal disease. Type I interferon (IFN)-response signatures in tubular cells and keratinocytes distinguished patients with LN from healthy control subjects. Moreover, a high IFN-response signature and fibrotic signature in tubular cells were each associated with failure to respond to treatment. Analysis of tubular cells from patients with proliferative, membranous and mixed LN indicated pathways relevant to inflammation and fibrosis, which offer insight into their histologic differences. In summary, we applied scRNA-seq to LN to deconstruct its heterogeneity and identify novel targets for personalized approaches to therapy

Estimation of Labetalol Hydrochloride in bulk and formulation by UV-Spectrophotometric Area Under Curve.

The current work was carried out for estimation of labetalol hydrochloride in bulk and pharmaceutical dosage form by utilizing area under curve method (AUC) method .For this purpose the wavelength range 200-400 nm was selected .Distilled Water was used as a solvent throughout the work. The linearity was observed in concentration range 5-25 µg/ml (r2 =0.9788) for the method. The present was found which can be used for routine quality control analysis for spectrophotometric estimation of labetalol hydrochloride in bulk and dosage form. Keywords: Labetalol hydrochloride, Area under curve (AUC), Distilled Water, UV Spectrophotometric

An Analysis of the TRANSITION Study

Funding Information: This study was funded by Novartis . Funding Information: This study was funded by Novartis. The authors thank Tripti Sahu of Novartis Healthcare Pvt. Ltd. for providing medical writing support in accordance with Good Publication Practice (GPP 2022) guidelines (https://www.ismpp.org/gpp-2022). Publisher Copyright: © 2023 The AuthorsBackground: Treatment of patients with heart failure with reduced ejection fraction (HFrEF) and renal dysfunction (RD) is challenging owing to the risk of further deterioration in renal function, especially after acute decompensated HF (ADHF). Methods and Results: We assessed the effect of RD (estimated glomerular filtration rate of ≥30 to <60 mL/min/1.73 m2) on initiation, up-titration, and tolerability of sacubitril/valsartan in hemodynamically stabilized patients with HFrEF admitted for ADHF (RD, n = 476; non-RD, n = 483). At week 10, the target dose of sacubitril/valsartan (97/103 mg twice daily) was achieved by 42% patients in RD subgroup vs 54% in non-RD patients (P < .001). Sacubitril/valsartan was associated with greater estimated glomerular filtration rate improvements in RD subgroup than non-RD (change from baseline least squares mean 4.1 mL/min/1.73 m2, 95% confidence interval 2.2–6.1, P < .001). Cardiac biomarkers improved significantly in both subgroups; however, compared with the RD subgroup, the improvement was greater in those without RD (N-terminal pro-brain natriuretic peptide, −28.6% vs −44.8%, high-sensitivity troponin T −20.3% vs −33.9%) (P < .001). Patients in the RD subgroup compared with those without RD experienced higher rates of hyperkalemia (16.3% vs 6.5%, P < .001), investigator-reported cardiac failure (9.7% vs 5.6%, P = .029), and renal impairment (6.4% vs 2.1%, P = .002). Conclusions: Most patients with HFrEF and concomitant RD hospitalized for ADHF tolerated early initiation of sacubitril/valsartan and showed significant improvements in estimated glomerular filtration rate and cardiac biomarkers. Clinical Trial Registration: NCT02661217.proofepub_ahead_of_prin

Estimation of Nortriptyline hydrochloride in Bulk and Formulation by UV-Spectrophotometric Area Under Curve Method

The simple, precise and accurate UV-Spectrophotometric method has been developed and validated for the estimation of nortriptyline hydrochloride in bulk and dosage form. In that work was carried out for estimation of nortriptyline hydrochloride in bulk and pharmaceutical dosage form by utilizing area under curve (AUC) method. For this purpose the wavelength range 200-400nm was selected. DMSO was used as solvent throughout the work. Linearity was observed in concentration range 5-25µg/ml (R2 =0.996) for the method. The present method was found which can be used for routine quality control analysis for spectrophotometric estimation of Nortriptyline hydrochloride in bulk and dosage form. Keywords: Nortriptyline hydrochloride, Area under curve (AUC), DMSO, UV-Spectrophotometric