Radiological evaluation of calcific tendinitis with ıntraosseous migration: a single-center experience

Amaç: Kalsiyum depositlerin kemik, kaslar ve subakromiyal-subdeltoid bursa gibi komşu dokulara göçü, tanısal zorluklara ve gereksiz prosedürlere yol açabilen nadir bir komplikasyondur. Bu çalışmanın amacı, rotator manşet kalsifik tendinitinin nadir görülen intraosseöz migrasyonunu tanımlamak ve bu vakaları demografik özellikler, ilişkili patolojiler ve radyolojik bulgular açısından değerlendirmektir. Gereç ve yöntem: Bu retrospektif çalışma, Ocak 2021 ile Eylül 2024 tarihleri arasında gerçekleştirilmiş ve 3,755 omuz MRG incelemesi gözden geçirilmiştir. Hariç tutulanlar arasında hareket artefaktı olan hastalar, pediatrik vakalar, travma veya cerrahi öyküsü olanlar ve enfeksiyon vakaları yer almıştır. İki radyolog kalsifik tendinit ve intraosseöz migrasyon vakalarını bağımsız olarak değerlendirmiş, bulgular demografik veriler ve ilişkili patolojilerle analiz edilmiştir. Bulgular: 3,000 tarama sonucunda vakaların %8,17'sinde kalsifik tendinit tespit edilmiştir. İntraosseöz komplikasyonlar toplam popülasyonun %0,5’inde ve kalsifik tendinit vakalarının %6,12'sinde gözlenmiştir. Kalsifik tendinit hastalarının çoğunluğu (%73,77) kadın olup, intraosseöz komplikasyonların %86,67’si kadın hastalarda görülmüştür (p=0.211 (Fisher's Exact Test)). İntraosseöz komplikasyonlar, supraspinatus ve infraspinatus tendonlarının daha yüksek tutulma oranlarıyla ilişkilendirilmiştir (%73'er), komplikasyonu olmayan hastalarda ise bu oranlar sırasıyla %63 ve %36 olarak gözlenmiştir (p<0.001). Sonuç: Kalsifik tendinit, nadir görülen intraosseöz uzanımlar gösterebilir ve doğru tanı için dikkatli görüntüleme gerektirir. MRG ve BT, bu vakaların tanısında kritik bir rol oynar. Tedavi edilmeyen vakalarda komplikasyonlar devam ederken, ultrason rehberliğinde yapılan enjeksiyon tedavisi etkili sonuçlar vermektedir. Kalsifik tendinit, görüntülemede tümörleri taklit edebileceğinden doğru ayırıcı tanı gereklidir. İntraosseöz komplikasyonların erken teşhisi ve uygun tedavisi esastır. Gelecekteki çalışmalar, daha geniş popülasyonlar ve uzun dönem takiplerle prognoz ve tedavi sonuçlarını daha iyi değerlendirmelidir.Purpose: Migration of calcific deposits into adjacent tissues, such as bones, muscles, and the subacromial-subdeltoid bursa, is a rare complication that can lead to diagnostic challenges and unnecessary procedures. This study aims to describe the uncommon intraosseous migration of rotator cuff calcific tendinitis and evaluate these cases concerning demographic characteristics, associated pathologies, and radiological findings. Materials and methods: This retrospective study, conducted between January 2021 and September 2024, reviewed 3.755 shoulder MRI scans. Exclusions included motion artifacts, pediatric cases, trauma or surgery history, and infections. Two radiologists independently evaluated cases of calcific tendinitis and intraosseous migration, analyzing findings against demographic data and related pathologies. Results: Out of 3.000 scans, calcific tendinitis was found in 8.17% of cases. Intraosseous complications occurred in 0.5% of the total population and 6.12% of tendinitis cases. Most calcific tendinitis patients (73.77%) were female, with 86.67% of intraosseous cases being women (p=0.211 (Fisher's Exact Test)). The supraspinatus tendon was most frequently affected (63% of cases), with effusion being the most common pathology (55%). Intraosseous complications showed higher involvement of the supraspinatus and infraspinatus tendons (73% each) compared to patients without complications (63% and 36%, p<0.001). Conclusion: Calcific tendinitis can present rare intraosseous extensions, requiring careful imaging for accurate diagnosis. MRI and CT play crucial roles in identifying these cases. Untreated cases show persistent complications, while ultrasound-guided injections provide effective treatment. Proper differential diagnosis is necessary as calcific tendinitis may mimic tumors. Early diagnosis and appropriate treatment of intraosseous complications are essential. Future studies should explore larger populations and long-term follow-up for better evaluation of prognosis and outcomes

