Bir devrimci:Muammer Aksoy

Taha Toros Arşivi, Dosya No: 176-Muammer-Erol Akso

The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene

OBJECTIVE: The aim of the present study was to reveal the possible effect of sulforaphane on oxidative stress and inflammation in rats liver with toxic hepatitis induced by acetaminophene. BACKGROUND: Sulforaphane is a compound with high antioxidant properties. Acetaminophen, which is a para-aminophenol derivative, can lead to fatal hepatic necrosis with direct hepatotoxic effects at high doses. METHODS: Thirty six male Sprague-Dawley rats were randomly divided into four groups. Control group (n = 9) was fed with standard rat chow and water for 3 days. Group APAP (n = 9) received a single dose acetaminophen 1 g/kg by oral gavage in addition to standard chow and water. Group SFN (n = 9) received sulforaphane 500 mu g/kg by oral gavage in addition to standard chow and water for 3 days. Group APAP+SFN (n = 9) received sulforaphane 500 mu g/kg and a single dose acetaminophen 1 g/kg by oral gavage in addition to standard chow and water. Acetaminophen was administered three hours after SFN administration. RESULTS: Neopterin, MDA, AST, ALT and CRP levels of group APAP were significantly increased compared to control group. GSH level of group APAP was significantly lower than in the control group. CONCLUSION: Sulforaphane is a protective agent against acetaminophen-induced liver damage and it can be added in the treatment protocol (Tab. 1, Fig. 5, Ref. 51). Text in PDF www.elis.sk

Childhood emotional trauma and cyberbullying perpetration among emerging adults: a multiple mediation model of the role of problematic social media use and psychopathology

Research suggests that a small minority of social media users experience problems as a result of their online use. The purpose of the present study was to examine the association of cyberbullying perpetration and problematic social media use with childhood emotional trauma, Cluster B (narcissistic, histrionic, antisocial, and borderline) personality traits, dissociative experiences (DEs), depression, and self-esteem in a nonclinical undergraduate sample. A total of 344 university students volunteered to complete a questionnaire that included measures on the aforementioned dimensions. Thirty-eight percent of the participants had emotional neglect and 27% had emotional abuse, while 44% of them demonstrated at least one cyberbullying perpetration behavior. Results indicated that cyberbullying perpetrators had higher scores on problematic social media use, dissociative experiences, Cluster B traits, depression and childhood emotional trauma, and lower on self-esteem. Path analysis demonstrated that, while adjusting for gender and age, childhood emotional trauma was directly and indirectly associated with cyberbullying perpetration via Cluster B traits. Moreover, depression and dissociation were directly associated with problematic social media use. The findings of this study emphasize the important direct role of childhood emotional trauma and pathological personality traits on cyberbullying perpetration

Changes in mechanical and morphological properties of AISI 420 stainless steels welded with M42 steel wire Associated with weld cooling medium

Bu çalışmada, AISI 420 martenzitik paslanmaz çeliklere TIG kaynak yöntemiyle Argon gazı korumalı ortamda, 75 amper 45cm/dk kaynak ilerleme hızıyla kaynak dikişleri çekilmiştir. Bu amaç için Ø 50mm çapında ve 2, 3.5, 5 ve 6.5 mm kalınlıklarında disk şeklinde parçalar hazırlanmıştır. 50 mm boyunca kaynak dikişi oluşturulan bu parçaların kaynaktan hemen sonra farklı soğutma sıvılarına daldırılarak oda sıcaklığına kadar soğumaları sağlanmıştır. Deney numunelerinin sertlik ölçümü kaynak dikişinden esas metale doğru gerçekleştirilmiştir. Mikroyapı karakteristikleri ise optik mikroskop, taramalı elektron mikroskobu (SEM) vasıtasıyla incelenmiştir. Sonuç olarak, östenitik yapının yüksek soğuma hızından etkilenerek martenzitik yapıya dönüşmesi gerçekleşmiştir. Bu tür paslanmaz çeliklerin kritik soğuma hızının altında soğutulmaması için uygun tedbirlerin alınması gereklidir.In this study, the method AISI 420 TIG welding of martensitic stainless steels in the protected environment of Ar gas and 75 amps and with a weld speed of 45cm/min was carried out. For this purpose, specimens of Ø 50mm diameter and thickness of 2, 3.5, 5 and 6 mm was sliced. Weld bead was formed along the specimen for about 50mm long and following the welding, specimens were immersed into a different cooling fluids to cool to room temperature. Microhardness measurement was carried out mainly from the base metal towards the weld seam. Microstructural characteristics were investigated by optical microscope, scanning electron microscopy (SEM). As a result, the martensitic transformation of the austenitic structure has been influenced by the high cooling rate. This type of stainless steel must not be cooled below a critical cooling rate and it is necessary to take the appropriate measures

Evaluation of the atorvastatin-induced structural changes in skeletal muscles of rats by light microscope

Çalışmamızda, bir statin türevi olan atorvastatinin sıçan iskelet kasında oluşturduğu yapısal değişikliklerin ışık mikroskobu düzeyinde incelenmesi ve değerlendirilmesi amaçlandı.40 adet erişkin erkek wistar albino rat; biri kontrol ve dokuzu deney grupları olmak üzere 10 eşit gruba bölündü. . Deneyin başlamasından sonra 5. 10. ve 15. günlerde sakrifiye edilen ratların quadriceps femoris kasları ışık mikroskobunda incelendi. Kontrol grubundan elde edilen kasların histopatolojik incelemelerinde herhangi bir yapısal değişikliğe rastlanmazken, diğer 9 deney grubundan elde edilen kas örneklerinde değişen derecelerde histopatolojik bulgular elde edildi. Genel olarak kaslarda dejenerasyon, kontraksiyon, nekroz, bağdoku artışı, mononükleer hücre infiltrasyonu, kas lifleri arasında vakuoler yapılar ve sentral nükleus belirgin artış göstermekteydi. Çalışmamızda bulgularımız, doz ve zaman arttıkça değişikliklerin belirgin olduğu gözlendi. Atorvastatinin iskelet kaslarında göstermiş olduğu toksik etki ile birlikte, klinik açıdan doz ve zaman baz alınarak, hasta tedavilerine ışık tutacağı kanaatine varıldı.In this study we evaluated toxic effects of atorvastatin on the development of muscle necrosis in rats at the light microscopic level .Male, adult 40 Wistar- albino rat used in this study. Rats divided into 10 equal groups as one control, 9 treatment groups. All rats were sacrified after 5th 10th and 15th days of the study.And their quadriceps femoris muscle tissues were examined in light microscopy. In control group there was no histopatologic changes determined on their muscle tissue samples. But on the other hand, in the treatment groups, some histopathologic changes were determined in different degrees. Generally our findings were degenaration, contraction, necrosis, fibrosis in the perimisial area, central nucleus on the muscle tissues. These findings were increased due to the high treatment dose and the long treatment time. Histopathologic changes were increased due to the high treatment dose and the long treatment time. Because of all these reasons, medical doctors will take care about the treatment dose and the long treatment time of the atorvastatin