A Novel Approach in Constraining Electron Spectra in Blazar Jets: The Case of Markarian 421

We report results from the observations of the well studied TeV blazar Mrk 421 with the Swift and the Suzaku satellites in December 2008. During the observation, Mrk 421 was found in a relatively low activity state, with the corresponding 2-10 keV flux of $3 \times 10^{-10}$ erg/s/cm^2. For the purpose of robust constraining the UV-to-X-ray emission continuum we selected only the data corresponding to truly simultaneous time intervals between Swift and Suzaku, allowing us to obtain a good-quality, broad-band spectrum despite a modest length (0.6 ksec) exposure. We analyzed the spectrum with the parametric forward-fitting SYNCHROTRON model implemented in XSPEC assuming two different representations of the underlying electron energy distribution, both well motivated by the current particle acceleration models: a power-law distribution above the minimum energy $\gamma_{\rm min}$ with an exponential cutoff at the maximum energy $\gamma_{\rm max}$, and a modified ultra-relativistic Maxwellian with an equilibrium energy $\gamma_{\rm eq}$. We found that the latter implies unlikely physical conditions within the blazar zone of Mrk 421. On the other hand, the exponentially moderated power-law electron distribution gives two possible sets of the model parameters: (i) flat spectrum $dN'_e/d\gamma \propto \gamma^{-1.91}$ with low minimum electron energy $\gamma_{\rm min}<10^3$, and (ii) steep spectrum $\propto \gamma^{-2.77}$ with high minimum electron energy $\gamma_{\rm min}\simeq 2\times10^4$. We discuss different interpretations of both possibilities in the context of a diffusive acceleration of electrons at relativistic, sub- or superluminal shocks. We also comment on how exactly the gamma-ray data can be used to discriminate between the proposed different scenarios.Comment: 18 pages, 2 figures; accepted for publication in the Astrophysical Journa

Synthesis, structure and reactivity of Pd and Ir complexes based on new lutidine-derived NHC/phosphine mixed pincer ligands

Coordination studies of new lutidine-derived hybrid NHC/phosphine ligands (CNP) to Pd and Ir have been performed. Treatment of the square-planar [Pd(CNP)Cl](AgCl2) complex 2a with KHMDS produces the selective deprotonation at the CH2P arm of the pincer to yield the pyridine-dearomatised complex 3a. A series of cationic [Ir(CNP)(cod)]+ complexes 4 has been prepared by reaction of the imidazolium salts 1 with Ir(acac)(cod). These derivatives exhibit in the solid state, and in solution, a distorted trigonal bipyramidal structure in which the CNP ligands adopt an unusual C(axial)–N(equatorial)–P(equatorial) coordination mode. Reactions of complexes 4 with CO and H2 yield the carbonyl species 5a(Cl) and 6a(Cl), and the dihydrido derivatives 7, respectively. Furthermore, upon reaction of complex 4b(Br) with base, selective deprotonation at the methylene CH2P arms is observed. The, thus formed, deprotonated Ir complex 8b reacts with H2 in a ligand-assisted process leading to the trihydrido complex 9b, which can also be obtained by reaction of 7b(Cl) with H2 in the presence of KOtBu. Finally, the catalytic activity of Ir–CNP complexes in the hydrogenation of ketones has been briefly assessed.CTQ2013-45011-P, CTQ2016-80814-R and CTQ2014 -51912-RE

A method to measure the mirror reflectivity of a prime focus telescope

We have developed a method to measure the mirror reflectivity of telescopes. While it is relatively easy to measure the local reflectivity of the mirror material, it is not so straightforward to measure the amount of light that it focuses in a spot of a given diameter. Our method is based on the use of a CCD camera that is fixed on the mirror dish structure and observes simultaneously part of the telescope's focal plane and the sky region around its optical axis. A white diffuse reflecting disk of known reflectivity is fixed in the telescopes focal plane. During a typical reflectivity measurement the telescope is directed to a selected star. The CCD camera can see two images of the selected star, one directly and another one as a spot focused by the mirror on the white disk. The ratio of the reflected starlight integrated by the CCD from the white disk to the directly measured one provides a precise result of the product of (mirror area x mirror reflectivity)

Components of genetic counsellor education: A systematic review of the peer-reviewed literature.

The need for appropriately trained genetic counsellors to support genetic healthcare is now acknowledged. However, while programmes for education of genetic counsellors exist in a number of countries, these do not conform to any specific international standards. As genetic techniques, educational standards and professional standards have been evolved, and with increasing mobility of genetic counsellors, it is of great importance to have some comparison of education and training between different countries. This systematic review was conducted to determine the components of educational programmes for genetic counsellors worldwide that have been published in peer-reviewed literature. Databases were searched for studies published in English from 2000 to 2014 related to the topic. We identified 406 potential papers, of these, 11 studies met the inclusion criteria. The findings indicate that, in most cases, the theoretical components of genetic counsellor programmes conform to the recommendations and requirements of relevant professional bodies. However, clinical preparation of genetic counsellors in real-life professional practice settings seems to be less well addressed as this is essential to ensure genetic counsellors are able to provide safe patient care after graduation. Further work to gain agreement internationally on genetic counsellor education is needed

A systematic review of interventions to provide genetics education for primary care

Main themes and categories derived from the analysis. Table showing the main themes and all categories of data included in those themes. (PDF 26 kb

Psychological aspects of pre-symptomatic testing for Machado–Joseph disease and familial amyloid polyneuropathy type I

Machado–Joseph disease [MJD, also spinocerebellar ataxia type 3 (SCA3)] and familial amyloid polyneuropathy type I (FAP-I or ATTR V30M) are neurodegenerative disorders, inherited in an autosomal dominant fashion, which have a high prevalence in Portugal, probably due to a founder effect. MJD and FAP-I are late-onset diseases, with symptoms emerging usually during adulthood. CGPP, which is the national reference centre for these disorders, has a genetic lab that offers diagnostic, pre-symptomatic and prenatal testing and an outpatient clinic to counsel and follow relatives at risk for hereditary ataxias, FAP- I and Huntington disease (HD). The present work is a review of our 10- year experience with psychological counselling of individuals at risk for MJD and FAP-I. Persons at risk for FAP-I may show a better response to pre-symptomatic testing than those who are at risk for MJD and HD because of the availability of liver transplantation, which may improve their health and life expectancy. Psychological well-being and specific distress of MJD and FAP-I test applicants, before undergoing genetic testing (baseline level) and 3 to 6 months after disclosure of test results, have shown a low level of change, both in identified carriers and non-carriers. A major goal of psychological characterization of at-risk individuals for MJD and FAP-I is to determine the factors that influence the uptake of genetic testing