Phytochemical profiling by UHPLC–ESI–MS/MS, in vitro antioxidant, in vivo antidiabetic, and pro-sexual effects of salvia balansae noë ex coss. flower extract in diabetic male rats

Our study assessed the phytochemical composition and the effects of Salvia balansae flower aqueous extract (FAE) on sexual dysfunction in diabetic rats. Total phenolic and flavonoid content, quantification of phytochemicals by ultrahigh performance liquid chromatography (UHPLC)-electrospray ionization (ESI)-tandem mass spectrometry (MS/MS) method, and in vitro antioxidant capacity of FAE extract were elucidated. For the in vivo study, diabetes was induced by one intraperitoneal injection of streptozotocin (STZ) (40 mg/kg), and treated diabetic rats were given FAE at 200 mg/kg. Rats were subjected to a sexual incentive motivation test (SIM) and a mating behavior test, and then serum testosterone levels and sperm quality were analyzed. Our study indicates that FAE contained a large amount of phenolic compounds and flavonoids, and 13 constituents were quantified; cynaroside (3.8 mg analyte/g extract) was the main compound, followed by rosmarinic acid (3.145 mg analyte/g extract), thus confirming its high antioxidant capacity. FAE treatment significantly reduced blood glucose levels, improved sexual motivation and copulatory behavior, increased testosterone levels, and enhanced sperm quality in diabetic-treated rats compared to diabetic untreated rats. The present work demonstrates the therapeutic potential of S. balansae flowers in enhancing reproductive function in diabetic rats, potentially through its antioxidant, antihyperglycemic, and aphrodisiac properties

GAMIFICATION AND GAME-BASED LEARNING IN MATHEMATICS EDUCATION FOR ADVANCING SDG 4: A SYSTEMATIC REVIEW AND QUALITATIVE SYNTHESIS OF CONTEMPORARY RESEARCH LITERATURE

Objectives: This study investigates how gamification and game-based learning (GBL) contribute to advancing Sustainable Development Goal 4 (SDG 4) by fostering inclusive, equitable, and high-quality education in mathematics. Theoretical Framework: The research draws on constructivist theories, Self-Determination Theory, and Flow Theory to understand the mechanisms through which educational games enhance learning outcomes. Method: A systematic qualitative synthesis was conducted, analyzing studies published between 2010 and 2023 across databases like ERIC, PsycINFO, and Scopus. Key themes were identified through thematic coding, supported by the CASP qualitative checklist for rigor. Results and Discussion: Findings indicate that gamification improves student engagement, motivation, and achievement. Gamification elements such as points and badges significantly enhance learning experiences. Emerging technologies like VR and AI further amplify the effectiveness of game-based approaches. However, challenges remain in addressing equity in technology access and aligning games with curricula. Research Implications: This review underscores the potential of gamification to support SDG 4 by promoting lifelong learning skills, reducing educational disparities, and fostering inclusivity. Teacher training and policy reforms are critical to scale these approaches effectively. Originality/Value: This research synthesizes contemporary findings to highlight the transformative role of gamification in mathematics education, emphasizing its alignment with the global agenda for sustainable and equitable education. © 2025, Editora Alumni In. All rights reserved

Numerical Solution of the Rosenau-KdV-RLW equation via combination of a polynomial scaling function collocation and finite difference method

