3,883 research outputs found
PI3Kα inhibition reduces obesity in mice
Partial inhibition of PI3K is one of the best-validated and evolutionary conserved manipulations to extend longevity. The best known health beneficial effects of reduced PI3K are related to metabolism and include increased energy expenditure, reduced nutrient storage, and protection from obesity. We have previously shown that a dual chemical inhibitor of the alpha and delta PI3K isoforms (CNIO-PI3Ki) reduces obesity in mice and monkeys, without evident toxic effects after long-term treatment. Here, we dissect the role of the alpha and delta PI3K isoforms by making use of selective inhibitors against PI3Kα (BYL-719 also known as alpelisib) or PI3Kδ (GS-9820 also known as acalisib). Treatment of mice with the above mentioned inhibitors indicated that BYL-719 increases energy expenditure in normal mice and efficiently reduces body weight in obese (ob/ob) mice, whereas these effects were not observed with GS-9820. Of note, the dose of BYL-719 required to reduce obesity was 10x higher than the equivalent dose of CNIO-PI3Ki, which could suggest that simultaneous inhibition of PI3K alpha and delta is more beneficial than single inhibition of the alpha isoform. In summary, we conclude that inhibition of PI3Kα is sufficient to increase energy expenditure and reduce obesity, and suggest that concomitant PI3Kα inhibition could play an auxiliary role
Obstructive Sleep Apnea Detection Methods Based on Heart Rate Variability Analysis: Opportunities for a Future Cinc Challenge
[EN] The effects of sleep-related disorders, such as obstructive sleep apnea (OSA), can be devastating either in children or adults. Misdiagnosis may lead to severe cardiovascular diseases. Besides, OSA consequences are often related to bad job performance, and road accidents. Nowadays, polysomnography (PSG) is still considered the gold standard for OSA diagnosis, but the required facilities are extremely high, thus reducing availability worldwide. For this reason, simpler and cost-effective diagnosing methods have been proposed in the late years. In this regard, the heart rate variability (HRV) has been demonstrated to strongly reflect apnea episodes during sleep. Hence, this work reviews the latest advances in the evaluation of OSA from the HRV perspective to consider its potentialities for a future revisited CinC Challenge.This research has been supported by grants DPI201783952-C3 from MINECO/AEI/FEDER EU, SBPLY/17/180501/000411 from Junta de Comunidades de Castilla-la Mancha and AICO/2019/036 from Generalitat Valenciana. Moreover, Daniele Padovano has held graduate research scholarships from Escuela Polit ' ecnica de Cuenca and Instituto de Tecnolog ' ias Audiovisuales, University of CastillaLa ManchaPadovano, D.; Martinez-Rodrigo, A.; Pastor, JM.; Rieta, JJ.; Alcaraz, R. (2020). Obstructive Sleep Apnea Detection Methods Based on Heart Rate Variability Analysis: Opportunities for a Future Cinc Challenge. IEEE. 1-4. https://doi.org/10.22489/CinC.2020.400S1
Kinematic and kinetic patterns related to free-walking in Parkinson's disease
The aim of this study is to compare the properties of free-walking at a natural pace
between mild Parkinson’s disease (PD) patients during the ON-clinical status and two control groups.
In-shoe pressure-sensitive insoles were used to quantify the temporal and force characteristics of a
5-min free-walking in 11 PD patients, in 16 young healthy controls, and in 12 age-matched healthy
controls. Inferential statistics analyses were performed on the kinematic and kinetic parameters
to compare groups’ performances, whereas feature selection analyses and automatic classification
were used to identify the signature of parkinsonian gait and to assess the performance of group
classification, respectively. Compared to healthy subjects, the PD patients’ gait pattern presented
significant differences in kinematic parameters associated with bilateral coordination but not in
kinetics. Specifically, patients showed an increased variability in double support time, greater gait
asymmetry and phase deviation, and also poorer phase coordination. Feature selection analyses
based on the ReliefF algorithm on the differential parameters in PD patients revealed an effect of
the clinical status, especially true in double support time variability and gait asymmetry. Automatic
classification of PD patients, young and senior subjects confirmed that kinematic predictors produced
a slightly better classification performance than kinetic predictors. Overall, classification accuracy of
groups with a linear discriminant model which included the whole set of features (i.e., demographics
and parameters extracted from the sensors) was 64.1
Wersync: A WEB-BASED PLATFORM FOR DISTRIBUTED MEDIA SYNCHRONIZATION AND SOCIAL INTERACTION
This paper presents Wersync, which is an adaptive and accurate web-based platform that enables distributed media
synchronization and social interaction across remote users. By using Wersync, users can create or join on-going sessions
for concurrently consuming the same media content with other remote users in a synchronized manner. Besides, social
interaction is provided by sharing the navigation control commands and by integrating synchronized text chat
channels. Additionally, two social presence mechanisms have been added to stimulate the participation of external
