171 research outputs found
Maternal caregivers have confluence of altered cortisol, high reward-driven eating, and worse metabolic health.
Animal models have shown that chronic stress increases cortisol, which contributes to overeating of highly palatable food, increased abdominal fat and lower cortisol reactivity. Few studies in humans have simultaneously examined these trajectories. We examined premenopausal women, either mothers of children with a diagnosis of an autism spectrum disorder (n = 92) or mothers of neurotypical children (n = 91). At baseline and 2-years, we assessed hair cortisol, metabolic health, and reward-based eating. We compared groups cross-sectionally and prospectively, accounting for BMI change. Caregivers, relative to controls, had lower cumulative hair cortisol at each time point, with no decreases over time. Caregivers also had stable levels of poor metabolic functioning and greater reward-based eating across both time points, and evidenced increased abdominal fat prospectively (all ps ≤.05), independent of change in BMI. This pattern of findings suggest that individuals under chronic stress, such as caregivers, would benefit from tailored interventions focusing on better regulation of stress and eating in tandem to prevent early onset of metabolic disease, regardless of weight status
Correction: Maternal caregivers have confluence of altered cortisol, high reward-driven eating, and worse metabolic health.
[This corrects the article DOI: 10.1371/journal.pone.0216541.]
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Impact of a nutritional supplement during gestation and early childhood on child salivary cortisol, hair cortisol, and telomere length at 4–6 years of age: a follow-up of a randomized controlled trial
Dysregulation of the stress response can occur early in life and may be affected by nutrition. Our objective was to evaluate the long-term effect of nutritional supplementation during gestation and early childhood on child cortisol and buccal telomere length (a marker of cellular aging) at 4–6 years of age. We conducted a follow-up study of children born to women who participated in a nutritional supplementation trial in Ghana. In one group, a lipid-based nutrient supplement (LNS) was provided to women during gestation and the first 6 months postpartum and to their infants from age 6 to 18 months. The control groups received either iron and folic acid (IFA) during gestation or multiple micronutrients during gestation and the first 6 months postpartum, with no infant supplementation. At age 4–6 years, we measured hair cortisol, buccal telomere length, and salivary cortisol before and after a stressor. Salivary cortisol was available for 364 children across all three trial arms and hair cortisol and telomere length were available for a subset of children (n = 275 and 278, respectively) from the LNS and IFA groups. Telomere length, salivary cortisol, and hair cortisol did not differ by supplementation group. Overall, these findings suggest that nutritional supplementation given during gestation and early childhood does not have an effect on child stress response or chronic stress in children at 4–6 years
Kinematics of charge transfer: Ar^++H2
This is the publisher's version, also available electronically from http://scitation.aip.org/content/aip/journal/jcp/67/6/10.1063/1.435181.Product angular and velocity vector distributions have been measured in a crossed beam experiment for the charge transfer process Ar++H2→Ar+H2 + at relative collision energies of 0.13, 0.48, and 3.44 eV. Charge transfer was found to occur by two distinct mechanisms: (1) a simple electron‐jump mechanism which preserves the quasirectilinear trajectories of the colliding species and which selectively produces H2 + in the vibrational state most nearly resonant with the reactant ion, and (2) an intimate‐collision mechanism which results in large‐angle scattering and which produces H2 + in a broad range of vibrational states
Common marmoset (Callithrix jacchus) personality, subjective well-being, hair cortisol level and AVPR1a, OPRM1, and DAT genotypes
We studied personality, subjective well-being, and hair cortisol level, in common marmosets Callithrix jacchus, a small, cooperatively breeding New World monkey, by examining their associations with one another and genotypes. Subjects were 68 males and 9 females that lived in the RIKEN Center for Life Science Technologies. Personality and subjective well-being were assessed by keeper ratings on two questionnaires, hair samples were obtained to assay cortisol level and buccal swabs were used to assess AVPR1a, OPRM1 and DAT genotypes. Three personality domains—Dominance, Sociability, and Neuroticism—were identified. Consistent with findings in other species, Sociability and Neuroticism were related to higher and lower subjective well-being, respectively. Sociability was also associated with higher hair cortisol levels. The personality domains and hair cortisol levels were heritable and associated with genotypes: the short form of AVPR1a was associated with lower Neuroticism and the AA genotype of the A111T SNP of OPRM1 was related to lower Dominance, lower Neuroticism, and higher hair cortisol level. Some genetic associations were not in directions that one would expect given findings in other species. These findings provide insights into the proximate and ultimate bases of personality in common marmosets, other primates and humans