In this paper, we established a polynomial scaling method to investigate the numerical solution of Rosenau-Korteweg De Vries-regularized long wave (Rosenau-KdV-RLW) equation. We start with discretization of the time variable of the equation using a finite difference approach equipped with a linearization. After the time discretization, we have used polynomial scaling functions for the discretization of the spatial variable. These two discretizations give us the desired discrete system of equations to obtain numerical solutions. We further derive an error estimate for the proposed method. We have applied the proposed method to Rosenau-KdV, Rosenau-RLW, and Rosenau-KdV-RLW equations and used error norms to examine the accuracy and reliability of the presented method. Also, to enhance accuracy of the results, we utilize Richardson extrapolation. The comparisons with the analytical solution and earlier studies that use different methods indicate that the proposed method is accurate and reliable.No fund is received for this work. The authors would like to thank to anonymous reviewers for their precious time and suggestions toward improving the paper

Evaluation of risk factors associated with epicardial fat tissue thickness in patients with stage 4 and stage 5 chronic kidney disease

Purpose: Chronic kidney disease (CKD) is a global public health issue, often associated with high mortality and morbidity, especially due to cardiovascular diseases. Epicardial adipose tissue (EAT), the visceral fat surrounding the heart, has been recognized as a significant factor in cardiovascular risk. This study aims to assess the relationship between EAT and body composition in patients with stage 4 and 5 CKD using bioelectrical impedance analysis (BIA). Methods: The study included 80 patients with stage 4 and 5 CKD who were not on dialysis. Body composition was measured using BIA, and EAT was assessed using transthoracic echocardiography(ECHO). Exclusion criteria included heart failure, morbid obesity, pregnancy, and pacemaker use, among others. Various demographic, clinical, and biochemical parameters were also recorded. Results: Patients with stage 5 CKD (6.7 ± 0.12) had significantly higher EAT compared to stage 4 CKD (5.9 ± 0.09) patients. EAT showed a positive correlation with age, BMI, blood pressure, C-reactive protein (CRP), and triglyceride levels, and a negative correlation with albumin and HDL levels. Multivariate analysis revealed that increased systolic blood pressure(SBP)(p:0.019),fat tissue mass (FTM)(p < 0.001), low HDL(p: 0.027), and low albumin(p < 0.001) were independent predictors of EAT. Conclusion: EAT is higher in advanced CKD patients and is associated with several cardiovascular risk factors. Measuring EAT in CKD patients using non-invasive methods like ECHO could be valuable in predicting cardiovascular risks. Addressing the factors that contribute to increased EAT may improve clinical outcomes for CKD patients. © The Author(s), under exclusive licence to Springer Nature B.V. 2025

Ability of CHA2DS2-VASc/R2CHA2DS2-VASc Scores to Predict Complications Related to Cardiac Implantable Electronic Devices

Background: Globally, the number of cardiac implantable electronic devices (CIEDs) is increasing. In our study, we aimed to investigate whether CHA2DS2-VASc and R2CHA2DS2-VASc scores are predictive of CIED-related complications. Methods: Our investigation was carried out with a multicenter retrospective design. Patients who underwent CIED surgery at two cardiac centers in Turkey between January 2011 and May 2023, 1676, were evaluated. The patients were divided into two groups according to their R2CHA2DS2-VASc scores. Patients with R2CHA2DS2-VASc ≥ 5 were included in group 1 (380 patients), and patients with R2CHA2DS2-VASc < 5 (1296 patients) were included in group 2. The primary outcome was defined as the cumulative events. Each component of cumulative events, such as hematoma, pericardial effusion, pneumothorax, and infection, was also defined as a secondary outcome. Results: The study's patient population had an average age of 62.9 ± 14 years. Pneumothorax (1.8% vs. 1.3%, p = 0.444), pericardial effusion or tamponade (0.35% vs. 0.2%, p = 0.659), and clinically significant hematoma (1.1% vs. 0.6%, p = 0.376) were comparable between the groups. Infection-related devices and cumulative events classified as primary outcomes were higher in the R2CHA2DS2-VASc ≥ 5 group (6.1% vs. 1.2%, p < 0.001; 7.6% vs. 3.2%, p < 0.001, respectively). Modeling analyses showed that the CHA2DS2-VASc score and HT were also independent predictors of device-related infection and cumulative events. Conclusion: In the R2CHA2DS2-VASc ≥ 5 groups, infection related to the device system and cumulative events were higher. Patients with an R2CHA2DS2-VASc score of 5 or more and a high CHA2DS2-VASc score should be evaluated more carefully regarding infection and cumulative events before and after the operation. © 2025 Wiley Periodicals LLC