users in on-going sessions on Wersync. By exclusively relying on standard web-based technologies, this platform
can guarantee cross-network, cross-platform and crossdevice support, which is a key point in the current heterogeneous media delivery ecosystem
Effect of reactive ion beam etching on the photoluminescence of CdTe epitaxial layers
We demonstrated the effect of reactive ion beam etching (RIBE) process on the PL properties of CdTe/sapphire metal organic vapor phase epitaxy layers. At optimum conditions, the RIBE attack does not make significant morphological changes but it results in an increase of the concentration of acceptor impurities. This was revealed by an increase of the overall photoluminescence (PL) intensity and, simultaneously, a decrease of the PL decay time, more important on the low energy side of PL spectrum due to the recombination of carriers in acceptor [email protected]
Electric Field Effect in Ultrathin Films near the Superconductor-Insulator Transition
The effect of an electric field on the conductance of ultrathin films of
metals deposited on substrates coated with a thin layer of amorphous Ge was
investigated. A contribution to the conductance modulation symmetric with
respect to the polarity of the applied electric field was found in regimes in
which there was no sign of glassy behavior. For films with thicknesses that put
them on the insulating side of the superconductor-insulator transition, the
conductance increased with electric field, whereas for films that were becoming
superconducting it decreased. Application of magnetic fields to the latter,
which reduce the transition temperature and ultimately quench
superconductivity, changed the sign of the reponse of the conductance to
electric field back to that found for insulators. We propose that this
symmetric response to capacitive charging is a consequence of changes in the
conductance of the a-Ge layer, and is not a fundamental property of the physics
of the superconductor-insulator transition as previously suggested.Comment: 4 pages text, 4 figure
Scaling behavior of the dipole coupling energy in two-dimensional disordered magnetic nanostructures
Numerical calculations of the average dipole-coupling energy in two-dimensional disordered magnetic nanostructures are
performed as function of the particle coverage . We observe that scales as with an
unusually small exponent --1.0 for coverages
. This behavior is shown to be primarly given by the
contributions of particle pairs at short distances, which is intrinsically
related to the presence of an appreciable degree of disorder. The value of
is found to be sensitive to the magnetic arrangement within the
nanostructure and to the degree of disorder. For large coverages
we obtain with , in agreement
with the straighforward scaling of the dipole coupling as in a periodic
particle setup. Taking into account the effect of single-particle anisotropies,
we show that the scaling exponent can be used as a criterion to distinguish
between weakly interacting () and strongly interacting
() particle ensembles as function of coverage.Comment: accepted for publication in Phys.Rev.
High‐temperature behavior of impurities and dimensionality of the charge transport in unintentionally and tin‐doped indium selenide
A systematic study of the electron transport and shallow impurity distribution in indium selenide above room temperature or after an annealing process is reported by means of far‐infrared‐absorption and Hall‐effect measurements. Evidences are found for the existence of a large concentration of deep levels (1012–1013 cm−2), related to impurities adsorbed to stacking faults in this material. Above room temperature impurities can migrate from those defect zones and then become shallow in the bulk. The subsequent large increase of 3D electrons can change the dimensionality of the electron transport, which in most cases was 2D. The temperature dependence of the resistivity parallel to the c axis can be explained by the observed increase of the 3D electron concentration, whose motion across the layers is limited by stacking‐fault‐related potential barriers. The observed macroscopic resistivity is thus determined by tunneling through those [email protected]
Near-field scanning optical microscopy to study nanometric structural details of LiNbO3 Zn-diffused channel waveguides
A near-field scanning optical microscope (NSOM) is used to perform structural and optical characterization of the surface layer after Zn diffusion in a channel waveguide fabricated on lithium niobate. A theoretical approach has been developed in order to extract refractive index contrast from NSOM optical transmission measurements (illumination configuration). As a result, different solid phases present on the sample surface can be identified, such as ZnO and ZnNb2O6. They appear like submicrometric crystallites aligned along the domain wall direction, whose origin can be ascribed to some strain relaxation mechanism during the annealing process after Zn [email protected]
Data preprocessing workflow for exhaled breath analysis by GC/MS using open sources
© 2020 The Authors. This document is made available under the CC-BY 4.0 license. http://creativecommons.org/licenses/by /4.0/
This document is the Accepted version of a Published Work that appeared in final form in Scientifc Reports. To access the final edited and published work see https://doi.org/10.1038/s41598-020-79014-
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