Potential applications of nanotechnology in thermochemical conversion of microalgal biomass
The rapid decrease in fossil reserves has significantly increased the demand of renewable and sustainable energy fuel resources. Fluctuating fuel prices and significant greenhouse gas (GHG) emission levels have been key impediments associated with the production and utilization of nonrenewable fossil fuels. This has resulted in escalating interests to develop new and improve inexpensive carbon neutral energy technologies to meet future demands. Various process options to produce a variety of biofuels including biodiesel, bioethanol, biohydrogen, bio-oil, and biogas have been explored as an alternative to fossil fuels. The renewable, biodegradable, and nontoxic nature of biofuels make them appealing as alternative fuels. Biofuels can be produced from various renewable resources. Among these renewable resources, algae appear to be promising in delivering sustainable energy options. Algae have a high carbon dioxide (CO2) capturing efficiency, rapid growth rate, high biomass productivity, and the ability to grow in non-potable water. For algal biomass, the two main conversion pathways used to produce biofuel include biochemical and thermochemical conversions. Algal biofuel production is, however, challenged with process scalability for high conversion rates and high energy demands for biomass harvesting. This affects the viable achievement of industrial-scale bioprocess conversion under optimum economy. Although algal biofuels have the potential to provide a sustainable fuel for future, active research aimed at improving upstream and downstream technologies is critical. New technologies and improved systems focused on photobioreactor design, cultivation optimization, culture dewatering, and biofuel production are required to minimize the drawbacks associated with existing methods. Nanotechnology has the potential to address some of the upstream and downstream challenges associated with the development of algal biofuels. It can be applied to improve system design, cultivation, dewatering, biomass characterization, and biofuel conversion. This chapter discusses thermochemical conversion of microalgal biomass with recent advances in the application of nanotechnology to enhance the development of biofuels from algae. Nanotechnology has proven to improve the performance of existing technologies used in thermochemical treatment and conversion of biomass. The different bioprocess aspects, such as reactor design and operation, analytical techniques, and experimental validation of kinetic studies, to provide insights into the application of nanotechnology for enhanced algal biofuel production are addressed
Individual, social, and environmental factors affecting salivary and fecal cortisol levels in captive pied tamarins (Saguinus bicolor)
This is the peer reviewed version of the following article: Price, E., Coleman, R., Ahsmann, J., Glendewar, G., Hunt, J., Smith, T. & Wormell, D. (2019). Individual, social, and environmental factors affecting salivary and fecal cortisol levels in captive pied tamarins (Saguinus bicolor). American Journal of Primatology, 81(8), which has been published in final form at https://doi.org/10.1002/ajp.23033. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-ArchivingPied tamarins (Saguinus bicolor) are endangered New World primates, and in captivity
appear to be very susceptible to stress. We measured cortisol in 214 saliva samples
from 36 tamarins and in 227 fecal samples from 27 tamarins, and investigated
the effects of age, sex, pregnancy, rearing history, social status, weight, group
composition, and enclosure type using generalized linear mixed models. There was no
effect of age on either fecal or salivary cortisol levels. Female pied tamarins in late
pregnancy had higher fecal cortisol levels than those in early pregnancy, or
nonpregnant females, but there was no effect of pregnancy on salivary cortisol.
Females had higher salivary cortisol levels than males, but there was no effect of
rearing history. However, for fecal cortisol, there was an interaction between sex and
rearing history. Hand‐reared tamarins overall had higher fecal cortisol levels, but
while male parent‐reared tamarins had higher levels than females who were parent‐
reared, the reverse was true for hand‐reared individuals. There was a trend towards
lower fecal cortisol levels in subordinate individuals, but no effect of status on
salivary cortisol. Fecal but not salivary cortisol levels declined with increasing weight.
We found little effect of group composition on cortisol levels in either saliva or feces,
suggesting that as long as tamarins are housed socially, the nature of the group is of
less importance. However, animals in off‐show enclosures had higher salivary and
fecal cortisol levels than individuals housed on‐show. We suggest that large on‐show
enclosures with permanent access to off‐exhibit areas may compensate for the
effects of visitor disturbance, and a larger number of tamarins of the same species
housed close together may explain the higher cortisol levels found in tamarins living
in off‐show accommodation, but further research is needed
An Institutional Postdoctoral Research Training Program: Predictors of Publication Rate and Federal Funding Success of Its Graduates
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