A comparative study on magnetic solid phase extraction and magnetic colloidal gel based-dispersive solid phase extraction methods for preconcentration of carmoisine (E 122) in food samples

Magnetic solid phase extraction (M-SPE) and magnetic colloidal gel based-dispersive solid phase extraction (MCG-dSPE) methods have been developed with the Fe3O4@XAD-16 magnetic nanoparticle for preconcentration carmosine in some food samples. The effects of some parameters on preconcentration of carmoisine were investigated such as pH, amount of magnetic nanoparticle, volume of deep eutectic solvent (DES), type of desorption solvent, vortex time (for adsorption and desorption), sample volume and extraction time for both methods. Then, the recovery results of carmoisine for both methods were compared and satisfactory recoveries were obtained from the MCG-dSPE method. Under the optimum conditions for the MCG-dSPE method, the limit of detection (LOD) and limit of quantification (LOQ), preconcentration factor (PF) and enhancement factor (EF) were calculated as 0.86 mu g L-1 and 2.89 mu g L-1, 100, 103, respectively. All results showed that the developed method is a fast and good technique that can be applied to real samples for the determination of carmoisine

Separation of Line Widths of HOD Peaks of Healthy and Diseased Blood and Urine Groups Using 400 MHz NMR

Line width studies of high field nuclear magnetic resonance (NMR) peaks have been seen more frequently in the recent literature. This study aims to compare the NMR line widths of HOD peaks of healthy and diseased blood, and densely bloody cysts taken from the jaw. Comparisons of HOD peak line widths in healthy and diseased urine were also made. For this purpose, the blood, serum, and urine of 29 cancer patients, 17 diabetic patients, 28 healthy volunteers, and 20 intensely bloody samples from jaw cysts were collected. Mixtures were prepared by adding the 0.02-mL sample to 0.98 mL D2O. Single-pulse proton NMR measurements were performed at 400 MHz, and line widths were obtained from the half-height of the blood HOD peak. Statistical evaluations show that the line width of cancerous blood is different from normal blood (P = 0.032), while the line width of diabetic blood is not different (p = 0.072), whereas other groups and bloody jaw cysts are completely different (p < 0.05). Similar results were found for urine groups. Line widths show a moderate correlation with each of the albumin and total protein groups (R around 0,56). Present data suggest that a comparison of healthy and diseased body fluids can be made by line width measurements of the HOD peak in the high NMR field. Data also suggest that the relaxivities of albumin (Ser-Alb), total protein (Ser-TP) are potential diagnostic indicators for cancerous blood

