10 research outputs found
A history of some fruit models in wax and other materials: scientific teaching aids and courtly table decorations
A role for atorvastatin and insulin combination in protecting from liver injury in a model of type 2 diabetes with hyperlipidemia
Non-alcoholic fatty liver disease (NAFLD) is a
major complication linked with the metabolic syndrome
associated with dyslipidemia, inflammation, and oxidative
stress. Impact of type 2 diabetes with hyperlipidemia in
NAFLD has to be established, as well as the utility of
commonly prescribed anti-diabetic and lipid-lowering
agents in improving liver injury markers. Genetic type 2
diabetic Goto–Kakizaki rats were fed with a high-fat diet to
test hepatic effects of type 2 diabetes with hyperlipidemia
and the effect of atorvastatin and insulin, individually and
in combination, in systemic and hepatic inflammatory and
oxidative stress markers. High-fat diet aggravated fasting
glycemia, systemic and liver lipids, and inflammatory and
oxidative stress markers. Individual treatments improved
glycemic and lipid profiles, but failed to improve inflammatory
markers, whereas insulin was able to reduce liver
oxidative stress parameters. Combination of insulin and
atorvastatin further improved glycemic and lipid profiles
and decreased circulating C-reactive protein levels and liver
inflammatory and oxidative stress markers. Insulin and
atorvastatin combination leads to better glycaemic and lipid
profiles and to better protection against liver inflammation
and oxidative stress, giving a superior level of liver
protection in type 2 diabetic with hyperlipidemia