Öğretmenlerin Düştüğü Zaman Tuzakları Ölçeği: Geçerlik ve Güvenirlik Çalışması

The aim of this study is to develop a valid and reliable scale to measure the time traps teachers fall into during the teaching-learning process. The sample consists of 234 final-year students continuing their education at the Faculty of Education in the first implementation and 233 pedagogical formation students in the second implementation. Expert opinion was sought for content and face validity of the scale, and exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were applied for construct validity. For reliability analysis, Cronbach's Alpha internal consistency, Spearman-Brown, and Guttmann split-half coefficients were calculated, and corrected item-total correlations were used for item analysis. In the first implementation, six items with low factor loadings were removed from the 50-item scale as a result of EFA. It was determined that the remaining items had sufficient factor loadings, were unidimensional, and explained 39.3% of the variance. After EFA, the Cronbach's Alpha internal consistency coefficient was found to be .96, Spearman-Brown and Guttmann split-half coefficients were calculated as .91, and the corrected item-total correlations ranged from .34 to .75. Following CFA, 21 items remained in the scale, and the fit indices for the unidimensional structure were within the recommended limits. After CFA, the Cronbach's Alpha internal consistency coefficient was found to be .91, Spearman-Brown and Guttmann split-half coefficients were calculated as .85, and the corrected item-total correlations ranged from .37 to .73.Bu araştırmanın amacı, öğrenme-öğretme sürecinde öğretmenlerin düştüğü zaman tuzaklarını ölçmeye yönelik geçerli ve güvenilir bir ölçek geliştirmektir. Örneklem, birinci uygulamada eğitim fakültesinde öğrenimine devam eden 234 son sınıf öğrencisi ve ikinci uygulamada 233 pedagojik formasyon öğrencisinden oluşmaktadır. Ölçeğin kapsam ve görünüş geçerliği için uzman görüşüne başvurulmuş, yapı geçerliği için açımlayıcı faktör analizi (AFA) ve doğrulayıcı faktör analizi (DFA) uygulanmıştır. Güvenirlik analizi için Cronbach Alfa iç tutarlık, Spearman Brown, Gutmann split-half katsayısı hesaplanmış ve madde analizi için düzeltilmiş madde toplam korelasyonlarından yararlanılmıştır. İlk uygulamada 50 maddeden oluşan ölçekten, AFA sonucunda faktör yükü düşük olan altı madde çıkarılmıştır. Kalan maddelerin yeterli faktör yüküne sahip, tek boyutlu bir yapıda olduğu ve açıklanan varyansın %39.3 olduğu belirlenmiştir. AFA sonrası Cronbach Alfa iç tutarlık katsayısı .96, Spearman-Brown ve Guttman split-half katsayıları .91 olarak hesaplanmış, düzeltilmiş madde toplam korelasyonlarının .34 ile .75 arasında değiştiği ortaya çıkmıştır. DFA sonucunda, ölçekte 21 madde kalmış ve tek boyutlu yapıya ilişkin uyum indekslerinin önerilen sınırlar içerisinde kaldığı belirlenmiştir. DFA sonrası Cronbach Alfa iç tutarlık katsayısı .91, Spearman-Brown ve Guttman split-half katsayıları .85 olarak hesaplanmış, düzeltilmiş madde toplam korelasyonlarının .37 ile .73 arasında değiştiği ortaya çıkmıştır

Evaluation of the effect of 9.5/11.5-fr ureteral access sheath use on acute kidney injury with the myo-inositol oxygenase biomarker in patients undergoing retrograde intrarenal surgery: a prospective, randomized, and controlled study

IntroductionWe aimed to investigate whether a low intrarenal pressure provided by ureteral access sheath (UAS) use had a positive effect on the prevention of acute kidney injury through the evaluation of the myo-inositol oxygenase (MIOX).Material and methodsThe patients were divided into two groups according to whether a 9.5/11.5-Fr UAS was used during retrograde intrarenal surgery (RIRS): UAS group and non-UAS group. RIRS was performed under gravity irrigation and manual pumping was not used. For the measurement of MIOX, 5 cc blood samples were taken from the patients preoperatively and four hours postoperatively.ResultsOperation time and hospital stay were significantly longer in the UAS group. The mean preoperative and postoperative MIOX values were 0.77 +/- 0.36 ng/ml and 0.74 +/- 0.38 ng/ml, respectively, in the UAS group, and 0.74 +/- 0.31 ng/ml and 0.83 +/- 0.40 ng/ml, respectively, in the non-UAS group. The mean MIOX change was -0.29 +/- 0.36 in the UAS group and 0.08 +/- 0.44 in the non-UAS group, indicating no significant difference between the groups.ConclusionEven if UAS is not used, significant acute kidney injury is not observed under gravity irrigation and therefore, if we avoid manual pumping, the intrarenal pressure remains low, thus potentially rendering the use of 9,5/11,5-Fr UAS unnecessary